keyword
https://read.qxmd.com/read/37064992/hemolytic-disease-of-newborn-due-to-abo-incompatibility-between-b-blood-group-mother-and-a-blood-group-neonate
#21
Suman S Routray, Debasish Mishra, Girija N Kanungo, Rachita Behera
ABO incompatibility between O blood group mother and non-O blood group neonate is common. It rarely causes anemia and hyperbilirubinemia in neonate, requiring invasive management. Direct antiglobulin test may be positive in these cases with immunoglobulin (Ig)-G antibody specificity. There are few cases of hemolytic disease of newborn due to ABO incompatibility between mother and newborn with non - O blood group mother. After obtaining consent from the patient, we reported a case of incompatibility in a B blood group mother and A blood group neonate, and it was managed with phototherapy...
March 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/36950413/incidence-and-risk-factors-of-acute-bilirubin-encephalopathy-in-neonates-with-hyperbilirubinemia-presenting-at-secondary-care-hospital
#22
JOURNAL ARTICLE
Saba Rauf, Bushra Salah Ud Din, Ghanwa Abbas, Zeeshan Nawaz
BACKGROUND & OBJECTIVES: In neonates, hyperbilirubinemia is the most common problem. Acute bilirubin encephalopathy is serious problem in less developed nations and their incidence varies with geographical location. Our objective was to find out the incidence and risk factors of acute bilirubin encephalopathy in neonates with hyperbilirubinemia. METHODS: This was a prospective cross sectional study carried out at the department of pediatrics, THQ Hospital, Pindigheb in Punjab from October 2020 to October 2021...
2023: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/36539195/bilirubin-measurement-through-a-smartphone-application-in-preterm-infants
#23
JOURNAL ARTICLE
Huseyin Ustun, Mehmet Yekta Oncel, Melike Kefeli, Melek Akar, Defne Engür
BACKROUND: Aim of the present study is to evaluate the feasibility and reliability of an smartphone application for monitore of bilirubin levels in preterm infants. METHODS: Preterm infants hospitalized in the neonatal intensive care unit with gestational age of<35 weeks were included. Exclusion criteria were parental reluctance and requirement of phototherapy in the last 12 hours. Measurements were obtained through a smartphone application (BiliScan) along with simultaneous transcutaneous device (Dräger JM 105) and venous blood biochemistry...
December 20, 2022: Klinische Pädiatrie
https://read.qxmd.com/read/36479277/abo-incompatible-pediatric-liver-transplantation-with-antibody-and-b-cell-depletion-free-immunosuppressive-protocol-in-high-consanguinity-communities
#24
JOURNAL ARTICLE
Mohammad Shagrani, Kishwer Kumar, Alastair Baker, Moheeb Al-Awwami, Hussa Alhussaini, Hadeel Almanea, Hind Alhumaidan, Raffaele Iorio, Hana Al-Khabbaz, Martin Burdelski, Roberto I Troisi, Dieter C Broering
UNLABELLED: The success of orthotopic liver transplantation as a life-saving treatment has led to new indications and a greater competition for organ grafts. Pediatric patients with acute liver-related crises can benefit from orthotopic liver transplantation, but organ availability in the limited time can be a major obstacle. Crossing ABO blood group barriers could increase the organs available to such patients. METHODS: From November 2010 to June 2015, 176 children aged 0...
December 2022: Transplantation Direct
https://read.qxmd.com/read/36431288/abo-incompatibility-between-the-mother-and-fetus-does-not-protect-against-anti-human-platelet-antigen-1a-immunization-by-pregnancy
#25
JOURNAL ARTICLE
Laila Miserre, Sandra Wienzek-Lischka, Andreas Mann, Nina Cooper, Sentot Santoso, Harald Ehrhardt, Ulrich J Sachs, Gregor Bein
(1) Background: ABO blood group incompatibility between the mother and fetus protects against anti-D immunization by pregnancy. The possible role of ABO incompatibility in protecting against anti-human platelet antigen-1a immunization is unclear. (2) Methods: This study retrospectively screened 817 families (mother-father-neonate trios) of suspected fetal and neonatal alloimmune thrombocytopenia for inclusion. ABO genotypes were determined in 118 mother-child pairs with confirmed alloimmune thrombocytopenia due to anti-HPA-1a antibodies, and 522 mother-child pairs served as the control group...
