keyword
https://read.qxmd.com/read/38454135/immunogenic-cell-death-in-cancer-targeting-necroptosis-to-induce-antitumour-immunity
#1
REVIEW
Pascal Meier, Arnaud J Legrand, Dieter Adam, John Silke
Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment, therapies should not only kill cancer cells but also activate the immune system against the tumour to eliminate any residual cancer cells that survive treatment. While current cancer therapies rely heavily on apoptosis - a largely immunologically silent form of cell death - there is growing interest in harnessing immunogenic forms of cell death such as necroptosis...
March 7, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/37908730/fe-iii-shikonin-supramolecular-nanomedicines-as-immunogenic-cell-death-stimulants-and-multifunctional-immunoadjuvants-for-tumor-vaccination
#2
JOURNAL ARTICLE
Wenjie Feng, Wanrui Shi, Yanqi Cui, Jiajun Xu, Shuwei Liu, Hang Gao, Shoujun Zhu, Yi Liu, Hao Zhang
Immunoadjuvants, as an indispensable component of tumor vaccines, can observably enhance the magnitude, breadth, and durability of antitumor immunity. However, current immunoadjuvants suffer from different issues such as weak immunogenicity, inadequate cellular internalization, poor circulation time, and mono-functional bioactivity. Methods: Herein, we construct Fe3+ -Shikonin metal-phenolic networks (FeShik) nanomedicines as immunogenic cell death (ICD) stimulants and multifunctional immunoadjuvants for tumor vaccination...
2023: Theranostics
https://read.qxmd.com/read/37833985/the-regulatory-effect-of-receptor-interacting-protein-kinase-3-on-camkii%C3%AE-in-tac-induced-myocardial-hypertrophy
#3
JOURNAL ARTICLE
Jianan Qian, Jingjing Zhang, Ji Cao, Xue Wang, Wei Zhang, Xiangfan Chen
Necroptosis is a newly discovered mechanism of cell death, and its key regulatory role is attributed to the interaction of receptor-interacting protein kinases (RIPKs) RIPK1 and RIPK3. Ca2+ /calmodulin-dependent protein kinase (CaMKII) is a newly discovered RIPK3 substrate, and its alternative splicing plays a fundamental role in cardiovascular diseases. In the present study, we aimed to explore the role and mechanism of necroptosis and alternative splicing of CaMKIIδ in myocardial hypertrophy. Transverse aortic constriction (TAC) was performed on wild-type and knockout mice to establish the model of myocardial hypertrophy...
September 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37824803/characterizing-the-crosstalk-between-programmed-cell-death-pathways-in-cytokine-storm-with-an-agent-based-model
#4
JOURNAL ARTICLE
Solomon Feuerwerker, R Chase Cockrell, Gary An
Background: There is increasing recognition of extensive crosstalk between programmed cell death pathways (PCDPs), such as apoptosis, pyroptosis, and necroptosis, resulting in a highly redundant system responsive to a breadth of potential pathogens. However, because pyroptosis and necroptosis propagate inflammation, these redundancies also present challenges for therapeutic control of dysregulated hyperinflammation seen in cytokine storm (CS) generated organ dysfunction. Hypothesis: We hypothesize that the conversion of existing knowledge regarding apoptosis, pyroptosis, and necroptosis into a computational model can enhance our understanding of the crosstalk between PCDPs via simulation experiments of microbe interactions and experimental interventions...
October 12, 2023: Surgical Infections
https://read.qxmd.com/read/37466500/ferroptosis-and-necroptosis-produced-autologous-tumor-cell-lysates-co-delivering-with-combined-immnoadjuvants-as-personalized-in-situ-nanovaccines-for-antitumor-immunity
#5
JOURNAL ARTICLE
Wanrui Shi, Wenjie Feng, Siyuan Li, Yanqi Cui, Shuwei Liu, Huan Jiang, Yi Liu, Hao Zhang
Nanovaccine-based immunotherapy has been considered as a major pillar to stimulate the host immune system to recognize and eradicate tumor cells as well as establish a long-term immune memory to prevent tumor relapse and metastasis. However, the weak specificity and low cross-presentation of antigens, as well as the immunosuppressive microenvironments of tumor tissues, are still the major obstacles on exerting the therapeutic performance of tumor nanovaccines sufficiently. Herein, we design and construct cytosine guanine dinucleotide (CpG) oligodeoxynucleotide (ODN)-loaded aluminum hydroxyphosphate nanoparticles covered by Fe-Shikonin metal-phenolic networks (MPNs) (Alum-CpG@Fe-Shikonin NPs) as personalized in situ nanovaccines for antitumor immunity...
