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JOURNAL ARTICLE
Gemma Reynolds, Marsali Maclean, Edward Robert Scheffer Cliff, Benjamin W Teh, Karin A Thursky, Monica A Slavin, Mary Ann Anderson, Eliza A Hawkes
No abstract text is available yet for this article.
April 16, 2024: Blood Advances
#2
JOURNAL ARTICLE
Tamana R Yousof, Celeste C Bouchard, Mihnea Alb, Edward G Lynn, Sárka Lhoták, Hua Jiang, Melissa MacDonald, Hui Li, Jae H Byun, Yumna Makda, Maria Athanasopoulos, Kenneth N Maclean, Nathan J Cherrington, Asghar Naqvi, Suleiman A Igdoura, Joan C Krepinsky, Gregory R Steinberg, Richard C Austin
Endoplasmic reticulum stress is associated with insulin resistance and the development of nonalcoholic fatty liver disease. Deficiency of the endoplasmic reticulum stress response T-cell death-associated gene 51 (TDAG51) (TDAG51-/- ) in mice promotes the development of high-fat diet (HFD)-induced obesity, fatty liver, and hepatic insulin resistance. However, whether this effect is due specifically to hepatic TDAG51 deficiency is unknown. Here, we report that hepatic TDAG51 protein levels are consistently reduced in multiple mouse models of liver steatosis and injury as well as in liver biopsies from patients with liver disease compared to normal controls...
February 2024: Journal of Biological Chemistry
#3
MULTICENTER STUDY
Antonio Creta, Nicoletta Ventrella, Mark J Earley, Malcolm Finlay, Simon Sporton, Edward Maclean, Vijayabharathy Kanthasamy, Bruna Costa Lemos Silva Di Nubila, Danilo Ricciardi, Vito Calabrese, Francesco Picarelli, Ross J Hunter, Pier D Lambiase, Richard J Schilling, Francesco Grigioni, Christopher Monkhouse, Amal Muthumala, Philip Moore, Rui Providencia, Anthony Chow
BACKGROUND: There is a paucity of data comparing vitamin K antagonists (VKAs) to direct oral anticoagulants (DOACs) at the time of cardiac implantable electronic device (CIED) surgery. Furthermore, the best management of DOACs (interruption vs continuation) is yet to be determined. OBJECTIVES: This study aimed to compare the incidence of device-related bleeds and thrombotic events based on anticoagulant type (DOAC vs VKA) and regimen (interrupted vs uninterrupted)...
January 2024: JACC. Clinical Electrophysiology
#4
JOURNAL ARTICLE
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K Nambiar, Ryan K Kim, Gabriel N Valbuena, Silvia Guglietta, Carsten Krieg, Mahnaz Darvish-Damavandi, Tatsuya Suwa, Alistair Easton, Lily Vs Hillson, Ashley K McCulloch, Ross K McMahon, Kathryn Pennel, Joanne Edwards, Sean M O'Cathail, Campbell S Roxburgh, Enric Domingo, Eui Jung Moon, Dadi Jiang, Yanyan Jiang, Qingyang Zhang, Albert C Koong, Trent M Woodruff, Edward E Graves, Tim Maughan, Simon Ja Buczacki, Manuel Stucki, Quynh-Thu Le, Simon J Leedham, Amato J Giaccia, Monica M Olcina
An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumors is still a challenge. Using an integrated screening approach to identify cancer-specific vulnerabilities, we identified complement receptor C5aR1 as a druggable target, which when inhibited improved radiotherapy, even in tumors displaying immunosuppressive features and poor CD8+ T cell infiltration. While C5aR1 is well-known for its role in the immune compartment, we found that C5aR1 is also robustly expressed on malignant epithelial cells, highlighting potential tumor cell-specific functions...
December 1, 2023: Journal of Clinical Investigation
#5
JOURNAL ARTICLE
Edd Maclean, Robert Cronshaw, David E Newby, Edward Nicol, Michelle C Williams
BACKGROUND: Information from cardiac computed tomography angiography can be summarized using visual semi-quantitative scores. However, the optimal method and their prognostic utility is unknown. METHODS: Five semi-quantitative scores were calculated in the SCOT-HEART trial, including segment involvement score (SIS), segment stenosis score (SSS), CT Leaman (CT-LeSc), multivessel aggregate stenosis score (MVAS), and CAD-RADS 2.0 including plaque modifier (P). Prediction of fatal or non-fatal myocardial infarction and major adverse cardiovascular events (MACE) was compared to the 10-year cardiovascular risk score...
September 4, 2023: Journal of Cardiovascular Computed Tomography
#6
JOURNAL ARTICLE
Emily B Hill, Iain R Konigsberg, Diana Ir, Daniel N Frank, Purevsuren Jambal, Elizabeth M Litkowski, Ethan M Lange, Leslie A Lange, Danielle M Ostendorf, Jared J Scorsone, Liza Wayland, Kristen Bing, Paul S MacLean, Edward L Melanson, Daniel H Bessesen, Victoria A Catenacci, Maggie A Stanislawski, Sarah J Borengasser
Obesity has been linked to the gut microbiome, epigenome, and diet, yet these factors have not been studied together during obesity treatment. Our objective was to evaluate associations among gut microbiota (MB), DNA methylation (DNAme), and diet prior to and during a behavioral weight loss intervention. Adults ( n = 47, age 40.9 ± 9.7 years, body mass index (BMI) 33.5 ± 4.5 kg/m2 , 77% female) with data collected at baseline (BL) and 3 months (3 m) were included. Fecal MB was assessed via 16S sequencing and whole blood DNAme via the Infinium EPIC array...
