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https://read.qxmd.com/read/30771534/rock-isoforms-differentially-modulate-cancer-cell-motility-by-mechanosensing-the-substrate-stiffness
#1
Yueting Peng, Zhongyuan Chen, Yu Chen, Shun Li, Ying Jiang, Hong Yang, Chunhui Wu, Fengming You, Chuan Zheng, Jie Zhu, Youhua Tan, Xiang Qin, Yiyao Liu
Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM stiffness in cancer is well known. However, the biomechanical behavior of tumor cells and the underlying mechanotransduction pathways remain unclear. Here, we used polyacrylamide (PAA) substrates to simulate tissue stiffness at different progress stages of breast cancer in vitro, and we observed that moderate substrate stiffness promoted breast cancer cell motility. The substrate stiffness directly activated integrin β1 and focal adhesion kinase (FAK), which accelerate focal adhesion (FA) maturation and induce the downstream cascades of intracellular signals of the RhoA/ROCK pathway...
February 13, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30771501/bcg-induced-formation-of-neutrophil-extracellular-traps-play-an-important-role-in-bladder-cancer-treatment
#2
Kangkang Liu, Erlin Sun, Mingde Lei, Limin Li, Jingda Gao, Xuewu Nian, Lining Wang
Bacillus Calmette-Guerin (BCG) is one of the most effective treatments for bladder cancer. Little attention has been paid to the possible role of neutrophils in BCG immunotherapy. In this study, we examined neutrophil extracellular traps (NETs) formation induced by BCG stimulation, and found that BCG-induced NETs exerted cytotoxicity, induced apoptosis and cell-cycle arrest, and inhibited migration in bladder tumor cells. BCG-activated tumor cells but not non-activated ones elicited NETs formation, in which IL-8 and TNF-α from activated tumor cells both took effect...
February 13, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30771425/long-non-coding-rna-fgf13-as1-inhibits-glycolysis-and-stemness-properties-of-breast-cancer-cells-through-fgf13-as1-igf2bps-myc-feedback-loop
#3
Fei Ma, Xu Liu, Shibo Zhou, Wenjie Li, Chunxiao Liu, Michelle Chadwick, Cheng Qian
LncRNAs have been proven to play crucial roles in various processes of breast cancer. LncRNA FGF13-AS1 has been identified as one of the 25 downregulated lncRNAs in breast cancer through analyzing data from two cohorts and TCGA by another group of our lab. In this study, we report that FGF13-AS1 expression is decreased in breast cancer tissue compared with corresponding normal tissue, and the downregulation of FGF13-AS1 is associated with poor prognosis. Functional studies show that FGF13-AS1 inhibits breast cancer cells proliferation, migration, and invasion by impairing glycolysis and stemness properties...
February 13, 2019: Cancer Letters
https://read.qxmd.com/read/30771276/regulation-and-related-mechanism-of-gsn-mrna-level-by-hnrnpk-in-lung-adenocarcinoma-cells
#4
Xiao-Hui Liu, Jie Ma, Jun-Xia Feng, Yun-Fang Zhang, Langxia Liu
Gelsolin (GSN) is an actin filament-capping protein that plays a key role in cell migration. Here we showed that heterogeneous nuclear ribonucleoprotein K (hnRNPK) regulates GSN expression level by binding to the 3'-untranslated region (3'UTR) of GSN mRNA in non-small cell lung cancers (NSCLC) H1299 cells which are highly metastatic and express high level of GSN. We found that hnRNPK overexpression increased the mRNA and protein level of GSN, whereas hnRNPK knockdown by siRNA decreased the mRNA and protein level of GSN in both H1299 and A549 cells, indicating a positive role of hnRNPK in the regulation of GSN expression...
December 1, 2018: Biological Chemistry
https://read.qxmd.com/read/30770989/cd110-promotes-pancreatic-cancer-progression-and-its-expression-is-correlated-with-poor-prognosis
#5
Zilong Yan, Kenoki Ohuchida, Biao Zheng, Takashi Okumura, Shin Takesue, Hiromichi Nakayama, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura
PURPOSE: This study aimed at investigating the function and significance of CD110 expression in pancreatic cancer. METHODS: We performed immunohistochemical staining for CD110 expression in tumor samples from 86 patients with pancreatic cancer. We evaluated clinical outcomes and other clinicopathological factors to determine the significance of CD110 on survival and liver metastasis. We examine thrombopoietin-CD110 signaling in cancer cell extravasation in vitro and in vivo...