July 19, 2023: ACS Nano
https://read.qxmd.com/read/36997101/necroptosis-signaling-and-mitochondrial-dysfunction-cross-talking-facilitate-cell-death-mediated-by-chelerythrine-in-glioma
#6
JOURNAL ARTICLE
Peng Wang, Shi-Yi Zheng, Ruo-Lin Jiang, Hao-Di Wu, Yong-Ang Li, Jiang-Long Lu, Xiong Ye, Bo Han, Li Lin
Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. Chelerythrine (CHE), a natural benzophenanthridine alkaloid, has been reported to exhibit the anti-tumor effects in a variety of cancer cells. However, the molecular target and the signaling process of CHE in glioma remain elusive. Here we investigated the underlying mechanisms of CHE in glioma cell lines and glioma xenograft mice model. Our results found that CHE-induced cell death is associated with RIP1/RIP3-dependent necroptosis rather than apoptotic cell death in glioma cells at the early time...
March 28, 2023: Free Radical Biology & Medicine
https://read.qxmd.com/read/35977488/endocytic-membrane-repair-by-escrt-iii-controls-antigen-export-to-the-cytosol-during-antigen-cross-presentation
#7
JOURNAL ARTICLE
Marine Gros, Elodie Segura, Derek C Rookhuizen, Blandine Baudon, Sandrine Heurtebise-Chrétien, Nina Burgdorf, Mathieu Maurin, Eugene A Kapp, Richard J Simpson, Patrycja Kozik, Jose A Villadangos, Mathieu J M Bertrand, Marianne Burbage, Sebastian Amigorena
Despite its crucial role in initiation of cytotoxic immune responses, the molecular pathways underlying antigen cross-presentation remain incompletely understood. The mechanism of antigen exit from endocytic compartments into the cytosol is a long-standing matter of controversy, confronting two main models: transfer through specific channels/transporters or rupture of endocytic membranes and leakage of luminal content. By monitoring the occurrence of intracellular damage in conventional dendritic cells (cDCs), we show that cross-presenting cDC1s display more frequent endomembrane injuries and increased recruitment of endosomal sorting complex required for transport (ESCRT)-III, the main repair system for intracellular membranes, relative to cDC2s...
August 16, 2022: Cell Reports
https://read.qxmd.com/read/35703348/cardiomyocyte-death-in-sepsis-mechanisms-and-regulation-review
#8
REVIEW
Geping Zhang, Dan Dong, Xianyao Wan, Yongli Zhang
Sepsis‑induced cardiac dysfunction is one of the most common types of organ dysfunction in sepsis; its pathogenesis is highly complex and not yet fully understood. Cardiomyocytes serve a key role in the pathophysiology of cardiac function; due to the limited ability of cardiomyocytes to regenerate, their loss contributes to decreased cardiac function. The activation of inflammatory signalling pathways affects cardiomyocyte function and modes of cardiomyocyte death in sepsis. Prevention of cardiomyocyte death is an important therapeutic strategy for sepsis‑induced cardiac dysfunction...
August 2022: Molecular Medicine Reports
https://read.qxmd.com/read/35398215/different-cell-death-mechanisms-are-involved-in-leprosy-pathogenesis
#9
JOURNAL ARTICLE
Jorge Rodrigues de Sousa, Luiz Fábio Magno Falcão, Gabriela Lobato Virgolino, Matheus Ferreira Santos Cruz, Vinicius Fialho Teixeira, Tinara Leila de Souza Aarão, Ismari Perinii Furlaneto, Francisca Regina Oliveira Carneiro, Gabriela Amin, Hellen Thais Fuzii, Juarez Antonio Simões Quaresma
Leprosy is a chronic granulomatous disease that remains a serious public health problem in developing countries. According to the Madrid classification, leprosy presents in four clinical forms: two immunologically unstable forms (indeterminate and borderline) and two stable polar forms (tuberculoid and lepromatous). In leprosy, the relationship of cell death to clinical disease outcome remains unclear. Therefore, we investigated the extent of autophagy and different cell death mechanisms-such as apoptosis, necroptosis, and pyroptosis-in cutaneous lesions of patients with leprosy, as well as the role of these mechanisms in clinical disease progression...
May 2022: Microbial Pathogenesis
https://read.qxmd.com/read/34903554/immunogenic-ferroptosis-and-where-to-find-it
#10
REVIEW
Robin Demuynck, Iuliia Efimova, Faye Naessens, Dmitri V Krysko
Ferroptosis is a recently discovered form of regulated cell death that is morphologically, genetically, and biochemically distinct from apoptosis and necroptosis, and its potential use in anticancer therapy is emerging. The strong immunogenicity of (early) ferroptotic cancer cells broadens the current concept of immunogenic cell death and opens up new possibilities for cancer treatment. In particular, induction of immunogenic ferroptosis could be beneficial for patients with cancers resistant to apoptosis and necroptosis...
