keyword
https://read.qxmd.com/read/38544627/unusual-presentation-of-corynebacterium-endocarditis-in-a-patient-without-conventional-risk-factors-a-case-report
#1
Abbas Mohammadi, Dima Youssef, Ashkan Mohammadi
Infective endocarditis (IE) is a widespread condition marked by the infection of native or prosthetic heart valves, the endocardial surface, or an indwelling cardiac device. While native-valve IE is uncommon, patients with IE represent a diverse spectrum. Some respond well to treatment with few complications, while others face severe complications and an increased risk of mortality. Various factors contribute to this outcome, including delayed diagnosis, underlying health conditions like immunocompromised status or chronic diseases, and intravenous drug use...
February 2024: Curēus
https://read.qxmd.com/read/38544616/unveiling-ureaplasma-a-case-report-of-a-rare-culprit-in-pyelonephritis
#2
Manish Shrestha, Devi Parvathy Jyothi Ramachandran Nair, Shefali Amin, Arpan Pokhrel, Salina Munankami
Ureaplasma species, typically considered commensal organisms of the human urogenital tract, have been implicated in various urinary tract infections (UTIs), including the rare and challenging presentation of pyelonephritis. This case report describes a unique instance of pyelonephritis induced by Ureaplasma , characterized by a negative routine urine culture and a lack of response to empirical antibiotic treatment, highlighting the complexities associated with diagnosing and managing infections caused by atypical pathogens...
February 2024: Curēus
https://read.qxmd.com/read/38542416/robust-fluorometric-aptamer-assay-for-direct-and-rapid-detection-of-clinical-isolates-of-candida-spec
#3
JOURNAL ARTICLE
Yiting Zhang, Hu Xing, Grigory Bolotnikov, Markus Krämer, Anil Bozdogan, Ann-Kathrin Kissmann, Tanja Weil, Barbara Spellerberg, Steffen Stenger, Frank Rosenau
Infections caused by yeasts of the genus Candida are likely to occur not only in immunocompromised patients but also in healthy individuals, leading to infections of the gastrointestinal tract, urinary tract, and respiratory tract. Due to the rapid increase in the frequency of reported Candidiasis cases in recent years, diagnostic research has become the subject of many studies, and therefore, we developed a polyclonal aptamer library-based fluorometric assay with high specificity and affinity towards Candida spec...
March 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542357/infectious-and-commensal-bacteria-in-rheumatoid-arthritis-role-in-the-outset-and-progression-of-the-disease
#4
REVIEW
Aleksandra Korzeniowska, Ewa Bryl
Rheumatoid arthritis (RA) is a chronic, autoimmune disease with a complex outset. Besides the genetic susceptibility in its pathogenesis, various environmental factors also participate. Of these, in recent years, there have been increasing reports of the involvement of bacteria in the disease's outset and development, especially gut microbiota and oral pathogens. Most recent reports about bacteria participation in RA pathogenesis focus on Prevotella copri and Porphyromonas gingivalis . There are also reports about the involvement of respiratory and urinary tract pathogens...
March 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541241/unravelling-the-antimicrobial-antibiofilm-suppressing-fibronectin-binding-protein-a-fnba-and-cna-virulence-genes-anti-inflammatory-and-antioxidant-potential-of-biosynthesized-solanum-lycopersicum-silver-nanoparticles
#5
JOURNAL ARTICLE
Alsayed E Mekky, Ahmed E M Abdelaziz, Fady Sayed Youssef, Shymaa A Elaskary, Aly A Shoun, Eman A Alwaleed, Mahmoud Ali Gaber, Abdulaziz A Al-Askar, Alhadary M Alsamman, Abdullah Yousef, Gehad AbdElgayed, Reda A Suef, Mohamed A Selim, Ebrahim Saied, Mohamed Khedr
Background and Objectives : Urinary tract infections [UTIs] are considered the third most known risk of infection in human health around the world. There is increasing appreciation for the pathogenicity of Gram-positive and Gram-negative strains in UTIs, aside from fungal infection, as they have numerous virulence factors. Materials and Methods : In this study, fifty urine samples were collected from patients suffering from UTI. Among the isolates of UTI microbes, six isolates were described as MDR isolates after an antibiotic susceptibility test carried out using ten different antibiotics...