February 15, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30770877/klf5-and-myc-modulated-linc00346-contributes-to-gastric-cancer-progression-through-acting-as-a-competing-endogeous-rna-and-indicates-poor-outcome
#6
Tong-Peng Xu, Pei Ma, Wen-Yu Wang, You Shuai, Yan-Fen Wang, Tao Yu, Rui Xia, Yong-Qian Shu
It was found in this study that long intergenic non-protein coding RNA 346 (LINC00346) was an lncRNA aberrantly expressed in gastric cancer (GC) based on multiple Gene Expression Omnibus (GEO) databases of GC cohorts. The LINC00346 gene was recurrently amplified and upregulated in GC, and its expression was positively correlated with poor pathologic stage, large tumor size, and poor prognosis. In addition, the oncogenic transcription factors KLF5 and MYC could bind to the LINC00346 promoter and enhance its expression...
February 15, 2019: Cell Death and Differentiation
https://read.qxmd.com/read/30770791/neto2-promotes-invasion-and-metastasis-of-gastric-cancer-cells-via-activation-of-pi3k-akt-nf-%C3%AE%C2%BAb-snail-axis-and-predicts-outcome-of-the-patients
#7
Jun-Yan Liu, Lei Jiang, Tao He, Jia-Jia Liu, Jun-Yan Fan, Xian-Hui Xu, Bo Tang, Yan Shi, Yong-Liang Zhao, Feng Qian, Yan Wang, You-Hong Cui, Pei-Wu Yu
Aberrant expression of neuropilin and tolloid-like 2 (NETO2) has been observed during the progression of some human carcinomas. However, the expression pattern and clinical relevance of NETO2 in gastric cancer (GC) remain to be elucidated. In this study, we found that NETO2 expression was higher in GC tissues compared with paired non-cancerous tissues. Moreover, the expression of NETO2 was positively correlated with clinical stage, invasion depth, lymph node metastasis, and tumor size, but inversely correlated with overall and disease-free survival rates...
February 15, 2019: Cell Death & Disease
https://read.qxmd.com/read/30770778/exosomes-from-glioma-cells-induce-a-tumor-like-phenotype-in-mesenchymal-stem-cells-by-activating-glycolysis
#8
Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang, Xuexi Wang
BACKGROUND: Exosomes are nanoscale membrane vesicles secreted by both normal and cancer cells, and cancer cell-derived exosomes play an important role in the cross-talk between cancer cells and other cellular components in the tumor microenvironment. Mesenchymal stem cells (MSCs) have tropism for tumors and have been used as tumor-tropic vectors for tumor therapy; however, the safety of such therapeutic use of MSCs is unknown. In this study, we investigated the role of glioma cell-derived exosomes in the tumor-like phenotype transformation of human bone marrow mesenchymal stem cells (hBMSCs) and explored the underlying molecular mechanisms...
February 15, 2019: Stem Cell Research & Therapy
https://read.qxmd.com/read/30770602/microrna-3191-promotes-migration-and-invasion-by-downregulating-tgfbr2-in-colorectal-cancer
#9
Hongjuan He, Xiaojuan Zhao, Ziqing Zhu, Le Du, Erfei Chen, Shuzhen Liu, Qiqi Li, Jing Dong, Jin Yang, Lei Lei
Mutations in transforming growth factor beta receptor II (TGFBR2) are detected in up to 30% of overall colorectal cancer (CRC). Dysregulation of some microRNAs participated in the CRC pathogenesis. In this study, we used the gene ontology analyses, the Kyoto Encyclopedia of Genes and Genomes pathway analyses and gene set enrichment analysis to indicate that miR-3191 was involved in the regulation of transforming growth factor beta (TGF-BETA) signal pathway in CRC. These bioinformatics results were supported by data obtained from CRC samples and experiments in vitro...
February 15, 2019: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/30770563/ras-erk1-2-signaling-promotes-the-development-of-uveal-melanoma-by-downregulating-h3k14ac
#10
Yaping Li, Weixuan Sun, Dajun Sun, Dexin Yin
Ras-extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) signaling has been proposed as the crucial regulators in the development of various cancers. Histone acetylation at H3 lysine 14 (H3K14ac) is closely associated with gene expression and DNA damage. However, whether H3K14ac participates in mediating Ras-ERK1/2-induced cell proliferation and migration in uveal melanoma cells remains unknown. The purpose of this study is to investigate the effect of H3K14ac on Ras-ERK1/2 affected uveal melanoma cell phenotypes...
February 15, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30770562/ras-pi3k-akt-signaling-promotes-the-occurrence-and-development-of-uveal-melanoma-by-downregulating-h3k56ac-expression
#11
Yaping Li, Dajun Sun, Weixuan Sun, Dexin Yin
BACKGROUND: Uveal melanoma (UM) is an intraocular malignant tumor characterized by rapid progression and recurrence. The current conventional treatments are unsatisfactory. Histone acetylation at H3 lysine 56 (H3K56ac) has been reported to be a tumor suppressor in breast cancer. However, whether H3K56ac prevents the occurrence and development of UM remains uninvestigated. The study aimed to explore the regulatory effect of H3K56ac on Ras-PI3K-AKT induced UM cells proliferation and migration...
