Jonathan J Molina, Kurt N Kohler, Christopher Gager, Marissa J Andersen, Ellsa Wongso, Elizabeth R Lucas, Andrew Paik, Wei Xu, Deborah L Donahue, Karla Bergeron, Aleksandra Klim, Michael G Caparon, Scott J Hultgren, Alana Desai, Victoria A Ploplis, Matthew J Flick, Francis J Castellino, Ana L Flores-Mireles
Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections. Catheter-induced inflammation promotes fibrinogen (Fg) and fibrin accumulation in the bladder which are exploited as a biofilm formation platform by CAUTI pathogens...
March 27, 2024: Nature Communications