August 16, 2023: Nutrients
#7
JOURNAL ARTICLE
Manjot Birk, Kara Sidhu, Marina Rosa Filezio, Vishwajeet Singh, Fabio Ferri-de-Barros, Vivien Chan, Geoffrey Shumilak, Andrew Nataraj, Holly Langston, Nicholas J Yee, Carlo Iorio, Nicholas Shkumat, Brett Rocos, Birgit Ertl-Wagner, David Lebel, Mark W Camp, Evan Dimentberg, Neil Saran, Melissa Laflamme, Jean A Ouellet, Jessica Wenghofer, Holly Livock, Luke Beaton, Andrew Tice, Kevin Smit, Ryan Graham, Matias Pereira Duarte, Marjolaine Roy-Beaudry, Isabelle Turgeon, Julie Joncas, Jean-Marc Mac-Thiong, Hubert Labelle, Soraya Barchi, Stefan Parent, Tara Gholamian, Holly Livock, Andrew Tice, Kevin Smit, Samuel Yoon, Amna Zulfiqar, Brett Rocos, Anne Murphy, Natasha Bath, Stanley Moll, Julia Sorbara, David Lebel, Mark W Camp, Jérémie Arthur Nallet, Brett Rocos, David Eduard Lebel, Reinhard Zeller, Jennifer A Dermott, Dorothy J Kim, Alison Anthony, Reinhard Zeller, David E Lebel, Zhi Wang, Jesse Shen, Youssef Kamel, Jia Liu, Daniel Shedid, Fidaa Al-Shakfa, Sung-Joo Yuh, Ghassan Boubez, Maroun Rizkallah, Maroun Rizkallah, Jesse Shen, Ghassan Boubez, Youssef Kamel, Jia Liu, Daniel Shedid, Fidaa Al-Shakfa, Frederic Lavoie, Sung-Joo Yug, Zhi Wang, Fatemeh Alavi, Christopher Nielsen, Raja Rampersaud, Stephen Lewis, Angela M Cheung, Chloe Cadieux, Renan Fernandes, Pawel Brzozowski, Radovan Zdero, Chris Bailey, Parham Rasoulinejad, Ahmed Cherry, Ragavan Manoharan, Mark Xu, Nisaharan Srikandarajah, Carlo Iorio, Aditya Raj, Christopher Nielsen, Raja Rampersaud, Stephen Lewis, Kristen Beange, Ryan Graham, Holly Livock, Kevin Smit, Ragavan Manoharan, Ahmed Cherry, Nisaharan Srikandarajah, Aditya Raj, Mark Xu, Carlo Iorio, Christopher J Nielsen, Y Raja Rampersaud, Stephen J Lewis, Ali Asghar Mohammadi Nasrabadi, Gemah Moammer, John Mc Phee, Taryn Walker, Jennifer C Urquhart, R Andrew Glennie, Y Raja Rampersaud, Charles G Fisher, Chris S Bailey, Brandon J Herrington, Renan R Fernandes, Jennifer C Urquhart, Parham Rasoulinejad, Fawaz Siddiqi, Christopher S Bailey, Jennifer Urquhart, Renan R Fernandes, R Andrew Glennie, Y Raja Rampersaud, Charles G Fisher, Chris S Bailey, Michael M H Yang, Jay Riva-Cambrin, Jonathan Cunningham, Steven Casha, Chloe N Cadieux, Jennifer Urquhart, Renan Fernandes, Andrew Glennie, Charles Fisher, Raja Rampersaud, Mark Xu, Ragavan Manoharan, Ahmed Cherry, Aditya Raj, Nish Srikandarajah, Carlo Iorio, Christopher Nielsen, Stephen Lewis, Raja Rampersaud, Ahmed Cherry, Aditya Raj, Greg McIntosh, Ragavan Manoharan, Jean-Christophe Murray, Christopher Nielsen, Mark Xu, Nisaharan Srikandarajah, Carlo Iorio, Anthony Perruccio, Mayilee Canizares, Raja Rampersaud, Dana El-Mughayyar, Erin Bigney, Eden Richardson, Neil Manson, Edward Abraham, Najmedden Attabib, Chris Small, George Kolyvas, Andre LeRoux, Canadian Spine Outcomes, Research Network Investigators, Jeff Hebert, Victor Baisamy, Maroun Rizkallah, Jesse Shen, Thierry Cresson, Carlos Vazquez, Zhi Wang, Ghassan Boubez, Tiffany Lung, Mayilee Canizares, Anthony Perruccio, Raja Rampersaud, Eric J Crawford, Robert A Ravinsky, Anthony V Perruccio, Y Raja Rampersaud, Peter C Coyte, Michael Bond, John Street, Charles Fisher, Raphaele Charest-Morin, Jason M Sutherland, Arthur R Bartolozzi, Ori Barzilai, Dean Chou, Ilya Laufer, Jorrit-Jan Verlaan, Arjun Sahgal, Laurence D Rhines, Daniel M Scuibba, Aron Lazary, Michael H Weber, James M Schuster, Stefano Boriani, Chetan Bettegowda, Paul M Arnold, Michelle J Clarke, Michael G Fehlings, Jeremy J Reynolds, Ziya L Gokaslan, Charles G Fisher, Nicolas Dea, Anne L Versteeg, Raphaele Charest-Morin, Ilya Laufer, William