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https://read.qxmd.com/read/30771431/squalamine-blocks-tumor-associated-angiogenesis-and-growth-of-human-breast-cancer-cells-with-or-without-her-2-neu-overexpression
#1
Diana C Márquez-Garbán, Manuel Gorrín-Rivas, Hsiao-Wang Chen, Colin Sterling, David Elashoff, Nalo Hamilton, Richard J Pietras
Angiogenesis is critical for breast cancer progression. Overexpression of HER-2/neu receptors occur in 25-30% of breast cancers, and treatment with trastuzumab inhibits HER-2-overexpressing tumor growth. Notably, HER-2-mediated signaling enhances vascular endothelial growth factor (VEGF) secretion to increase tumor-associated angiogenesis. Squalamine (aminosterol compound) suppresses VEGF-induced activation of kinases in vascular endothelial cells and inhibits tumor-associated angiogenesis. We assessed antitumor effects of squalamine either alone or with trastuzumab in nude mice bearing breast tumor xenografts without (MCF-7) or with HER2-overexpression (MCF-7/HER-2)...
February 13, 2019: Cancer Letters
https://read.qxmd.com/read/30771426/caveolin-1-enhances-metastasis-formation-in-a-human-model-of-embryonal-rhabdomyosarcoma-through-erk-signaling-cooperation
#2
Silvia Codenotti, Fiorella Faggi, Roberto Ronca, Paola Chiodelli, Elisabetta Grillo, Michele Guescini, Francesca Megiorni, Francesco Marampon, Alessandro Fanzani
Rhabdomyosarcoma (RMS) is a pediatric soft tissue tumor classified in two major subtypes namely embryonal and alveolar, which have distinctive histopathological and genetic signatures and worse outcomes in the presence of metastases. Here, in order to evaluate the role of Caveolin-1 (Cav-1) in embryonal RMS dissemination, we employed an experimental in vivo metastasis assay using immunodeficient NOD/SCID mice. We found that the intravenous injection of human RD cells engineered for Cav-1 overexpression promoted the formation of lung metastases compared to parental cells...
February 13, 2019: Cancer Letters
https://read.qxmd.com/read/30769841/overexpression-of-stdreb2-transcription-factor-enhances-drought-stress-tolerance-in-cotton-gossypium-barbadense-l
#3
Mohamed A El-Esawi, Aisha A Alayafi
Drought stress significantly restricts plant growth and crop productivity. Cotton is the most important textile fiber and oilseed crop worldwide, and its cultivation is affected by drought stress, particularly in dry regions. Improving cotton tolerance to drought stress using the advanced genetic engineering technologies is a promising strategy to maintain crop production and fiber quality and meet the increasing worldwide fiber and oil demand. Dehydration-responsive element binding (DREB) transcription factors play a main role in regulating stresses-tolerance pathways in plant...
February 14, 2019: Genes
https://read.qxmd.com/read/30768638/huntingtin-associates-with-the-actin-cytoskeleton-and-%C3%AE-actinin-isoforms-to-influence-stimulus-dependent-morphology-changes
#4
Adelaide Tousley, Maria Iuliano, Elizabeth Weisman, Ellen Sapp, Heather Richardson, Petr Vodicka, Jonathan Alexander, Neil Aronin, Marian DiFiglia, Kimberly B Kegel-Gleason
One response of cells to growth factor stimulus involves changes in morphology driven by the actin cytoskeleton and actin associated proteins which regulate functions such as cell adhesion, motility and in neurons, synaptic plasticity. Previous studies suggest that Huntingtin may be involved in regulating morphology however, there has been limited evidence linking endogenous Huntingtin localization or function with cytoplasmic actin in cells. We found that depletion of Huntingtin in human fibroblasts reduced adhesion and altered morphology and these phenotypes were made worse with growth factor stimulation, whereas the presence of the Huntington's Disease mutation inhibited growth factor induced changes in morphology and increased numbers of vinculin-positive focal adhesions...
2019: PloS One
https://read.qxmd.com/read/30766657/inhalation-of-bacterial-cellulose-nanofibrils-triggers-an-inflammatory-response-and-changes-lung-tissue-morphology-of-mice
#5
Ricardo Silva-Carvalho, João P Silva, Pedro Ferreirinha, Alexandre F Leitão, Fábia K Andrade, Rui M Gil da Costa, Cecília Cristelo, Morsyleide F Rosa, Manuel Vilanova, F Miguel Gama
In view of the growing industrial use of Bacterial cellulose (BC), and taking into account that it might become airborne and be inhaled after industrial processing, assessing its potential pulmonary toxic effects assumes high relevance. In this work, the murine model was used to assess the effects of exposure to respirable BC nanofibrils (nBC), obtained by disintegration of BC produced by Komagataeibacter hansenii . Murine bone marrow-derived macrophages (BMMΦ) were treated with different doses of nBC (0.02 and 0...
