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Edward Maclean

Ghanasyam Rallapalli, Pilar Corredor-Moreno, Edward Chalstrey, Martin Page, Daniel MacLean
BACKGROUND: Traditional Map based Cloning approaches, used for the identification of desirable alleles, are extremely labour intensive and years can elapse between the mutagenesis and the detection of the polymorphism. High throughput sequencing based Mapping-by-sequencing approach requires an ordered genome assembly and cannot be used with fragmented, un-scaffolded draft genomes, limiting its application to model species and precluding many important organisms. RESULTS: We addressed this gap in resource and presented a computational method and software implementations called CHERIPIC (Computing Homozygosity Enriched Regions In genomes to Prioritise Identification of Candidate variants)...
January 7, 2019: BMC Bioinformatics
Danielle M Ostendorf, Edward L Melanson, Ann E Caldwell, Seth A Creasy, Zhaoxing Pan, Paul S MacLean, Holly R Wyatt, James O Hill, Victoria A Catenacci
Background: Evidence in humans is equivocal in regards to whether resting energy expenditure (REE) decreases to a greater extent than predicted for the loss of body mass with weight loss, and whether this disproportionate decrease in REE persists with weight-loss maintenance. Objectives: We aimed to1) determine if a lower-than-predicted REE is present in a sample of successful weight-loss maintainers (WLMs) and 2) determine if amount of weight loss or duration of weight-loss maintenance are correlated with a lower-than-predicted REE in WLMs...
October 1, 2018: American Journal of Clinical Nutrition
Carrie Howard, Thomas W Clements, Janet P Edwards, Anthony R MacLean, W Donald Buie, Elijah Dixon, Sean C Grondin, Anthony Gomes, Michael McColl, Sean P Cleary, Shiva Jayaraman, Renelle Daigle, Chad G Ball
Background: The management of patients with synchronous colorectal liver metastases (sCRLM) has evolved significantly (improved chemotherapy, hepatic surgery advancements, colonic stenting, consultation synergies). We sought to better understand surgeon viewpoints on optimal referral patterns and the delivery of simultaneous resections. Methods: A 40 question on-line survey was offered to members of the Canadian surgical community. Statistical analysis was descriptive...
August 2018: Hepatobiliary Surgery and Nutrition
Erin D Giles, Sonali Jindal, Elizabeth A Wellberg, Troy Schedin, Steven M Anderson, Ann D Thor, Dean P Edwards, Paul S MacLean, Pepper Schedin
BACKGROUND: Obesity and type II diabetes are linked to increased breast cancer risk in postmenopausal women. Patients treated with the antidiabetic drug metformin for diabetes or metabolic syndrome have reduced breast cancer risk, a greater pathologic complete response to neoadjuvant therapy, and improved breast cancer survival. We hypothesized that metformin may be especially effective when targeted to the menopausal transition, as this is a lifecycle window when weight gain and metabolic syndrome increase, and is also when the risk for obesity-related breast cancer increases...
June 14, 2018: Breast Cancer Research: BCR
Matthew G Teeter, Colin J MacLean, Lyndsay E Somerville, James L Howard, Richard W McCalden, Brent A Lanting, Edward M Vasarhelyi
Patients with THA using a ceramic head and using an OxZr head were each matched to patients with a CoCr head. Mean implantation time was 5 years. There was no difference in steady state wear rate between the ceramic (0.066 ± 0.050 mm/year) and CoCr match groups (0.052 ± 0.041 mm/year), or between the OxZr (0.022 ± 0.029 mm/year) and CoCr match groups (0.048 ± 0.071 mm/year). Follow-up into the second decade will be necessary before any changes in THA wear rate from using ceramic or OxZr bearings may be appreciated clinically with available imaging techniques...