December 2021: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/34801852/molecular-pathways-involved-in-covid-19-and-potential-pathway-based-therapeutic-targets
#11
REVIEW
Masoumeh Farahani, Zahra Niknam, Leila Mohammadi Amirabad, Nasrin Amiri-Dashatan, Mehdi Koushki, Mohadeseh Nemati, Fahima Danesh Pouya, Mostafa Rezaei-Tavirani, Yousef Rasmi, Lobat Tayebi
Deciphering the molecular downstream consequences of severe acute respiratory syndrome coronavirus (SARS-CoV)- 2 infection is important for a greater understanding of the disease and treatment planning. Furthermore, greater understanding of the underlying mechanisms of diagnostic and therapeutic strategies can help in the development of vaccines and drugs against COVID-19. At present, the molecular mechanisms of SARS-CoV-2 in the host cells are not sufficiently comprehended. Some of the mechanisms are proposed considering the existing similarities between SARS-CoV-2 and the other members of the β-CoVs, and others are explained based on studies advanced in the structure and function of SARS-CoV-2...
November 12, 2021: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/34782457/lipofuscin-causes-atypical-necroptosis-through-lysosomal-membrane-permeabilization
#12
JOURNAL ARTICLE
Chendong Pan, Kalpita Banerjee, Guillermo L Lehmann, Dena Almeida, Katherine A Hajjar, Ignacio Benedicto, Zhichun Jiang, Roxana A Radu, David H Thompson, Enrique Rodriguez-Boulan, Marcelo M Nociari
Lipofuscin granules enclose mixtures of cross-linked proteins and lipids in proportions that depend on the tissue analyzed. Retinal lipofuscin is unique in that it contains mostly lipids with very little proteins. However, retinal lipofuscin also presents biological and physicochemical characteristics indistinguishable from conventional granules, including indigestibility, tendency to cause lysosome swelling that results in rupture or defective functions, and ability to trigger NLRP3 inflammation, a symptom of low-level disruption of lysosomes...
November 23, 2021: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/34480965/novel-insights-into-ripk1-as-a-promising-target-for-future-alzheimer-s-disease-treatment
#13
REVIEW
Shang Li, Lailiang Qu, Xiaobing Wang, Lingyi Kong
Alzheimer's disease (AD) is an intractable neurodegenerative disease showing a clinical manifestation with memory loss, cognitive impairment and behavioral dysfunction. The predominant pathological characteristics of AD include neuronal loss, β-amyloid (Aβ) deposition and hyperphosphorylated Tau induced neurofibrillary tangles (NFTs), while considerable studies proved these could be triggered by neuronal death and neuroinflammation. Receptor-interacting protein kinase 1 (RIPK1) is a serine/threonine kinase existed at the cross-point of cell death and inflammatory signaling pathways...
September 1, 2021: Pharmacology & Therapeutics
https://read.qxmd.com/read/34166763/apoptosis-autophagy-necrosis-and-their-multi-galore-crosstalk-in-neurodegeneration
#14
REVIEW
Suraiya Saleem
The progression of neurodegenerative disorders is mainly characterized by immense neuron loss and death of glial cells. The mechanisms which are active and regulate neuronal cell death are namely necrosis, necroptosis, autophagy and apoptosis. These death paradigms are governed by a set of molecular determinants that are pivotal in their performance and also exhibit remarkable overlapping functional pathways. A large number of such molecules have been demonstrated to be involved in the switching of death paradigms in various neurodegenerative diseases...
August 10, 2021: Neuroscience
https://read.qxmd.com/read/33316542/cytotoxic-activity-of-human-dendritic-cells-induces-ripk1-dependent-cell-death
#15
JOURNAL ARTICLE
Zsófia Varga, Evelin Rácz, Anett Mázló, Mónika Korodi, Anikó Szabó, Tamás Molnár, Árpád Szöőr, Zoltán Veréb, Attila Bácsi, Gábor Koncz
Dendritic cells (DCs), as potent phagocytes engulf dead cells and present peptide fragments of tumor antigens or pathogens derived from infected cells to naïve CD8+ T-lymphocytes. Dendritic cells can also induce apoptosis in target cells, thus getting an opportunity to sample their microenvironment. Here, we present that the supernatants of LPS- or CL075-activated DCs induced cell death in different cell lines, but during the differentiation to mature DCs, they lost their cytotoxic potential. Dexamethasone-pre-treated tolerogenic DCs induced less intensive death indicating that the tissue microenvironment can downregulate DC-mediated killing...
