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JOURNAL ARTICLE
Alfio Spina, Stefano De Benedetti, Giuditta Carlotta Heinzl, Giulia Ceravolo, Chiara Magni, Davide Emide, Giulia Castorina, Gabriella Consonni, Michele Canale, Alessio Scarafoni
Lupin species provide essential nutrients and bioactive compounds. Within pulses, they have one of the highest contents of proteins and fibers and are among the poorest in carbohydrates. The Mediterranean region is an important cradle area of the origin and domestication of cultivated white lupin ( Lupinus albus L.). In this work, we present the characterization of 19 white lupin landraces collected from several sites in southern Italy, characterized by different pedoclimatic conditions. The protein contents and electrophoretic patterns, total polyphenols, phytic acid, lipids and phosphorous content, and reducing and anti-tryptic activities have been determined for each landrace...
March 10, 2024: Plants (Basel, Switzerland)
#22
JOURNAL ARTICLE
Francesco Pasqualetti, Michela Gabelloni, Lorenzo Faggioni, Giovanni Donato Aquaro, Fabrizio De Vietro, Vincenzo Mendola, Nicola Spina, Jessica Frey, Nicola Montemurro, Martina Cantarella, Mario Caccese, Giovanni Gadducci, Noemi Giannini, Silvia Valenti, Riccardo Morganti, Tamara Ius, Maria Caffo, Giuseppe Vergaro, Mirco Cosottini, Antonio Giuseppe Naccarato, Giuseppe Lombardi, Guido Bocci, Emanuele Neri, Fabiola Paiar
Purpose: Clinical evidence suggests an association between comorbidities and outcome in patients with glioblastoma (GBM). We hypothesised that the internal carotid artery (ICA) calcium score could represent a promising prognostic biomarker in a competing risk analysis in patients diagnosed with GBM. Methods: We validated the use of the ICA calcium score as a surrogate marker of the coronary calcium score in 32 patients with lung cancer. Subsequently, we assessed the impact of the ICA calcium score on overall survival in GBM patients treated with radio-chemotherapy...
March 6, 2024: Journal of Clinical Medicine
#23
REVIEW
Pasquale Iozzo, Noemi Spina, Giovanna Cannizzaro, Valentina Gambino, Agostina Patinella, Stefano Bambi, Ercole Vellone, Rosaria Alvaro, Roberto Latina
(1) Background: Older patients who attend emergency departments are frailer than younger patients and are at a high risk of adverse outcomes; (2) Methods: To conduct this systematic review, we adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines. We systematically searched literature from PubMed, Embase, OVID Medline® , Scopus, CINAHL via EBSCOHost, and the Cochrane Library up to May 2023, while for grey literature we used Google Scholar. No time restrictions were applied, and only articles published in English were included...
February 23, 2024: Journal of Clinical Medicine
#24
JOURNAL ARTICLE
Lizeth Castillo Ramirez, María Del Rocío Guillen Nuñez, Àngel Manuel Jùarez Lemus, Ricardo Plancarte Sànchez, Viviana Andrea Villar Herrera, Gian Marco Gutierrez Herrera
Objectives An observational, retrospective, longitudinal, and analytical study aimed to evaluate the effectiveness of the erector spinae plane (ESP) block in managing pain in patients with vertebral fractures secondary to tumoral activity. This study included patients treated at the Pain Clinic who underwent ESP block. The objectives were to describe demographic characteristics, oncological diagnosis, vertebral fracture features, imaging techniques, medications used, and the level of ESP block. Additionally, pain levels were assessed using a numerical analog scale, and the consumption of opioid analgesic medications before and after the ESP block, during follow-up consultations, along with patient satisfaction...
