keyword
https://read.qxmd.com/read/38531547/nocturnal-gastro-oesophageal-reflux-and-respiratory-symptoms-are-increased-in-sleep-apnoea-comparison-with-the-general-population
#1
JOURNAL ARTICLE
Össur Ingi Emilsson, Thor Aspelund, Christer Janson, Bryndis Benediktsdottir, Sigurdur Juliusson, Greg Maislin, Allan I Pack, Brendan T Keenan, Thorarinn Gislason
AIM: To assess respiratory symptoms and nocturnal gastro-oesophageal reflux (nGER) among untreated obstructive sleep apnoea (OSA) patients, compared with the general population. Also, if nGER associates differently with respiratory symptoms among OSA patients. METHODS: 2 study cohorts were included: 822 newly diagnosed subjects with moderate-severe OSA and 738 Icelandic general population study participants. All participants answered the same questionnaires. Those reporting nGER symptoms at least once per week were defined as 'with nGER'; those without nGER symptoms and without nGER medication were defined as 'no nGER'; and other participants were defined as having 'possible nGER'...
March 25, 2024: BMJ Open Respiratory Research
https://read.qxmd.com/read/38477950/comparing-budesonide-and-fluticasone-propionate-in-children-with-moderate-to-severe-asthma-a-pilot-randomized-controlled-trial
#2
JOURNAL ARTICLE
Mansour Sadeghzadeh, Parisa Khoshnevisasl, Akefeh Ahmadiafshar, Nima Motamed, Azadeh Pourmarjani
The aim of asthma treatment is to reduce airway inflammation by avoiding environmental triggers and using daily anti-inflammatory medications. This study aimed to compare the effects of fluticasone propionate (FP) and budesonide (Bud) on the clinical symptoms and control of asthma in children with moderate to severe asthma. In this open-label study, children with moderate to severe asthma were randomly selected to receive either FP 250 mcg or Bud 400 mcg for 3 months. Asthma control test scores were measured in both groups monthly...
December 28, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38446620/are-nighttime-respiratory-symptoms-assessed-by-asthma-control-test-affected-by-comorbidities
#3
JOURNAL ARTICLE
Alida Benfante, Alessandra Tomasello, Chiara Caponetto, Salvatore Battaglia, Nicola Scichilone
OBJECTIVE: Nocturnal symptoms are common in the asthmatic population, reflecting an exaggerated airway narrowing overnight due to several factors; it is questioned to what extent the awakenings documented in the clinical assessment of asthma control are due to the disease itself or to comorbidities. To answer this question, we aimed to evaluate to what proportion rhinitis, gastroesophageal reflux and the likelihood of being affected by OSAS were related to poor asthma control, by means of ACT evaluation...
March 11, 2024: Journal of Asthma
https://read.qxmd.com/read/38373820/respiratory-symptoms-exacerbations-and-sleep-disturbances-are-more-common-among-participants-with-asthma-and-chronic-airflow-limitation-an-epidemiological-study-in-estonia-iceland-and-sweden
#4
JOURNAL ARTICLE
Stephanie Mindus, Thorarinn Gislason, Bryndis Benediktsdottir, Rain Jogi, Robert Moverare, Andrei Malinovschi, Christer Janson
BACKGROUND: Chronic airflow limitation (CAL) is a hallmark of chronic obstructive pulmonary disease but is also present in some patients with asthma. We investigated respiratory symptoms, sleep and health status of participants with and without CAL with particular emphasis on concurrent asthma using data from adult populations in Iceland, Estonia and Sweden investigated within the Burden of Obstructive Lung Disease study. METHODS: All participants underwent spirometry with measurements of forced expiratory volume in 1 s (FEV1 ) and forced vital capacity (FVC) before and after bronchodilation...
February 19, 2024: BMJ Open Respiratory Research
https://read.qxmd.com/read/38365985/a-pilot-study-to-assess-the-effects-of-preventing-fluid-retention-in-the-legs-by-wearing-compression-stockings-on-overnight-airway-narrowing-in-mild-asthma
#5
JOURNAL ARTICLE
Xiaoshu Cao, Cristina O Francisco, Swati A Bhatawadekar, Joseph Makanjuola, Susan M Tarlo, Matthew B Stanbrook, Mark D Inman, Azadeh Yadollahi
PURPOSE: Nocturnal asthma is a sign of asthma worsening and could be partially due to more fluid drawn into the thorax during sleep by gravitational force and/or pharyngeal collapse in those with obstructive sleep apnea. Wearing compression stockings during the day reduces fluid shift from the legs to the neck overnight. However, the potential effect of wearing compression stockings to reduce fluid accumulation in the leg and to improve nocturnal small airway narrowing in patients with asthma has not been investigated...
