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M D Arguisuelas, J F Lisón, J Doménech-Fernández, I Martínez-Hurtado, P Salvador Coloma, D Sánchez-Zuriaga
BACKGROUND: Flexion-relaxation response of the lumbar erector spinae has been previously studied after different interventions such as exercise programs or spinal manipulation, in subjects with chronic low back pain. The objective of the study was to investigate the effects of an isolated myofascial release protocol on erector spinae myoelectric activity and lumbar spine kinematics in chronic low back pain. METHODS: Thirty-six participants, with nonspecific chronic low back pain, were randomized to myofascial release group (n = 18) receiving four sessions of myofascial treatment, each lasting 40 min, and to control group (n = 18) receiving a sham myofascial release...
February 14, 2019: Clinical Biomechanics
Fabio Spina, Laura Brizzi, Giliola Spattini, Fabio Faiola, Francesco Birettoni
BACKGROUND: Previous ultrasonographic studies of Sapajus apella to determine the normal anatomy and physiology are incomplete. The aim of this study was to determine normal ultrasonographic appearance and measurements of all abdominal organs and structures of interest. METHODS: Twelve adult monkeys were recruited considered healthy on the basis of history, physical examination, and general blood work. To avoid additional anesthesia, the ultrasonographic examinations were performed during routine screening, annually scheduled by the Unit of Cognitive Primatology & Primate Center, CNR-Rome, where the animals were housed...
February 19, 2019: Journal of Medical Primatology
Gabriel G Carlo, Leonardo Ermann, Alejandro M F Rivas, María E Spina
We study the properties of classical and quantum stable structures in a three-dimensional (3D) parameter space corresponding to the dissipative kicked top. This is a model system in quantum and classical chaos that gives a starting point for many body examples. We are able to identify the influence of these structures in the spectra and eigenstates of the corresponding (super)operators. This provides a complementary view with respect to the typical two-dimensional parameter space systems found in the literature...
January 2019: Physical Review. E
Min-Jyue Huang, Kazunori Nosaka, Ho-Seng Wang, Kuo-Wei Tseng, Hsin-Lian Chen, Tai-Ying Chou, Trevor C Chen
PURPOSE: Low-intensity eccentric contractions with a load corresponding to 10% of maximal voluntary isometric contraction strength (10% EC) attenuate muscle damage in a subsequent bout of higher-intensity eccentric contractions performed within 2 weeks for the elbow flexors, knee flexors and knee extensors. However, it is not known whether this strategy could be applied to other muscles. This study investigated whether 10% EC would confer damage protective effect on high-intensity eccentric contractions (80% EC) for nine different muscle groups...
February 18, 2019: European Journal of Applied Physiology
Christopher A Smith, Kelly M Martin
No abstract text is available yet for this article.
February 19, 2019: Korean Journal of Anesthesiology
Yongzhong Li, Xuyang Zhang, Jie Dai, Jiasheng Wang, Hao Wu, Junhui Liu, Jian Chen, Yixiao Zhu, Fengdong Zhao
BACKGROUND: Previous studies of percutaneous endoscopic lumbar discectomy (PELD) for the treatment of lumbar disc herniation (LDH) have shown good clinical results. However, there is limited information about the post-operative improvement in back muscle function. We aimed to determine whether changes in neuromuscular patterns, assessed using the flexion-relaxation phenomenon (FRP), could be observed following PELD surgery. METHODS: Thirty patients participated in the study...
February 15, 2019: World Neurosurgery
Vadim Goz, Christopher Anthony, Andrew Pugely, Brandon Lawrence, Nicholas Spina, Darrel Brodke, William Ryan Spiker
Study Design: Observational study. Objectives: Perioperative patient anxiety is a major concern in orthopedic surgery. Mobile messaging applications have been used in a number of healthcare settings. The goal of this project is to develop a novel mobile messaging application aimed at decreasing perioperative patient anxiety in spine surgery patients. Methods: Postoperative recovery journals were collected from patients undergoing spine surgery...
February 2019: Global Spine Journal
Vasanth Rao Kadam, Medhat Wahba
No abstract text is available yet for this article.
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Alexander von Glinski, Emre Yilmaz, Silvia Mrotzek, Eike Marek, Birger Jettkant, Alexis Brinkemper, Christian Fisahn, Thomas A Schildhauer, Jan Geßmann
The Hybrid Assistive Limb Lumbar Type (HAL) is an active exoskeleton that provides motion according to the wearer's voluntary drive. It was developed to support back muscles during repetitive lifting tasks. The purpose of this paper was to determine if the myoelectric activity of the back muscles is reduced or altered when using the HAL and to investigate a possible influence of its use on the cardiovascular system. Fourteen healthy young men without lower back pain underwent a freestyle, symmetrical-lifting protocol...
February 14, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Sung Woo Moon, Ji Soo Choi, Sang Hoon Lee, Kyung Soo Jung, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Joon Chang, Song Yee Kim
BACKGROUND: Sarcopenia can contribute to negative outcomes in patients with various lung diseases. However, whether sarcopenia affects prognosis in patients with idiopathic pulmonary fibrosis (IPF) has not been reported. Simple measures of muscle mass, derived from chest computed tomography (CT), are increasingly being used to identify patients with sarcopenia. We hypothesized that skeletal muscle mass could be a predictor of prognosis in IPF patients. METHODS: We retrospectively evaluated 180 patients diagnosed with IPF between January 2010 and December 2015 at a tertiary care hospital in South Korea...
