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RANDOMIZED CONTROLLED TRIAL
Jared H Dahle, Danielle M Ostendorf, Zhaoxing Pan, Paul S MacLean, Daniel H Bessesen, Steven B Heymsfield, Edward L Melanson, Victoria A Catenacci
OBJECTIVE: Mathematical equations that predict resting energy expenditure (REE) are widely used to derive calorie prescriptions during weight-loss interventions. Although such equations are known to introduce group- and individual-level error into REE prediction, their validity has largely been assessed in weight-stable populations. Therefore, this study sought to characterize how weight change affects the validity of commonly used REE predictive models throughout a 12-month weight-loss intervention...
October 2021: Obesity
#22
JOURNAL ARTICLE
Laurel D Quirke, Paul H Maclean, Neville A Haack, Sara J Edwards, Axel Heiser, Jennifer L Juengel
Modulation of the immune system is known to be important for successful pregnancy but how immune function might differ between the lymph nodes draining the reproductive tract and peripheral lymph nodes is not well understood. Additionally, if immune system changes in response to the presence of an embryo during early pregnancy, and if this response differs in local versus peripheral immune tissue, has not been well characterized. To address these questions, we examined expression of genes important for immune function using NanoString technology in the ampulla and isthmus of the oviduct, endometrium, lymph nodes draining the reproductive tract (lumbo-aortic and medial iliac) as well as a peripheral lymph node (axillary), the spleen and circulating immune cells from ewes on day 5 of the estrous cycle or pregnancy...
July 8, 2021: Journal of Animal Science
#23
JOURNAL ARTICLE
Janet C Siebert, Maggie A Stanislawski, Adnin Zaman, Danielle M Ostendorf, Iain R Konigsberg, Purevsuren Jambal, Diana Ir, Kristen Bing, Liza Wayland, Jared J Scorsone, Catherine A Lozupone, Carsten Görg, Daniel N Frank, Daniel Bessesen, Paul S MacLean, Edward L Melanson, Victoria A Catenacci, Sarah J Borengasser
OBJECTIVE: Identifying predictors of weight loss and clinical outcomes may increase understanding of individual variability in weight loss response. We hypothesized that baseline multiomic features, including DNA methylation (DNAme), metabolomics, and gut microbiome, would be predictive of short-term changes in body weight and other clinical outcomes within a comprehensive weight loss intervention. METHODS: Healthy adults with overweight or obesity (n = 62, age 18-55 years, BMI 27-45 kg/m2 , 75...
May 2021: Obesity
#24
Ana da Silva Filipe, James G Shepherd, Thomas Williams, Joseph Hughes, Elihu Aranday-Cortes, Patawee Asamaphan, Shirin Ashraf, Carlos Balcazar, Kirstyn Brunker, Alasdair Campbell, Stephen Carmichael, Chris Davis, Rebecca Dewar, Michael D Gallagher, Rory Gunson, Verity Hill, Antonia Ho, Ben Jackson, Edward James, Natasha Jesudason, Natasha Johnson, E Carol McWilliam Leitch, Kathy Li, Alasdair MacLean, Daniel Mair, David A McAllister, John T McCrone, Sarah E McDonald, Martin P McHugh, A Keith Morris, Jenna Nichols, Marc Niebel, Kyriaki Nomikou, Richard J Orton, Áine O'Toole, Massimo Palmarini, Benjamin J Parcell, Yasmin A Parr, Andrew Rambaut, Stefan Rooke, Sharif Shaaban, Rajiv Shah, Joshua B Singer, Katherine Smollett, Igor Starinskij, Lily Tong, Vattipally B Sreenu, Elizabeth Wastnedge, Matthew T G Holden, David L Robertson, Kate Templeton, Emma C Thomson
No abstract text is available yet for this article.
March 2021: Nature Microbiology
#25
Ana da Silva Filipe, James G Shepherd, Thomas Williams, Joseph Hughes, Elihu Aranday-Cortes, Patawee Asamaphan, Shirin Ashraf, Carlos Balcazar, Kirstyn Brunker, Alasdair Campbell, Stephen Carmichael, Chris Davis, Rebecca Dewar, Michael D Gallagher, Rory Gunson, Verity Hill, Antonia Ho, Ben Jackson, Edward James, Natasha Jesudason, Natasha Johnson, E Carol McWilliam Leitch, Kathy Li, Alasdair MacLean, Daniel Mair, David A McAllister, John T McCrone, Sarah E McDonald, Martin P McHugh, A Keith Morris, Jenna Nichols, Marc Niebel, Kyriaki Nomikou, Richard J Orton, Áine O'Toole, Massimo Palmarini, Benjamin J Parcell, Yasmin A Parr, Andrew Rambaut, Stefan Rooke, Sharif Shaaban, Rajiv Shah, Joshua B Singer, Katherine Smollett, Igor Starinskij, Lily Tong, Vattipally B Sreenu, Elizabeth Wastnedge, Matthew T G Holden, David L Robertson, Kate Templeton, Emma C Thomson
No abstract text is available yet for this article.
