Valentine Léopold, Osoul Chouchane, Joe M Butler, Alex R Schuurman, Erik H A Michels, Justin de Brabander, Bauke V Schomakers, Michel van Weeghel, Daisy I Picavet-Havik, Anita E Grootemaat, Renée A Douma, Tom D Y Reijnders, Augustijn M Klarenbeek, Brent Appelman, W Joost Wiersinga, Nicole N van der Wel, Jeroen den Dunnen, Riekelt H Houtkooper, Cornelis Van't Veer, Tom van der Poll
BACKGROUND: Alterations in platelet function have been implicated in the pathophysiology of COVID-19 since the beginning of the pandemic. While early reports linked hyperactivated platelets to thromboembolic events in COVID-19, subsequent investigations demonstrated hyporeactive platelets with a procoagulant phenotype. Mitochondria are important for energy metabolism and the function of platelets. OBJECTIVES: Here, we sought to map the energy metabolism of platelets in a cohort of noncritically ill COVID-19 patients and assess platelet mitochondrial function, activation status, and responsiveness to external stimuli...
October 2023: Research and Practice in Thrombosis and Haemostasis