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Michael Geylis, Guy Bec, Dana Danino, Ruth Schreiber, Dima Hassan, Karen Nalbandyan, Amit Nahum
We present a 5-year-old female with minimal change nephrotic syndrome (MCNS). Within several months, she became steroid-dependent with progression of edema and ascites. Imaging studies revealed abnormal solid mass and liver cysts and she was diagnosed with both abdominal Hodgkin's lymphoma (cHD) and large hepatic cystic echinococcosis (CE). Association between MCNS and cHL or with CE has been described in the literature in adults and rarely in the pediatric population. We report, for the first time, a simultaneous occurrence of all three: MCNS, cHL, and CE...
February 20, 2019: Pediatric Hematology and Oncology
Brian Tsang, Jason Arsenault, Robert M Vernon, Hong Lin, Nahum Sonenberg, Lu-Yang Wang, Alaji Bah, Julie D Forman-Kay
Activity-dependent translation requires the transport of mRNAs within membraneless protein assemblies known as neuronal granules from the cell body toward synaptic regions. Translation of mRNA is inhibited in these granules during transport but quickly activated in response to neuronal stimuli at the synapse. This raises an important question: how does synaptic activity trigger translation of once-silenced mRNAs? Here, we demonstrate a strong connection between phase separation, the process underlying the formation of many different types of cellular granules, and in vitro inhibition of translation...
February 14, 2019: Proceedings of the National Academy of Sciences of the United States of America
Tomáš Andrašina, Josef Jaroš, Tomáš Jůza, Tomáš Rohan, Dalibor Červinka, Michal Crha, Vlastimil Válek, Nahum S Goldberg
PURPOSE: To compare the accumulation and effect of liposomal doxorubicin in liver tissue treated by radiofrequency ablation (RFA) and irreversible electroporation (IRE) in in vivo porcine models. MATERIALS AND METHODS: Sixteen RFA and 16 IRE procedures were performed in healthy liver of two groups of three pigs. Multi-tined RFA parameters included: 100 W, target temperature 105°C for 7 min. 100 IRE pulses were delivered using two monopolar electrodes at 2250 V, 1 Hz, for 100 µsec...
February 13, 2019: Cardiovascular and Interventional Radiology
S Nahum Goldberg
No abstract text is available yet for this article.
February 12, 2019: Radiology
Bruno Biagianti, Melissa Fisher, Benjamin Brandrett, Danielle Schlosser, Rachel Loewy, Mor Nahum, Sophia Vinogradov
Cognitive impairment in schizophrenia is often severe, enduring, and contributes significantly to chronic disability. A standardized platform for identifying cognitive impairments and measuring treatment effects in cognition is a critical aspect of comprehensive evaluation and treatment for individuals with schizophrenia. In this project, we developed and tested a suite of ten web-based, neuroscience-informed cognitive assessments that are designed to enable the interpretation of specific deficits that could signal that an individual is experiencing cognitive difficulties...
February 4, 2019: Schizophrenia Research
Samuel L Rice, Reto Bale, David J Breen, Thierry de Baere, Alban Denys, Boris Guiu, Nahum Goldberg, Edward Kim, Robert J Lewandowski, Thomas Helmberger, Martijn Mejerjink, Philippe L Pereira, Luigi Solbiati, Stephen B Solomon, Constantinos T Sofocleous
No abstract text is available yet for this article.
March 1, 2019: International Journal of Radiation Oncology, Biology, Physics
Slavé Petrovski, Vimla Aggarwal, Jessica L Giordano, Melissa Stosic, Karen Wou, Louise Bier, Erica Spiegel, Kelly Brennan, Nicholas Stong, Vaidehi Jobanputra, Zhong Ren, Xiaolin Zhu, Caroline Mebane, Odelia Nahum, Quanli Wang, Sitharthan Kamalakaran, Colin Malone, Kwame Anyane-Yeboa, Russell Miller, Brynn Levy, David B Goldstein, Ronald J Wapner
BACKGROUND: Identification of chromosomal aneuploidies and copy number variants that are associated with fetal structural anomalies has substantial value. Although whole-exome sequencing (WES) has been applied to case series of a few selected prenatal cases, its value in routine clinical settings has not been prospectively assessed in a large unselected cohort of fetuses with structural anomalies. We therefore aimed to determine the incremental diagnostic yield (ie, the added value) of WES following uninformative results of standard investigations with karyotype testing and chromosomal microarray in an unselected cohort of sequential pregnancies showing fetal structural anomalies...