November 17, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36407223/cord-platelet-count-of-full-term-neonates-in-relation-to-abo-incompatibility-and-glucose-6-phosphate-dehydrogenase-levels-a-retrospective-cohort-study
#26
JOURNAL ARTICLE
Sameer Y Al-Abdi, Abbas M Al-Omran, Hesham A Shapan
Background The immunoglobulin G of mothers with O blood type may sensitize the platelets of their neonates with A (O-A incompatibility) or B (O-B incompatibility) blood type. As the expression and antigenicity of the B antigen on platelets is less than that of the A antigens, we have hypothesized that platelet count is higher in the O-B incompatibility group compared to the O-A incompatibility group. There is controversy about whether glucose-6-phosphate dehydrogenase (G6PD) deficiency, without evidence of hemolysis, is associated with a lower platelet count than G6PD-normal...
October 2022: Curēus
https://read.qxmd.com/read/36344813/abo-hemolytic-disease-of-the-newborn-a-need-for-clarity-and-consistency-in-diagnosis
#27
REVIEW
Jon F Watchko
The diagnosis of ABO hemolytic disease of the newborn (ABO HDN) has been the subject of considerable debate and clinical confusion. Its use as an overarching default diagnosis for hyperbilirubinemia in all ABO incompatible neonates regardless of serological findings is problematic and lacks diagnostic precision. Data on hemolysis indexed by carbon monoxide (CO) levels in expired air (ETCOc) and blood (COHbc) support an essential role for a positive direct antiglobulin test (DAT) in making a more precise diagnosis of ABO HDN...
February 2023: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/36342344/a-cross-sectional-study-of-haemolytic-disease-of-the-newborn-in-uganda
#28
JOURNAL ARTICLE
Aggrey Dhabangi, Jolly Nankunda, Violet Okaba, Sarah Nakubulwa, Heather A Hume, Walter H Dzik, Nancy M Heddle
BACKGROUND AND OBJECTIVES: Haemolytic disease of the newborn (HDN) is an immune haemolytic anaemia from maternal alloantibodies. Rh immunoglobulin (RhIg) prophylaxis can prevent alloimmunization to the D antigen. However, RhIg is not universally available in Uganda. ABO incompatibility also causes HDN. We determined the prevalence of HDN among newborn infants with jaundice in Uganda. MATERIALS AND METHODS: We conducted a prospective cross-sectional study at Kawempe National Referral Hospital, Kampala, Uganda...
November 7, 2022: Vox Sanguinis
https://read.qxmd.com/read/36254256/early-indicators-of-neonatal-onset-hereditary-thrombotic-thrombocytopenia-purpura
#29
JOURNAL ARTICLE
Jing Liu, Yuelun Zhang, Zhuo Li, Zhenghong Li, Lejia Zhang, Shan Jian, Changyan Wang, Yuqing Song, Zichao Lv, Xiaoyan Tang, Lijuan Gou, Juan Xiao
Background: Neonatal-onset hereditary thrombotic thrombocytopenia purpura (hTTP) is often misdiagnosed due to its rarity. It begins with jaundice, similar to infants with ABO incompatibility. Objective: To explore early indicators of neonatal-onset hTTP. Methods: This study was a retrospective case series of newborns with hTTP and ABO incompatibility. We compared the clinical characteristics and laboratory test results in these two groups...
October 2022: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/36119547/neonatal-and-maternal-risk-factors-for-indirect-hyperbilirubinemia-a-cross-sectional-study-from-bahrain
#30
JOURNAL ARTICLE
Hasan M Isa, Noor Y AlBuainain, Fatema Y Bunajem, Abdulrahman S Masood, Yusuf A Bucheery
RESULTS: Out of 555 records, 404 neonates were included. Among those, 209 (51%) were males and 275 (68.1%) were Bahraini. The median indirect bilirubin level at presentation was 218 (interquartile range, 174-270) μ mol/L. ABO incompatibility was the commonest risk factor for neonatal indirect hyperbilirubinemia ( n = 152, 37.6%) followed by glucose-6-phosphate dehydrogenase (G6PD) deficiency ( n = 130/400, 32.5%). Age (>25 years) was the commonest maternal risk factor ( n = 331, 81...
2022: International Journal of Pediatrics
https://read.qxmd.com/read/36114364/determinants-of-neonatal-jaundice-in-ethiopia-a-systematic-review-and-meta-analysis
#31
REVIEW
Habtamu Gebrehana Belay, Getachew Arage Debebe, Alemu Degu Ayele, Bekalu Getnet Kassa, Gedefaye Nibret Mihretie, Mulugeta Dile Worke
BACKGROUND: Neonatal jaundice is a common condition characterized by a yellowish discoloration of the skin, conjunctiva, and sclera caused by elevated serum or plasma bilirubin levels during the newborn period. The condition is usually not dangerous, but it can progress to severe hyperbilirubinemia, which can lead to acute bilirubin encephalopathy and kernicterus, a bilirubin-induced neurological damage. Therefore, this study aimed to assess the pooled prevalence of neonatal jaundice and its determinants in Ethiopia...