February 17, 2024: Sleep & Breathing
https://read.qxmd.com/read/38290114/challenging-case-a-multidisciplinary-approach-to-demystifying-chronic-sleep-impairment-in-an-infant-with-a-complex-medical-and-behavioral-profile
#6
JOURNAL ARTICLE
Erica Gleason, Kristina Malik, Elise Sannar, Dana Kamara, Verenea Serrano, Marilyn Augustyn
X is a 22-month-old White male infant with a complex medical history, including diagnoses of FBXO11 mutation, hypotonia, restrictive lung disease and mild intermittent asthma, laryngotracheomalacia, obstructive sleep apnea (OSA), feeding difficulties with a history of aspiration, gastroesophageal reflux disease (GERD), and developmental delays. X's medical presentation has resulted in multiple prior medical admissions for respiratory failure due to acute illnesses, procedures and treatments including gastrojejunostomy (GJ) tube dependence, supraglottoplasty to reshape tissues of the upper larynx, and the use of biphasic positive airway pressure (BiPAP) at night and room air during the day when he is at baseline...
January 30, 2024: Journal of Developmental and Behavioral Pediatrics: JDBP
https://read.qxmd.com/read/38246348/adverse-childhood-experiences-and-related-events-are-associated-with-asthma-symptoms-in-children
#7
JOURNAL ARTICLE
Adali Martinez, Morgan Ye, Danielle Hessler, Rosemarie de la Rosa, Mindy Benson, Rachel Gilgoff, Kadiatou Koita, Monica Bucci, Nadine Burke Harris, Dayna Long, Neeta Thakur
OBJECTIVE: To examine the association between Adverse Childhood Experiences (ACEs) and related events and asthma symptom burden in children. METHODS: This is a cross-sectional study of baseline data from 147 participants with asthma from a cohort of children enrolled in the Pediatric ACEs Screening and Resiliency Study. Participants completed the PEdiatric ACEs and Related Life Events Screener (PEARLS) tool, a 17-item questionnaire, capturing three domains of childhood adversity- child maltreatment, household challenges and social context...
January 19, 2024: Academic Pediatrics
https://read.qxmd.com/read/38235258/sensitization-to-oil-palm-pollen-associates-with-risks-and-severity-of-allergic-diseases
#8
JOURNAL ARTICLE
Yang Yie Sio, Gallego Allaine Victoria Nanong, Jie Ann Lim, Sri Anusha Matta, Yee-How Say, Keng Foo Teh, Yi Ru Wong, Smyrna Moti Rawanan Shah, Kavita Reginald, Fook Tim Chew
BACKGROUND: Elaeis guineensis (Ela g, oil palm) pollen is one of the most predominant species of inhalant allergens in the tropical Southeast Asia region; however, its association with the manifestation of allergic diseases remains largely unexplored. This study aimed to determine the sensitization pattern of oil palm pollen and associate this with the risk and severity of allergic diseases. METHODS: Participants were recruited as a part of the Singapore and Malaysia cross-sectional genetic and epidemiological study (SMCSGES)...
January 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38101459/gastroesophageal-reflux-and-snoring-are-related-to-asthma-and-respiratory-symptoms-results-from-a-nordic-longitudinal-population-survey
#9
JOURNAL ARTICLE
Rima Mir Fakhraei, Eva Lindberg, Bryndís Benediktsdóttir, Cecilie Svanes, Ane Johannessen, Mathias Holm, Lars Modig, Karl A Franklin, Andrei Malinovschi, Thorarinn Gislason, Rain Jõgi, Christine Cramer, Christer Janson, Össur Ingi Emilsson
AIM: To study if individuals with nocturnal gastroesophageal reflux (nGER) and habitual snoring are more likely to develop asthma and respiratory symptoms (i.e. wheeze, cough, chest tightness, breathlessness) than those without these conditions, and if these associations are additive. METHODS: We used data from the population-based prospective questionnaire study Respiratory Health in Northern Europe (RHINE) (11,024 participants), with data from 1999 and 2011. Participants with heartburn or belching after going to bed, at least 1 night/week, were considered to have nGER...
