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Adolescent heart

Anusha Jegatheeswaran, Marshall L Jacobs, Christopher A Caldarone, Paul M Kirshbom, William G Williams, Eugene H Blackstone, William M DeCampli, Kim F Duncan, Linda M Lambert, Henry L Walters, Christo I Tchervenkov, Brian W McCrindle
OBJECTIVES: Improved survival after congenital heart surgery has led to interest in functional health status. We sought to identify factors associated with self-reported functional health status in adolescents and young adults with repaired interrupted aortic arch. METHODS: Follow-up of survivors (aged 13-24 years) from a 1987 to 1997 inception cohort of neonates included completion of functional health status questionnaires (Child Health Questionnaire-CF87 [age <18 years, n = 51] or the Short Form [SF]-36 [age ≥18 years, n = 66]) and another about 22q11 deletion syndrome (22q11DS) features (n = 141)...
January 11, 2019: Journal of Thoracic and Cardiovascular Surgery
E Thomaseo Burton, Tanganyika Wilder, Bettina M Beech, Marino A Bruce
Caregiver feeding practices have been linked to youth health outcomes. The present study examined associations among caregiver feeding practices and blood pressure in 212 African American adolescents via the Child Feeding Practices Questionnaire. Results revealed a positive association between caregivers' concern about their child's weight and diastolic blood pressure, which was more acute for older adolescent boys. Caregivers' perceived responsibility for the quality and quantity of food their child receives was also associated with lower diastolic blood pressure in older adolescent boys...
April 2019: Family & Community Health
Saravanakumar Jeevanandam, K M Prathibha
Introduction: A bidirectional relationship between testosterone and obesity is explained by the hypogonadal obesity cycle and evidence from reports stating that weight loss leads to increased testosterone levels. There is an alarming rise in the prevalence of obesity among children and adolescents. The objectives of the present study were to measure the 2D:4D ratio of adolescent students and study its association with neck circumference (NC). Materials and Methods: After obtaining ethical clearance, the study was conducted on 168 adolescents pursuing their undergraduate education in a South Indian university...
November 2018: Indian Journal of Endocrinology and Metabolism
Isabelle Khalifa, Ran D Goldman
Question I recently saw in my office a patient whom I had initially diagnosed with anorexia nervosa 6 months earlier and she was continuing to lose weight. Her physical examination findings in the office revealed a blood pressure of 85/55 mm Hg and a heart rate of 55 beats/min at rest. Should patients such as this one be sent to the hospital for inpatient monitoring and treatment? Answer There is a lack of clear evidence-based guidelines for hospital admission of adolescents with anorexia nervosa, resulting in a high degree of variation in practices among physicians...
February 2019: Canadian Family Physician Médecin de Famille Canadien
Holger Burchert, Adam J Lewandowski
PURPOSE OF REVIEW: Around 10% of the global population is born preterm (< 37 weeks' gestation). Preterm birth is associated with an increased risk of cardiovascular events, with preterm-born individuals demonstrating a distinct cardiac phenotype. This review aims to summarize the main phenotypic features of the preterm heart and directions for future research to develop novel intervention strategies. RECENT FINDINGS: Being born between 28 and 31 weeks' gestation results in a 4-fold higher risk of heart failure in childhood and adolescence and 17-fold increased risk when born less than 28 weeks' gestation...
February 14, 2019: Current Treatment Options in Cardiovascular Medicine
T Nadesan, N Keough, F Suleman, Z Lockhat, A van Schoor
Surface anatomy is considered a fundamental part of anatomy curricula and clinical practice. Recent studies have reappraised surface anatomy using CT, but the adolescent age group has yet to be appraised. Sixty adolescent thoracoabdominal CT scans (aged 12-18 years) were examined. The surface anatomy of the central veins, cardiac apex, diaphragmatic openings and structures in relation to the sternal angle plane were analyzed. The results showed that the brachiocephalic vein (left & right) formed mostly posterior to the sternoclavicular joint...
February 13, 2019: Clinical Anatomy
Michael Burch, Thej Kumar Nallagangula, Eimear Nic Lochlainn, Thomas Severin, Lalit Thakur, Thomas Jaecklin, Aneesh Thomas George, Susan Solar-Yohay, Joseph W Rossano, Robert E Shaddy
Unlike the adult heart failure (HF) patient population, there is scarce of information on the overall burden of HF in the pediatric population across geographies and within different age groups. Areas covered: A systematic review aims to describe and quantify the economic, humanistic, and societal burden of pediatric (age <18 years) HF on patients and caregivers. Eighteen published studies over a period of 10-years (Jan 1st 2006- May 20th 2016) were identified through Embase, Medline, Cochrane Library and selected congresses...