February 15, 2019: Respiratory Research
Jeff L Xu, Jorge Con, Jian Hou, Shalvi B Parikh, Joshua M Junge, Bernd Dotzauer
No abstract text is available yet for this article.
January 1, 2019: American Surgeon
Steve Roberts, Thomas Engelhardt
No abstract text is available yet for this article.
February 13, 2019: Minerva Anestesiologica
Madan Narayanan, Arun Venkataraju
No abstract text is available yet for this article.
February 13, 2019: Regional Anesthesia and Pain Medicine
Jeff L Xu, Jorge Con, Jian Hou, Shalvi B Parikh, Joshua M Junge, Bernd Dotzauer
No abstract text is available yet for this article.
January 1, 2019: American Surgeon
Carlos Rodrigues Almeida, Ana Raquel Oliveira, Pedro Cunha
Supplementary strategies, in combination with conventional analgesia, for pain control after lumbar fusion surgery remain limited. Here, we describe a 79-year-old woman who experienced pain (10/10 on a numerical rating scale) on post-operative day 1 after undergoing L2 to S1 spine fusion. Erector spinae plane (ESP) blocks were performed at T8 and, after a bolus of ropivacaine 0.2% (20 ml) per side, perineural catheters were placed bilaterally. Continuous infusion (5 ml/h) of ropivacaine 0.2% per side was maintained for 48 h...
February 13, 2019: Pain Practice: the Official Journal of World Institute of Pain
Quentin Baca, Carole Lin, Kelly O'Hare, Brenda Golianu, Ban Tsui
We read with great interest the excellent editorial by Dr.Bosenberg addressing innovative peripheral nerve blocks1 . As highlighted by Dr.Bosenberg, the newly described erector spinae plane (ESP) peripheral nerve block is used across multiple surgical specialties to provide perioperative pain control.2 With patient's father consent, we would like to share our recent experience with using continuous ESP for management of refractory pain in a pediatric patient receiving palliative care. This article is protected by copyright...
February 13, 2019: Paediatric Anaesthesia
Mitsuhiro Masaki, Xiang Ji, Taishi Yamauchi, Hiroshige Tateuchi, Noriaki Ichihashi
PURPOSE: The present study aimed to clarify the effects of the trunk position on muscle stiffness that reflects elongation of the lumbar erector spinae and lumbar multifidus muscles using ultrasonic shear wave elastography (SWE). METHODS: The study included ten healthy men. The shear elastic modulus of the left lumbar erector spinae and lumbar multifidus muscles were evaluated using ultrasonic SWE. Measurement postures for the left lumbar erector spinae muscle were (1) prone position (Rest), (2) sitting position with the trunk flexed (Flexion), (3) the Flexion position adding right trunk lateral flexion (Flexion-Lateral Flexion), and (4) the Flexion position adding right trunk rotation (Flexion-Rotation 1)...
February 12, 2019: European Journal of Applied Physiology
Nadejda Beliakova-Bethell, Amey Mukim, Cory H White, Savitha Deshmukh, Hosiana Abewe, Douglas D Richman, Celsa A Spina
Histone deacetylase (HDAC) inhibitors (HDACi) have been widely tested in clinical trials for their ability to reverse HIV latency, but have yielded only limited success. One HDACi, suberoylanilide hydroxamic acid (SAHA), exhibits off-target effects on host gene expression predicted to interfere with induction of HIV transcription. Romidepsin (RMD) has higher potency and specificity for class I HDACs implicated in maintaining HIV provirus in the latent state. More robust HIV reactivation has indeed been achieved with RMD use ex vivo than with SAHA; however, reduction of viral reservoir size has not been observed in clinical trials...
February 11, 2019: Journal of Biological Chemistry
S D Adhikary, W M Liu, E Fuller, H Cruz-Eng, K J Chin
Regional anaesthesia is often helpful in improving respiratory function and analgesia following multiple rib fractures. The erector spinae plane block has become the technique of choice in our institution due to its relative simplicity and purported safety. The aim of this retrospective cohort study was to determine its effectiveness in improving respiratory and analgesic outcomes. We reviewed electronic medical records of patients with traumatic rib fractures admitted to a level-one trauma centre between January 2016 and July 2017, who also received erector spinae plane blocks...
February 10, 2019: Anaesthesia
Johannes Popow, Heribert Arnhof, Gerd Bader, Helmut Berger, Alessio Ciulli, David Covini, Christian Dank, Teresa Gmaschitz, Peter Greb, Jale Karolyi-Oezguer, Manfred Koegl, Darryl McConnell, Mark Pearson, Maria Rieger, Jörg Rinnenthal, Vanessa Roessler, Andreas Schrenk, Markus Spina, Steffen Steurer, Nicole Trainor, Elisabeth Traxler, Corinna Wieshofer, Andreas Zoephel, Peter Ettmayer
The focal adhesion tyrosine kinase (PTK2) is often over-expressed in human hepatocellular carcinoma (HCC) and several reports have linked PTK2 depletion and/or pharmacological inhibition to reduced tumorigenicity. However, the clinical relevance of targeting PTK2 still remains to be proven. Here we present two highly selective and functional PTK2 PROTACs utilizing VHL and cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 (cereblon-based) degrades PTK2 with a median DC50 of 30 nM to > 80 % across a panel of eleven HCC cell lines...
February 9, 2019: Journal of Medicinal Chemistry
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