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Stage 4 colorectal cancer

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https://read.qxmd.com/read/30785889/early-stage-serrated-adenocarcinomas-are-divided-into-several-molecularly-distinct-subtypes
#1
Daiki Hirano, Yuji Urabe, Shinji Tanaka, Koki Nakamura, Yuki Ninomiya, Ryo Yuge, Ryohei Hayashi, Shiro Oka, Yasuhiko Kitadai, Fumio Shimamoto, Koji Arihiro, Kazuaki Chayama
Serrated adenocarcinoma (SAC) is considered the end stage of the serrated neoplasia pathway. Although SAC prognosis is not widely recognized, the serrated pathway-associated subtype consistently exhibits unfavorable prognosis in genetic studies. Herein, we classified molecularly distinct subtypes of serrated adenocarcinomas and clarified their associated clinicopathological characteristics and genetic changes. We examined 38 early-stage colorectal SACs. Of these, 24 were classified into three molecularly distinct groups by colon cancer subtyping (CCS)...
2019: PloS One
https://read.qxmd.com/read/30766628/stent-experiences-in-emergency-conditions-in-acute-mechanical-intestinal-obstruction-caused-by-colorectal-cancer
#2
Savas Bayrak, Cihad Tatar, Erdem Kinaci, Ekrem Cakar, Sukru Colak, Mert Mahsuni Sevinc, Hasan Bektas
Introduction: Stent treatment can be applied to avoid surgery in surgically risky patients or to turn a high-risk emergency operation into a lower-risk elective operation and save time. Aim: In this study, the techniques, clinical efficacy, safety and complications of endoscopic stents applied in emergency conditions were evaluated in patients with acute mechanical intestinal obstruction (AMIO) due to colorectal cancer. Material and methods: Between 2013 and 2015, 23 patients with an average age of 69...
January 2019: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://read.qxmd.com/read/30765268/association-of-multidimensional-comorbidities-with-survival-toxicity-and-unplanned-hospitalizations-in-older-adults-with-metastatic-colorectal-cancer-treated-with-chemotherapy
#3
Ki Hyang Kim, Jae Jin Lee, Jongphil Kim, Jun-Min Zhou, Fabio Gomes, Marina Sehovic, Martine Extermann
BACKGROUND: Studies of older patients with colorectal cancer(CRC) have found inconsistent results about the correlation of various comorbidities with overall survival(OS) and treatment tolerance. To refine our understanding, we evaluated this correlation using the Cumulative Illness Rating Scale-Geriatric(CIRS-G) and heat maps to identify subgroups with the highest impact. METHODS: We retrospectively reviewed 153 patients aged 65 years and older with stage IV CRC undergoing chemotherapy...
February 11, 2019: Journal of Geriatric Oncology
https://read.qxmd.com/read/30764801/immediate-term-cognitive-impairment-following-intravenous-iv-chemotherapy-a-prospective-pre-post-design-study
#4
Omar F Khan, Ellen Cusano, Soundouss Raissouni, Mica Pabia, Johanna Haeseker, Nicholas Bosma, Jenny J Ko, Haocheng Li, Aalok Kumar, Michael M Vickers, Patricia A Tang
BACKGROUND: Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset is not known. This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to assess cognitive impairment immediately post-chemotherapy. METHODS: Patients aged 18-80 years receiving first-line intravenous chemotherapy for any stage of breast or colorectal cancer were eligible. Patient symptoms, peripheral neuropathy and Stanford Sleepiness Scale were assessed...
February 14, 2019: BMC Cancer
https://read.qxmd.com/read/30761122/layn-is-a-prognostic-biomarker-and-correlated-with-immune-infiltrates-in-gastric-and-colon-cancers
#5
Jing-Hua Pan, Hong Zhou, Laura Cooper, Jin-Lian Huang, Sheng-Bin Zhu, Xiao-Xu Zhao, Hui Ding, Yun-Long Pan, Lijun Rong
Background: Layilin (LAYN) is a critical gene that regulates T cell function. However, the correlations of LAYN to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear. Methods: LAYN expression was analyzed via the Oncomine database and Tumor Immune Estimation Resource (TIMER) site. We evaluated the influence of LAYN on clinical prognosis using Kaplan-Meier plotter, the PrognoScan database and Gene Expression Profiling Interactive Analysis (GEPIA). The correlations between LAYN and cancer immune infiltrates was investigated via TIMER...