March 21, 2024: Medicina
https://read.qxmd.com/read/38539119/promiscuous-persistent-and-problematic-insights-into-current-enterococcal-genomics-to-guide-therapeutic-strategy
#6
REVIEW
David Hourigan, Ewelina Stefanovic, Colin Hill, R Paul Ross
Vancomycin-resistant enterococci (VRE) are major opportunistic pathogens and the causative agents of serious diseases, such as urinary tract infections and endocarditis. VRE strains mainly include species of Enterococcus faecium and E. faecalis which can colonise the gastrointestinal tract (GIT) of patients and, following growth and persistence in the gut, can transfer to blood resulting in systemic dissemination in the body. Advancements in genomics have revealed that hospital-associated VRE strains are characterised by increased numbers of mobile genetic elements, higher numbers of antibiotic resistance genes and often lack active CRISPR-Cas systems...
March 28, 2024: BMC Microbiology
https://read.qxmd.com/read/38538626/fibrinolytic-deficiencies-predispose-hosts-to-septicemia-from-a-catheter-associated-uti
#7
JOURNAL ARTICLE
Jonathan J Molina, Kurt N Kohler, Christopher Gager, Marissa J Andersen, Ellsa Wongso, Elizabeth R Lucas, Andrew Paik, Wei Xu, Deborah L Donahue, Karla Bergeron, Aleksandra Klim, Michael G Caparon, Scott J Hultgren, Alana Desai, Victoria A Ploplis, Matthew J Flick, Francis J Castellino, Ana L Flores-Mireles
Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections. Catheter-induced inflammation promotes fibrinogen (Fg) and fibrin accumulation in the bladder which are exploited as a biofilm formation platform by CAUTI pathogens...
March 27, 2024: Nature Communications
https://read.qxmd.com/read/38537707/prevalence-of-antimicrobial-use-and-healthcare-associated-infections-in-the-uae-results-from-the-first-nationwide-point-prevalence-survey
#8
JOURNAL ARTICLE
Najiba Abdulrazzaq, Ayman Chkhis
OBJECTIVES: The WHO's Global Antimicrobial Resistance Surveillance System (GLASS) 2017-2018 reported a significant increase in antimicrobial resistance among nosocomial pathogens. This was the first national point of prevalence survey in United Arab Emirates. METHODS: A one-day multicenter cross-sectional survey using a unified web-based platform was conducted in forty-four hospitals across the country from 3 to 23 November 2019 to estimate the prevalence of antimicrobial use and healthcare-associated infections among both governmental and private sectors...
March 25, 2024: Infectious diseases now
https://read.qxmd.com/read/38537577/epidemiology-and-microbiology-of-catheter-associated-urinary-tract-infections-a-14-year-surveillance-study-at-a-tertiary-care-center-in-lebanon
#9
JOURNAL ARTICLE
Abdel Hadi Shmoury, Wael Hanna, Johnny Zakhour, Nada Kara Zahreddine, Souha S Kanj
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) are the most common device-associated healthcare-acquired infections and pose a significant burden on patients and healthcare systems worldwide. However, there is a paucity of data on CAUTI epidemiology and microbiology in the Middle East and North Africa (MENA) region, including Lebanon. METHODS: This 14-year retrospective cohort study was conducted at a tertiary care center in Lebanon. It analyzed data on all adult patients diagnosed with CAUTI between January 2009 and December 2022 in intensive care units (ICUs) and between June 2011 and December 2022 in regular units...
March 22, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38535596/the-influence-of-l-lysine-alpha-oxidase-on-the-biofilm-formation-of-opportunistic-microorganisms-associated-with-inflammatory-diseases-of-the-urinary-tract
#10
JOURNAL ARTICLE
Alexandr Senyagin, Nadezhda Sachivkina, Milana Das, Anna Arsenyuk, Ramziya Mannapova, Alfir Mannapov, Tursumbai Kubatbekov, Dmitriy Svistunov, Olesya Petrukhina, Andrey Zharov, Natallia Zhabo
Urinary tract infections occupy a special niche among diseases of infectious etiology. Many microorganisms associated with urinary tract infections, such as Klebsiella oxytoca , Enterococcus spp., Morganella morganii , Moraxella catarrhalis , Pseudomonas aeruginosa , Proteus mirabilis , Staphylococcus aureus , Staphylococcus spp., and Candida spp., can form biofilms. The aim of this research was to study the effect of the enzyme L-lysine-Alpha-oxidase (LO) produced by the fungus Trichoderma harzianum Rifai on the biofilm formation process of microorganisms associated with urinary tract infections...