January 18, 2021: Nature Microbiology
#26
JOURNAL ARTICLE
Ana da Silva Filipe, James G Shepherd, Thomas Williams, Joseph Hughes, Elihu Aranday-Cortes, Patawee Asamaphan, Shirin Ashraf, Carlos Balcazar, Kirstyn Brunker, Alasdair Campbell, Stephen Carmichael, Chris Davis, Rebecca Dewar, Michael D Gallagher, Rory Gunson, Verity Hill, Antonia Ho, Ben Jackson, Edward James, Natasha Jesudason, Natasha Johnson, E Carol McWilliam Leitch, Kathy Li, Alasdair MacLean, Daniel Mair, David A McAllister, John T McCrone, Sarah E McDonald, Martin P McHugh, A Keith Morris, Jenna Nichols, Marc Niebel, Kyriaki Nomikou, Richard J Orton, Áine O'Toole, Massimo Palmarini, Benjamin J Parcell, Yasmin A Parr, Andrew Rambaut, Stefan Rooke, Sharif Shaaban, Rajiv Shah, Joshua B Singer, Katherine Smollett, Igor Starinskij, Lily Tong, Vattipally B Sreenu, Elizabeth Wastnedge, Matthew T G Holden, David L Robertson, Kate Templeton, Emma C Thomson
Coronavirus disease 2019 (COVID-19) was first diagnosed in Scotland on 1 March 2020. During the first month of the outbreak, 2,641 cases of COVID-19 led to 1,832 hospital admissions, 207 intensive care admissions and 126 deaths. We aimed to identify the source and number of introductions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into Scotland using a combined phylogenetic and epidemiological approach. Sequencing of 1,314 SARS-CoV-2 viral genomes from available patient samples enabled us to estimate that SARS-CoV-2 was introduced to Scotland on at least 283 occasions during February and March 2020...
January 2021: Nature Microbiology
#27
JOURNAL ARTICLE
Edd Maclean, Joban Sehmi, Gajen Kanaganayagam, Edward David Nicol
OBJECTIVES: In outpatients with suspected ischaemic symptoms, we investigated the impact of risk factor profile on the prognostic value of coronary artery calcium scoring (CACS) and CT coronary angiography (CTCA). METHODS: 772 consecutive patients underwent CACS and CTCA; 52 patients (6.7%) with significant coronary artery lesions underwent revascularisation within 60 days and were excluded. 720 remaining patients were followed up for 38.1±17.4 months. RESULTS: Late presentation (after 60 days) major adverse cardiovascular events (MACEs) were recorded in 27 patients (3...
October 27, 2020: Heart
#28
JOURNAL ARTICLE
Clare Nicholson, Mark J Edwards, Alan J Carson, Paula Gardiner, Dawn Golder, Kate Hayward, Susan Humblestone, Helen Jinadu, Carrie Lumsden, Julie MacLean, Lynne Main, Lindsey Macgregor, Glenn Nielsen, Louise Oakley, Jason Price, Jessica Ranford, Jasbir Ranu, Ed Sum, Jon Stone
BACKGROUND: People with functional neurological disorder (FND) are commonly seen by occupational therapists; however, there are limited descriptions in the literature about the type of interventions that are likely to be helpful. This document aims to address this issue by providing consensus recommendations for occupational therapy assessment and intervention. METHODS: The recommendations were developed in four stages. Stage 1: an invitation was sent to occupational therapists with expertise in FND in different countries to complete two surveys exploring their opinions regarding best practice for assessment and interventions for FND...
October 2020: Journal of Neurology, Neurosurgery, and Psychiatry
#29
JOURNAL ARTICLE
Edward Ferdian, Avan Suinesiaputra, Kenneth Fung, Nay Aung, Elena Lukaschuk, Ahmet Barutcu, Edd Maclean, Jose Paiva, Stefan K Piechnik, Stefan Neubauer, Steffen E Petersen, Alistair A Young
PURPOSE: To demonstrate the feasibility and performance of a fully automated deep learning framework to estimate myocardial strain from short-axis cardiac MRI-tagged images. MATERIALS AND METHODS: In this retrospective cross-sectional study, 4508 cases from the U.K. Biobank were split randomly into 3244 training cases, 812 validation cases, and 452 test cases. Ground truth myocardial landmarks were defined and tracked by manual initialization and correction of deformable image registration using previously validated software with five readers...