January 2019: Toxicological Research
https://read.qxmd.com/read/30765660/-two-cases-of-resectable-intra-abdominal-desmoid-tumor-after-laparoscopic-gastrectomy-for-gastric-cancer
#6
Takashi Ajiki, Junichiro Yamauchi, Keiichi Shirasaki, Shota Fujita, Mamoru Sato, Tomoya Ikeda, Tomoya Miura, Katsuo Tsuchihara
Case 1: A 52-year-old man underwent laparoscopic total gastrectomy for gastric cancer. After 2 years, a follow-up computed tomography(CT)scan showed a large, solid 10 cm-sized mass in his left upper abdomen. Under the diagnosis of a suspected mesenchymal tumor, a tumor resection with a partial resection of the upper jejunum and transverse colon was performed. Case 2: A 61-year-old man underwent laparoscopic pylorus-preserving gastrectomy for gastric cancer. After 1.5 years, follow-up CT showed a tumor of 2 cm in diameter near the greater curvature side of the upper stomach...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/30765014/the-relationship-between-stress-and-temperature-distribution-during-tension-test-of-glass-fiber-reinforced-plastic-by-fiber-orientation-variation
#7
Jin-Woo Kim
In this study, effects of variations in the fiber orientation for GFRP tension test on strength and temperature distributions were experimentally investigated. The temperature measurement method for test specimen was proposed in an IR thermography. Lock-in method, which is one of technique in IR thermography to measure the temperature of specimen as a function of time, was utilized to monitor changes in the temperature distribution during crack propagation process. At the maximum stress point, the temperature was significantly increased...
July 1, 2019: Journal of Nanoscience and Nanotechnology
https://read.qxmd.com/read/30764989/effect-of-molding-condition-on-lap-joint-of-glass-fiber-reinforced-plastic
#8
Dong-Gi Lee, Jin-Woo Kim
In this study, materials with each different fiber content ratio and fiber orientation state were used in the study for the decision of molding condition of GFRP and the condition of lap joint. Clarify joint strength and lap joint efficiency during high temperature and compression press lap joint molding of GFRP and research data regarding the lap length of the joint part was presented. Thus, the purpose of this study is to contribute to the substitution of existing products as well as usage development in the non-automobile field and also to find out precise dynamic characteristics as designing data of structures...
July 1, 2019: Journal of Nanoscience and Nanotechnology
https://read.qxmd.com/read/30760620/differential-influence-of-il-9-and-il-17-on-actin-cytoskeleton-regulates-the-migration-potential-of-human-keratinocytes
#9
Sreya Das, Srisathya Srinivasan, Ankita Srivastava, Sushant Kumar, Gargi Das, Suman Das, Alka Dwivedi, Atharva Karulkar, Khushi Makkad, Richa Bilala, Ankit Gupta, Abhijeet Sawant, Chitra Nayak, Prakriti Tayalia, Rahul Purwar
T cells mediate skin immune surveillance by secreting specific cytokines and regulate numerous functions of keratinocytes, including migration during homeostasis and disease pathogenesis. Keratinocyte migration is mediated mainly by proteolytic cleavage of the extracellular matrix and/or by cytoskeleton reorganization. However, the cross-talk between T cell cytokines and actomyosin machinery of human primary keratinocytes (HPKs), which is required for cytoskeleton reorganization and subsequent migration, remains poorly examined...
February 13, 2019: Journal of Immunology: Official Journal of the American Association of Immunologists
https://read.qxmd.com/read/30759828/finer-shm-coverage-of-inter-plies-and-bondings-in-smart-composite-by-dual-sinusoidal-placed-distributed-optical-fiber-sensors
#10
Venkadesh Raman, Monssef Drissi-Habti, Preshit Limje, Aghiad Khadour
Designing of new generation offshore wind turbine blades is a great challenge as size of blades are getting larger (typically larger than 100 m). Structural Health Monitoring (SHM), which uses embedded Fiber Optics Sensors (FOSs), is incorporated in critical stressed zones such as trailing edges and spar webs. When FOS are embedded within composites, a 'penny shape' region of resin concentration is formed around the section of FOS. The size of so-formed defects are depending on diameter of the FOS. Penny shape defects depend of FOS diameter...