January 31, 2019: Lancet
Kira Nahum Sacks, Michael Friger, Ilana Shoham-Vardi, Ruslan Sergienko, Efrat Spiegel, Daniella Landau, Eyal Sheiner
INTRODUCTION: There are contradicting findings in the current literature regarding the association between in-utero exposure to preeclampsia and the long-term neuropsychiatric health of the offspring. The objective of this study is to assess whether prenatal exposure to preeclampsia increases the risk of long-term neuropsychiatric morbidity. METHODS: A retrospective population-based cohort study compared neuropsychiatric morbidity between singletons exposed and unexposed to preeclampsia...
January 31, 2019: Early Human Development
Rimma Goldberg, Cristiano Scotta, Dianne Cooper, Einat Nissim-Eliraz, Eilam Nir, Scott Tasker, Peter M Irving, Jeremy Sanderson, Paul Lavender, Fowzia Ibrahim, Jonathan Corcoran, Toby Prevost, Nahum Y Shpigel, Federica Marelli-Berg, Giovanna Lombardi, Graham M Lord
BACKGROUND & AIMS: Crohn's disease (CD) is characterized by an imbalance of effector and regulatory T cells in the intestinal mucosa. The efficacy of anti-adhesion therapies led us to investigate whether impaired trafficking of T-regulatory (Treg) cells contributes to the pathogenesis of CD. We also investigated whether proper function could be restored to Treg cells by ex vivo expansion in the presence of factors that activate their regulatory activities. METHODS: We measured levels of the integrin α4β7 on Treg cells isolated from peripheral blood or lamina propria of patients with CD and healthy individuals (controls)...
January 17, 2019: Gastroenterology
Amarilla B Mandola, Jacov Levy, Amit Nahum, Nurit Hadad, Rachel Levy, Anna Rylova, Amos J Simon, Atar Lev, Raz Somech, Arnon Broides
Neutrophil chemotactic defects have been reported previously in patients with hyper-IgE syndrome. Bi-allelic mutations in dedicator of cytokinesis 8 (DOCK8) gene usually cause an autosomal recessive hyper-IgE syndrome phenotype. Data are lacking about expression of DOCK8 protein in neutrophils or the possible role of DOCK8 in neutrophil function. We sought to determine if DOCK8 protein is expressed in neutrophils and if DOCK8 plays a role in neutrophil function. The expression of DOCK8 protein was assessed in neutrophils from healthy volunteers with and without activators...
January 28, 2019: Immunological Investigations
Elhanan Nahum, Gili Kadmon, Eytan Kaplan, Avichai Weissbach, Hanan Hijazi, Orly Haskin, Yael Mozer-Glassberg
PURPOSE: To compare the application of three standardized definitions of acute kidney injury (AKI), using corrected serum creatinine values, in children immediately after liver transplantation. METHODS: Retrospective search of a tertiary pediatric hospital database yielded 77 patients (age < 18 years) who underwent liver transplantation in 2007-2017. Serum creatinine levels during the 24 h before and after surgery were corrected to daily fluid balance, and the prevalence of AKI was calculated using the Pediatric RIFLE (pRIFLE), AKI Network (AKIN), and Kidney Disease Improving Global Outcomes (KDIGO) criteria...
April 2019: Journal of Critical Care
John J Dziak, Jamie R T Yap, Daniel Almirall, James R McKay, Kevin G Lynch, Inbal Nahum-Shani
Sequential multiple assignment randomized trials (SMARTs) are a useful and increasingly popular approach for gathering information to inform the construction of adaptive interventions to treat psychological and behavioral health conditions. Until recently, analysis methods for data from SMART designs considered only a single measurement of the outcome of interest when comparing the efficacy of adaptive interventions. Lu et al. proposed a method for considering repeated outcome measurements to incorporate information about the longitudinal trajectory of change...
January 20, 2019: Multivariate Behavioral Research
Abbas Al-Kurd, Ronit Grinbaum, Ala'a Abubeih, Ido Mizrahi, Amram Kupietzky, Nachum Emil Eliezer Lourie, Haggi Mazeh, Nahum Beglaibter
BACKGROUND: The effect of age and gender on outcomes of revisional bariatric surgery has not been assessed. METHODS: A retrospective analysis of patients undergoing revision from laparoscopic adjustable gastric banding (LAGB) to laparoscopic roux en Y gastric bypass (LRYGB) between 2007 and 2017 was performed. Patients were divided according to gender and age (<50 and ≥ 50 years), and the outcomes of the subgroups were compared. RESULTS: During the study period, 161 revisional LRYGBs were performed...