June 2018: Journal of Orthopaedics
Mark McMullan, Maryam Rafiqi, Gemy Kaithakottil, Bernardo J Clavijo, Lorelei Bilham, Elizabeth Orton, Lawrence Percival-Alwyn, Ben J Ward, Anne Edwards, Diane G O Saunders, Gonzalo Garcia Accinelli, Jonathan Wright, Walter Verweij, Georgios Koutsovoulos, Kentaro Yoshida, Tsuyoshi Hosoya, Louisa Williamson, Philip Jennings, Renaud Ioos, Claude Husson, Ari M Hietala, Adam Vivian-Smith, Halvor Solheim, Dan MaClean, Christine Fosker, Neil Hall, James K M Brown, David Swarbreck, Mark Blaxter, J Allan Downie, Matthew D Clark
Accelerating international trade and climate change make pathogen spread an increasing concern. Hymenoscyphus fraxineus, the causal agent of ash dieback, is a fungal pathogen that has been moving across continents and hosts from Asian to European ash. Most European common ash trees (Fraxinus excelsior) are highly susceptible to H. fraxineus, although a minority (~5%) have partial resistance to dieback. Here, we assemble and annotate a H. fraxineus draft genome, which approaches chromosome scale. Pathogen genetic diversity across Europe and in Japan, reveals a strong bottleneck in Europe, though a signal of adaptive diversity remains in key host interaction genes...
June 2018: Nature Ecology & Evolution
Kazuo Imaizumi, Edward S Ruthazer, Jason N MacLean, Charles C Lee
No abstract text is available yet for this article.
2018: Frontiers in Neural Circuits
Philip I Terrill, Carolyn Dakin, Bradley A Edwards, Stephen J Wilson, Joanna E MacLean
STUDY OBJECTIVES: Pulse-oximetry (SpO2 ) allows the identification of important clinical physiology. However, summary statistics such as mean values and desaturation incidence do not capture the complexity of the information contained within continuous recordings. The aim of this study was to develop an objective method to quantify important SpO2 characteristics; and assess its utility in healthy infant and preterm neonate cohorts. METHODS: An algorithm was developed to calculate the desaturation incidence, depth, and duration...
May 2018: Pediatric Pulmonology
Qiue Yang, Mei Li, Owen B Spiller, Diego O Andrey, Philip Hinchliffe, Hui Li, Craig MacLean, Pannika Niumsup, Lydia Powell, Manon Pritchard, Andrei Papkou, Yingbo Shen, Edward Portal, Kirsty Sands, James Spencer, Uttapoln Tansawai, David Thomas, Shaolin Wang, Yang Wang, Jianzhong Shen, Timothy Walsh
MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, competitive ability and significant degradation in cell membrane and cytoplasmic structures, compared to expression of catalytically inactive MCR-1 (E246A) or MCR-1 soluble component. Lipopolysaccharide (LPS) extracted from mcr-1 strains induces lower production of IL-6 and TNF, when compared to control LPS...
December 12, 2017: Nature Communications
Victoria A Catenacci, Zhaoxing Pan, Danielle Ostendorf, Sarah Brannon, Wendolyn S Gozansky, Mark P Mattson, Bronwen Martin, Paul S MacLean, Edward L Melanson, William Troy Donahoo
OBJECTIVE: To evaluate the safety and tolerability of alternate-day fasting (ADF) and to compare changes in weight, body composition, lipids, and insulin sensitivity index (Si) with those produced by a standard weight loss diet, moderate daily caloric restriction (CR). METHODS: Adults with obesity (BMI ≥30 kg/m(2) , age 18-55) were randomized to either zero-calorie ADF (n = 14) or CR (-400 kcal/day, n = 12) for 8 weeks. Outcomes were measured at the end of the 8-week intervention and after 24 weeks of unsupervised follow-up...
September 2016: Obesity
Ghanasyam Rallapalli, Diane Go Saunders, Kentaro Yoshida, Anne Edwards, Carlos A Lugo, Steve Collin, Bernardo Clavijo, Manuel Corpas, David Swarbreck, Matthew Clark, J Allan Downie, Sophien Kamoun, Dan MacLean
In 2013, in response to an epidemic of ash dieback disease in England the previous year, we launched a Facebook-based game called Fraxinus to enable non-scientists to contribute to genomics studies of the pathogen that causes the disease and the ash trees that are devastated by it. Over a period of 51 weeks players were able to match computational alignments of genetic sequences in 78% of cases, and to improve them in 15% of cases. We also found that most players were only transiently interested in the game, and that the majority of the work done was performed by a small group of dedicated players...
