Bo Tan, Sucai Dong, Robert L Shepard, Lisa Kays, Kenneth D Roth, Sandaruwan Geeganage, Ming-Shang Kuo, Genshi Zhao
Nicotinamide phosphoribosyltransferase (NAMPT) has been extensively studied due to its essential role in NAD(+) biosynthesis in cancer cells and the prospect of developing novel therapeutics. To understand how NAMPT regulates cellular metabolism, we have shown that the treatment with FK866, a specific NAMPT inhibitor, leads to attenuation of glycolysis by blocking the glyceraldehyde 3-phosphate dehydrogenase step (Tan, B., Young, D. A., Lu, Z. H., Wang, T., Meier, T. I., Shepard, R. L., Roth, K., Zhai, Y., Huss, K...
June 19, 2015: Journal of Biological Chemistry