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Rafael Marins Rezende, Maria do Carmo Gouveia Pelúzio, Franciany de Jesus Silva, Emanuel Mattos Della Lucia, Lukiya Silva Campos Favarato, Hercia Stampini Duarte Martino, Antônio José Natali
The objective of this study was to verify the effects of aerobic exercise associated with tryptophan (TRP) supplementation on hyperalgesia, as well as on cortisol, IL-6 and TNF concentrations in female rats with experimental fibromyalgia (FM). Female Wistar rats (initial body weight: ~ 350 g; age: 12 months) were randomly divided into 5 groups: CON (Control); F (Fibromyalgia induced); FE (Fibromyalgia induced plus exercise); FES (Fibromyalgia induced plus exercise and TRP supplementation) and FS (Fibromyalgia induced plus TRP supplementation)...
2019: PloS One
Joht Singh Chandan, Tom Thomas, Karim Raza, Siddhartha Bandyopadhyay, Krishnarajah Nirantharakumar, Julie Taylor
INTRODUCTION: A growing body of evidence is identifying the link between a history of child maltreatment and a variety of adverse health outcomes ultimately leading to significant social and healthcare burden. Initial work has identified a potential association between child maltreatment and the development of a selection of somatic and visceral central sensitivity syndromes: fibromyalgia, chronic fatigue syndrome, temporomandibular joint disorder, chronic lower back pain, chronic neck pain, chronic pelvic pain, interstitial cystitis, vulvodynia, chronic prostatitis, tension-type headache, migraine, myofascial pain syndrome, irritable bowel syndrome and restless legs syndrome...
February 19, 2019: BMJ Open
Hugo Jario de Almeida Silva, Caio Alano de Almeida Lins, Thaiza Teixeira Xavier Nobre, Vanessa Patrícia Soares de Sousa, Renata Trajano Jorge Caldas, Marcelo Cardoso de Souza
INTRODUCTION: Physical exercises have been recommended to improve the overall well-being of patients with fibromyalgia, with the main objective of repairing the effects of lack of physical conditioning and of improving the symptoms, especially pain and fatigue. Although widely recommended and widely known, few studies support the use of Pilates as an effective method in improving the symptoms of the disease, comparing it with other well-founded exercise modalities. This protocol was developed to describe the design of a randomised controlled study with a blind evaluator that evaluates the effectiveness of mat Pilates, comparing it with aquatic aerobic exercises, in improving pain in women with fibromyalgia...
February 19, 2019: BMJ Open
Anais Le Fur Bonnabesse, Mathilde Cabon, Gildas L'Heveder, Aurélie Kermarrec, Bertrand Quinio, Alain Woda, Serge Marchand, Amandine Dubois, Marie-Agnes Giroux-Metges, Fabrice Rannou, Laurent Misery, Céline Bodéré
INTRODUCTION: The main symptom of fibromyalgia (FM) is diffuse pain. There is currently no aetiological treatment for FM. However, all pain associations and best practice guidelines strongly advocate the practice of aerobic physical activity to improve the symptoms of FM subjects. The mechanisms of dysfunctional pain are mostly central and related to stress axis dysfunction (autonomic nervous system and corticotropic axis). Our main objective is to assess the efficacy of a specific training programme on endogenous pain control mechanisms in female patients with FM...
January 25, 2019: BMJ Open
Emma D Deeks
Mirogabalin besylate (hereafter mirogabalin) [Tarlige® ] is an orally administered gabapentinoid developed by Daiichi Sankyo for the treatment of peripheral neuropathic pain (PNP), including diabetic PNP and post-herpetic neuralgia. The drug binds to and modulates the α2 δ-1 subunit of the voltage-gated calcium channels widely found in the nervous system in areas that mediate pain transmission and processing. Mirogabalin has a unique binding profile and long duration of action. The drug is approved in Japan for the treatment of PNP and is in clinical development for this indication elsewhere in Asia...
February 19, 2019: Drugs
Kensuke Saeki, Shun-Ichi Yasuda, Masami Kato, Mayumi Kano, Yuki Domon, Naohisa Arakawa, Yutaka Kitano
Mirogabalin, a novel ligand for the α2 δ subunit of voltage-gated calcium channels, is under the development for the treatment of neuropathic pain. Mirogabalin specifically and potently binds to α2 δ subunits, and it shows analgesic effects in both peripheral and central neuropathic pain models in rats. To expand pharmacological findings on mirogabalin and provide additional information of its potential for chronic pain therapy, we examined the effects of mirogabalin in 2 experimental models of fibromyalgia, namely, the intermittent cold stress model (ICS model) and the unilateral intramuscular acidic saline injection model (Sluka model)...