July 29, 2015: ELife
Jacqueline Willmore, Edward Ellis, Vera Etches, Lise Labrecque, Carla Osiowy, Anton Andonov, Cameron McDermaid, Anna Majury, Camille Achonu, Maurica Maher, Brenda MacLean, Isra Levy
OBJECTIVE: To determine whether transmission of blood-borne pathogens (BBPs) (hepatitis B virus [HBV], hepatitis C virus [HCV] and HIV) occurred as a result of endoscopy reprocessing failures identified during an inspection of a nonhospital endoscopy clinic in 2011. METHODS: The present analysis was a retrospective cohort study. Registered notification letters were mailed to 6992 patients who underwent endoscopy from 2002 to 2011 at one Canadian nonhospital endoscopy clinic, informing them of the infection control lapse and offering BBP testing...
March 2015: Canadian Journal of Infectious Diseases & Medical Microbiology
Simon B M MacLean, Christopher Timmis, Scott Evans, Dominik Lawniczak, Amit Nijran, Edward Bache
PURPOSE: To review the records of 50 children who underwent open joint washout for septic arthritis with (n=25) or without (n=25) preoperative antibiotics. METHODS: Records of 50 children who underwent open joint washout for presumed septic arthritis with (n=25) or without (n=25) preoperative antibiotics were reviewed. 17 boys and 8 girls aged 3 weeks to 16 years (median, 1.5 years) who were prescribed preoperative antibiotics before joint washout were compared with 12 boys and 13 girls aged one month to 14 years (median, 2 years) who were not...
April 2015: Journal of Orthopaedic Surgery
Harold E Bays, Eliot A Brinton, Joseph Triscari, Erluo Chen, Darbie Maccubbin, Alexandra A MacLean, Kendra L Gibson, Rae Ann Ruck, Amy O Johnson-Levonas, Edward A O'Neill, Yale B Mitchel
BACKGROUND: The degree of glycemic control in patients with type 2 diabetes mellitus (T2DM) may alter lipid levels and may alter the efficacy of lipid-modifying agents. OBJECTIVE: Evaluate the lipid-modifying efficacy of extended-release niacin/laropiprant (ERN/LRPT) in subgroups of patients with T2DM with better or poorer glycemic control. METHODS: Post hoc analysis of clinical trial data from patients with T2DM who were randomized 4:3 to double-blind ERN/LRPT or placebo (n=796), examining the lipid-modifying effects of ERN/LRPT in patients with glycosylated hemoglobin or fasting plasma glucose levels above and below median baseline levels...
2015: Vascular Health and Risk Management
Robert D Annett, Sarah Hile, Edward Bedrick, Alicia S Kunin-Batson, Kevin R Krull, Leanne Embry, Willliam E MacLean, Robert B Noll
OBJECTIVES: To provide one of the first prospective reports examining neuropsychological outcomes for children treated with 1800 cGy whole brain radiotherapy (WBRT) and prophylactic chemotherapy versus prophylactic chemotherapy alone for acute lymphoblastic leukemia (ALL). Acute and long-term neuropsychological toxicities associated with WBRT are compared. METHODS: This multisite study included 188 children, ages 4-21 years at enrollment, who were assessed with standardized neuropsychological tests at 9, 21, and 48 months after diagnosis with intermediate risk ALL...
February 2015: Psycho-oncology
Louise Maclean, David Reiss, Seán Whyte, Simon Christopherson, Edward Petch, Catherine Penny
Stalking is a well-recognized social phenomenon, one that particularly affects health care professionals, especially psychiatrists and other mental health workers; however, the nature and effects of stalking of psychiatrists have not been examined in detail. This study is a qualitative thematic analysis of the free-text responses of 2,585 psychiatrists in the United Kingdom (approximately 25% of all U.K. psychiatrists), almost 11 percent of whom described being stalked according to a strict research definition, and 21 percent of whom perceived themselves as having been stalked...