Teixeira, Ori Barzilai, Alessandro Gasbarrini, Michael G Fehlings, Dean Chou, Michael G Johnson, Ziya L Gokaslan, Nicolas Dea, Jorrit-Jan Verlaan, Tony Goldschlager, John H Shin, John E O'Toole, Daniel M Sciubba, Chetan Bettegowda, Michelle J Clarke, Michael H Weber, Addisu Mesfin, Norio Kawahara, Rory Goodwin, Alexander Disch, Aron Lazary, Stefano Boriani, Arjun Sahgal, Laurence Rhines, Charles G Fisher, Anne L Versteeg, Roxanne Gal, Leilani Reich, Angela Tsang, Allan Aludino, Arjun Sahgal, Jorrit-Jan Verlaan, Charles G Fisher, Lenny Verkooijen, Maroun Rizkallah, Zhi Wang, Sung-Joo Yuh, Daniel Shedid, Jesse Shen, Fidaa Al-Shakfa, Céline Belguendouz, Rayan AlKafi, Ghassan Boubez, Mark A MacLean, Miltiadis Georgiopoulos, Raphaele Charest-Morin, Niccole Germscheid, C Rory Goodwin, Michael Weber, Ao Spine International, Maroun Rizkallah, Ghassan Boubez, Hao Zhang, Fidaa Al-Shakfa, Pamela Brindamour, Danielle Boule, Jesse Shen, Daniel Shedid, Sung-Joo Yuh, Zhi Wang, Marcia Rebecca Correale, Leslie Jayne Soever, Raja Rampersaud, Claudia Cristina Malic, Melanie Dubreuil, Kate Duke, Stephen P Kingwell, Zihan Lin, Mark A MacLean, Lisa C Julien, Glenn Patriquin, Jason LeBlanc, Ryan Green, Jacob Alant, Sean Barry, R Andrew Glennie, William Oxney, Sean D Christie, Mohamed Sarraj, Abdullah Alqahtani, Patrick Thornley, Frank Koziarz, Christopher S Bailey, Millaray Freire-Archer, Kunal Bhanot, Edward Kachur, Mohit Bhandari, Colby Oitment, Armaan K Malhotra, Michael Balas, Blessing N R Jaja, Erin M Harrington, Johann Hofereiter, Rachael H Jaffe, Yingshi He, James P Byrne, Jefferson R Wilson, Christopher D Witiw, Kennedy C M Brittain, Sean Christie, Saranyan Pillai, Marcel F Dvorak, Nathan Evaniew, Melody Chen, Zeina Waheed, Naama Rotem-Kohavi, Nader Fallah, Vanessa K Noonan, Charles G Fisher, Raphaële Charest-Morin, Nicolas Dea, Tamir Ailon, John Street, Brian K Kwon, Ryan V Sandarage, Ahmad Galuta, Diana Ghinda, Jason C S Kwan, Eve C TsaI, Laureen D Hachem, James Hong, Alexander Velumian, Andrea J Mothe, Charles H Tator, Michael G Fehlings, Husain Shakil, Blessing N R Jaja, Peng Zhang, Rachael Jaffe, Armaan K Malhotra, Jefferson R Wilson, Christopher D Witiw, Naama Rotem-Kohavi, Marcel F Dvorak, Nicolas Dea, Nathan Evaniew, Melody Chen, Zeina Waheed, Jijie Xu, Nader Fallah, Vanessa Noonan, Brian Kwon, Charlotte Dandurand, Sander Muijs, Marcel Dvorak, Klaus Schnake, Cumhur, Ouml Ner, Ryan Greene, Bradley Furlong, Jenna Smith-Forrester, Michelle Swab, Sean D Christie, Amanda Hall, Erika Leck, Emily Marshall, Sean Christie, Marcel F Dvorak, F Cumhur, Ouml Ner, Alexander R Vaccaro, Lorin M Benneker, Shanmuganathan Rajasekaran, Mohammad El-Sharkawi, Eugen Cezar Popescu, Jin Wee Tee, Jerome Paquet, John C France, Richard Allen, William F Lavelle, Miguel Hirschfeld, Spyros Pneumaticos, Charlotte Dandurand, Cumhur, Ouml Ner, Sander Muijs, Klaus Schnake, Marcel Dvorak, Renan Rodrigues Fernandes, Patrick Thornley, Jennifer Urquhart, Sean Kelly, Nasser Alenezi, Abdulmajeed Alahmari, Fawaz Siddiqi, Supriya Singh, Parham Rasoulinejad, Christopher Bailey, Nathan Evaniew, Lukas D Burger, Nicolas Dea, David W Cadotte, Greg McIntosh, Bradley Jacobs, Loïc St-Laurent-Lebeux, Étienne Bourassa-Moreau, Mohamed Sarraj, Meerab Majeed, Daipayan Guha, Markian Pahuta, Mathieu Laflamme, Greg McIntosh, Nicolas Dea, Alex B Bak, Mohammed A Alvi, Ali Moghaddamjou, Michael G Fehlings, Yan Gabriel Morais David Silva, Julien Goulet, Greg McIntosh, Sonia Bedard, Newton Pimenta, Jocelyn Blanchard, Jerome Couture, Bernard LaRue, Csorn Investigators, Tyler Adams, Erin Cunningham, Dana El-Mughayyar, Erin