March 15, 2024: Pathogens
https://read.qxmd.com/read/38535544/pathogens-causing-pediatric-community-acquired-urinary-tract-infections-and-their-increasing-antimicrobial-resistance-a-nationwide-study
#11
JOURNAL ARTICLE
Vered Shkalim Zemer, Shai Ashkenazi, Yoel Levinsky, Yael Richenberg, Eyal Jacobson, Shay Nathanson, Tzippy Shochat, Shiri Kushnir, Moriya Cohen, Avner Herman Cohen
Urinary tract infections (UTIs) in childhood are common and are associated with considerable acute morbidity and long-term complications. The need for updated data to optimize empiric antibiotic therapy is crucial. We aimed to investigate the pathogens causing pediatric community acquired UTIs, their correlation with demographic characteristics, and trends in their antimicrobial resistance. This nationwide cross-sectional study included all 53,203 children (<18 years) diagnosed with UTI in community outpatient clinics in the following selected years: 2007, 2011, 2015, 2019 and 2021...
February 24, 2024: Pathogens
https://read.qxmd.com/read/38534652/decline-in-esbl-production-and-carbapenem-resistance-in-urinary-tract-infections-among-key-bacterial-species-during-the-covid-19-pandemic
#12
JOURNAL ARTICLE
Ibraheem Altamimi, Khalifa Binkhamis, Abdullah Alhumimidi, Ibrahim M Alabdulkarim, Abdulrahman Almugren, Hadi Alhemsi, Abdulaziz Altamimi, Abeer Almazyed, Seham Elbih, Razan Alghunaim, Abdullah Altamimi
The COVID-19 pandemic has led to significant changes in healthcare practices, including increased antibiotic usage. This study aimed to investigate the impact of the pandemic on the prevalence of extended-spectrum β-lactamase (ESBL) production and carbapenem resistance among key bacterial species causing urinary tract infections (UTIs). Conducted at King Fahad Medical City in Riyadh from January 2018 to December 2022, the study analyzed urine samples from 9697 UTI patients. Patients were categorized into 'pre-COVID-19' and 'during COVID-19' groups...
February 26, 2024: Antibiotics
https://read.qxmd.com/read/38534115/-proteus-mirabilis-urer-coordinates-cellular-functions-required-for-urease-activity
#13
JOURNAL ARTICLE
Madison J Fitzgerald, Melanie M Pearson, Harry L T Mobley
UNLABELLED: A hallmark of Proteus mirabilis infection of the urinary tract is the formation of stones. The ability to induce urinary stone formation requires urease, a nickel metalloenzyme that hydrolyzes urea. This reaction produces ammonia as a byproduct, which can serve as a nitrogen source and weak base that raises the local pH. The resulting alkalinity induces the precipitation of ions to form stones. Transcriptional regulator UreR activates expression of urease genes in a urea-dependent manner...
March 27, 2024: Journal of Bacteriology
https://read.qxmd.com/read/38534100/plant-phenolics-inhibit-focal-adhesion-kinase-and-suppress-host-cell-invasion-by-uropathogenic-escherichia-coli
#14
JOURNAL ARTICLE
Adam J Lewis, Amanda C Richards, Alejandra A Mendez, Bijaya K Dhakal, Tiffani A Jones, Jamie L Sundsbak, Danelle S Eto, Alexis A Rousek, Matthew A Mulvey
Traditional folk treatments for the prevention and management of urinary tract infections (UTIs) and other infectious diseases often include plants and plant extracts that are rich in phenolic compounds. These have been ascribed a variety of activities, including inhibition of bacterial interactions with host cells. Here, we tested a panel of four well-studied phenolic compounds-caffeic acid phenethyl ester (CAPE), resveratrol, catechin, and epigallocatechin gallate-for the effects on host cell adherence and invasion by uropathogenic Escherichia coli (UPEC)...
March 27, 2024: Infection and Immunity
https://read.qxmd.com/read/38530950/machine-learning-assistant-colorimetric-sensor-arrays-for-intelligent-and-rapid-diagnosis-of-urinary-tract-infection
#15
JOURNAL ARTICLE
Jianyu Yang, Ge Li, Shihong Chen, Xiaozhi Su, Dong Xu, Yueming Zhai, Yuhang Liu, Guangxuan Hu, Chunxian Guo, Hong Bin Yang, Luigi G Occhipinti, Fang Xin Hu
Urinary tract infections (UTIs), which can lead to pyelonephritis, urosepsis, and even death, are among the most prevalent infectious diseases worldwide, with a notable increase in treatment costs due to the emergence of drug-resistant pathogens. Current diagnostic strategies for UTIs, such as urine culture and flow cytometry, require time-consuming protocols and expensive equipment. We present here a machine learning-assisted colorimetric sensor array based on recognition of ligand-functionalized Fe single-atom nanozymes (SANs) for the identification of microorganisms at the order, genus, and species levels...