March 2024: Curēus
#25
Rowan Saloner, Adam Staffaroni, Eric Dammer, Erik C B Johnson, Emily Paolillo, Amy Wise, Hilary Heuer, Leah Forsberg, Argentina Lario Lago, Julia Webb, Jacob Vogel, Alexander Santillo, Oskar Hansson, Joel Kramer, Bruce Miller, Jingyao Li, Joseph Loureiro, Rajeev Sivasankaran, Kathleen Worringer, Nicholas Seyfried, Jennifer Yokoyama, William Seeley, Salvatore Spina, Lea Grinberg, Lawren VandeVrede, Peter Ljubenkov, Ece Bayram, Andrea Bozoki, Danielle Brushaber, Ciaran Considine, Gregory Day, Bradford Dickerson, Kimiko Domoto-Reilly, Kelley Faber, Douglas Galasko, Daniel Geschwind, Nupur Ghoshal, Neill Graff-Radford, Chadwick Hales, Lawrence Honig, Ging-Yuek Hsiung, Edward Huey, John Kornak, Walter Kremers, Maria Lapid, Suzee Lee, Irene Litvan, Corey McMillan, Mario Mendez, Toji Miyagawa, Alexander Pantelyat, Belen Pascual, Henry Paulson, Leonard Petrucelli, Peter Pressman, Eliana Ramos, Katya Rascovsky, Erik Roberson, Rodolfo Savica, Allison Snyder, A Campbell Sullivan, Carmela Tartaglia, Marijne Vandebergh, Bradley Boeve, Howie Rosen, Julio Rojas, Adam Boxer, Kaitlin Casaletto
The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. We leveraged aptamer-based proteomics (> 4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations ( C9orf72 , GRN , MAPT ) compared to 39 noncarrier controls. Network analysis identified 31 protein co-expression modules. Proteomic signatures of genetic FTLD clinical severity included increased abundance of RNA splicing (particularly in C9orf72 and GRN ) and extracellular matrix (particularly in MAPT ) modules, as well as decreased abundance of synaptic/neuronal and autophagy modules...
March 28, 2024: Research Square
#26
JOURNAL ARTICLE
Derek Smith, Ban C H Tsui, Cynthia Khoo
Regional anesthesia nerve blocks are increasingly used for patients undergoing cardiac surgery as part of multimodal pain management. Though rare, local anesthetic systemic toxicity (LAST) is a severe complication that requires vigilant monitoring. We present a case of a postcardiac surgery patient who developed LAST multiple days after surgery from lidocaine via an erector spinae plane catheter. This episode was determined to be a result of impaired lidocaine metabolism from liver shock caused by worsening pulmonary hypertension...
April 1, 2024: A&A Practice
#27
JOURNAL ARTICLE
Hiroyuki Koga, Shunsuke Yamada, Masahiro Takeda, Takanori Ochi, Shogo Seo, Soichi Shibuya, Yuta Yazaki, Naho Fujiwara, Rumi Arii, Geoffrey J Lane, Atsuyuki Yamataka
Purpose: Retroperitoneal robotic-assisted pyeloplasty (ret-RAP) for ureteropelvic junction obstruction (UPJO) requires a larger retroperitoneal space (RS) to maintain specified distances between robotic (da Vinci) trocars and between trocars and the region of interest. A modified closed technique (MOT) and conventional closed technique (COT) were compared for creating an adequate RS with optical trocars. Methods: RS access in children with UPJO who underwent ret-RAP ( n = 30) was MOT ( n = 15) and COT ( n = 15)...
April 4, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
#28
JOURNAL ARTICLE
Faranak Mahmoudi Alami, Mohammad Taghipour, Ghadamali Talebi, Payam Sa'adat, Tahere Seyedhoseinpoor, Hamid Vahidi Rad, Sorayya Khafri
OBJECTIVES: Evaluation of spinal muscle morphology may be critical because of its impact on segmental stability and control of the lumbar spine in the subset of patients with clinical lumbar segmental instability (LSI). The purpose of this study was to compare lumbar muscle morphology in CNLBP patients with clinical LSI, CNLBP patients without clinical LSI. METHODS: This case-control study included 30 patients with CNLBP (15 with clinical LSI and 15 without clinical LSI) and 15 subjects without LBP...
2024: PloS One
#29
JOURNAL ARTICLE
Adrian Scutelnic, Anita van de Munckhof, Angel T Miraclin, Sanjith Aaron, Sajid Hameed, Mohammad Wasay, Oxana Grosu, Katarzyna Krzywicka, Mayte Sánchez van Kammen, Erik Lindgren, Tiago Moreira, Roberto Acampora, Alberto Negro, Theodoros Karapanayiotides, Shadi Yaghi, Anna Revert, Elisa Cuadrado Godia, Sebastian Garcia-Madrona, Paolino La Spina, Francesco Grillo, Fabrizio Giammello, Thanh N Nguyen, Mohamad Abdalkader, Alina Buture, Maria Sofia Cotelli, Nicolas Raposo, Georgios Tsivgoulis, Paolo Candelaresi, Antonio Ciacciarelli, Joshua Mbroh, Tatiana Batenkova, Pasquale Scoppettuolo, Marialuisa Zedde, Rosario Pascarella, Kateryna Antonenko, Espen S Kristoffersen, Johanna A Kremer Hovinga, Katarina Jood, Diana Aguiar de Sousa, Sven Poli, Turgut Tatlisumak, Jukka Putaala, Jonathan M Coutinho, José M Ferro, Marcel Arnold, Mirjam R Heldner
INTRODUCTION: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. PATIENTS AND METHODS: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison...