Bigney, Amanda Vandewint, Niel Manson, Edward Abraham, Chris Small, Najmedden Attabib, Eden Richardson, Jeffery Hebert, Michael Bond, John Street, Charles Fisher, Raphaele Charest-Morin, Jason M Sutherland, Troy Hillier, Chris S Bailey, Charles Fisher, Raja Rampersaud, Prosper Koto, R Andrew Glennie, Alex Soroceanu, Fred Nicholls, Ken Thomas, Nathan Evaniew, Peter Lewkonia, Jacques Bouchard, Brad Jacobs, David Ben-Israel, Eric J Crawford, Charles Fisher, Nicolas Dea, Eldon Spackman, Raja Rampersaud, Kenneth C Thomas, Nisaharan Srikandarajah, Jean-Christophe Murray, Christopher Nielsen, Ragavan Manoharan, Ahmed Cherry, Aditiya Raj, Mark Xu, Carlo Iorio, Chris Bailey, Nicolas Dea, Charles Fisher, Hamilton Hall, Neil Manson, Kenneth Thomas, Mayilee Canizares, Yoga Raja Rampersaud, Jennifer Urquhart, Renan R Fernandes, R Andrew Glennie, Y Raja Rampersaud, Charles G Fisher, Chris Bailey, Michael M H Yang, Rena Far, Tolulope Sajobi, Jay Riva-Cambrin, Steven Casha, Michael Bond, John Street, Charles Fisher, Raphaele Charest-Morin, Jason M Sutherland, Yan Silva, Newton Godoy Pimenta, Bernard LaRue, Sonia Bedard, Sonia Cheng Oviedo, Julien Goulet, Jerome Couture, Jocelyn Blanchard, James McDonald, Fares Al-Jahdali, Jennifer Urquhart, Abdulmajeed Alahmari, Raja Rampersaud, Charles Fisher, Chris Bailey, Andrew Glennie, Nathan Evaniew, Matthew Coyle, Y Raja Rampersaud, Christopher S Bailey, W Bradley Jacobs, David W Cadotte, Kenneth C Thomas, Najmedden Attabib, Jérôme Paquet, Andrew Nataraj, Sean D Christie, Michael H Weber, Philippe Phan, Raphaële Charest-Morin, Charles G Fisher, Hamilton Hall, Greg McIntosh, Nicolas Dea, Armaan K Malhotra, Aileen M Davis, Yingshi He, Erin M Harrington, Blessing N R Jaja, Mary P Zhu, Husain Shakil, Nicolas Dea, W Bradley Jacobs, David W Cadotte, Jérôme Paquet, Michael H Weber, Philippe Phan, Sean D Christie, Andrew Nataraj, Christopher S Bailey, Michael G Johnson, Charles G Fisher, Neil Manson, Y Raja Rampersaud, Kenneth C Thomas, Hamilton Hall, Michael G Fehlings, Henry Ahn, Howard J Ginsberg, Christopher D Witiw, Jefferson R Wilson, Alwalaa Althagafi, Greg McIntosh, Raphaële Charest-Morin, Michael A Rizzuto, Tamir Ailon, Nicolas Dea, Nathan Evaniew, Bradley W Jacobs, Jerome Paquet, Raja Rampersaud, Hamilton Hall, Christopher S Bailey, Michael Weber, Michael G Johnson, Andrew Nataraj, Najmedden Attabib, David W Cadotte, Neil Manson, Alexandra Stratton, Sean D Christie, Kenneth C Thomas, Jefferson R Wilson, Charles G Fisher, Raphaele Charest-Morin, Alex B Bak, Mohammed A Alvi, Ali Moghaddamjou, Michael G Fehlings, Alex B Bak, Mohammed A Alvi, Ali Moghaddamjou, Michael G Fehlings, Alex Soroceanu, Fred Nicholls, Ken Thomas, Nathan Evaniew, Paul Salo, Jacques Bouchard, Brad Jacobs, Charlotte Dandurand, Pedram Farimani Laghaei, Tamir Ailon, Raphaele Charest-Morin, Nicolas Dea, Marcel Dvorak, Charles Fisher, Brian K Kwon, Scott Paquette, John Street, Alex Soroceanu, Fred Nicholls, Ken Thomas, Nathan Evaniew, Jacques Bouchard, Paul Salo, Brad Jacobs, Vishal P Varshney, Ramesh Sahjpaul, Scott Paquette, Jill Osborn, Alex B Bak, Ali Moghaddamjou, Michael G Fehlings, Erika Leck, Emily Marshall, Sean Christie, Lior M Elkaim, Oliver J Lasry, Aditya Raj, Jean-Christophe Murray, Ahmed Cherry, Greg McIntosh, Christopher Nielsen, Nisaharan Srikandarajah, Ragavan Manoharan, Carlo Iorio, Mark Xu, Anthony Perruccio, Mayilee Canizares, Yoga Raja Rampersaud, Alexandra Stratton, Sarah Tierney, Eugene K Wai, Philippe Phan, Stephen Kingwell, Marie-Claude Magnan, Alex Soroceanu, Fred Nicholls, Ken Thomas, Nathan Evaniew, Paul Salo, Jacques