December 13, 2023: Respiratory Medicine
https://read.qxmd.com/read/38083154/a-wireless-wearable-patch-for-remote-monitoring-of-respiratory-and-cardiac-rhythm-in-children
#10
JOURNAL ARTICLE
Faizan Javed, Juana Cerna Sanchez, Scott MacLean, Vincent Lam, Lewis O'Flynn, Melisa Tanverdi, Andrew H Liu
Remote patient monitoring (RPM) is an innovative strategy to promote health and improve patient management and care. Recent advances in healthcare technologies have seen the emergence of wearable sensors allowing longitudinal physiological measurements in any environment. This paper introduces a wireless wearable patch 'Leo' for continuous remote monitoring of physiological data at home and healthcare settings. This includes single lead ECG, chest impedance, heart rate (HR), respiration rate (RR) and body posture...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38078144/efficacy-of-%C3%AE-2-adrenergic-receptor-agonist-combined-with-corticosteroid-in-the-treatment-of-children-with-cough-variant-asthma
#11
JOURNAL ARTICLE
Jun-Yi Cao, Ying-Chun Wang, Xiao-Xia Deng
BACKGROUND: Cough variant asthma (CVA) is one of the most common respiratory diseases in children, which has a serious impact on the quality of life and daily activities of children. For severe CVA, immunomodulatory drugs are needed. AIM: To evaluate the efficacy of salmeterol combined with budesonide in the treatment of pediatric CVA. METHODS: 130 children with CVA from January 2020 to December 2022 were prospectively selected and randomly divided into an observation group (salmeterol combined with budesonide) and a control group (budesonide combined with a placebo)...
November 6, 2023: World Journal of Clinical Cases
https://read.qxmd.com/read/38065704/development-and-validation-of-a-new-asthma-questionnaire-to-help-achieve-a-high-level-of-control-in-school-age-children-and-adolescents
#12
JOURNAL ARTICLE
Mayumi Matsunaga, Yasunori Sato, Mizuho Nagao, Masanori Ikeda, Chikako Motomura, Makoto Kameda, Yukinori Yoshida, Akihiko Terada, Isao Miyairi, Takao Fujisawa
BACKGROUND: Maintaining good asthma control minimizes the risk of exacerbations and lung function decline and is a primary goal of asthma management. The Japanese Pediatric Asthma Guidelines (JPGL) employs different classification criteria for control status from other guidelines, stressing a higher level of control. Based on JPGL, we previously developed a caregiver-completed questionnaire for assessing and achieving best asthma control in preschoolers. In this study, we aimed to develop a questionnaire for school-age children and adolescents...
December 7, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/38009701/exploring-the-relationship-between-asthma-its-severity-and-anxiety-symptoms-in-pediatric-patients-a-case-control-study
#13
JOURNAL ARTICLE
Sheykhi Mahdi, Ali Pourvali, Yazdan Ghandi, Anita Alaghmand, Maryam Zamanian, Tina Eslambeik, Amin Tajerian
BACKGROUND: Asthma is a global health concern, especially among children, and is associated with various underlying mechanisms. Childhood exposure to early life stress and anxiety can potentially exacerbate asthma symptoms and complicate its management. While some studies have suggested the benefits of psychological therapies as adjuncts to medication in asthma management, evidence remains inconsistent, emphasizing the need for rigorous evaluation. METHOD: This case-control study involved 120 children aged 5-15, with 60 children having asthma and 60 healthy controls...
November 27, 2023: Journal of Asthma
https://read.qxmd.com/read/37984349/response-to-various-biologics-in-patients-with-both-asthma-and-chronic-obstructive-pulmonary-disease
#14
Marek Lommatzsch, Sebastian Niels Mohme, Paul Stoll, J Christian Virchow
INTRODUCTION: Patients can have features of both chronic obstructive pulmonary disease (COPD) and asthma. However, there is still no consensus how to precisely define this patient population. In addition, there are little data on the effectiveness of biologics in these patients. METHOD: Presence of COPD was defined by a smoking history of ≥10 pack years (PY), a postbronchodilator FEV1/FVC ratio < lower limit of normal (LLN) and FEV1 < 80% predicted, a carbon monoxide diffusion capacity (DLCO) < LLN, and dyspnoea on exertion as a leading symptom...
2023: Respiration; International Review of Thoracic Diseases
https://read.qxmd.com/read/37979362/the-relationship-between-exposure-to-environmental-noise-and-risk-of-atopic-dermatitis-asthma-and-allergic-rhinitis
#15
JOURNAL ARTICLE
Yongho Lee, Seunghyun Lee, Seula Park, Seong-Kyu Kang, June-Hee Lee, Dong-Wook Lee, Won-Jun Choi, Wanhyung Lee
BACKGROUND: Noise is defined as unwanted sound. It may induce negative emotions and mental health problems and may even lead to increased suicide risk. However, the impact of noise exposure on environmental diseases and disease severity is not well understood. This study aimed to elucidate the association between night-time noise exposure and the prevalence of environmental diseases in South Korea. METHODS: We conducted an analysis of the Environmental Disease Database provide by the National Health Insurance Service (NHIS) from 2013 to 2017...