February 15, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30770102/long-non-coding-rna-dnm3os-promotes-tumor-progression-and-emt-in-gastric-cancer-by-associating-with-snail
#12
Shuchang Wang, Bo Ni, Zizhen Zhang, Chaojie Wang, Lulu Wo, Cixiang Zhou, Qian Zhao, Enhao Zhao
Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in tumor development and progression. In the present study, we explored the expression and biological role of the lncRNA DNM3OS in gastric cancer (GC). We observed that DNM3OS was upregulated in GC tissues and cell lines, and high DNM3OS expression was correlated with malignant features and served as an indicator of a poor prognosis for GC patients. DNM3OS knockdown inhibited the proliferation of GC cells, and reduced DNM3OS suppressed tumor growth in vivo...
February 12, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30769871/novel-ran-rcc1-inhibitory-peptide-loaded-nanoparticles-have-anti-cancer-efficacy-in-vitro-and-in-vivo
#13
Yusuf A Haggag, Kyle B Matchett, Robert A Falconer, Mohammad Isreb, Jason Jones, Ahmed Faheem, Paul McCarron, Mohamed El-Tanani
The delivery of anticancer agents to their subcellular sites of action is a significant challenge for effective cancer therapy. Peptides, which are integral to several oncogenic pathways, have significant potential to be utilised as cancer therapeutics due to their selectivity, high potency and lack of normal cell toxicity. Novel Ras protein-Regulator of chromosome condensation 1 (Ran-RCC1) inhibitory peptides designed to interact with Ran, a novel therapeutic target in breast cancer, were delivered by entrapment into polyethylene glycol-poly (lactic-co-glycolic acid) PEG-PLGA polymeric nanoparticles (NPs)...
February 14, 2019: Cancers
https://read.qxmd.com/read/30769863/anti-invasion-and-antiangiogenic-effects-of-stellettin-b-through-inhibition-of-the-akt-girdin-signaling-pathway-and-vegf-in-glioblastoma-cells
#14
Shu-Yu Cheng, Nan-Fu Chen, Pi-Yu Lin, Jui-Hsin Su, Bing-Hung Chen, Hsiao-Mei Kuo, Chun-Sung Sung, Ping-Jyun Sung, Zhi-Hong Wen, Wu-Fu Chen
Angiogenesis and invasion are highly related with tumor metastatic potential and recurrence prediction in the most aggressive brain cancer, glioblastoma multiforme (GBM). For the first time, this study reveals that marine-sponge-derived stellettin B reduces angiogenesis and invasion. We discovered that stellettin B reduces migration of glioblastoma cells by scratch wound healing assay and invasion via chamber transwell assay. Further, stellettin B downregulates Akt/Mammalian Target of Rapamycin (Akt/mTOR) and Signal transducer and activator of transcription 3 (Stat3) signaling pathways, which are essential for invasion and angiogenesis in glioblastoma...
February 14, 2019: Cancers
https://read.qxmd.com/read/30769285/tumoral-nox4-recruits-m2-tumor-associated-macrophages-via-ros-pi3k-signaling-dependent-various-cytokine-production-to-promote-nsclc-growth
#15
Jiahao Zhang, Huachao Li, Qipeng Wu, Yueming Chen, Yanchao Deng, Zhicheng Yang, Luyong Zhang, Bing Liu
M2-type tumor-associated macrophages (TAMs) infiltration contributes to cancer malignant progression. However, the mechanisms for controlling recruitment and M2 polarization of macrophages by cancer cells are largely unclear. NADPH oxidase 4 (NOX4) is abundantly expressed in non-small cell lung cancer (NSCLC) and mediates cancer progression. NOXs are in close relation with cancer-related inflammation, nevertheless, whether tumoral NOXs influence microenvironmental macrophages remains undentified. This study found that there was a close association between NOX4 expression and macrophage chemotaxis in patients with NSCLC analyzed using TCGA RNA-sequencing data...
