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https://read.qxmd.com/read/30772229/global-longitudinal-strain-as-a-predictor-of-first-and-subsequent-arrhythmic-events-in-remotely-monitored-icd-patients-with-structural-heart-disease
#1
Federico Guerra, Alessandro Malagoli, Daniele Contadini, Erika Baiocco, Alessio Menditto, Paolo Bonelli, Luca Rossi, Concetta Sticozzi, Alessia Zanni, Jianwen Cai, Poulami Maitra, Giovanni Q Villani, Alessandro Capucci
OBJECTIVES: This study sought to assess speckle-tracking-derived parameters as predictors of first and subsequent ventricular events in patients with structural heart disease and implantable cardioverter-defibrillators (ICD). BACKGROUND: Left ventricular ejection fraction (LVEF), the current primary parameter of risk stratification for ventricular arrhythmias (VAs) in structural heart diseases is burdened by many limitations. METHODS: In this retrospective, observational study, all consecutive patients with structural heart disease were admitted for ICD implantation...
February 11, 2019: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/30760299/binge-eating-disorder-treatment-goes-online-feasibility-usability-and-treatment-outcome-of-an-internet-based-treatment-for-binge-eating-disorder-study-protocol-for-a-three-arm-randomized-controlled-trial-including-an-immediate-treatment-a-waitlist-and-a-placebo
#2
Simone Munsch, Andrea Wyssen, Pierre Vanhulst, Denis Lalanne, Sharon T Steinemann, Alexandre Tuch
BACKGROUND: Binge-eating disorder (BED) is characterized by recurrent episodes of loss of control over eating and is related to a higher prevalence of other mental disorders and somatic consequences associated with overweight and obesity. In community-based samples, 2-4% of women and 1-3% men are diagnosed with BED. Psychotherapeutic interventions focusing on maintenance factors of disturbed eating behavior have proven to be effective. However, treatment access is limited for a considerable number of patients with BED...
February 13, 2019: Trials
https://read.qxmd.com/read/30758247/smartphone-application-versus-pedometer-to-promote-physical-activity-in-prostate-cancer-patients
#3
Byung Joo Lee, Yong Hyun Park, Ji Youl Lee, Soo Jin Kim, Yongjun Jang, Jong In Lee
BACKGROUND: Recently, the application of smartphone in medical field has received great attention. INTRODUCTION: The objective of this study was to compare the effectiveness of smartphone-based and conventional pedometer-based exercise monitoring systems in promoting home exercise among prostate cancer patients. METHODS: Prostate cancer patients who have undergone surgery or androgen deprivation therapy were recruited. All participants were provided with physical activity goals based on their activities and were advised to achieve these goals during their home exercise period...
February 13, 2019: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://read.qxmd.com/read/30742386/-immediate-and-long-term-effectiveness-of-combined-application-of-magnetolaser-therapy-and-red-light-in-complex-treatment-of-patients-with-chronic-nonbacterial-prostatitis
#4
T V Kulishova, A I Neimark, A A Kryanga, A V Gazamatov
The aim of the study was to increase the efficiency of complex treatment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with the combined effect of magnetolaser therapy (MLT) and red light. MATERIALS AND METHODS: We examined and included in the study 120 men with a verified diagnosis of CP/CPPS (III B), at the stage of exacerbation. By envelope method, patients were divided into two randomized groups. The main group consisted of 60 patients who received a basic treatment complex, including medicamentous therapy, prostate massage, diet therapy, a complex of therapeutic gymnastics, and the combined effect of MLT and red light of 10 procedures per course...
December 2018: Urologii︠a︡
https://read.qxmd.com/read/30741538/photoactivatable-organic-semiconducting-pro-nanoenzymes
#5
Jingchao Li, Jiaguo Huang, Yan Lyu, Jingsheng Huang, Yuyan Jiang, Chen Xie, Kanyi Pu
Therapeutic enzymes hold great promise for cancer therapy; however, in vivo remote control of enzymatic ac-tivity to improve their therapeutic specificity remains challenging. This study reports the development of an organic semiconducting pro-nanoenzyme (OSPE) with a photoactivatable feature for metastasis-inhibited can-cer therapy. Upon near-infrared (NIR) light irradiation, this pro-nanoenzyme not only generates cytotoxic sin-glet oxygen (1O2) for photodynamic therapy (PDT), but also triggers a spontaneous cascade reaction to induce the degradation of ribonucleic acid (RNA) specifically in tumor microenvironment...