Bouchard, Brad Jacobs, Barend Spanninga, Thomáy-Claire A Hoelen, Scott Johnson, Jacobus J C Arts, Chris S Bailey, Jennifer C Urquhart, R Andrew Glennie, Y Raja Rampersaud, Charles G Fisher, Jordan J Levett, Lior M Elkaim, Naif M Alotaibi, Michael H Weber, Nicolas Dea, Muhammad M Abd-El-Barr, Ahmed Cherry, Albert Yee, Nadia Jaber, Michael Fehlings, Erin Cunningham, Tyler Adams, Dana El-Mughayyar, Erin Bigney, Amanda Vandewint, Neil Manson, Edward Abraham, Chris Small, Najmedden Attabib, Eden Richardson, Jeffery Hebert, Joel Werier, Kevin Smit, James Villeneuve, Adam Sachs, Hesham Abdelbary, Yusra Kassim Al-Mosuli, Kawan Rakhra, Philippe Phan, Kosei Nagata, Jeffrey L Gum, Morgan E Brown, Christy L Daniels, Leah Y Carreon, John-Peter Bonello, Robert Koucheki, Aazad Abbas, Johnathan Lex, Nicholas Nucci, Cari Whyne, Jeremie Larouche, Henry Ahn, Joel Finkelstein, Stephen Lewis, Jay Toor, Nathan J Lee, Lindsay D Orosz, Jeffrey L Gum, Gregory T Poulter, Ehsan Jazini, Colin M Haines, Christopher R Good, Ronald A Lehman, Eric J Crawford, Robert A Ravinsky, Anthony V Perruccio, Peter C Coyte, Y Raja Rampersaud, Millaray Freire-Archer, Mohamed Sarraj, Fawaz AlShaalan, Alex Koziarz, Patrick Thornley, Haitham Alnemari, Colby Oitment, Lalita Bharadwaj, Dana El-Mughayyar, Erin Bigney, Neil Manson, Edward Abraham, Chris Small, Najmedden Attabib, Eden Richardson, Jill Kearney, Uday Kundap, Csorn Investigators, Jeffrey Hebert, Lior M Elkaim, Jordan J Levett, Farbod Niazi, Rakan Bokhari, Naif M Alotaibi, Oliver J Lasry, Vincent Bissonnette, David Yen, Varun S Muddaluru, Pranjan Gandhi, Alexander Mastrolonardo, Daipayan Guha, Markian A Pahuta, Sean D Christie, Trevor Vandertuin, Gillian Ritcey, Daniel Rainham, Mamdoh Alhawsawi, Rohail Mumtaz, Mark Abdelnour, Feras Qumquji, Alex Soroceanu, Ganesh Swamy, Kenneth Thomas, Eugene Wai, Philippe Phan, Fenil R Bhatt, Lindsay D Orosz, Tarek Yamout, Christopher R Good, Thomas C Schuler, Tiffany Nguyen, Ehsan Jazini, Colin M Haines, Marcelo Oppermann, Shaurya Gupta, Joel Ramjist, Priscila Santos Oppermann, Victor X D Yang, Jordan J Levett, Lior M Elkaim, Farbod Niazi, Michael H Weber, Christian Ioro-Morin, Marco Bonizzato, Alexander G Weil, Marcelo Oppermann, Joel Ramjist, Shaurya Gupta, Priscila S Oppermann, Victor X D Yang, Youngkyung Jung, Varun Muddalaru, Pranjan Gandhi, Daipayan Guha, Robert Koucheki, John-Peter Bonello, Aazad Abbas, Johnathan R Lex, Nicholas Nucci, Cari Whyne, Albert Yee, Henry Ahn, Joel Finkelstein, Jeremie Larouche, Stephen Lewis, Jay Toor, Alaina Dhawan, Jillian Dhawan, Ajay N Sharma, Daniel B Azzam, Ahmed Cherry, Michael G Fehlings, Lindsay D Orosz, Nathan J Lee, Tarek Yamout, Jeffrey L Gum, Ronald A Lehman, Gregory T Poulter, Colin M Haines, Ehsan Jazini, Christopher R Good, Barzany B Ridha, Amit Persad, Daryl Fourney, Elizabeth Byers, Michelle Gallagher, James Sugar, Justin L Brown, Zhi Wang, Jesse Shen, Ghassan Boubez, Fidaa Al-Shakfa, Sung-Joo Yuh, Daniel Shedid, Maroun Rizkallah, Manmohan Singh, Pankaj Kumar Singh, Peyton Lloyd Lawrence, Shevaughn Dell, Ronette Goodluck-Tyndall, Kevin Wade, Mark Morgan, Carl Bruce, Yan Gabriel Morais David Silva, Newton Pimenta, Bernard LaRue, Salman Aldakhil, Jocelyn Blanchard, Jerome Couture, Julien Goulet, Drew A Bednar, Ruheksh Raj, Jennifer Urquhart, Chris Bailey, Sean D Christie, Ryan Greene, Jennyfer Paulla Galdino Chaves, Mohammed Zarrabian, Leif Sigurdson, Ragavan Manoharan, Ahmed Cherry, Carlo Iorio, Nisaharan Srikandarajah, Mark Xu, Aditya Raj, Christopher J Nielsen, Yoga Raja Rampersaud, Stephen J Lewis
No abstract text is available yet for this article.