November 23, 2020: Immunobiology
https://read.qxmd.com/read/32515732/squalene-emulsion-based-vaccine-adjuvants-stimulate-cd8-t-cell-but-not-antibody-responses-through-a-ripk3-dependent-pathway
#16
JOURNAL ARTICLE
Eui Ho Kim, Matthew C Woodruff, Lilit Grigoryan, Barbara Maier, Song Hee Lee, Pratushya Mandal, Mario Cortese, Muktha S Natrajan, Rajesh Ravindran, Huailiang Ma, Miriam Merad, Alexander D Gitlin, Edward S Mocarski, Joshy Jacob, Bali Pulendran
The squalene-based oil-in-water emulsion (SE) vaccine adjuvant MF59 has been administered to more than 100 million people in more than 30 countries, in both seasonal and pandemic influenza vaccines. Despite its wide use and efficacy, its mechanisms of action remain unclear. In this study we demonstrate that immunization of mice with MF59 or its mimetic AddaVax (AV) plus soluble antigen results in robust antigen-specific antibody and CD8 T cell responses in lymph nodes and non-lymphoid tissues. Immunization triggered rapid RIPK3-kinase dependent necroptosis in the lymph node which peaked at 6 hr, followed by a sequential wave of apoptosis...
June 9, 2020: ELife
https://read.qxmd.com/read/32339554/emerging-roles-for-human-glycolipid-transfer-protein-superfamily-members-in-the-regulation-of-autophagy-inflammation-and-cell-death
#17
REVIEW
Shrawan K Mishra, Yong-Guang Gao, Xianqiong Zou, Daniel J Stephenson, Lucy Malinina, Edward H Hinchcliffe, Charles E Chalfant, Rhoderick E Brown
Glycolipid transfer proteins (GLTPs) were first identified over three decades ago as ~24kDa, soluble, amphitropic proteins that specifically accelerate the intermembrane transfer of glycolipids. Upon discovery that GLTPs use a unique, all-α-helical, two-layer 'sandwich' architecture (GLTP-fold) to bind glycosphingolipids (GSLs), a new protein superfamily was born. Structure/function studies have provided exquisite insights defining features responsible for lipid headgroup selectivity and hydrophobic 'pocket' adaptability for accommodating hydrocarbon chains of differing length and unsaturation...
April 2020: Progress in Lipid Research
https://read.qxmd.com/read/31900335/immunodominant-ah1-antigen-deficient-necroptotic-but-not-apoptotic-murine-cancer-cells-induce-antitumor-protection
#18
JOURNAL ARTICLE
Tania Løve Aaes, Hanne Verschuere, Agnieszka Kaczmarek, Liesbeth Heyndrickx, Bartosz Wiernicki, Iris Delrue, Bram De Craene, Joachim Taminau, Tinneke Delvaeye, Mathieu J M Bertrand, Wim Declercq, Geert Berx, Dmitri V Krysko, Sandy Adjemian, Peter Vandenabeele
Immunogenic cell death (ICD) occurs when a dying cell releases cytokines and damage-associated molecular patterns, acting as adjuvants, and expresses Ags that induce a specific antitumor immune response. ICD is studied mainly in the context of regulated cell death pathways, especially caspase-mediated apoptosis marked by endoplasmic reticulum stress and calreticulin exposure and, more recently, also in relation to receptor-interacting protein kinase-driven necroptosis, whereas unregulated cell death like accidental necrosis is nonimmunogenic...
January 3, 2020: Journal of Immunology
https://read.qxmd.com/read/31818855/the-evolutionary-origins-of-programmed-cell-death-signaling
#19
JOURNAL ARTICLE
Kay Hofmann
Programmed cell death (PCD) pathways are found in many phyla, ranging from developmentally programmed apoptosis in animals to cell-autonomous programmed necrosis pathways that limit the spread of biotrophic pathogens in multicellular assemblies. Prominent examples for the latter include animal necroptosis and pyroptosis, plant hypersensitive response (HR), and fungal heterokaryon incompatibility (HI) pathways. PCD pathways in the different kingdoms show fundamental differences in execution mechanism, morphology of the dying cells, and in the biological sequelae...
December 9, 2019: Cold Spring Harbor Perspectives in Biology
https://read.qxmd.com/read/30514519/cell-death-at-the-cross-roads-of-host-pathogen-interaction-in-mycobacterium-tuberculosis-infection
#20
REVIEW
Krishnaveni Mohareer, Suman Asalla, Sharmistha Banerjee
Tuberculosis (TB) continues to be the leading cause of death by any single infectious agent, accounting for around 1.7 million annual deaths globally, despite several interventions and support programs by national and international agencies. With the development of drug resistance in Mycobacterium tuberculosis (M. tb), there has been a paradigm shift in TB research towards host-directed therapy. The potential targets include the interactions between host and bacterial proteins that are crucial for pathogenesis...
December 2018: Tuberculosis
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