April 4, 2024: European Stroke Journal
#30
C Genovese, C E Rizzo, I La Spina, P Tripodi, A C Biondo, V Lo Prete, M P A Genovese, D G Balsamo, G Cipriano, G Genovese, A Nicita, G La Spada, V La Fauci, R Squeri
BACKGROUND: Adolescence is a critical phase of development characterized by numerous physical, psychological and social changes. During this stage, individuals may engage in experimentation and risky behavior, leading to increased vulnerability to addiction. This article aims to present the results of a survey based on the HBSC (Health Behavior in School-aged Children) surveillance model in a province of Southern Italy for primary and secondary school students. METHODS: We conducted a prospective study from March 2020 to April 2023 through the administration of a questionnaire to students of the healthcare faculties of the University of Messina and primary and secondary school students, composed of 19 items and based on HBSC surveillance...
2024: La Clinica Terapeutica
#31
JOURNAL ARTICLE
Yinchuan He, Hongtao Dong, Ming Lei, Jianan Liu, Hongru Xie, Zepei Zhang, Jun Pang, Mengyue Jin, Jian Wang, Ziming Geng, Jing'an Zhang, Gang Li, Qilong Yang, Lin Meng, Jun Miao
BACKGROUND: Patients with idiopathic scoliosis commonly present with an imbalance of the paraspinal muscles. However, it is unclear whether this muscle imbalance is an underlying cause or a result of idiopathic scoliosis. This study aimed to investigate the role of paraspinal muscles in the development of idiopathic scoliosis based on surface electromyography (sEMG) and radiographic analyses. METHODS: This was a single-center prospective study of 27 patients with single-curve idiopathic scoliosis...
April 3, 2024: BMC Musculoskeletal Disorders
#32
JOURNAL ARTICLE
Paul Köhli, Lukas Schönnagel, Jan Hambrecht, Jiaqi Zhu, Erika Chiapparelli, Ali E Güven, Gisberto Evangelisti, Krizia Amoroso, Roland Duculan, Bernhard Michalski, Jennifer Shue, Koki Tsuchiya, Marco D Burkhard, Andrew A Sama, Federico P Girardi, Frank P Cammisa, Carol A Mancuso, Alexander P Hughes
BACKGROUND/CONTEXT: Degenerative lumbar spondylolisthesis (DLS) is a prevalent spinal condition that can result in significant disability. DLS is thought to result from a combination of disc and facet joint degeneration, as well as various biological, biomechanical, and behavioral factors. One hypothesis is the progressive degeneration of segmental stabilizers, notably the paraspinal muscles, contributes to a vicious cycle of increasing slippage. PURPOSE: To examine the correlation between paraspinal muscle status on MRI and severity of slippage in patients with symptomatic DLS...
April 1, 2024: Spine Journal: Official Journal of the North American Spine Society
#33
JOURNAL ARTICLE
Li Fang Wang, Hong Xiang Feng, Yu Hui Shi, Yan Li, Meng Tao Zheng, Tegeleqi Bu, Zhen Rong Zhang
INTRODUCTION: Postoperative pain after thoracic surgery impairs patients' quality of life and increases the incidence of respiratory complications. Optimised analgesia strategies include minimally invasive incisions, regional analgesia and early chest tube removal. However, little is known about the optimal analgesic regimen for uniportal video-assisted thoracoscopic surgery (uVATS). METHODS AND ANALYSIS: We will conduct a single-centre, prospective, single-blind, randomised trial...
April 2, 2024: BMJ Open
#34
JOURNAL ARTICLE
Oliver Ludwig, Linda Wilhelm, Michael Fröhlich
[Purpose] The aim of this study was to examine whether the forward tilt of the sacrum, which can be measured using an inclinometer, correlates with pelvic tilt and is therefore suitable for therapeutic use as part of a postural assessment for treatment planning or for preventive screening. [Participants and Methods] In 121 athletes (22 females, 99 males), we measured the forward tilt of the sacrum in habitual stance using a digital inclinometer attached to the skin at the level of the posterior superior spinae...