2023: Canadian Journal of Surgery. Journal Canadien de Chirurgie
#8
JOURNAL ARTICLE
Michael G Thomas, Kate McGonagle, Paul Rowland, David A Robinson, Peter G Dodd, Isabel Camino-Díaz, Lorna Campbell, Juan Cantizani, Pablo Castañeda, Daniel Conn, Peter D Craggs, Darren Edwards, Liam Ferguson, Andrew Fosberry, Laura Frame, Panchali Goswami, Xiao Hu, Justyna Korczynska, Lorna MacLean, Julio Martin, Nicole Mutter, Maria Osuna-Cabello, Christy Paterson, Imanol Peña, Erika G Pinto, Caterina Pont, Jennifer Riley, Yoko Shishikura, Frederick R C Simeons, Laste Stojanovski, John Thomas, Karolina Wrobel, Robert J Young, Filip Zmuda, Fabio Zuccotto, Kevin D Read, Ian H Gilbert, Maria Marco, Timothy J Miles, Pilar Manzano, Manu De Rycker
There is an urgent need for new treatments for Chagas disease, a parasitic infection which mostly impacts South and Central America. We previously reported on the discovery of GSK3494245/DDD01305143, a preclinical candidate for visceral leishmaniasis which acted through inhibition of the Leishmania proteasome. A related analogue, active against Trypanosoma cruzi , showed suboptimal efficacy in an animal model of Chagas disease, so alternative proteasome inhibitors were investigated. Screening a library of phenotypically active analogues against the T...
July 28, 2023: Journal of Medicinal Chemistry
#9
JOURNAL ARTICLE
David J Pascall, Elen Vink, Rachel Blacow, Naomi Bulteel, Alasdair Campbell, Robyn Campbell, Sarah Clifford, Chris Davis, Ana da Silva Filipe, Noha El Sakka, Ludmila Fjodorova, Ruth Forrest, Emily Goldstein, Rory Gunson, John Haughney, Matthew T G Holden, Patrick Honour, Joseph Hughes, Edward James, Tim Lewis, Oscar MacLean, Martin McHugh, Guy Mollett, Tommy Nyberg, Yusuke Onishi, Ben Parcell, Surajit Ray, David L Robertson, Shaun R Seaman, Sharif Shabaan, James G Shepherd, Katherine Smollett, Kate Templeton, Elizabeth Wastnedge, Craig Wilkie, Thomas Williams, Emma C Thomson
OBJECTIVES: To determine how the intrinsic severity of successively dominant SARS-CoV-2 variants changed over the course of the pandemic. METHODS: A retrospective cohort analysis in the NHS Greater Glasgow and Clyde (NHS GGC) Health Board. All sequenced non-nosocomial adult COVID-19 cases in NHS GGC with relevant SARS-CoV-2 lineages (B.1.177/Alpha, Alpha/Delta, AY.4.2 Delta/non-AY.4.2 Delta, non-AY.4.2 Delta/Omicron, and BA.1 Omicron/BA.2 Omicron) during analysis periods were included...
June 1, 2023: Journal of Infection
#10
JOURNAL ARTICLE
David J Pascall, Elen Vink, Rachel Blacow, Naomi Bulteel, Alasdair Campbell, Robyn Campbell, Sarah Clifford, Chris Davis, Ana da Silva Filipe, Noha El Sakka, Ludmila Fjodorova, Ruth Forrest, Emily Goldstein, Rory Gunson, John Haughney, Matthew T G Holden, Patrick Honour, Joseph Hughes, Edward James, Tim Lewis, Samantha Lycett, Oscar MacLean, Martin McHugh, Guy Mollett, Yusuke Onishi, Ben Parcell, Surajit Ray, David L Robertson, Sharif Shabaan, James G Shepherd, Katherine Smollett, Kate Templeton, Elizabeth Wastnedge, Craig Wilkie, Thomas Williams, Emma C Thomson
OBJECTIVES: The SARS-CoV-2 Alpha variant was associated with increased transmission relative to other variants present at the time of its emergence and several studies have shown an association between Alpha variant infection and increased hospitalisation and 28-day mortality. However, none have addressed the impact on maximum severity of illness in the general population classified by the level of respiratory support required, or death. We aimed to do this. METHODS: In this retrospective multi-centre clinical cohort sub-study of the COG-UK consortium, 1475 samples from Scottish hospitalised and community cases collected between 1st November 2020 and 30th January 2021 were sequenced...
2023: PloS One
#11
JOURNAL ARTICLE
Mark A MacLean, Chris Bailey, Charles Fisher, Yoga Raja Rampersaud, Ryan Greene, Edward Abraham, Nicholas Dea, Hamilton Hall, Neil Manson, Raymond Andrew Glennie
UNLABELLED: The subjective degenerative spondylolisthesis instability classification (S-DSIC) system attempts to define preoperative instability associated with degenerative lumbar spondylolisthesis (DLS). The system guides surgical decision-making based on numerous indicators of instability that surgeons subjectively assess and incorporate. A more objective classification is warranted in order to decrease variation among surgeons. In this study, our objectives included (1) proposing an objective version of the DSIC system (O-DSIC) based on the best available clinical and biomechanical data and (2) comparing subjective surgeon perceptions (S-DSIC) with an objective measure (O-DSIC) of instability related to DLS...
