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JOURNAL ARTICLE
Antonio J Chemello, Casey C Fowler
UNLABELLED: AB5 -type toxins are a diverse family of protein toxins composed of an enzymatic active (A) subunit and a pentameric delivery (B) subunit. Salmonella enterica serovar Typhi's typhoid toxin features two A subunits, CdtB and PltA, in complex with the B subunit PltB. Recently, it was shown that S . Typhi encodes a horizontally acquired B subunit, PltC, that also assembles with PltA/CdtB to produce a second form of typhoid toxin. S . Typhi therefore produces two AB5 toxins with the same A subunits but distinct B subunits, an evolutionary twist that is unique to typhoid toxin...
March 19, 2024: MBio
#22
JOURNAL ARTICLE
Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages.
Taylor A Stepien, Larissa A Singletary, Fermin E Guerra, Joyce E Karlinsey, Stephen J Libby, Sarah L Jaslow, Margaret R Gaggioli, Kyle D Gibbs, Dennis C Ko, Michael A Brehm, Dale L Greiner, Leonard D Shultz, Ferric C Fang
UNLABELLED: Salmonella serovars Typhi and Paratyphi cause a prolonged illness known as enteric fever, whereas other serovars cause acute gastroenteritis. Mechanisms responsible for the divergent clinical manifestations of nontyphoidal and enteric fever Salmonella infections have remained elusive. Here, we show that S . Typhi and S . Paratyphi A can persist within human macrophages, whereas S . Typhimurium rapidly induces apoptotic macrophage cell death that is dependent on Salmonella pathogenicity island 2 (SPI2)...
March 18, 2024: MBio
#23
JOURNAL ARTICLE
Florian Marks, Justin Im, Se Eun Park, Gi Deok Pak, Hyon Jin Jeon, Lady Rosny Wandji Nana, Marie-France Phoba, Lisette Mbuyi-Kalonji, Ondari D Mogeni, Biruk Yeshitela, Ursula Panzner, Ligia María Cruz Espinoza, Tigist Beyene, Michael Owusu-Ansah, Sampson Twumasi-Ankrah, Melese Yeshambaw, Ashenafi Alemu, Oluwafemi J Adewusi, Olukemi Adekanmbi, Ellen Higginson, Akinlolu Adepoju, Sarah Agbi, Enoch G Cakpo, Veronica O Ogunleye, Gaëlle Nkoji Tunda, Odion O Ikhimiukor, Jules Mbuyamba, Trevor Toy, Francis Opoku Agyapong, Isaac Osei, John Amuasi, Tsiriniaina Jean Luco Razafindrabe, Tiana Mirana Raminosoa, Gabriel Nyirenda, Njariharinjakampionona Randriamampionona, Hyeong Won Seo, Hyejin Seo, Mohamadou Siribie, Megan E Carey, Michael Owusu, Christian G Meyer, Ndrainaharimira Rakotozandrindrainy, Nimarko Sarpong, Mathilde Razafindrakalia, Ravomialisoa Razafimanantsoa, Moussa Ouedraogo, Yeonseon J Kim, Jooah Lee, Raphaël M Zellweger, Sophie S Y Kang, Ju Yeon Park, John A Crump, Liselotte Hardy, Jan Jacobs, Denise O Garrett, Jason R Andrews, Nimesh Poudyal, Deok Ryun Kim, John D Clemens, Stephen G Baker, Jerome H Kim, Gordon Dougan, Jonathan D Sugimoto, Sandra Van Puyvelde, Aderemi Kehinde, Oluwafemi A Popoola, Vittal Mogasale, Robert F Breiman, William R MacWright, Abraham Aseffa, Birkneh Tilahun Tadesse, Andrea Haselbeck, Yaw Adu-Sarkodie, Mekonnen Teferi, Abdramane Soura Bassiahi, Iruka N Okeke, Octavie Lunguya-Metila, Ellis Owusu-Dabo, Raphaël Rakotozandrindrainy
BACKGROUND: Typhoid Fever remains a major cause of morbidity and mortality in low-income settings. The Severe Typhoid in Africa programme was designed to address regional gaps in typhoid burden data and identify populations eligible for interventions using novel typhoid conjugate vaccines. METHODS: A hybrid design, hospital-based prospective surveillance with population-based health-care utilisation surveys, was implemented in six countries in sub-Saharan Africa...