February 11, 2019: Journal of the American Chemical Society
https://read.qxmd.com/read/30741455/upconverting-carbon-nanodots-from-edta-as-near-infrared-activated-phototheranostic-agents
#6
M Carmen Ortega-Liebana, M Mar Encabo-Berzosa, Alvaro Casanova, M Desiree Pereboom, Octavio Alda, Jose Luis Hueso, Jesus Santamaria
This work describes the synthesis of nitrogen-doped carbon nanodots (CNDs) synthesized from ethylene diamine tetra acetic acid (EDTA) as a precursor and their application as luminescent agents with a dual-mode theranostic role as near-infrared (NIR) triggered imaging and photodynamic therapy agents. Interestingly, these fluorescent CNDs are more rapidly and selectively internalized in tumor cells and exhibit no cytotoxicity until remotely activated with a NIR illumination source. These CNDs are excellent candidates for photo-theranostic purposes, i...
February 11, 2019: Chemistry: a European Journal
https://read.qxmd.com/read/30740656/optimizing-outcomes-for-children-with-non-hodgkin-lymphoma-in-low-and-middle-income-countries-by-early-correct-diagnosis-reducing-toxic-death-and-preventing-abandonment
#7
REVIEW
Guillermo Chantada, Catherine G Lam, Scott C Howard
In high-income countries, more than 90% of children with mature B-cell lymphomas are cured with frontline therapy. However, cure requires prompt and correct diagnosis, careful risk stratification, very intense chemotherapy and meticulous supportive care, together with logistical support for patients who live far from the cancer centre or face financial barriers to receiving care. In low- and middle-income countries (LMIC), cure rates range from 20% to 70% because of lack of diagnosis, misdiagnosis, abandonment of treatment, toxic death and excess relapse with reduced-intensity regimens...
February 10, 2019: British Journal of Haematology
https://read.qxmd.com/read/30737607/prevalence-and-current-therapy-in-chronic-liver-disorders
#8
REVIEW
Muhammad Daniyal, Muhammad Akram, Rida Zainab, Naveed Munir, Aamir Sharif, Syed Muhammad Ali Shah, Bin Liu, Wei Wang
BACKGROUND: Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of medicinal plants was effective in the treatment of infectious and non-infectious diseases. Hepatitis and liver cirrhosis associated with many clinical manifestations can be treated with allopathic medicines, but reports of a number of side effects including immunosuppression, bone marrow suppression, and renal complications have motivated researchers to explore more natural herbal medicines with low or no side effects and with high efficacy in treating hepatic diseases...
February 8, 2019: Inflammopharmacology
https://read.qxmd.com/read/30736874/centers-for-medicare-and-medicaid-services-positive-airway-pressure-adherence-criteria-may-limit-treatment-to-many-medicare-beneficiaries
#9
Sreelatha Naik, Moh'd Al-Halawani, Iouri Kreinin, Meir Kryger
STUDY OBJECTIVES: Centers for Medicare and Medicaid Services (CMS) reimbursement for positive airway pressure (PAP) devices for obstructive sleep apnea treatment is dependent on patients meeting adherence expectations within the first 3 months on therapy. Adherence is defined as usage of the device for at least 4 hours per night on 70% of nights during a consecutive 30-day period. We hypothesize that the adherence pattern may be established beyond this initial period, which may limit the opportunity to treat many patients...
February 4, 2019: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/30724269/long-term-rhythm-monitoring-with-an-implantable-loop-recorder-in-patients-after-the-first-clinical-atrial-fibrillation-episode-towards-an-individualized-management
#10
Panteleimon E Papakonstantinou, Emmanuel N Simantirakis
Although atrial fibrillation (AF) is an arrhythmia with a variable clinical profile (symptomatic and asymptomatic episodes), the first symptomatic episode leads to its initial diagnosis in most cases. Nowadays, continuous and remote long- term cardiac rhythm monitoring is feasible by the use of implantable loop recorders. The data concerning the AF recurrences and progression after the first ECG- documented clinical AF episode demonstrates that a high percentage of patients may not suffer any other AF recurrence, or may present a low recurrence rate of the arrhythmia in the future...
