João Lobo, Sofia Canete-Portillo, Maria Del Carmen Rodriguez Pena, Jesse K McKenney, Manju Aron, Felipe Massicano, Brandon M Wilk, Manavalan Gajapathy, Donna M Brown, Dilek E Baydar, Andres Matoso, Nathalie Rioux-Leclerq, Chin-Chen Pan, Maria S Tretiakova, Kiril Trpkov, Sean R Williamson, Soroush Rais-Bahrami, Alexander C Mackinnon, Shuko Harada, Elizabeth A Worthey, Cristina Magi-Galluzzi
Juxtaglomerular cell tumor (JGCT) is a rare neoplasm, part of the family of mesenchymal tumors of the kidney. Although the pathophysiological and clinical correlates of JGCT are well-known, as these tumors are an important cause of early-onset arterial hypertension refractory to medical treatment, their molecular background is unknown, with only few small studies investigating their karyotype. Herein we describe a multi-institutional cohort of JGCTs diagnosed by experienced genitourinary pathologists, evaluating clinical presentation and outcome, morphologic diversity and, importantly, the molecular features...
April 11, 2024: Modern Pathology