January 3, 2019: American Journal of Surgery
Méndez-Sánchez Nahum, Dibildox-Martinez Miguel, Sosa-Noguera Jahir, Sánchez-Medal Ramón, J Francisco Flores-Murrieta
BACKGROUND: Fibrosis is a response to chronic liver disease that results in excessive accumulation of extracellular matrix proteins and formation of scar tissue. Fibrosis represents a clinical challenge of worldwide significance. Several studies have demonstrated that many natural products and herbal medicines have activity against liver fibrosis, and extracts of milk thistle such as silymarin and silybin are the natural compounds most commonly prescribed for liver diseases. Therefore, we sought to assess and compare the pharmacokinetic properties and bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules and conventional silymarin tablets in healthy Mexican volunteers...
January 11, 2019: BMC Pharmacology & Toxicology
Ramona S Bruckner, Einat Nissim-Eliraz, Noga Marsiano, Eilam Nir, Hadar Shemesh, Martin Leutenegger, Claudia Gottier, Silvia Lang, Marianne R Spalinger, Sebastian Leibl, Gerhard Rogler, Simcha Yagel, Michael Scharl, Nahum Y Shpigel
Background and Aims: Enteric fistulas represent a severe and medically challenging co-morbidity commonly affecting Crohn's disease [CD] patients. Gut fistulas do not develop in animal models of the disease. We have used transplantation of the human fetal gut into mice as a novel platform for studying inflammatory enterocutaneous fistulas. Methods: Human fetal gut segments were transplanted subcutaneously into mature SCID mice, where they grew and fully developed over the course of several months...
December 24, 2018: Journal of Crohn's & Colitis
Zhihua Cai, Yun Xia, Zheng Bao, Haojie Mao
To better understand head injuries, human head finite element (FE) models have been reported in the literature. In scenarios where the head is directly impacted and measurements of head accelerations are not available, a high-quality skull model, as well as a high-quality brain model, is needed to predict the effect of impact on the brain through the skull. Furthermore, predicting cranial bone fractures requires comprehensively validated skull models. Lastly, high-quality meshes for both the skull and brain are needed for accurate strain/stress predictions across the entire head...
December 24, 2018: Computer Methods in Biomechanics and Biomedical Engineering
Nahum Méndez-Sánchez, Felipe Zamarripa-Dorsey, Arturo Panduro, Emma Purón-González, Edgar Ulises Coronado-Alejandro, Carlos Alejandro Cortez-Hernández, Fátima Higuera de la Tijera, José Luis Pérez-Hernández, Eira Cerda-Reyes, Heriberto Rodríguez-Hernández, Vania César Cruz-Ramón, Oscar Lenin Ramírez-Pérez, Nancy Edith Aguilar-Olivos, Olga Fabiola Rodríguez-Martínez, Samantha Cabrera-Palma, Guillermo Cabrera-Álvarez
AIM: To investigate the main current etiologies of cirrhosis in Mexico. METHODS: We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period (January 2012-December 2017)...
December 6, 2018: World Journal of Clinical Cases
Mythily Ganapathi, Odelia Nahum, Brynn Levy
Chromosomal microarray is a high resolution genomic technology to diagnose genetic conditions associated with losses or gains of the human genome. This technology is currently routinely used in numerous clinical settings, including postnatal diagnosis of disorders with genetic etiologies such as intellectual disability, developmental delay, neurocognitive phenotypes, congenital anomalies, and prenatal diagnosis wherein the referral could be ultrasound anomalies, advanced maternal age, and normal course of pregnancy...
2019: Methods in Molecular Biology
Christie M Buchovecky, Odelia Nahum, Brynn Levy
When biopsying a fetal tissue like chorionic villi or amniotic fluid, there is a chance of getting some maternal material that could contaminate the fetal specimen and might lead to a misdiagnosis. Thus, all prenatal samples should be subjected to testing for maternal cell contamination. This is done using quantitative fluorescent PCR (QF-PCR) of short tandem repeat (STR) markers.
2019: Methods in Molecular Biology
Odelia Nahum, Amanda Thomas, Brynn Levy
A prenatal noninvasive genetic screening test that yields a positive result typically warrants further direct assessment of fetal DNA following an invasive procedure. The precious nature of these invasively acquired samples, combined with the time sensitive nature with which results should be reported, demands that the methodologies used for analysis be quick, efficient, and dependable.Prenatal diagnosis has been performed using DNA extracted from amniotic fluid and chorionic villi for several decades, and more recently methodologies have been developed to extract cell free fetal DNA from amniotic fluid...
2019: Methods in Molecular Biology
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