February 12, 2019: Sensors
https://read.qxmd.com/read/30758990/prostaglandin-e2-inhibits-pro-fibrotic-function-of-human-pulmonary-fibroblasts-by-disrupting-ca2-signaling
#11
Subhendu Mukherjee, Wei Sheng, Alexander Michkov, Krishna Sriarm, Rui Sun, Anna Dvorkin-Gheva, Paul A Insel, Luke J Janssen
We have shown that calcium (Ca2+ ) oscillations in human pulmonary fibroblasts (HPFs) contribute to pro-fibrotic effects of TGFβ and that disruption of these oscillations blunts features of pulmonary fibrosis. Prostaglandin E2 (PGE2 ) exerts anti-fibrotic effects in the lung but the mechanisms for this action are not well defined. We thus sought to explore interactions between PGE2 and the pro-fibrotic agent transforming growth factor beta (TGFβ) in pulmonary fibroblasts (PFs) isolated from patients with or without idiopathic pulmonary fibrosis (IPF)...
February 13, 2019: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/30745416/rla8-a-new-and-highly-effective-quadruple-ppars-%C3%AE-%C3%AE-%C3%AE-and-gpr40-agonist-to-reverse-nonalcoholic-steatohepatitis-and-fibrosis
#12
Menghua Li, Wei Chen, Lili Wang, Jialin Sun, Lei Zhou, Yucong Shi, Chuhan Wang, Bohua Zhong, Weiguo Shi, Zhongwu Guo
Nonalcoholic fatty liver disease (NAFLD) is a very common chronic hepatic disease, with nonalcoholic steatohepatitis (NASH) as a major and severe subcategory that can lead to cirrhosis and hepatocellular carcinoma, thereby a high mortality rate. Currently, there has been no approved drug to treat NAFLD or NASH. The current study has presented RLA8, a novel and balanced quadruple agonist for hepatic lipid metabolism and inflammation-related peroxisome proliferator-activated receptors (PPARs)-α/γ/δ and G-protein-coupled receptor 40 (GPR40), as a NASH drug candidate...
February 11, 2019: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/30745336/atrophy-oxidative-switching-and-ultrastructural-defects-in-skeletal-muscle-of-ataxia-telangiectasia-mouse-model
#13
Valentina Tassinari, Vincenzo De Gennaro, Gina La Sala, Daniela Marazziti, Giulia Bolasco, Salvatore Aguanno, Luciana De Angelis, Fabio Naro, Manuela Pellegrini
Ataxia Telangiectasia is a rare, multi system disease caused by ATM kinase deficiency. Atm knockout mice recapitulate premature aging, immunodeficiency, cancer predisposition, growth retardation and motor defects but not cerebellar neurodegeneration and ataxia. We explored if Atm loss is responsible of skeletal muscle defects by investigating myofiber morphology, oxidative/glycolytic activity, myocyte ultrastructural architecture and neuromuscular junctions. Atm knockout mice showed reduced muscle and fiber size...
February 11, 2019: Journal of Cell Science
https://read.qxmd.com/read/30742921/preparation-and-characterization-of-edible-starch-film-reinforced-by-laver
#14
Ying Chen, Long Yu, Xiaoyan Ge, Hongsheng Liu, Amjad Ali, Yanfei Wang, Ling Chen
Edible starch film reinforced by laver was developed and characterized. The relationship between processing technologies, microstructures and performances was established. When the laver was added into cold starch suspension, the laver flack (fiber) simply act as reinforcing agent to improve the mechanical properties of the starch matrix, which results in increasing modulus and tensile strength. When the laver was added into hot starch suspension and mixed under shear stress, the protein containing in laver will release out and mix with starch, which results in a starch-protein-laver fiber hybrid composites...
February 8, 2019: International Journal of Biological Macromolecules
https://read.qxmd.com/read/30741445/exodontia-induced-muscular-hypofunction-by-itself-or-associated-to-chronic-stress-impairs-masseter-muscle-morphology-and-its-mitochondrial-function
#15
Yamba Carla Lara Pereira, Glauce Crivelaro Nascimento, Daniela Mizusaki Iyomasa, Rodrigo Alberto Restrepo Fernández, Ricardo Alexandre Calzzani, Christie Ramos Andrade Leite-Panissi, Pedro Duarte Novaes, Mamie Mizusaki Iyomasa
Stress is associated with orofacial pain sensitivity and is qualified as a temporomandibular disorder risk factor. During stressful periods, painful thresholds of masticatory muscles in individuals suffering muscle facial pain are significantly lower than in controls, but the exact physiologic mechanism underlying this relation remains unclear. Our hypothesis is that chronic unpredictable stress and masticatory hypofunction induce morphologic and metabolic masseter muscle changes in rats. For test this hypothesis, adult Wistar rats were submitted to chronic unpredictable stress and/or exodontia of left molars and the left masseter muscle was removed for analysis...