February 5, 2019: Minerva Cardioangiologica
https://read.qxmd.com/read/30722961/similarities-and-differences-in-antimicrobial-prescribing-between-major-city-hospitals-and-regional-and-remote-hospitals-in-australia
#11
Jaclyn L Bishop, Thomas R Schulz, David C M Kong, Rodney James, Kirsty L Buising
Many regional and remote hospitals (RRHs) do not have the specialist services that usually support antimicrobial stewardship (AMS) programmes in major city hospitals. It is not known if this is associated with higher rates of inappropriate antimicrobial prescribing. The aim of this study was to identify similarities and differences in antimicrobial prescribing patterns between major city hospitals and RRHs in Australia. The Australian Hospital National Antimicrobial Prescribing Survey (H-NAPS) datasets from 2014, 2015 and 2016 (totalling 47,876 antimicrobial prescriptions) were analysed...
February 2019: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/30719216/circulating-mediators-of-remote-ischemic-preconditioning-search-for-the-missing-link-between-non-lethal-ischemia-and-cardioprotection
#12
REVIEW
Muntasir Billah, Anisyah Ridiandries, Usaid Allahwala, Harshini Mudaliar, Anthony Dona, Stephen Hunyor, Levon M Khachigian, Ravinay Bhindi
Acute myocardial infarction (AMI) is one of the leading causes of mortality and morbidity worldwide. There has been an extensive search for cardioprotective therapies to reduce myocardial ischemia-reperfusion (I/R) injury. Remote ischemic preconditioning (RIPC) is a phenomenon that relies on the body's endogenous protective modalities against I/R injury. In RIPC, non-lethal brief I/R of one organ or tissue confers protection against subsequent lethal I/R injury in an organ remote to the briefly ischemic organ or tissue...
January 4, 2019: Oncotarget
https://read.qxmd.com/read/30718935/remote-antimicrobial-stewardship-a-solution-for-meeting-the-joint-commission-stewardship-standard
#13
C K Howell, Jesse Jacob, Steve Mok
Purpose: The purpose of this study was to determine the time required for antimicrobial stewardship (AS) activities at a small community hospital (SCH) as well as barriers to remote AS to satisfy The Joint Commission (TJC)'s AS standard. Methods: This was a prospective chart review and time study conducted in patients identified by a clinical decision support application as potential opportunities for antimicrobial therapy modification at a SCH between December 12, 2016, and March 31, 2017. Potential interventions were communicated electronically to the clinical pharmacy specialist, who would then communicate the recommendations to the patient's provider...
February 2019: Hospital Pharmacy
https://read.qxmd.com/read/30717844/increasing-role-of-remote-monitoring-of-cardiac-resynchronization-therapy-devices-in-improving-outcomes
#14
REVIEW
Suneet Mittal
Remote monitoring has become an essential component of the care of patients with a cardiac implantable electronic device, including those undergoing cardiac resynchronization therapy-defibrillator implantations. It allows for earlier detection of battery- and lead-related issue, atrial and ventricular arrhythmias, and may facilitate early identification of patients at risk for developing an exacerbation of heart failure. The data for the clinical utility of remote monitoring have been mixed. Additional studies are ongoing to determine how best to detect heart failure in these patients and how best to manage these patients based on the information...
March 2019: Cardiac Electrophysiology Clinics
https://read.qxmd.com/read/30712097/a-feasibility-study-examining-the-impact-of-yoga-on-psychosocial-health-and-symptoms-in-pediatric-outpatients-receiving-chemotherapy
#15
Eliana Stein, Meera Rayar, Upasana Krishnadev, Abha Gupta, Shannon Hyslop, Erin Plenert, Tal Schechter-Finkelstein, Lillian Sung
PURPOSE: Pediatric cancer patients experience symptoms that negatively impact quality of life; yoga may be an effective intervention. The primary objective was to determine the feasibility of a 10-week, weekly individualized yoga intervention for children and adolescents receiving outpatient cancer therapy primarily delivered remotely using Skype. Secondary objectives were to describe depression, anxiety, anger, fatigue, quality of life, and symptoms at 5 and 10 weeks after enrollment...