March 26, 2024: ACS Sensors
https://read.qxmd.com/read/38529069/isolation-and-characterization-of-cholera-toxin-gene-positive-vibrio-cholerae-non-o1-non-o139-isolated-from-urinary-tract-infection-a-case-report
#16
Reem Aljindan, Reema Allahham, Rana Alghamdi, Ibrahim Alhabib, Samia AlNassri, Wala Alkhalifa, Asim Diab, Amer Alomar, Lamya Yamani, Nasreldin Elhadi
BACKGROUND: Urinary tract infection (UTI) caused by V. cholerae is rare and less common. V. cholerae is a Gram-negative bacterium motile using single polar flagellum and, originally, is a waterborne microbe found in aquatic and estuarine environments. Toxigenic V. cholerae is well-known as a causative agent of acute and excessive watery diarrhea after ingesting food and water contaminated with this bacterium. CASE PRESENTATION: A 27-year-old male patient presented to the emergency department on 17th July 2021 with burning micturition, normal vital signs, and no fever, vomiting, or diarrhea...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38526818/therapeutic-effects-of-orally-administration-of-viable-and-inactivated-probiotic-strains-against-murine-urinary-tract-infection
#17
REVIEW
Vo Thi Hong Van, Zhen-Shu Liu, Yueh-Jen Hsieh, Wei-Chen Shiu, Bo-Yuan Chen, Yu-We Ku, Po-Wen Chen
Urinary tract infections (UTIs) are highly prevalent bacterial infections that pose significant health risks. Specific probiotic strains have been recommended for UTI control and management of antibiotic resistance. Otherwise, para-probiotics, defined as inactivated probiotic cells, offer potential advantages by minimizing risks associated with live microorganisms. However, the effectiveness of heat-killed probiotic strains against UTIs remains uncertain. Additionally, lactoferrin (LF), an iron-binding glycoprotein, exhibits immunomodulatory, antimicrobial, and anti-inflammatory properties...
December 15, 2023: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38525539/regulation-of-renal-aquaporin-water-channels-in-acute-pyelonephritis
#18
JOURNAL ARTICLE
Christina V Ernstsen, Marianna Ranieri, Frédéric H Login, Isra K Mahmoud, Jacob R Therkildsen, Giovanna Valenti, Helle Praetorius, Rikke Nørregaard, Lene N Nejsum
Acute pyelonephritis (APN) is most frequently caused by uropathogenic Escherichia coli (UPEC), which ascends from the bladder to the kidneys during a urinary tract infection. Patients with APN have been reported to have reduced renal concentration capacity under challenged conditions, polyuria and increased aquaporin-2 (AQP2) excretion in the urine. We have recently shown increased AQP2 accumulation in the plasma membrane in cell cultures exposed to E. coli lysates and in the apical plasma membrane of inner medullary collecting ducts in a 5-day APN mouse model...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38525477/mechanisms-of-antibiotic-resistance-and-developments-in-therapeutic-strategies-to-combat-klebsiella-pneumoniae-infection
#19
REVIEW
Yanping Li, Suresh Kumar, Lihu Zhang
Infections with drug-resistant bacteria have become one of the greatest public health challenges, and K. pneumoniae is among the top six drug-resistant bacteria. K. pneumoniae often causes nosocomial infections, leading to illnesses such as pneumonia, liver abscesses, soft tissue infections, urinary tract infections, bacteremia, and in some cases death. As the pathogen continues to evolve and its multidrug resistance increases, K. pneumoniae poses a direct threat to humans. Drug resistance in K. pneumoniae may occur due to the formation of biofilms, efflux pumps, and the production of β-lactamases...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38525078/characterization-of-es10-lytic-bacteriophage-isolated-from-hospital-waste-against-multidrug-resistant-uropathogenic-e-coli
#20
JOURNAL ARTICLE
Aneela Nawaz, Sabeena Zafar, Abdulrahman H Alessa, Nauman Ahmed Khalid, Muqaddas Shahzadi, Alina Majid, Malik Badshah, Aamer Ali Shah, Samiullah Khan
Escherichia coli is the major causative agent of urinary tract infections worldwide and the emergence of multi-drug resistant determinants among clinical isolates necessitates the development of novel therapeutic agents. Lytic bacteriophages efficiently kill specific bacteria and seems promising approach in controlling infections caused by multi-drug resistant pathogens. This study aimed the isolation and detailed characterization of lytic bacteriophage designated as ES10 capable of lysing multidrug-resistant uropathogenic E...
2024: Frontiers in Microbiology
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