February 15, 2019: Naunyn-Schmiedeberg's Archives of Pharmacology
José M Pego-Reigosa, Juliana Restrepo Vélez, Chiara Baldini, Íñigo Rúa-Figueroa Fernández de Larrinoa
The information about comorbidities (excluding lymphoma) in primary Sjögren's syndrome (pSS) is relatively scarce. Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clinical practice. On the other hand, the incidence of cardiovascular events and cancer in pSS is low, so information about them comes from large epidemiological studies or meta-analysis...
February 15, 2019: Rheumatology
José V Pardo, Robert C Larson, Rachel J Spencer, Joel T Lee, Jeffrey D Pasley, Carolyn J Torkelson, Alice A Larson
OBJECTIVES: Fibromyalgia syndrome (FMS) is a chronically painful condition whose symptoms are widely reported to be exacerbated by stress. We hypothesized that female patients with FMS differ from healthy female controls in their sympathetic responses, a fact that may unmask important biomarkers and factors that contribute to the etiology of FMS. METHODS: In a pilot study, blood pressure (BP), skin temperature, thermogenic activity, circulating glucose, and pain sensitivity of 13 patients and 11 controls at room temperature (24°C) were compared to that after exposure to cold (19°C)...
February 12, 2019: Clinical Journal of Pain
Lakshmana Swamy, Paul Monach, Alan Fine, Anthony C Breu
No abstract text is available yet for this article.
August 2018: Federal Practitioner: for the Health Care Professionals of the VA, DoD, and PHS
S Ranque-Garnier, C Eldin, C Sault, D Raoult, A Donnet
Lyme disease is caused by bacteria of the B. burgdorferi sensu lato complex, and can give polymorphic clinical manifestations that can affect several organs such as the skin, the central nervous system, or the joints. In recent years, patients' associations and physicians have been supporting the hypothesis that this infection would manifest as chronic generalized musculoskeletal pain symptoms, named "chronic Lyme disease". Fibromyalgia is a clinical presentation characterized by chronic generalized musculoskeletal pain with a major impact on quality of life and social and psychological functioning...
February 11, 2019: Médecine et Maladies Infectieuses
Chelsea M Kaplan, Andrew Schrepf, Deniz Vatansever, Tony E Larkin, Ishtiaq Mawla, Eric Ichesco, Laura Kochlefl, Steven E Harte, Daniel J Clauw, George A Mashour, Richard E Harris
A critical component of brain network architecture is a robust hub structure, wherein hub regions facilitate efficient information integration by occupying highly connected and functionally central roles in the network. Across a wide range of neurological disorders, hub brain regions seem to be disrupted, and the character of this disruption can yield insights into the pathophysiology of these disorders. We applied a brain network-based approach to examine hub topology in fibromyalgia, a chronic pain condition with prominent central nervous system involvement...
January 16, 2019: Pain
Jae-Yeon Lee, Soo-Hee Choi, Ki-Soon Park, Yoo Bin Choi, Hee Kyung Jung, Dasom Lee, Joon Hwan Jang, Jee Youn Moon, Do-Hyung Kang
Complex regional pain syndrome (CRPS) and fibromyalgia (FM) share many features. Both can cause severe pain and are considered to have a mechanism of action, including dysfunction of the sympathetic nervous system. However, they have clinical differences in pain range and degree. The present study aimed to find neurophysiologic differences between CRPS and FM using quantitative electroencephalography (QEEG). Thirty-eight patients with CRPS and 33 patients with FM were included in the analysis. Resting-state QEEG data were grouped into frontal, central, and posterior regions to analyze for regional differences...
February 2019: Medicine (Baltimore)
David C Houghton, Thomas W Uhde, Jeffrey J Borckardt, Bernadette M Cortese
OBJECTIVE: Enhanced odor sensitivity is a phenomenon that potentially underlies conditions such as multiple chemical sensitivity (MCS). Currently, there are no treatments that have been shown to effectively decrease odor sensitivity. Given similarities of odor hypersensitivity/MCS to pain sensitization disorders such as fibromyalgia, there may be a potential for interventions that improve pain tolerance to modulate odor sensitivity. METHODS: This exploratory study randomized 72 healthy community adult volunteers to receive one of six treatments in between two assessments of thermal pain tolerance and odor threshold...
February 12, 2019: Psychosomatic Medicine
Tomoko Udo, Carlos M Grilo
OBJECTIVE: To examine psychiatric and somatic correlates of DSM-5 eating disorders (EDs)-anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED)-in a nationally representative sample of adults in the United States. METHOD: A national sample of 36,309 adult participants in the national epidemiologic survey on alcohol and related conditions III (NESARC-III) completed structured diagnostic interviews (AUDADIS-5) to determine psychiatric disorders, including EDs, and reported 12-month diagnosis of chronic somatic conditions...
