Wenzhi Zhan, Feng Wu, Yunhui Zhang, Lin Lin, Wen Li, Wei Luo, Fang Yi, Yuanrong Dai, Suyun Li, Jiangtao Lin, Yadong Yuan, Chen Qiu, Yong Jiang, Limin Zhao, Meihua Chen, Zhongmin Qiu, Ruchong Chen, Jiaxing Xie, Chunxing Guo, Mei Jiang, Xiaohong Yang, Guochao Shi, Dejun Sun, Rongchang Chen, Nanshan Zhong, Huahao Shen, Kefang Lai
BACKGROUND: Cough-variant asthma (CVA) may respond differently to antiasthmatic treatment. There are limited data on the heterogeneity of CVA. OBJECTIVE: We aimed to classify patients with CVA using cluster analysis based on clinicophysiologic parameters and to unveil the underlying molecular pathways of these phenotypes with transcriptomic data of sputum cells. METHODS: We applied k-mean clustering to 342 newly physician-diagnosed patients with CVA from a prospective multicenter observational cohort using 10 prespecified baseline clinical and pathophysiologic variables...
September 2023: Journal of Allergy and Clinical Immunology