April 2024: Lancet Global Health
#24
JOURNAL ARTICLE
Rabab Batool, Zoya Haq Qamar, Rehana Abdus Salam, Mohammad Tahir Yousafzai, Per Ashorn, Farah Naz Qamar
BACKGROUND: Typhoid is a serious public health threat in many low-income and middle-income countries. Several vaccines for typhoid have been recommended by WHO for typhoid prevention in endemic countries. This study aimed to review the efficacy of typhoid vaccines against culture-confirmed Salmonella enterica serovar Typhi. METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase for studies published in English between Jan 1, 1986 and Nov 2, 2023...
April 2024: Lancet Global Health
#25
JOURNAL ARTICLE
Haslinda Haslinda, Yunita Sari Pane
BACKGROUND: Typhoid fever is an acute disease caused by Salmonella typhimurium that can invade the liver and cause symptoms of hepatomegaly,jaundice.Biochemically, these symptoms can be assessed by seeing the SGPT and SGOT levels increase. Pirdot Leaf is an herbal plant found in the Toba area of North Sumatra which has a lot of bioactive potential,namely flavonoids,steroids, saponins. Flavonoids are active substances that can overcome the inflammatory process, it is expected that the administration of Pirdot leaf extract can reduce levels of SGOT and SGPT in mice induced Salmonella Typhimurium...
2024: Medical Archives
#26
JOURNAL ARTICLE
Kun Xiong, Luxin Deng, Zhan Li, Haiyan Gong, Jie Chen, Mintao Huang, Xiancai Rao, Yanguang Cong
Multiple TonB dependent transporters (TBDTs) contribute to bacterial virulence due to the importance roles that their substrates play in bacterial growth, and possess vaccine potential. A putative TBDT, YncD, had been identified as one of in vivo induced antigens during human infection of typhoid fever, and is required for the pathogenicity of Salmonella enterica Serovar Typhi. The present study was aimed to determine the function and immunogenicity of YncD. Homologous recombination method was used to construct an yncD-deletion mutant and cirA-iroN-fepA-deletion mutant from the wild-type S...
March 12, 2024: World Journal of Microbiology & Biotechnology
#27
JOURNAL ARTICLE
Negin Esfandiari, Ehsan Mosa Farkhani, Laleh Sharifi, Saied Bokaie
BACKGROUND: Despite the declining trend, salmonellosis is still an important preventable cause of death in Iran and the world, especially in certain age and occupational subgroups, and the need for preventive measures, especially raising awareness of at-risk groups, is necessary. METHODS: Data were obtained from the Ministry of Health covering the years 2013 to 2019. The data were then stratified by year, season, month, and province of death as well as sex, age group, belonging to rural vs...
December 2023: Iranian Journal of Public Health
#28
JOURNAL ARTICLE
Aurelie Dahlia Yemeli Piankeu, Siméon Pierre Chegaing Fodouop, Michel Noubom, Emmanuel Boris Gomseu Djoumsie, Georges Ful Kuh, Donatien Gatsing
BACKGROUND: Enteric fever is a great public health problem associated with significant illness and death in many endemic countries, and its clinical diagnosis is still daunting. The aim of this study was to determine the prevalence and risk factors of S. Typhi among febrile patients in Bafoussam and to evaluate the diagnostic performances of Widal and Typhidot tests. METHODS: This was a cross-sectional study among 336 participants visiting three hospitals in Bafoussam from August 1, 2021, to November 31, 2021...