November 16, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/37892689/revisiting-asthma-obstructive-sleep-apnea-overlap-current-knowledge-and-future-needs
#16
REVIEW
Damini Saxena, Ikuyo Imayama, Muhammad Adrish
Asthma and obstructive sleep apnea are highly prevalent conditions with a high cost burden. In addition to shared risk factors, existing data suggest a bidirectional relationship between asthma and OSA, where each condition can impact the other. Patients with asthma often complain of sleep fragmentation, nocturnal asthma symptoms, daytime sleepiness, and snoring. The prevalence of OSA increases with asthma severity, as evidenced by multiple large studies. Asthma may lower the threshold for arousal in OSA, resulting in the hypopnea with arousal phenotype...
October 16, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37860588/diltiazem-for-clozapine-induced-generalized-hyperhidrosis
#17
Emma M Kenton, Samantha M Zoellner, Leigh Anne Nelson
BACKGROUND: Clozapine can be associated with significant side effects and tolerability issues. Hyperhidrosis occurs less commonly and is unanticipated by clinicians because of clozapine's significant anticholinergic activity. CASE REPORT: A 34-year-old female developed clozapine-induced nocturnal, generalized hyperhidrosis following initial titration to 400 mg/day. Dose reduction did not decrease the side effect. Treatment with an anticholinergic medication could not be initiated because of constipation...
August 2023: Mental Health Clinician
https://read.qxmd.com/read/37833518/do-nocturnal-asthma-attacks-influence-sleep-parameters-and-inflammatory-markers-a-cross-sectional-population-based-study
#18
JOURNAL ARTICLE
Maingredy Rodrigues Souza, Daniela Santoro Rosa, Tathiana A Alvarenga, Priscila K Morelhão, Sergio Tufik, Monica L Andersen
PURPOSE: To evaluate the effects of nocturnal asthma on sleep parameters and inflammatory markers according to the severity of the condition in participants in the São Paulo Epidemiologic Sleep Study (EPISONO). METHODS: Data from the 2007 and 2018 editions of the EPISONO study were utilized. Subjects completed validated sleep and respiratory questionnaires, underwent nocturnal polysomnography and spirometry tests, and provided blood samples for the assessment of inflammatory parameters...
October 14, 2023: Sleep & Breathing
https://read.qxmd.com/read/37781650/acute-hdm-exposure-shows-time-of-day-and-sex-based-differences-in-the-severity-of-lung-inflammation-and-circadian-clock-disruption
#19
JOURNAL ARTICLE
Ashokkumar Srinivasan, Allan Giri, Santhosh Kumar Duraisamy, Alexander Alsup, Mario Castro, Isaac Kirubakaran Sundar
BACKGROUND: Asthma is a chronic inflammatory disease that shows a time-of-day response to variations in symptoms/severity. However, how the lung circadian clock influences time-of-day response and sex-based differences in house dust mite (HDM)-induced airway inflammation and remodeling has not been thoroughly investigated. OBJECTIVE: We sought to determine whether acute HDM exposure in wild-type mice shows time-of-day response and sex-based differences in allergic airway inflammation and circadian clock disruption in the lungs...
November 2023: J Allergy Clin Immunol Glob
https://read.qxmd.com/read/37620110/managing-moderate-to-severe-paediatric-asthma-a-scoping-review-of-the-efficacy-and-safety-of-fluticasone-propionate-salmeterol
#20
REVIEW
Paulo Marcio Pitrez, Sira Nanthapisal, Ana Paula Beltran Moschione Castro, Chirag Teli, Abhijith P G
BACKGROUND: Fluticasone propionate/salmeterol xinafoate (FP/SAL) is an inhaled corticosteroid (ICS) and long-acting β2 -agonist (LABA) combination, indicated for the regular treatment of children (aged >4 years) with asthma that is inadequately controlled with ICS monotherapy plus as-needed short-acting β2 -agonists, or already adequately controlled with ICS/LABA. OBJECTIVE: Compared with the adult population, fewer clinical studies have investigated the efficacy of FP/SAL in paediatric patients with moderate and moderate-to-severe asthma...
August 2023: BMJ Open Respiratory Research
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