February 6, 2019: Redox Biology
https://read.qxmd.com/read/30768984/systems-biology-analyses-reveal-hyperactivation-of-transforming-growth-factor-beta-and-jnk-signaling-pathways-in-esophageal-cancer
#16
Andrew E Blum, Srividya Venkitachalam, Durgadevi Ravillah, Aruna K Chelluboyina, Ann Marie Kieber-Emmons, Lakshmeswari Ravi, Adam Kresak, Apoorva K Chandar, Sanford D Markowitz, Marcia I Canto, Jean S Wang, Nicholas J Shaheen, Yan Guo, Yu Shyr, Joseph E Willis, Amitabh Chak, Vinay Varadan, Kishore Guda
BACKGROUND & AIMS: Esophageal adenocarcinoma (EAC) is resistant to standard chemoradiation treatments and few targeted therapies are available. We used large-scale tissue profiling and pharmacogenetic analyses to identify deregulated signaling pathways in EAC tissues that might be targeted to slow tumor growth or progression. METHODS: We collected 397 biopsy specimens from patients with EAC and non-malignant Barrett's esophagus (BE), with or without dysplasia...
February 12, 2019: Gastroenterology
https://read.qxmd.com/read/30768358/rcc2-a-regulator-of-the-rala-signaling-pathway-is-identified-as-a-novel-therapeutic-target-in-cisplatin-resistant-ovarian-cancer
#17
Shipeng Gong, Yongning Chen, Fanliang Meng, Yadi Zhang, Huan Wu, Chanyuan Li, Guangping Zhang
Currently, cisplatin (DDP) is the first-line chemotherapeutic agent used for treatment of ovarian cancer, but gradually acquired drug resistance minimizes its therapeutic outcomes. We aimed to identify crucial genes associated with DDP resistance in ovarian cancer and uncover potential mechanisms. Two sets of gene expression data were downloaded from Gene Expression Omnibus, and bioinformatics analysis was conducted. In our study, the differentially expressed genes between DDP-sensitive and DDP-resistant ovarian cancer were screened in GSE15709 and GSE51373 database, and chromosome condensation 2 regulator (RCC2) and nucleoporin 160 were identified as 2 genes that significantly up-regulated in DDP-resistant ovarian cancer cell lines compared with DDP-sensitive cell lines...
February 15, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/30767381/the-selective-cyclooxygenase-2-inhibitor-mavacoxib-trocoxcil%C3%A2-exerts-anti-tumour-effects-in-vitro-independent-of-cyclooxygenase-2-expression-levels
#18
Emma A Hurst, Lisa Y Pang, David J Argyle
The inducible inflammatory enzyme cyclooxygenase-2 (COX-2) and its product prostaglandin E2 (PGE2 ) are prominent tumour promoters, and expression of COX-2 is elevated in a number of tumours of both humans and canines. Targeting COX-2 in cancer is an attractive option due to readily available non-steroidal anti-inflammatory drugs (NSAIDs), and there is a clear epidemiological link between NSAID use and cancer risk. In this study we aim to establish the anti-tumourigenic effects of the selective, long-acting COX-2 inhibitor mavacoxib...
February 15, 2019: Veterinary and Comparative Oncology
https://read.qxmd.com/read/30767270/upregulation-of-long-noncoding-rna-snhg20-promotes-cell-growth-and-metastasis-in-esophageal-squamous-cell-carcinoma-via-modulating-atm-jak-pd-l1-pathway
#19
Chunrong Zhang, Feng Jiang, Chuan Su, Pengfei Xie, Lin Xu
Increasing evidence have proved that long noncoding RNAs (lncRNAs) play significant roles in tumorigenesis and development of various cancers. However, the effect of small nucleolar RNA host gene 20 (SNHG20) on the progression of esophageal squamous cell carcinoma (ESCC) remains to be discovered. Herein, we aim to find out the function and the possible mechanism of SNHG20 in ESCC progression. In our study, we demonstrate that SNHG20 is markedly upregulated in ESCC tissues and cell lines. Besides, the level of SNHG20 is closely associated with tumor size, lymph node metastasis, TNM stage, and tumor grade...
February 14, 2019: Journal of Cellular Biochemistry
https://read.qxmd.com/read/30767203/nlrc3-inhibits-mct-induced-pulmonary-hypertension-in-rats-via-attenuating-pi3k-activation
#20
Li-Huang Zha, Jun Zhou, Tang-Zhiming Li, Hui Luo, Men-Qiu Zhang, Sheng Li, Zai-Xin Yu
Phosphoinositide 3-kinase (PI3K) activation plays a critical role in the pulmonary vascular remodeling of pulmonary hypertension (PH). The nucleotide-oligomerization domain (NOD)-like receptor subfamily C3 (NLRC3) inhibits proliferation and inflammation via PI3K signaling in cancer. We previously showed NLRC3 was significantly reduced in PH patients, but the mechanism of function remains unclear. This study aimed to determine the potential role of NLRC3 in PH. We found that NLRC3 was downregulated in the pulmonary arteries of PH animal models and platelet-derived growth factor-BB (PDGF-BB) stimulated pulmonary arterial smooth muscle cells (PASMCs)...
February 14, 2019: Journal of Cellular Physiology
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