April 2024: Journal of Physical Therapy Science
#35
Abhijit Satpati, Alexander V Soloviev, Felipe L Pereira, Mihovil Mladinov, Eva Larsen, Renata E P Leite, Claudia K Suemoto, Roberta D Rodriguez, Vitor R Paes, Christine Walsh, Salvatore Spina, William W Seeley, Carlos A Pasqualucci, Wilson Jacob Filho, Thomas C Neylan, Lea T Grinberg
BACKGROUND: Sleep-wake dysfunction is an early and common event in Alzheimer's disease (AD). The lateral hypothalamic area (LHA) regulates the sleep and wake cycle through wake-promoting orexinergic and sleep-promoting melanin-concentrating hormone (MCH) neurons. These neurons share close anatomical proximity with functional reciprocity. This study investigated the pattern of neuronal loss (ORX and MCH) in the LHA in AD. Understanding the degeneration pattern of these neurons will be instrumental in designing potential therapeutics to slow down the disease progression and remediate the sleep-wake dysfunction in AD...
March 12, 2024: bioRxiv
#36
JOURNAL ARTICLE
Onur Balaban, Ali Eman, Bedirhan Günel, Ali Fuat Erdem
No abstract text is available yet for this article.
April 2024: Journal of the Turkish Society of Algology
#37
JOURNAL ARTICLE
Abdulhakim Şengel, Nuray Altay, Mehmet Demir
OBJECTIVES: Intravenous opioids and local anesthetic infiltrations are traditionally used to relieve postoperative pain. With developments in the field of regional anesthesia, several methods are now available for postoperative analgesia. This study aimed to investigate the efficacy of the erector spinae plane block (ESPB) in reducing both intraoperative opioid consumption and postoperative analgesic use in patients undergoing percutaneous nephrolithotomy (PCNL). METHODS: A total of 60 patients who underwent PCNL were divided into two groups: 30 patients who received ESPB (Group I) and 30 patients in the control group (Group II)...
April 2024: Journal of the Turkish Society of Algology
#38
JOURNAL ARTICLE
Cristiano Bendinelli, Marianna D'Angelo, Fabio Leonardi, Natali Verdier, Francesca Cozzi, Rocco Lombardo, Diego A Portela
OBJECTIVE: To compare the perioperative cumulative opioid consumption and the incidence of cardiovascular complications in dogs undergoing hemilaminectomy in which either an erector spinae plane (ESP) block or systemic opioids were administered. STUDY DESIGN: Prospective randomized clinical trial. ANIMALS: A total of 60 client-owned dogs. METHODS: Dogs were randomized to one of three groups: an ESP block (group ESP), a constant rate infusion of fentanyl (group FNT, positive control) or a single dose of methadone as premedication (group MTD, negative control)...
February 10, 2024: Veterinary Anaesthesia and Analgesia
#39
JOURNAL ARTICLE
Siu-Chuen Pang, Zaheen Ahmed Iqbal, Daniel Hung-Kay Chow
BACKGROUND: Trolley bags have gained popularity among students, but there is limited research comparing them to backpack-style school bags. OBJECTIVE: This study aimed to compare how carrying a backpack versus a trolley bag affects the activity of trunk and lower limb muscles in secondary school students. METHODS: Electromyographic activity was measured in 25 students (13.4±1.1 years) as they walked on level ground and up/down stairs while carrying both types of bags...
March 25, 2024: Work: a Journal of Prevention, Assessment, and Rehabilitation
#40
JOURNAL ARTICLE
Koji Murofushi, Tsuyoshi Morito, Hiroshi Akuzawa, Tomoki Oshikawa, Yu Okubo, Koji Kaneoka, Sho Mitomo, Kazuyoshi Yagishita
INTRODUCTION: Core stability is crucial for preventing and rehabilitating lumbar spine injuries. An external focus instruction using a paper balloon is an effective way to activate the trunk muscles. However, the degree of trunk and lower extremity muscle activation during single leg stance with external focus instruction using a paper balloon is unknown. This study aimed to investigate the core muscle involving activity in the trunk and lower extremities on both the support and non-support sides with or without using external focus instruction using a paper balloon during isometric single-leg stance...
2024: Frontiers in sports and active living
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