2019: Frontiers in Immunology
https://read.qxmd.com/read/30745610/cancer-relapse-in-surgical-patients-who-received-perioperative-transfusion-of-blood-and-blood-products-a-case-control-study
#6
R Subha, Kurian Cherian, Archana Nair, Rachel Cherian Koshy, Jagathnath Krishna
Background and Aims: Immunomodulatory consequences of allogeneic blood transfusion may outweigh the advantages of improved oxygen delivery and tissue perfusion, especially in patients with cancer. In colorectal cancer, there is evidence of cancer relapse in patients who received transfusion. This retrospective analysis was undertaken to evaluate the relationship between perioperative blood transfusion and cancer recurrence in patients undergoing oncosurgery. Methods: In this case-control study, we retrospectively analysed the case sheets of 194 patients who had perioperative transfusion and underwent cancer surgery from March to December 2013(Study group, Cases)...
January 2019: Indian Journal of Anaesthesia
https://read.qxmd.com/read/30741768/is-the-pathologic-response-of-t3-rectal-cancer-to-high-dose-rate-endorectal-brachytherapy-comparable-to-external-beam-radiotherapy
#7
Richard Garfinkle, Sebastian Lachance, Te Vuong, Alexandre Mikhail, Vincent Pelsser, Adrian Gologan, Nancy A Morin, Carol-Ann Vasilevsky, Marylise Boutros
BACKGROUND: Endorectal brachytherapy is an attractive option in the neoadjuvant setting for locally advanced rectal cancer, but it is not considered standard of care. OBJECTIVE: This study aimed to compare pathologic outcomes of patients with clinical T3 rectal cancer who underwent high-dose-rate endorectal brachytherapy with those who underwent conventional external beam radiotherapy. DESIGN: This study is a retrospective chart review. SETTINGS: This study was conducted in a single large tertiary academic colorectal surgery practice in Canada...
March 2019: Diseases of the Colon and Rectum
https://read.qxmd.com/read/30739887/the-prognostic-value-of-kras-and-braf-in-stage-i-iii-colorectal-cancer-a-systematic-review
#8
Gaetano Gallo, Giuseppe Sena, Giuseppina Vescio, Matteo Papandrea, Rosario Sacco, Mario Trompetto, Giuseppe Sammarco
BACKGROUND: Colorectal cancer (CRC) is one of the leading cause of cancer deaths worldwide. The aetiology of CRC is complex and involves interaction on environmental and genetic factors. The two most important pathways are the EGFR (Epidermal Grow Factor Receptor) signaling pathway, with the involvement of KRAS and BRAF, and the DNA mismatch repair (MMR). Generally, KRAS and BRAF mutations are mutually exclusive. They are both able to cause RAS/RAF/MAPK signaling pathway upregulation and are necessary for CRC development...
February 4, 2019: Annali Italiani di Chirurgia
https://read.qxmd.com/read/30738630/mortality-in-incident-maintenance-dialysis-patients-versus-incident-solid-organ-cancer-patients-a-population-based-cohort
#9
Kyla L Naylor, S Joseph Kim, Eric McArthur, Amit X Garg, Megan K McCallum, Gregory A Knoll
RATIONALE & OBJECTIVE: The mortality rate is high among dialysis patients, but how this compares with other diseases such as cancer is poorly understood. We compared the survival of maintenance dialysis patients with that for patients with common cancers to enhance the understanding of the burden of end-stage kidney disease. STUDY DESIGN: Population-based cohort study. SETTING & PARTICIPANTS: 33,500 incident maintenance dialysis patients in Ontario, Canada, and 532,452 incident patients with cancer (women: breast, colorectal, lung, or pancreas; men: prostate, colorectal, lung, or pancreas) from 1997 to 2015 using administrative health care databases...
January 28, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/30738427/a-genome-wide-association-study-identifies-single-nucleotide-polymorphisms-associated-with-time-to-metastasis-in-colorectal-cancer
#10
Michelle E Penney, Patrick S Parfrey, Sevtap Savas, Yildiz E Yilmaz
BACKGROUND: Differentiating between cancer patients who will experience metastasis within a short time and who will be long-term survivors without metastasis is a critical aim in healthcare. The microsatellite instability (MSI)-high tumor phenotype is such a differentiator in colorectal cancer, as patients with these tumors are unlikely to experience metastasis. Our aim in this study was to determine if germline genetic variations could further differentiate colorectal cancer patients based on the long-term risk and timing of metastasis...