2013: Journal of the American Academy of Psychiatry and the Law
Gazi S Hossain, Edward G Lynn, Kenneth N Maclean, Ji Zhou, Jeffrey G Dickhout, Sárka Lhoták, Bernardo Trigatti, John Capone, Jaerang Rho, Damu Tang, Christopher A McCulloch, Imtisal Al-Bondokji, Mary J Malloy, Clive R Pullinger, John P Kane, Yonghong Li, Dov Shiffman, Richard C Austin
BACKGROUND: Apoptosis caused by endoplasmic reticulum (ER) stress contributes to atherothrombosis, the underlying cause of cardiovascular disease (CVD). T-cell death-associated gene 51 (TDAG51), a member of the pleckstrin homology-like domain gene family, is induced by ER stress, causes apoptosis when overexpressed, and is present in lesion-resident macrophages and endothelial cells. METHODS AND RESULTS: To study the role of TDAG51 in atherosclerosis, male mice deficient in TDAG51 and apolipoprotein E (TDAG51(-/-)/ApoE(-/-)) were generated and showed reduced atherosclerotic lesion growth (56 ± 5% reduction at 40 weeks, relative to ApoE(-/-) controls, P<0...
June 2013: Journal of the American Heart Association
Dan Maclean, Kentaro Yoshida, Anne Edwards, Lisa Crossman, Bernardo Clavijo, Matt Clark, David Swarbreck, Matthew Bashton, Patrick Chapman, Mark Gijzen, Mario Caccamo, Allan Downie, Sophien Kamoun, Diane Go Saunders
Ash dieback is a devastating fungal disease of ash trees that has swept across Europe and recently reached the UK. This emergent pathogen has received little study in the past and its effect threatens to overwhelm the ash population. In response to this we have produced some initial genomics datasets and taken the unusual step of releasing them to the scientific community for analysis without first performing our own. In this manner we hope to 'crowdsource' analyses and bring the expertise of the community to bear on this problem as quickly as possible...
2013: GigaScience
Sana Basseri, Sárka Lhoták, Morgan D Fullerton, Rengasamy Palanivel, Hua Jiang, Edward G Lynn, Rebecca J Ford, Kenneth N Maclean, Gregory R Steinberg, Richard C Austin
Regulation of energy metabolism is critical for the prevention of obesity, diabetes, and hepatic steatosis. Here, we report an important role for the pleckstrin homology-related domain family member, T-cell death-associated gene 51 (TDAG51), in the regulation of energy metabolism. TDAG51 expression was examined during adipocyte differentiation. Adipogenic potential of preadipocytes with knockdown or absence of TDAG51 was assessed. Weight gain, insulin sensitivity, metabolic rate, and liver lipid content were also compared between TDAG51-deficient (TDAG51(-/-)) and wild-type mice...
January 2013: Diabetes
Margaret C Neville, Steven M Anderson, James L McManaman, Thomas M Badger, Maya Bunik, Nikhat Contractor, Tessa Crume, Dana Dabelea, Sharon M Donovan, Nicole Forman, Daniel N Frank, Jacob E Friedman, J Bruce German, Armond Goldman, Darryl Hadsell, Michael Hambidge, Katie Hinde, Nelson D Horseman, Russell C Hovey, Edward Janoff, Nancy F Krebs, Carlito B Lebrilla, Danielle G Lemay, Paul S MacLean, Paula Meier, Ardythe L Morrow, Josef Neu, Laurie A Nommsen-Rivers, Daniel J Raiten, Monique Rijnkels, Victoria Seewaldt, Barry D Shur, Joshua VanHouten, Peter Williamson
This paper resulted from a conference entitled "Lactation and Milk: Defining and refining the critical questions" held at the University of Colorado School of Medicine from January 18-20, 2012. The mission of the conference was to identify unresolved questions and set future goals for research into human milk composition, mammary development and lactation. We first outline the unanswered questions regarding the composition of human milk (Section I) and the mechanisms by which milk components affect neonatal development, growth and health and recommend models for future research...
June 2012: Journal of Mammary Gland Biology and Neoplasia
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