2022: JB & JS Open Access
#12
JOURNAL ARTICLE
Emily B Hill, Janet C Siebert, Deaunabah N Yazza, Danielle M Ostendorf, Kristen Bing, Liza Wayland, Jared J Scorsone, Daniel H Bessesen, Paul S MacLean, Edward L Melanson, Victoria A Catenacci, Sarah J Borengasser
OBJECTIVE: Identifying associations among circulating proteins, dietary intakes, and clinically relevant indicators of cardiometabolic health during weight loss may elucidate biologically relevant pathways affected by diet, allowing for an incorporation of precision nutrition approaches when designing future interventions. This study hypothesized that plasma proteins would be associated with diet and cardiometabolic health indicators within a behavioral weight-loss intervention. METHODS: This secondary data analysis included participants (n = 20, mean [SD], age: 40...
November 2022: Obesity
#13
JOURNAL ARTICLE
Danielle M Ostendorf, Ann E Caldwell, Adnin Zaman, Zhaoxing Pan, Kristen Bing, Liza T Wayland, Seth A Creasy, Daniel H Bessesen, Paul MacLean, Edward L Melanson, Victoria A Catenacci
BACKGROUND: The standard of care for treating overweight and obesity is daily caloric restriction (DCR). While this approach produces modest weight loss, adherence to DCR declines over time and weight regain is common. Intermittent fasting (IMF) is an alternative dietary strategy for reducing energy intake (EI) that involves >60% energy restriction on 2-3 days per week, or on alternate days, with habitual intake on fed days. While numerous studies have evaluated IMF as a weight loss strategy, there are several limitations including lack of a standard-of-care DCR control, failure to provide guideline-based behavioral support, and failure to rigorously evaluate dietary and PA adherence using objective measures...
August 29, 2022: Trials
#14
REVIEW
MacLean C Sellars, Catherine J Wu, Edward F Fritsch
Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review the essential immunologic concepts underpinning natural immunity and highlight the multiple unique challenges faced by vaccines targeting cancer. Recent technological advances in mass spectrometry, neoantigen prediction, genetically and pharmacologically engineered mouse models, and single-cell omics have revealed new biology, which can help to bridge this divide. We particularly focus on translationally relevant aspects, such as antigen selection and delivery and the monitoring of human post-vaccination responses, and encourage more aggressive exploration of novel approaches...
July 21, 2022: Cell
#15
JOURNAL ARTICLE
Jason A Röhr, B Edward Sartor, Joel N Duenow, Zilun Qin, Juan Meng, Jason Lipton, Stephen A Maclean, Udo Römer, Michael P Nielsen, Suling Zhao, Jaemin Kong, Matthew O Reese, Myles A Steiner, N J Ekins-Daukes, André D Taylor
Improving solar energy collection in aquatic environments would allow for superior environmental monitoring and remote sensing, but the identification of optimal photovoltaic technologies for such applications is challenging as evaluation requires either field deployment or access to large water tanks. Here, we present a simple bench-top characterization technique that does not require direct access to water and therefore circumvents the need for field testing during initial trials of development. Employing LEDs to simulate underwater solar spectra at various depths, we compare Si and CdTe solar cells, two commercially available technologies, with GaInP cells, a technology with a wide bandgap close to ideal for underwater solar harvesting...
July 15, 2022: IScience
#16
JOURNAL ARTICLE
Marijana Vujkovic, Shweta Ramdas, Kim M Lorenz, Xiuqing Guo, Rebecca Darlay, Heather J Cordell, Jing He, Yevgeniy Gindin, Chuhan Chung, Robert P Myers, Carolin V Schneider, Joseph Park, Kyung Min Lee, Marina Serper, Rotonya M Carr, David E Kaplan, Mary E Haas, Matthew T MacLean, Walter R Witschey, Xiang Zhu, Catherine Tcheandjieu, Rachel L Kember, Henry R Kranzler, Anurag Verma, Ayush Giri, Derek M Klarin, Yan V Sun, Jie Huang, Jennifer E Huffman, Kate Townsend Creasy, Nicholas J Hand, Ching-Ti Liu, Michelle T Long, Jie Yao, Matthew Budoff, Jingyi Tan, Xiaohui Li, Henry J Lin, Yii-Der Ida Chen, Kent D Taylor, Ruey-Kang Chang, Ronald M Krauss, Silvia Vilarinho, Joseph Brancale, Jonas B Nielsen, Adam E Locke, Marcus B Jones, Niek Verweij, Aris Baras, K Rajender Reddy, Brent A Neuschwander-Tetri, Jeffrey B Schwimmer, Arun J Sanyal, Naga Chalasani, Kathleen A Ryan, Braxton D Mitchell, Dipender Gill, Andrew D Wells, Elisabetta Manduchi, Yedidya Saiman, Nadim Mahmud, Donald R Miller, Peter D Reaven, Lawrence S Phillips, Sumitra Muralidhar, Scott L DuVall, Jennifer S Lee, Themistocles L Assimes, Saiju Pyarajan, Kelly Cho, Todd L Edwards, Scott M Damrauer, Peter W Wilson, J Michael Gaziano, Christopher J O'Donnell, Amit V Khera, Struan F A Grant, Christopher D Brown, Philip S Tsao, Danish Saleheen, Luca A Lotta, Lisa Bastarache, Quentin M Anstee, Ann K Daly, James B Meigs, Jerome I Rotter, Julie A Lynch, Daniel J Rader, Benjamin F Voight, Kyong-Mi Chang
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases, we performed a multiancestry genome-wide association study (GWAS) in the Million Veteran Program (MVP) including 90,408 cALT cases and 128,187 controls. Seventy-seven loci exceeded genome-wide significance, including 25 without prior NAFLD or alanine aminotransferase associations, with one additional locus identified in European American-only and two in African American-only analyses (P < 5 × 10-8 )...