February 27, 2020: Radiology. Cardiothoracic imaging
#30
MULTICENTER STUDY
Angela N Viaene, Edward B Lee, MacLean P Nasrallah
BACKGROUND: Pituicytoma is a rare tumor of the sella and suprasellar region. It is common for these tumors to be misdiagnosed radiographically as pituitary adenomas, meningiomas, and craniopharyngiomas. Histologically, pituicytomas are also known to show variable morphology. These factors often complicate intraoperative consultation, especially when tissue is limited. METHODS: A database search (January 1990-June 2019) identified 13 surgically resected pituicytomas that were sent for intraoperative consultation...
April 2020: Diagnostic Cytopathology
#31
JOURNAL ARTICLE
Constance van Eeghen, Melinda Edwards, Bonita S Libman, Charles D MacLean, Amanda G Kennedy
Objective: Use an established quality improvement method, Lean A3, to improve the process of opioid prescribing in an academic rheumatology ambulatory clinic. Methods: This retrospective pre-postintervention analysis of rheumatology records included patients prescribed opioids at least once during the study period. Lean A3 was used to develop a Controlled Substance Visit Protocol to standardize eight recommended elements of the opioid prescribing workflow. Analyses included changes in the recommended workflow elements and changes in opioid prescribing volume...
November 2019: ACR open rheumatology
#32
JOURNAL ARTICLE
Erin D Giles, Ian L Brown, Paul S MacLean, Zhaoxing Pan, Edward L Melanson, Kennon J Heard, Marc-Andre Cornier, Tyson Marden, Janine A Higgins
The in vivo net energy content of resistant starch (RS) has not been measured in humans so it has not been possible to account for the contribution of RS to dietary energy intake. We aimed to determine the in vivo net energy content of RS and examine its effect on macronutrient oxidation. This was a randomized, double-blind cross-over study. Eighteen healthy adults spent 24 h in a whole room indirect calorimeter to measure total energy expenditure (TEE), substrate oxidation, and postprandial metabolites in response to three diets: 1) digestible starch (DS), 2) RS (33% dietary fiber; RS), or 3) RS with high fiber (RSF, 56% fiber)...
October 16, 2019: Nutrients
#33
JOURNAL ARTICLE
Sepehr Bahadorani, Kyle Maclean, Kendall Wannamaker, Edward Rickie Chu, Nathan Gresores, Jeong-Hyeon Sohn, Roberto Diaz-Rohena, Michael A Singer
Purpose: Central serous chorioretinopathy (CSCR) is a common retinopathy that is often observed until resolution. The purpose of this study is to evaluate the effects of topical nonsteroidal anti-inflammatory drugs (NSAIDs) on timing of CSCR recovery. Methods: An IRB-approved retrospective review was conducted on patients that had been diagnosed with a new-onset, symptomatic case of CSCR. Patients were either observed only (13 untreated eyes) or treated with topical bromfenac or nepafenac (14 eyes) over an average of about a 4-5 week follow-up period...
2019: Clinical Ophthalmology
#34
JOURNAL ARTICLE
Stavros G Memtsoudis, Crispiana Cozowicz, Janis Bekeris, Dace Bekere, Jiabin Liu, Ellen M Soffin, Edward R Mariano, Rebecca L Johnson, Mary J Hargett, Bradley H Lee, Pamela Wendel, Mark Brouillette, George Go, Sang J Kim, Lila Baaklini, Douglas Wetmore, Genewoo Hong, Rie Goto, Bridget Jivanelli, Eriphyli Argyra, Michael J Barrington, Alain Borgeat, Jose De Andres, Nabil M Elkassabany, Philippe E Gautier, Peter Gerner, Alejandro Gonzalez Della Valle, Enrique Goytizolo, Paul Kessler, Sandra L Kopp, Patricia Lavand'Homme, Catherine H MacLean, Carlos B Mantilla, Daniel MacIsaac, Alexander McLawhorn, Joseph M Neal, Michael Parks, Javad Parvizi, Lukas Pichler, Jashvant Poeran, Lazaros A Poultsides, Brian D Sites, Otto Stundner, Eric C Sun, Eugene R Viscusi, Effrossyni G Votta-Velis, Christopher L Wu, Jacques T Ya Deau, Nigel E Sharrock
BACKGROUND: Evidence-based international expert consensus regarding anaesthetic practice in hip/knee arthroplasty surgery is needed for improved healthcare outcomes. METHODS: The International Consensus on Anaesthesia-Related Outcomes after Surgery group (ICAROS) systematic review, including randomised controlled and observational studies comparing neuraxial to general anaesthesia regarding major complications, including mortality, cardiac, pulmonary, gastrointestinal, renal, genitourinary, thromboembolic, neurological, infectious, and bleeding complications...