2024: Canadian Journal of Infectious Diseases & Medical Microbiology
#29
Reda H Mithany, Amarah Shaikh, Catherine Scott, Mazin Abdalla, Matthew Graham, Ioannis N Gerogiannis
Salmonella typhi, commonly known for causing typhoid fever, is recognized as a bacterium responsible for a wide range of gastrointestinal and systemic infections. While its systemic manifestations have been well-documented, its association with localized gastrointestinal complications, such as appendicitis, remains relatively rare and less explored. This case report presents a compelling clinical case of a 55-year-old patient who presented with symptoms of gastrointestinal distress and was diagnosed with S...
January 2024: Curēus
#30
REVIEW
Jing Han, Nesreen Aljahdali, Shaohua Zhao, Hailin Tang, Heather Harbottle, Maria Hoffmann, Jonathan G Frye, Steven L Foley
Salmonella enterica is the leading cause of bacterial foodborne illness in the USA, with an estimated 95% of salmonellosis cases due to the consumption of contaminated food products. Salmonella can cause several different disease syndromes, with the most common being gastroenteritis, followed by bacteremia and typhoid fever. Among the over 2,600 currently identified serotypes/serovars, some are mostly host-restricted and host-adapted, while the majority of serotypes can infect a broader range of host species and are associated with causing both livestock and human disease...
January 4, 2024: EcoSal Plus
#31
JOURNAL ARTICLE
Z H Xie, L F Li, H S Zhu, W L Huang, J W Lin, W Chen, J M Ou
Objective: To analyze the incidence trend and epidemiological characteristics of typhoid fever in Fujian Province from 2011 to 2022, and understand the high-incidence population and hotspot areas, and provide evidences to develop more targeted prevention and control measures. Methods: The surveillance data of typhoid fever during 2011-2022 in Fujian Province were obtained from the National Disease Reporting Information System and analyzed with SAS 9.4. The spatial autocorrelation analysis of typhoid fever incidence at county/district levels was performed with ArcGlS 10...
February 10, 2024: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
#32
M M Muhammed, K J Bwala, J O Okoruwa
Typhoid fever is caused by Salmonella typhi and Salmonella paratyphi. It is a disease of developing countries and is seen among people of low socio-economic status. Patients can develop complications like typhoid intestinal perforation which is associated with higher mortality. A 15-year-old female presented to the emergency pediatric unit with fever, abdominal pain and abdominal distension. She was septic, in respiratory distress, and had marked generalized abdominal tenderness with guarding. An assessment of generalized peritonitis secondary to typhoid intestinal perforation was made...
January 31, 2024: West African Journal of Medicine
#33
JOURNAL ARTICLE
Jong-Hoon Kim, Jungsoon Choi, Chaelin Kim, Gi Deok Pak, Prerana Parajulee, Andrea Haselbeck, Se-Eun Park, Vittal Mogasale, Hyon Jin Jeon, Annie J Browne, Ellis Owusu-Dabo, Raphaël Rakotozandrindrainy, Abdramane Soura Bassiahi, Mekonnen Teferi, Octavie Lunguya-Metila, Christiane Dolecek, Virginia E Pitzer, John A Crump, Simon I Hay, Florian Marks
BACKGROUND: With more than 1.2 million illnesses and 29,000 deaths in sub-Saharan Africa in 2017, typhoid fever continues to be a major public health problem. Effective control of the disease would benefit from an understanding of the subnational geospatial distribution of the disease incidence. METHOD: We collated records of the incidence rate of typhoid fever confirmed by culture of blood in Africa from 2000 to 2022. We estimated the typhoid incidence rate for sub-Saharan Africa on 20 km × 20 km grids by exploring the association with geospatial covariates representing access to improved water and sanitation, health conditions of the population, and environmental conditions...
February 26, 2024: PLoS Neglected Tropical Diseases
#34
Leopoldo F M Machado, Jorge E Galán
Salmonella enterica serovar Typhi and Paratyphi A are the cause of typhoid and paratyphoid fever in humans, which are systemic life-threatening illnesses. Both serovars are exclusively adapted to the human host, where they can cause life-long persistent infection. A distinct feature of these serovars is the presence of a relatively high number of degraded coding sequences coding for metabolic pathways, most likely a consequence of their adaptation to a single host. As a result of convergent evolution, these serovars shared many of the degraded coding sequences although often affecting different genes in the same metabolic pathway...