February 12, 2019: Expert Review of Pharmacoeconomics & Outcomes Research
Ahmad Kautsar, Najib Advani, Murti Andriastuti
Background: Iron-induced cardiomyopathy remains the leading cause of mortality in patients with β-thalassemia major. Iron overload cardiomyopathy, which may be reversible through iron chelation, is characterized by early diastolic dysfunction. Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a sensitive biomarker of diastolic dysfunction. Aim: The aim of the study is to evaluate the diagnostic value of NT-proBNP as a surrogate marker of iron overload examined with magnetic resonance imaging T2-star (MRI T2*)...
January 2019: Annals of Pediatric Cardiology
Fátima Derlene da Rocha Araújo, Rose Mary Ferreira da Lisboa Silva, Camilla Andrade Lima Oliveira, Zilda Maria Alves Meira
Objective: The objective of this study is to evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet-lymphocyte ratio, from the hemograms obtained from children and adolescents with dilated cardiomyopathy (DCM), and to correlate them with the levels of B-type natriuretic peptide (BNP) and with the clinical evolution of these patients in the long term. Materials and Methods: Follow-up of 57 patients with DCM was made retrospectively, with hemogram and BNP level determination being performed after optimized therapy for heart failure...
January 2019: Annals of Pediatric Cardiology
Yinkun Yan, Junting Liu, Xiaoyuan Zhao, Hong Cheng, Guimin Huang, Dongqing Hou, Jie Mi
INTRODUCTION: Cardiovascular diseases remain the leading cause of death and disease burden in China and worldwide. We aimed to evaluate the status of cardiovascular health among urban Chinese children and adolescents. METHODS: We conducted a cross-sectional study comprising 12,618 children and adolescents aged 6-18 years, who were recruited from Chinese urban areas during 2013-2015. The poor, intermediate, and ideal levels of 7 cardiovascular health metrics, including smoking, body mass index, dietary intake, physical activity, blood pressure, blood glucose, and total cholesterol were defined according to revised American Heart Association criteria...
February 8, 2019: Annals of Medicine
Ying Xu, Qin Gu
BACKGROUND: The Swan-Ganz catheter is a reliable method used to monitor hemodynamics in intensive care units. Pump-controlled retrograde trial off is a new weaning test for veno-arterial extracorporeal membrane oxygenation in recent years. The objective of this report is to describe a case in which pulmonary artery flotation catheter hemodynamic monitoring in combination with pump-controlled retrograde trial off was sufficient for veno-arterial extracorporeal membrane oxygenation weaning...
February 8, 2019: Perfusion
John J Leddy, Mohammad N Haider, Michael J Ellis, Rebekah Mannix, Scott R Darling, Michael S Freitas, Heidi N Suffoletto, Jeff Leiter, Dean M Cordingley, Barry Willer
Importance: Sport-related concussion (SRC) is a significant public health problem without an effective treatment. Objective: To assess the effectiveness of subsymptom threshold aerobic exercise vs a placebo-like stretching program prescribed to adolescents in the acute phase of recovery from SRC. Design, Setting, and Participants: This multicenter prospective randomized clinical trial was conducted at university concussion centers. Male and female adolescent athletes (age 13-18 years) presenting within 10 days of SRC were randomly assigned to aerobic exercise or a placebo-like stretching regimen...
February 4, 2019: JAMA Pediatrics
Myrto Boukovala, Jan Müller, Peter Ewert, Alfred Hager
With rising survival rates of patients with congenital heart disease (CHD), functional health variables have become the key aspect in treatment evaluation. The effectiveness of various treatment options on the health-related quality of life (HRQoL) and the objectively measured exercise capacity as peak oxygen uptake (VO2 peak) remains rather unclear and hence, its investigation is the primary aim of this study. Data from 1014 patients (≥14-years-old, various CHD) were retrospectively reviewed. The patients had completed at least twice the SF-36 questionnaire on HRQoL prior to a cardiopulmonary exercise test...
January 8, 2019: American Journal of Cardiology
Javier Navarro-Zaragoza, Clara Ros-Simó, María-Victoria Milanés, Olga Valverde, María-Luisa Laorden
AIMS: Oxidative stress caused by exposure to drugs of abuse such as ethanol or 3, 4 methylenedioxymethamphetamine (MDMA) may derive from direct or indirect effects in many organs including the heart. The aim of the present work was to evaluate cardiac sympathetic activity and the expression and activation of two antioxidant proteins: heat shock protein27 (HSP27) and thioredoxin-1 (Trx-1) after voluntary binge ethanol consumption, alone and in combination with MDMA. MATERIAL AND METHODS: Adolescent mice received MDMA, ethanol or both...