November 2022: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/36089589/severe-neonatal-hyperbilirubinemia-secondary-to-combined-rhc-hemolytic-disease-congenital-hypothyroidism-and-large-adrenal-hematoma-a-case-report
#32
JOURNAL ARTICLE
Chengiun Dai, Chun Chen, Liqiong Jiang, Yilin Zhu, Chunlin Wang
BACKGROUND: ABO blood group incompatibility, neonatal sepsis, G-6-PD deficiency, thyroid dysfunction, and hereditary spherocytosis are all probable causes of neonatal hyperbilirubinemia. However, the etiology of some hyperbilirubinemia is extremely complicated, which may be caused by multiple factors, resulting in severe jaundice. We report a case of severe jaundice due to three causes, showing the significance for the investigation of the etiology of neonatal hyperbilirubinemia. CASE PRESENTATION: At 96 h of life, a full-term and vaginal delivery male infant with yellowish discoloration of body was transferred to our hospital...
September 11, 2022: BMC Pediatrics
https://read.qxmd.com/read/36051115/clinical-features-and-genetic-variations-of-severe-neonatal-hyperbilirubinemia-five-case-reports
#33
Fen Lin, Jian-Xin Xu, Yong-Hao Wu, Yu-Bin Ma, Li-Ye Yang
BACKGROUND: Neonatal hyperbilirubinemia is a common problem faced by pediatricians. The role of genetic factors in neonatal jaundice has been gradually recognized. This study aims to identify genetic variants that influence the bilirubin level in five patients using next-generation sequencing (NGS). CASE SUMMARY: Five neonates with severe hyperbilirubinemia were retrospectively studied. They exhibited bilirubin encephalopathy, hypothyroidism, ABO blood type incompatibility hemolysis, glucose-6-phosphate dehydrogenase ( G6PD ) deficiency and premature birth, respectively...
July 16, 2022: World Journal of Clinical Cases
https://read.qxmd.com/read/35975373/intravenous-immunoglobulin-in-hemolytic-disease-of-the-newborn-a-moving-target-in-time
#34
JOURNAL ARTICLE
G Vardar, M A Okan, N Karadag, S Topcuoglu, E Ozalkaya, H O Karatepe, G Karatekin
BACKGROUND: Alloimmune hemolytic disease of the newborn (AIHDN) results in hemolysis, anemia, hyperbilirubinemia with the potential for brain damage. Intravenous immunoglobulin (IVIG) has been investigated as an alternative low-risk procedure for the treatment of AIHDN in addition to traditional treatment methods such as phototherapy and exchange transfusion (ET). AIM: To evaluate the effectiveness of IVIG therapy in decreasing ET needs based on risk factors and clinical outcomes...
August 2022: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/35800274/risk-factors-for-neonatal-hyperbilirubinemia-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Qun Lin, Daomou Zhu, Caihua Chen, Yonghong Feng, Fenfen Shen, Zhenkui Wu
BACKGROUND: Hyperbilirubinemia is the most common cause of neonatal hospitalization and, although it generally has a good prognosis, a significant percentage of neonatal patients maintain a high bilirubin level, which can lead to severe complications, including lifelong disability such as growth retardation, encephalopathy, autism and hearing impairment. The study of risk factors for neonatal hyperbilirubinemia has been controversial. Therefore, we evaluated the risk factors of neonatal hyperbilirubinemia using a meta-analysis...
June 2022: Translational Pediatrics
https://read.qxmd.com/read/35747579/predicting-significant-hyperbilirubinemia-in-abo-incompatibility-is-cord-direct-antiglobulin-test-useful
#36
JOURNAL ARTICLE
Sphurti Chowdhary, Usha Devi, Sethuraman Giridhar
To study the prevalence of direct antiglobulin test (DAT) positivity and outcomes in babies with ABO incompatibility and the role of DAT in predicting need for phototherapy. This was an analytical retrospective cohort study conducted in a tertiary care hospital in South India. DAT was performed routinely in cord blood of all neonates born to O positive mothers. The case records of neonates ≥ 35 weeks of gestation and birth weight > 2000 gm with ABO setting born between January 2019 and December 2020 were reviewed and outcomes were analyzed...