February 9, 2019: BMC Cancer
https://read.qxmd.com/read/30734025/low-carbohydrate-diet-score-and-macronutrient-intake-in-relation-to-survival-after-colorectal-cancer-diagnosis
#11
Mingyang Song, Kana Wu, Jeffrey A Meyerhardt, Omer Yilmaz, Molin Wang, Shuji Ogino, Charles S Fuchs, Edward L Giovannucci, Andrew T Chan
Background: A low-carbohydrate diet may improve cancer survival, but relevant clinical evidence remains limited. Methods: We followed 1542 stages I to III colorectal cancer (CRC) patients who completed a validated food frequency questionnaire between 6 months and 4 years after diagnosis. We calculated overall, animal-, and plant-rich, low-carbohydrate diet scores and examined their associations with CRC-specific and overall mortality using Cox proportional hazards regression after adjusting for potential predictors for cancer survival...
November 2018: JNCI cancer spectrum
https://read.qxmd.com/read/30719633/prognostic-value-of-primary-tumor-sidedness-for-unresectable-stage-iv-colorectal-cancer-a-retrospective-study
#12
Dai Shida, Taro Tanabe, Narikazu Boku, Atsuo Takashima, Takefumi Yoshida, Shunsuke Tsukamoto, Yukihide Kanemitsu
BACKGROUND: When treated with molecular targeted agents, patients with unresectable colorectal cancer with right-sided tumors have poorer prognoses than those with left-sided tumors. While primary tumor sidedness may have prognostic value, the prognostic value of tumor sidedness in chemotherapy regimens without targeted therapy is unclear. METHODS: Our study population comprised 678 consecutive patients with unresectable stage IV colorectal cancer who received systemic chemotherapy at the National Cancer Center Hospital in Japan from 1999 to 2015...
February 4, 2019: Annals of Surgical Oncology
https://read.qxmd.com/read/30719125/prognostic-value-of-the-tumor-size-in-resectable-colorectal-cancer-with-different-primary-locations-a-retrospective-study-with-the-propensity-score-matching
#13
Xiao Li, Bang An, Jincai Ma, Bo He, Jianni Qi, Wenwen Wang, Chengyong Qin, Qi Zhao
Objective: To investigate the prognostic value of the tumor size in colorectal cancer (CRC) patients with different primary tumor locations. Patients and methods: We retrospectively recruited 3971 stage I-III CRC patients with curative resection. The propensity score matching technique was conducted to reduce the selection bias, producing a propensity score matched cohort of 1347 pairs of patients based on the tumor size (≤4 cm and >4 cm groups). Kaplan-Meier survival analyses and univariate and multivariate analyses were used to compare the overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) between the two groups...
2019: Journal of Cancer
https://read.qxmd.com/read/30712552/the-association-between-body-mass-index-and-postoperative-complications-30-day-mortality-and-long-term-survival-in-dutch-patients-with-colorectal-cancer
#14
J H C Arkenbosch, F N van Erning, H J Rutten, D Zimmerman, J H W de Wilt, S Beijer
INTRODUCTION: This retrospective study aims to examine the association between body mass index (BMI) and serious postoperative complications, 30-day mortality and overall survival in colorectal cancer (CRC) patients. MATERIALS AND METHODS: All CRC patients diagnosed between 2008 and 2013 in the south-eastern part of the Netherlands were included. Patients were categorized into four BMI groups: underweight (<18.5), normal weight (18.5 ≥ BMI<25), overweight (25 ≥ BMI<30), and obese (≥30)...
February 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30712157/colorectal-cancer-in-young-adults
#15
REVIEW
Anand Venugopal, Elena M Stoffel
PURPOSE OF REVIEW: Routine screening for colorectal cancer (CRC) in adults > 50 years of age has led to overall reductions in CRC incidence and CRC-related mortality. Yet CRC incidence among young adults age < 50 continues to increase without a clear explanation. This review examines the changing epidemiology of CRC and emerging evidence regarding the influence of genetic and lifestyle factors on risk for colorectal neoplasia. RECENT FINDINGS: Young-onset CRC (yCRC), defined as CRC diagnosed in individuals younger than age 50, is a heterogeneous disease...