February 11, 2019: Microscopy Research and Technique
https://read.qxmd.com/read/30740755/olive-oil-inhibits-aging-signs-induced-by-chronic-stress-in-ex-vivo-human-skin-via-inhibition-of-the-extracellular-signal-related-kinase-1-2-and-c-jun-pathways
#16
Bruna Romana-Souza, Andréa Monte-Alto-Costa
OBJECTIVE: Chronic stress-induced oxidative damage and protease synthesis cause a loss of extracellular matrix components promoting human skin aging. The administration of antioxidant compounds, such as those observed in olive oil, may attenuate stress-induced aging signs in human skin. Thus, the aim of this study was to investigate the effect of olive oil administration in ex vivo stressed human skin. METHODS: Explants of human skin were treated with high levels of epinephrine (as observed in stressed patients) and olive oil in medium for 13 days...
February 10, 2019: International Journal of Cosmetic Science
https://read.qxmd.com/read/30740044/schwann-cell-precursors-generate-the-majority-of-chromaffin-cells-in-zuckerkandl-organ-and-some-sympathetic-neurons-in-paraganglia
#17
Maria Eleni Kastriti, Polina Kameneva, Dmitry Kamenev, Viacheslav Dyachuk, Alessandro Furlan, Marek Hampl, Fatima Memic, Ulrika Marklund, Francois Lallemend, Saida Hadjab, Laura Calvo-Enrique, Patrik Ernfors, Kaj Fried, Igor Adameyko
In humans, neurosecretory chromaffin cells control a number of important bodily functions, including those related to stress response. Chromaffin cells appear as a distinct cell type at the beginning of midgestation and are the main cellular source of adrenalin and noradrenalin released into the blood stream. In mammals, two different chromaffin organs emerge at a close distance to each other, the adrenal gland and Zuckerkandl organ (ZO). These two structures are found in close proximity to the kidneys and dorsal aorta, in a region where paraganglioma, pheochromocytoma and neuroblastoma originate in the majority of clinical cases...
2019: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/30735809/the-role-of-tissue-remodeling-in-mechanics-and-pathogenesis-of-abdominal-aortic-aneurysms
#18
Justyna A Niestrawska, Peter Regitnig, Christian Viertler, Tina U Cohnert, Anju R Babu, Gerhard A Holzapfel
Arterial walls can be regarded as composite materials consisting of collagen fibers embedded in an elastic matrix and smooth muscle cells. Remodeling of the structural proteins has been shown to play a significant role in the mechanical behavior of walls during pathogenesis of abdominal aortic aneurysms (AAA). In this study, we systematically studied the change in the microstructure, histology and mechanics to link them to AAA disease progression. We performed biaxial extension tests, second-harmonic generation imaging and histology on 15 samples from the anterior part of AAA walls harvested during open aneurysm surgery...
February 5, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30735808/non-invasive-in-vivo-quantification-of-human-skin-tension-lines
#19
D Laiacona, J M Cohen, K Coulon, Z W Lipsky, C Maiorana, R Boltyanskiy, E R Dufresne, G K German
Human skin is a composite tissue that exhibits anisotropic mechanical properties. This anisotropy arises primarily from the alignment of collagen and elastin fibers in the dermis, which causes the skin to exhibit greater tension in one direction, making it appear stiffer. A diverse number of skin tension guidelines have been developed to assist surgeons in making incisions that produce the least conspicuous scars. However, skin anisotropy is believed to vary from subject to subject, and no single guideline is universally recognized as the best to implement for surgical applications...
February 5, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30735229/changes-in-murine-subbasal-corneal-nerves-after-scopolamine-induced-dry-eye-stress-exposure
#20
Cem Simsek, Takashi Kojima, Taeko Nagata, Murat Dogru, Kazuo Tsubota
Purpose: To evaluate the morphologic changes in the corneal subbasal nerve (CSN) plexus in wild-type (WT) mice after exposure to scopolamine-induced dry eye stress (DES) by using in vivo confocal microscopy. Methods: Twenty right eyes of twenty (n = 20) 8-week-old WT BALB/c male mice were investigated. The mice were divided into two experimental groups; 10 eyes of 10 mice exposed to DES for 28 days and 10 eyes of 10 mice were used as a control group. All mice underwent examinations for aqueous tear secretion quantity, tear film breakup time (TBUT), corneal vital staining...
February 1, 2019: Investigative Ophthalmology & Visual Science
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