February 14, 2024: bioRxiv
#35
JOURNAL ARTICLE
Purity Kasiano, Susan Kavai, Susan Kiiru, Andrew Nyerere, Samuel Kariuki
INTRODUCTION: Multiple studies have shown that typhoid fever is endemic in developing countries characterized by poor hygiene. A unique way of Salmonella Typhi (S.Typhi) pathogenicity is establishing a persistent, usually asymptomatic carrier state in some infected individuals who excrete large numbers of bacteria in faeces. This study aimed to determine the isolation rate of S.Typhi from blood and stool samples among cases and asymptomatic individuals in the Mukuru informal settlement and identify antibiotic resistance patterns within the same population...
2024: PloS One
#36
JOURNAL ARTICLE
Philip M Ashton, Angeziwa Chunga Chirambo, James E Meiring, Priyanka D Patel, Maurice Mbewe, Niza Silungwe, Kenneth Chizani, Happy Banda, Robert S Heyderman, Zoe A Dyson, Peter MacPherson, Marc Y R Henrion, Kathryn E Holt, Melita A Gordon
BACKGROUND: Ciprofloxacin is the first-line drug for treating typhoid fever in many countries in Africa with a high disease burden, but the emergence of non-susceptibility poses a challenge to public health programmes. Through enhanced surveillance as part of vaccine evaluation, we investigated the occurrence and potential determinants of ciprofloxacin non-susceptibility in Blantyre, Malawi. METHODS: We conducted systematic surveillance of typhoid fever cases and antibiotic prescription in two health centres in Blantyre, Malawi, between Oct 1, 2016, and Oct 31, 2019, as part of the STRATAA and TyVAC studies...
February 14, 2024: The Lancet. Microbe
#37
JOURNAL ARTICLE
Chenghao Jia, Qianzhe Cao, Zining Wang, Annemieke van den Dool, Min Yue
Typhoid fever is caused by Salmonella enterica serotype Typhi (Salmonella Typhi). Syndromes in patients vary from asymptomatic carriers to severe or death outcomes, which are frequently reported in African and Southeast Asian countries. It is one of the most common waterborne transmission agents, whose transmission is likely impacted by climate change. Here, we claimed the evidence and consequences of climate-related foodborne and waterborne diseases have increased and provided possible mitigations against Typhoidal Salmonella dissemination...
February 2024: Microbial Biotechnology
#38
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Enteric fever, a systemic infection caused by Salmonella enterica serovars Typhi and Paratyphi A, remains a major cause of morbidity and mortality in low-income and middle-income countries. Enteric fever is preventable through the provision of clean water and adequate sanitation and can be successfully treated with antibiotics. However, high levels of antimicrobial resistance (AMR) compromise the effectiveness of treatment. We provide estimates of the prevalence of AMR S Typhi and S Paratyphi A in 75 endemic countries, including 30 locations without data...
March 2024: Lancet Global Health
#39
JOURNAL ARTICLE
Kahan Mehta, Maruya Joshi, Mohamed A Omar
No abstract text is available yet for this article.
February 2024: Health Science Reports
#40
JOURNAL ARTICLE
Yogesh Hooda, Shuborno Islam, Rathin Kabiraj, Hafizur Rahman, Himadree Sarkar, Kesia E da Silva, Rajan Saha Raju, Stephen P Luby, Jason R Andrews, Samir K Saha, Senjuti Saha
Typhoid-conjugate vaccines (TCVs) provide an opportunity to reduce the burden of typhoid fever, caused by Salmonella Typhi, in endemic areas. As policymakers design vaccination strategies, accurate and high-resolution data on disease burden is crucial. However, traditional blood culture-based surveillance is resource-extensive, prohibiting its large-scale and sustainable implementation. Salmonella Typhi is a water-borne pathogen, and here, we tested the potential of Typhi-specific bacteriophage surveillance in surface water bodies as a low-cost tool to identify where Salmonella Typhi circulates in the environment...
February 2024: PLoS Neglected Tropical Diseases
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