Yanyan Zhang, Fen He, Wei Hu, Jingqi Sun, Hongyan Zhao, Yuzhi Cheng, Zhanyou Tang, Jiarui He, Xiangyuan Wang, Tairan Liu, Cong Luo, Zhongwei Lu, Mei Xiang, Yiting Liao, Yihao Wang, Junjun Li, Jiliang Xia
Iron contributes to tumor initiation and progression; however, excessive intracellular free Fe2+ can be toxic to cancer cells. Our findings confirmed that multiple myeloma (MM) cells exhibited elevated intracellular iron levels and increased ferritin, a key protein for iron storage, compared with normal cells. Interestingly, Bortezomib (BTZ) was found to trigger ferritin degradation, increase free intracellular Fe2+ , and promote ferroptosis in MM cells. Subsequent mechanistic investigation revealed that BTZ effectively increased NCOA4 levels by preventing proteasomal degradation in MM cells...
April 22, 2024: Annals of Hematology