September 2019: British Journal of Anaesthesia
#35
JOURNAL ARTICLE
Chintamani Atreya, Simone Glynn, Michael Busch, Steve Kleinman, Edward Snyder, Sara Rutter, James AuBuchon, Willy Flegel, David Reeve, Dana Devine, Claudia Cohn, Brian Custer, Raymond Goodrich, Richard J Benjamin, Anna Razatos, Jose Cancelas, Stephen Wagner, Michelle Maclean, Monique Gelderman, Andrew Cap, Paul Ness
No abstract text is available yet for this article.
May 29, 2019: Transfusion
#36
JOURNAL ARTICLE
Angela N Viaene, Edward B Lee, Jason N Rosenbaum, Ilya M Nasrallah, MacLean P Nasrallah
Pituicytoma is a rare, poorly characterized tumor of the sellar region that is thought to be derived from neurohypophyseal pituicytes. Resection of pituicytomas is often associated with significant morbidity including diabetes insipidus and panhypopituitarism. Most of the literature on this tumor exists as small case series or case reports. Here we describe a cohort of fourteen pituicytoma resections from eleven patients. The average follow-up on these cases is 3.7 years with some patients having over 10 years of follow-up data available in the electronic medical record...
May 2, 2019: Acta Neuropathologica Communications
#37
JOURNAL ARTICLE
David M Presby, Matthew R Jackman, Michael C Rudolph, Vanessa D Sherk, Rebecca M Foright, Julie A Houck, Ginger C Johnson, David J Orlicky, Edward L Melanson, Janine A Higgins, Paul S MacLean
Prevalence of obesity is exacerbated by low rates of successful long-term weight loss maintenance (WLM). In part, relapse from WLM to obesity is due to a reduction in energy expenditure (EE) that persists throughout WLM and relapse. Thus, interventions that increase EE might facilitate WLM. In obese mice that were calorically restricted to reduce body weight by ~20%, we manipulated EE throughout WLM and early relapse using intermittent cold exposure (ICE; 4°C, 90 min/day, 5 days/wk, within the last 3 h of the light cycle)...
May 1, 2019: American Journal of Physiology. Endocrinology and Metabolism
#38
JOURNAL ARTICLE
Danielle M Ostendorf, Ann E Caldwell, Seth A Creasy, Zhaoxing Pan, Kate Lyden, Audrey Bergouignan, Paul S MacLean, Holly R Wyatt, James O Hill, Edward L Melanson, Victoria A Catenacci
OBJECTIVE: The objective of this study was to compare physical activity energy expenditure (PAEE) and total daily energy expenditure (TDEE) in successful weight loss maintainers (WLM) with normal weight controls (NC) and controls with overweight/obesity (OC). METHODS: Participants were recruited in three groups: WLM (n = 25, BMI 24.1 ± 2.3 kg/m2 ; maintaining ≥ 13.6-kg weight loss for ≥ 1 year), NC (n = 27, BMI 23.0 ± 2.0 kg/m2 ; similar to current BMI of WLM), and OC (n = 28, BMI 34...
March 2019: Obesity
#39
JOURNAL ARTICLE
Ghanasyam Rallapalli, Pilar Corredor-Moreno, Edward Chalstrey, Martin Page, Daniel MacLean
BACKGROUND: Traditional Map based Cloning approaches, used for the identification of desirable alleles, are extremely labour intensive and years can elapse between the mutagenesis and the detection of the polymorphism. High throughput sequencing based Mapping-by-sequencing approach requires an ordered genome assembly and cannot be used with fragmented, un-scaffolded draft genomes, limiting its application to model species and precluding many important organisms. RESULTS: We addressed this gap in resource and presented a computational method and software implementations called CHERIPIC (Computing Homozygosity Enriched Regions In genomes to Prioritise Identification of Candidate variants)...
January 7, 2019: BMC Bioinformatics
#40
JOURNAL ARTICLE
Danielle M Ostendorf, Edward L Melanson, Ann E Caldwell, Seth A Creasy, Zhaoxing Pan, Paul S MacLean, Holly R Wyatt, James O Hill, Victoria A Catenacci
Background: Evidence in humans is equivocal in regards to whether resting energy expenditure (REE) decreases to a greater extent than predicted for the loss of body mass with weight loss, and whether this disproportionate decrease in REE persists with weight-loss maintenance. Objectives: We aimed to1) determine if a lower-than-predicted REE is present in a sample of successful weight-loss maintainers (WLMs) and 2) determine if amount of weight loss or duration of weight-loss maintenance are correlated with a lower-than-predicted REE in WLMs...
October 1, 2018: American Journal of Clinical Nutrition
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