February 2, 2019: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://read.qxmd.com/read/30709922/artificial-intelligence-and-the-radiologist-the-future-in-the-armed-forces-medical-services
#16
Debraj Sen, R Chakrabarti, S Chatterjee, D S Grewal, K Manrai
Artificial intelligence (AI) involves computational networks (neural networks) that simulate human intelligence. The incorporation of AI in radiology will help in dealing with the tedious, repetitive, time-consuming job of detecting relevant findings in diagnostic imaging and segmenting the detected images into smaller data. It would also help in identifying details that are oblivious to the human eye. AI will have an immense impact in populations with deficiency of radiologists and in screening programmes...
January 31, 2019: Journal of the Royal Army Medical Corps
https://read.qxmd.com/read/30703330/photoactivatable-prodrug-of-doxazolidine-targeting-exosomes
#17
Ryo Tamura, Alla Balabanova, Samuel A Frakes, Austin Bargmann, Jan Grimm, Tad H Koch, Hang Hubert Yin
Natural lipid nanocarriers, exosomes, carry cell signaling materials such as DNA and RNA for intercellular communications. Exosomes derived from cancer cells contribute the progression and metastasis of cancer cells by transferring oncogenic signaling molecules to neighbor and remote premetastatic sites. Therefore, applying the unique properties of exosomes for cancer therapy has been expected in science, medicine and drug discovery fields. Herein, we report that an exosome-targeting prodrug system, designated MARCKS-ED-Photodoxaz, could spatiotemporally control the activation of an exquisitely cytotoxic agent, doxazolidine (doxaz), with UV light...
January 31, 2019: Journal of Medicinal Chemistry
https://read.qxmd.com/read/30695680/the-wet-bridge-transfer-system-a-novel-tool-to-assess-exogenous-surfactant-as-a-vehicle-for-intrapulmonary-drug-delivery
#18
Brandon Baer, Edwin J A Veldhuizen, Fred Possmayer, Cory Yamashita, Ruud Veldhuizen
Due to its branching structure, drug delivery to the peripheral areas of the lung is a major challenge. Consequently, most pulmonary therapies utilize large systemic dosing, with the potential for adverse side effects. One proposed strategy to overcome this challenge is to use exogenous surfactant, a material capable of distributing throughout the lung, as a pulmonary drug delivery vehicle. The objective was to develop and test an in vitro system to rapidly assess surfactant based therapies prior to animal studies...
November 2018: Discovery Medicine
https://read.qxmd.com/read/30693884/a-dosimetric-comparison-between-applicators-used-for-brachytherapy-in-carcinoma-cervix-a-single-institute-prospective-study
#19
Aparna Suryadevara, M Vijay Kumar, E Vasundhara, Krishnam R Alluri, Shabbir Ahamed, Srikanth Guduru
INTRODUCTION: Cervical cancer is the second most common cancer among Indian women. Radical radiotherapy with external beam radiation therapy (EBRT) and brachytherapy is the standard treatment for FIGO stage IB2 to IVA. An appropriate selection of brachytherapy applicator is needed according to the patient's anatomy. The two most commonly used applicators for intracavitary radiotherapy (ICR), Fletcher's and Henschke, have dosimetric differences which are not well studied with two-dimensional (2D)-based planning which is the most common method used for women with carcinoma cervix in India...
July 2018: Indian Journal of Cancer
https://read.qxmd.com/read/30692842/utilization-and-perception-of-live-blogging-coverage-of-an-international-manual-physical-therapy-conference
#20
Michael A Pascoe, Eric K Robertson
Objective : The purpose of this study was to investigate the utilization and perception of live blogged sessions of a physical therapy (PT) conference. Methods : Sessions at an international PT conference were covered in real time using a live-blogging platform. Session coverage could be viewed remotely using computers and mobile devices. Viewers could interact with the content by clicking on links and using the comment feature. Sessions could also be replayed following their conclusion. An online survey of user perceptions was made available the week following the conference...
February 2019: Journal of Manual & Manipulative Therapy
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