June 2022: Nature Genetics
#17
JOURNAL ARTICLE
Diva J Amon, Randi D Rotjan, Brian R C Kennedy, Gerard Alleng, Rafael Anta, Eriatera Aram, Thera Edwards, Marcia Creary-Ford, Kristina M Gjerde, Judith Gobin, Laura-Ashley Henderson, Alexis Hope, Raquel Khan Ali, Sebastian Lanser, Keith Lewis, Hannah Lochan, Scott MacLean, Nabuti Mwemwenikarawa, Brennan Phillips, Betarim Rimon, Stacey-Ann Sarjursingh, Tooreka Teemari, Aranteiti Tekiau, Alan Turchik, Henri Vallès, Kareati Waysang, Katherine L C Bell
The deep ocean is the largest ecosystem on the planet, constituting greater than 90% of all habitable space. Over three-quarters of countries globally have deep ocean within their Exclusive Economic Zones. While maintaining deep-ocean function is key to ensuring planetary health, deficiencies in knowledge and governance, as well as inequitable global capacity, challenge our ability to safeguard the resilience of this vast realm, leaving the fate of the deep ocean in the hands of a few. Historically, deep-ocean scientific exploration and research have been the purview of a limited number of nations, resulting in most of humankind not knowing the deep ocean within their national jurisdiction or beyond...
July 4, 2022: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
#18
JOURNAL ARTICLE
Paul Elliott, David Haw, Haowei Wang, Oliver Eales, Caroline E Walters, Kylie E C Ainslie, Christina Atchison, Claudio Fronterre, Peter J Diggle, Andrew J Page, Alexander J Trotter, Sophie J Prosolek, Deborah Ashby, Christl A Donnelly, Wendy Barclay, Graham Taylor, Graham Cooke, Helen Ward, Ara Darzi, Steven Riley
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections were rising during early summer 2021 in many countries as a result of the Delta variant. We assessed reverse transcription polymerase chain reaction swab positivity in the Real-time Assessment of Community Transmission–1 (REACT-1) study in England. During June and July 2021, we observed sustained exponential growth with an average doubling time of 25 days, driven by complete replacement of the Alpha variant by Delta and by high prevalence at younger, less-vaccinated ages...
December 17, 2021: Science
#19
JOURNAL ARTICLE
Arthur Wickenhagen, Elena Sugrue, Spyros Lytras, Srikeerthana Kuchi, Marko Noerenberg, Matthew L Turnbull, Colin Loney, Vanessa Herder, Jay Allan, Innes Jarmson, Natalia Cameron-Ruiz, Margus Varjak, Rute M Pinto, Jeffrey Y Lee, Louisa Iselin, Natasha Palmalux, Douglas G Stewart, Simon Swingler, Edward J D Greenwood, Thomas W M Crozier, Quan Gu, Emma L Davies, Sara Clohisey, Bo Wang, Fabio Trindade Maranhão Costa, Monique Freire Santana, Luiz Carlos de Lima Ferreira, Lee Murphy, Angie Fawkes, Alison Meynert, Graeme Grimes, Joao Luiz Da Silva Filho, Matthias Marti, Joseph Hughes, Richard J Stanton, Eddie C Y Wang, Antonia Ho, Ilan Davis, Ruth F Jarrett, Alfredo Castello, David L Robertson, Malcolm G Semple, Peter J M Openshaw, Massimo Palmarini, Paul J Lehner, J Kenneth Baillie, Suzannah J Rihn, Sam J Wilson
Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses relevant to COVID-19, we used interferon-stimulated gene (ISG) expression screening to reveal that 2′-5′-oligoadenylate synthetase 1 (OAS1), through ribonuclease L, potently inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
October 29, 2021: Science
#20
RANDOMIZED CONTROLLED TRIAL
Maggie A Stanislawski, Daniel N Frank, Sarah J Borengasser, Danielle M Ostendorf, Diana Ir, Purevsuren Jambal, Kristen Bing, Liza Wayland, Janet C Siebert, Daniel H Bessesen, Paul S MacLean, Edward L Melanson, Victoria A Catenacci
Altered gut microbiota has been linked to obesity and may influence weight loss. We are conducting an ongoing weight loss trial, comparing daily caloric restriction (DCR) to intermittent fasting (IMF) in adults who are overweight or obese. We report here an ancillary study of the gut microbiota and selected obesity-related parameters at the baseline and after the first three months of interventions. During this time, participants experienced significant improvements in clinical health measures, along with altered composition and diversity of fecal microbiota...
September 18, 2021: Nutrients
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