January 2019: International Journal of Eating Disorders
Ilke Coskun Benlidayi
Fibromyalgia is a multifaceted disease. The clinical picture of fibromyalgia covers numerous comorbidities. Each comorbidity stands as a distinct condition. However, common pathophysiologic factors are occupied in their background. Along with the genetic, environmental and neuro-hormonal factors, inflammation has been supposed to have role in the pathogenesis of fibromyalgia. The aim of the present article was to review the current literature regarding the potential role of inflammation in the pathogenesis and treatment of fibromyalgia...
February 13, 2019: Rheumatology International
Gaia Favero, Francesca Bonomini, Caterina Franco, Rita Rezzani
Fibromyalgia syndrome (FMS) is considered a musculoskeletal disorder associated to other symptoms including chronic pain. Since the hypothesis of FMS etiogenesis is consistent with mitochondrial dysfunction and oxidative stress, we evaluated the pathophysiological correlation among these factors studying some proteins involved in the mitochondrial homeostasis. We focused our attention on the roles of peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α), mitofusin2 (Mfn2), and coenzyme Q10 (CoQ10) in reserpine-induced myalgic (RIM) rats that manifest fibromyalgia-like chronic pain symptoms...
February 11, 2019: International Journal of Molecular Sciences
María Dolores Onieva-Zafra, María Laura Parra-Fernández, Elia Fernandez-Martinez
Despite the plethora of treatments available for patients with fibromyalgia, there is insufficient evidence to date as to what the ideal treatment approach is. This study sought to determine the effectiveness of a home program of audio-recorded guided imagery relaxation on people with fibromyalgia. This experimental 8-week longitudinal trial design was undertaken with 60 people diagnosed with fibromyalgia who were randomly assigned to either a guided imagery intervention group or a control group. Pain at tender points, anxiety, self-efficacy, quality of sleep, quality of life, and the impact of the fibromyalgia were determined at baseline, at 4 weeks, and at 8 weeks...
March 2019: Holistic Nursing Practice
Ciro Conversano, Andrea Poli, Rebecca Ciacchini, Paul Hitchcott, Laura Bazzichi, Angelo Gemignani
Although the mechanisms underlying fibromyalgia are not yet clear, many attempts have been made to implement pharmacological therapy and help patients manage its psychological and physical symptoms. Recent evidence has shown that an interdisciplinary multidimensional approach encompassing psychological factors, emotion regulation strategies and education on illness is more effective in improving quality of life, both in the short- and long-term, than usual treatments alone. The purpose of this review is to provide an updated overview of the available literature regarding the role of psychoeducation on fibromyalgia symptoms and health outcomes...
January 2019: Clinical and Experimental Rheumatology
Roberto Casale, Gennaro Boccia, Zaira Symeonidou, Fabiola Atzeni, Allberto Batticciotto, Fausto Salaffi, Piercarlo Sarzi-Puttini, Paolo Riccardo Brustio, Alberto Rainoldi
OBJECTIVES: Neuromuscular efficiency (NME) is impaired in fibromyalgia (FM). Hyperbaric oxygen therapy (HBOT) is a medical treatment using 100% of oxygen through an oxygen mask. HBOT in FM induces changes in cortical excitability and a secondary reduction in pain and muscle fatigue. However, there are still no direct data indicating changes in muscle fatigue. The aim of this study was to assess whether the reduction in muscle fatigue so far attributed to a central effect of HBOT can be directly detected by means of non-invasive sEMG as a change in NME...
January 2019: Clinical and Experimental Rheumatology
Fabiola Atzeni, Roberto Casale, Alessandra Alciati, Ignazio Francesco Masala, Alberto Batticciotto, Rossella Talotta, Maria Chiara Gerardi, Fausto Salaffi, Piercarlo Sarzi-Puttini
OBJECTIVES: Fibromyalgia (FM) is a syndrome of unknown aetiology that is characterised by widespread musculoskeletal pain, fatigue and disordered sleep, and often associated with neuropsychiatric and cognitive symptoms. Current treatment options are only partially effective, but hyperbaric oxygen therapy (HBOT) seems to be capable of relieving some of the symptoms. The aim of this study was to evaluate the efficacy and safety of HBOT after fewer sessions than generally used, chosen on the basis of pre-clinical and clinical data showing its rapid and sustained antinociceptive effect...
January 2019: Clinical and Experimental Rheumatology
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