July 2022: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/35700699/risk-factors-predicting-the-need-for-phototherapy-in-glucose-6-phosphate-dehydrogenase-deficient-infants-in-a-large-retrospective-cohort-study
#37
JOURNAL ARTICLE
Krishna Revanna Gopagondanahalli, Rashmi Arun Mittal, Abdul Alim Abdul Haium, Bin Huey Quek, Pratibha Agarwal, Lourdes Mary Daniel, Mei Chien Chua, Victor Samuel Rajadurai
INTRODUCTION: Glucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of severe neonatal hyperbilirubinemia. This study evaluates the risk factors predicting the need for phototherapy in G6PD-deficient neonates after 72 h of age and assesses the safety of early discharge. METHODS: A retrospective cohort study of 681 full-term G6PD-deficient infants with a birth weight ≥2,500 g over 4 years was conducted. We compared the baseline characteristics, bilirubin level on day 4 (after 72 h of life), day of peak bilirubin, G6PD levels, and concomitant ABO incompatibility between the group that required phototherapy (Group A) and those who did not (Group B)...
2022: Neonatology
https://read.qxmd.com/read/35667836/the-spectrum-of-abo-haemolytic-disease-of-the-fetus-and-newborn-in-neonates-born-to-group-o-mothers
#38
JOURNAL ARTICLE
Manvi Talwar, Ashish Jain, Ratti Ram Sharma, Praveen Kumar, Subhas Chandra Saha, Lakhvinder Singh
BACKGROUND AND OBJECTIVES: ABO haemolytic disease of the fetus and newborn (HDFN) is a lesser recognized entity; however, the severity may vary in neonates. This prospective observational study was performed to determine the severity and risk of ABO-HDFN in neonates born to O group mothers. MATERIALS AND METHODS: A total of 260 neonates born to non-alloimmunized blood group O mothers were recruited. Blood group O neonates were excluded from the study. Neonatal direct antiglobulin test (DAT) was performed using the column agglutination technique...
June 6, 2022: Vox Sanguinis
https://read.qxmd.com/read/35613928/new-roles-for-albumin-globulin-ratio-in-the-early-onset-hyperbilirubinemia-among-infants-born-weighing-1-000-to-2-499-grams
#39
JOURNAL ARTICLE
Takashi Imamura, Yuji Kanai, Shuhei Yamaguchi, Yoshiyuki Namai
INTRODUCTION:  Early-onset hyperbilirubinemia (EOH) is a clinical issue for premature infants. We predicted that EOH management would be improved by fast results from common laboratory tests. Total serum bilirubin (TSB) level and the albumin/globulin ratio may contribute to improving the management of EOH. OBJECTIVE:  The aim of the study is to examine the relationship between EOH and perinatal variables among infants born weighing 1,000 to 2,499 g...
May 25, 2022: American Journal of Perinatology
https://read.qxmd.com/read/35573949/intravenous-immunoglobulin-use-in-hemolytic-disease-due-to-abo-incompatibility-to-prevent-exchange-transfusion
#40
JOURNAL ARTICLE
Emel Okulu, Omer Erdeve, Ilknur Kilic, Ozgur Olukman, Sebnem Calkavur, Gokhan Buyukkale, Merih Cetinkaya, Dilek Ulubas, Nihal Demirel, Deniz Hanta, Sabahattin Ertugrul, Nazli Dilay Gultekin, Oguz Tuncer, Nihat Demir, Leyla Bilgin, Nejat Narli, Duran Yildiz, Demet Terek, Ozge Altun Koroglu, Canan Seren, Elif Ozyazici, Ramazan Ozdemir, Hatice Turgut, Fatma Narter, Yasemin Akin, Ahmet Ozyazici, Aysegul Zenciroglu, Huseyin Selim Asker, Zeynel Gokmen, Musa Salihli, Ali Bulbul, Umut Zubarioglu, Begum Atasay, Esin Koc
INTRODUCTION: Intravenous immunoglobulin (IVIG) has been widely used to treat the hemolytic disease of the newborn (HDN). Although it has been shown that IVIG treatment reduces the duration of phototherapy and hospitalization, the use of IVIG in hemolytic disease due to ABO incompatibility has been controversial in recent years. This study aimed to investigate the role of IVIG in the prevention of exchange transfusion in infants with ABO HDN who presented with bilirubin levels at or above the level of exchange transfusion...
2022: Frontiers in Pediatrics
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