January 29, 2019: Life Sciences
Soichiro Kitamura, Etsuko Tsuda
As an acquired ischemic heart disease in childhood, coronary-artery disease caused by Kawasaki disease (KD) has been known worldwide since the mid-1970s. KD patients who develop coronary-artery obstructive disease often need revascularization some time in their life. Coronary-artery revascularization for KD coronary lesions can be done with the surgical coronary-artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) procedures. However, the characteristics of coronary-arterial lesions caused by KD significantly differ from atherosclerotic coronary disease in adults...
January 29, 2019: Children
Jeremy M Steele, Tamar J Preminger, Francine G Erenberg, Lu Wang, Katherine Dell, Tarek Alsaied, Kenneth G Zahka
OBJECTIVES: To determine the prevalence, age of onset, and risk factors for overweight and obesity in children with congenital heart disease (CHD). STUDY DESIGN: Children with CHD who were seen at our institution from 1996 to 2017 were studied. Patients were full-time residents of the United States and were receiving all cardiac care at our institution. Patients were categorized by age and CHD diagnosis. The date of last normal weight for age and the date of first recorded weight in the range of overweight and obese were documented...
January 30, 2019: Congenital Heart Disease
Sheeraz Habash, Kai Thorsten Laser, Julia Moosmann, Roland Reif, Werner Adler, Martin Glöckler, Deniz Kececioglu, Sven Dittrich
New echocardiographic modalities including pulmonary artery acceleration time (PAAT) and right ventricular ejection time (RVET) are evolving to facilitate an early non-invasive diagnosis for pulmonary hypertension (PH) in adults. In children, PAAT depends on age, body surface area (BSA) and heart rate (HR) and is used to predict PH. Normal values of RVET and their role to predict PH in children are still missing. PAAT/RVET-index correlates negatively with PH. We hypothesized that this index is a good predictor for PH in children and adolescents independent of age, BSA and HR and RVET is significantly reduced in PH...
January 28, 2019: International Journal of Cardiovascular Imaging
Yoshitsugu Oki, Makoto Kawai, Kosuke Minai, Kazuo Ogawa, Yasunori Inoue, Satoshi Morimoto, Toshikazu Tanaka, Tomohisa Nagoshi, Takayuki Ogawa, Michihiro Yoshimura
High serum uric acid (UA) has been reported to be associated with left ventricular (LV) dysfunction; however, the relationship between UA and plasma B-type natriuretic peptide (BNP), a sensitive biomarker of heart failure, is still unclear. This study investigated their relationship to provide an accurate assessment of high UA. The study patients consisted of 3,077 subjects who underwent cardiac catheterization because of various cardiovascular disorders. Since the explanatory factors of multiple regression analysis were mostly confounding with each other, subgroup analysis was performed by quartering the study population using the respective risk factors and by covariance structure analysis...
January 24, 2019: Scientific Reports
Serena Francesca Flocco, Federica Dellafiore, Rosario Caruso, Alessandro Giamberti, Angelo Micheletti, Diana Gabriela Negura, Luciane Piazza, Mario Carminati, Massimo Chessa
AIMS: The aim of this study was to assess the impact of a transition clinic model on adolescent congenital heart disease (CHD) patients' health perception outcomes. The transition clinic model consists of multidisciplinary standardized interventions to educate and support CHD patients and represents a key element in the adequate delivery of care to these individuals during their transition from childhood to adulthood. Currently, empirical data regarding the impact of transition clinic models on the improvement of health perceptions in CHD adolescent patients are lacking...
January 22, 2019: Journal of Cardiovascular Medicine
Andrew H Schapiro, Mantosh S Rattan, Ryan A Moore, Jonathan R Dillman
History A 17-year-old white male adolescent was re-evaluated for a withheld cardiac condition initially detected during prenatal imaging at an outside institution. He had previously experienced intermittent episodes of shortness of breath, chest pain, and palpitations with exertion, but more recently he had been asymptomatic. He had no other comorbidities and no family history of congenital heart disease, cardiomyopathy, arrhythmia, or sudden cardiac death. At physical examination, the patient had a grade II/IV rumbling systolic murmur best heard at the left upper sternal border...
February 2019: Radiology
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