February 2, 2019: Current Treatment Options in Gastroenterology
https://read.qxmd.com/read/30710321/toll-like-receptor-4-and-matrix-metalloproteases-11-and-13-as-predictors-of-tumor-recurrence-and-survival-in-stage-ii-colorectal-cancer
#16
Noemi Eiro, Juan Francisco Carrión, Sandra Cid, Alejandro Andicoechea, José Luis García-Muñiz, Luis O González, Francisco J Vizoso
Current clinical-pathologic stratification factors do not allow clear identification of high-risk stage II colorectal cancer (CRC) patients. Therefore, the identification of additional prognostic markers is desirable. Toll-like receptor (TLR)-4 is activated during tumorigenesis and matrix metalloproteases (MMPs) are involved in invasion and metastasis. We aimed to evaluate the expression and clinical relevance of TLR4, MMP11 and MMP13 for patients with stage II CRC. Immunohistochemistry was used to study the expression of TLR4, MMP11 and MMP13 in 96 patients with stage II CRC...
February 1, 2019: Pathology Oncology Research: POR
https://read.qxmd.com/read/30706852/tumor-budding-in-laryngeal-carcinoma
#17
Sumeyye Ekmekci, Ulku Kucuk, Seda Kokkoz, Ebru Cakir, Murat Gumussoy
Background: Tumor budding was defined as a single cancer cell or a cluster of fewer than five cancer cells in the stroma of the invasive tumor margin. It has been suggested as a prognostic factor in various cancers, such as esophageal, lung, colorectal, and endometrial. There are only a few studies about the prognostic signifi cance of tumor budding in laryngeal carcinomas. Materials and Methods: A total of 81 patients with laryngeal carcinoma diagnosed between 2011 and 2016 and treated by partial or total laryngectomy were evaluated...
January 2019: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/30706232/survival-in-patients-with-high-grade-colorectal-neuroendocrine-carcinomas-the-role-of-surgery-and-chemotherapy
#18
Adam C Fields, Pamela Lu, Benjamin M Vierra, Frances Hu, Jennifer Irani, Ronald Bleday, Joel E Goldberg, Garrett M Nash, Nelya Melnitchouk
BACKGROUND: Colorectal neuroendocrine tumors are a rare malignancy, yet their incidence appears to be increasing. The optimal treatment for the high-grade subset of these tumors remains unclear. We aimed to examine the relationship between different treatment modalities and outcomes for patients with high-grade neuroendocrine carcinomas (HGNECs) of the colon and rectum. METHODS: The National Cancer Database (2004-2015) was used to identify patients diagnosed with colorectal HGNECs...
January 31, 2019: Annals of Surgical Oncology
https://read.qxmd.com/read/30704375/-what-matters-to-you-a-longitudinal-qualitative-study-of-norwegian-patients-perspectives-on-their-pathways-with-colorectal-cancer
#19
Frank Hansen, Gro K Rosvold Berntsen, Anita Salamonsen
PURPOSE: Person-centred care (PCC) is a well-acknowledged goal throughout the western world both within the health care services sector and for the patients themselves. To be able to create a future health care system that includes improved PCC, we need more in-depth knowledge of what matters to patients, how "what matters" might change over time, and tentative descriptions of commonalities across patients' perspectives. The aim of this study is to contribute to this knowledge base...
December 2018: International Journal of Qualitative Studies on Health and Well-being
https://read.qxmd.com/read/30693389/the-oncological-and-surgical-safety-of-robot-assisted-surgery-in-colorectal-cancer-outcomes-of-a-longitudinal-prospective-cohort-study
#20
F Polat, L H Willems, K Dogan, C Rosman
BACKGROUND: Colorectal cancer is one of the most common cancers worldwide. Laparoscopic colorectal surgery (LCRS) is a frequently used modality. A new development in minimally invasive surgery is robot-assisted colorectal surgery (RACRS). METHODS: Prospectively collected data of 378 consecutive patients who underwent RACRS or LCRS for stage I-III colorectal cancer from Dec 2014 to Oct 2017 were analyzed. Primary outcome was oncological outcome (radical margins, number of retrieved lymph nodes, locoregional recurrence)...
January 28, 2019: Surgical Endoscopy
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