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Loandi Richter, Erika M Du Plessis, Stacey Duvenage, Lise Korsten
Extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase-producing Enterobacteriaceae are no longer restricted to the health care system, but represent increased risks related to environmental integrity and food safety. Fresh produce has been increasingly reported to constitute a reservoir of multidrug-resistant (MDR) potential human pathogenic Enterobacteriaceae. This study aimed to detect, identify, and characterize the antimicrobial resistance of ESBL/AmpC-producing Enterobacteriaceae isolates from fresh vegetables at point of sale...
February 20, 2019: Foodborne Pathogens and Disease
Barlebo Ahlborn Lise, Olga Østrup
Circulating tumor DNA (ctDNA) refers to the fraction of cell-free DNA in a patient's blood originating from tumor cells. Increased knowledge about tumor genomics, improvements in targeted therapies, and accompanying advances in DNA-sequencing technologies have increased the interest in using ctDNA as a minimally invasive tool in cancer diagnostics and treatment. Especially, early tumor detection including identification of minimal residual disease and stratification of adjuvant therapy are promising approaches...
February 19, 2019: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Lisebet Skeie Skarpaas, Lise Aasen Haveraaen, Milada Cvancarova Småstuen, William S Shaw, Randi Wågø Aas
OBJECTIVES: The aim of this study was to assess if the reported provision of a coordinator was associated with time to first return to work (RTW) and first full RTW among sick-listed employees who participated in different rapid-RTW programmes in Norway. DESIGN: The study was designed as a cohort study. SETTING: Rapid-RTW programmes financed by the regional health authority in hospitals and Norwegian Labour and Welfare Administration in Norway...
February 18, 2019: BMJ Open
Maxime Hentzien, Moustapha Dramé, Cyrille Delpierre, Clotilde Allavena, André Cabié, Lise Cuzin, David Rey, Pascal Pugliese, Guy Hédelin, Firouzé Bani-Sadr
OBJECTIVE: The objective was to evaluate the association between age-related comorbidities (ARCs) and 5-year HIV-related excess mortality in people living with HIV aged ≥60 years. DESIGN: Cohort study using relative survival analysis (Estève's model). SETTING: The French multicentre prospective Dat'AIDS cohort that involves 12 French hospitals. PARTICIPANTS: Inclusion of 1415 HIV-1 infected patients actively followed aged ≥60 years on January 2008, with a 5-year follow-up period in the late combination antiretroviral therapy era...
January 25, 2019: BMJ Open
Mavish S Chaudry, Gunnar H Gislason, Anne-Lise Kamper, Marianne Rix, Anders R Larsen, Andreas Petersen, Paal S Andersen, Robert L Skov, Emil L Fosbøl, Henrik Westh, Henrik C Schønheyder, Thomas L Benfield, Vance G Fowler, Christian Torp-Pedersen, Niels E Bruun
INTRODUCTION: Staphylococcus aureus bacteremia (SAB) is a high-risk infection and feared complication related to hemodialysis. This study aimed to investigate incidence and risk factors for SAB depending on hemodialysis access type. METHODS: The Danish National Registry on Regular Dialysis and Transplantation was used to identify patients from January 1, 1996 to December 31, 2011 with end-stage kidney disease. Patients were followed until death, the first episode of SAB, or end of study (December 31, 2011)...
February 19, 2019: Hemodialysis International
Dominique Penther, Pierre-Julien Viailly, Sylvain Latour, Pascaline Etancelin, Elodie Bohers, Hélène Vellemans, Vincent Camus, Anne Lise Menard, Sophie Coutant, Hélène Lanic, Emilie Lemasle, Fanny Drieux, Liana Veresezan, Philippe Ruminy, Anna Raimbault, Jean Soulier, Thierry Frebourg, Hervé Tilly, Fabrice Jardin
Burkitt lymphoma (BL) is characterized by a translocation of the MYC oncogene that leads to the upregulation of MYC expression, cell growth and proliferation. It is well-established that MYC translocation is not a sufficient genetic event to cause BL. Next-generation sequencing has recently provided a comprehensive analysis of the landscape of additional genetic events that contribute to BL lymphomagenesis. Refractory BL or relapsing BL are almost always incurable as a result of the selection of a highly chemoresistant clonally related cell population...
February 18, 2019: Genes, Chromosomes & Cancer
Even Fjære, Lene Secher Myrmel, Ditte Olsen Lützhøft, Hanne Andersen, Jacob Bak Holm, Pia Kiilerich, Rita Hannisdal, Bjørn Liaset, Karsten Kristiansen, Lise Madsen
Low-fat diets and exercise are generally assumed to ameliorate obesity-related metabolic dysfunctions, but the importance of exercise vs. dietary changes is debated. Male C57BL/6J mice were fed a high-fat/high-sucrose (HF/HS) diet to induce obesity and then either maintained on the HF/HS or shifted to low-fat (LF) diets containing either salmon or entrecote. For each diet, half of the animals exercised voluntarily for 8 weeks. We determined body composition, glucose tolerance, insulin sensitivity and hepatic triacylglycerol levels...
January 18, 2019: Journal of Nutritional Biochemistry
Thibaut Lizée, Ethan Basch, Pierre Trémolières, Eric Voog, Julien Domont, Guillaume Peyraga, Thierry Urban, Jaafar Bennouna, Anne-Lise Septans, Magali Balavoine, Bruno Detournay, Fabrice Denis
BACKGROUND: A multicenter randomized clinical trial in France found an overall survival benefit of web-based patient-reported outcome (PRO)-based surveillance following initial treatment for lung cancer compared with conventional surveillance. The aim of this study was to assess the cost-effectiveness of this PRO-based surveillance in lung cancer patients. METHODS: This medico-economic analysis employed data from the clinical trial, augmented by abstracted chart data and costs of consultations, imaging, transportations, information technology, and treatments...
February 15, 2019: Journal of Thoracic Oncology
Nathan Kuppermann, Peter S Dayan, Deborah A Levine, Melissa Vitale, Leah Tzimenatos, Michael G Tunik, Mary Saunders, Richard M Ruddy, Genie Roosevelt, Alexander J Rogers, Elizabeth C Powell, Lise E Nigrovic, Jared Muenzer, James G Linakis, Kathleen Grisanti, David M Jaffe, John D Hoyle, Richard Greenberg, Rajender Gattu, Andrea T Cruz, Ellen F Crain, Daniel M Cohen, Anne Brayer, Dominic Borgialli, Bema Bonsu, Lorin Browne, Stephen Blumberg, Jonathan E Bennett, Shireen M Atabaki, Jennifer Anders, Elizabeth R Alpern, Benjamin Miller, T Charles Casper, J Michael Dean, Octavio Ramilo, Prashant Mahajan
Importance: In young febrile infants, serious bacterial infections (SBIs), including urinary tract infections, bacteremia, and meningitis, may lead to dangerous complications. However, lumbar punctures and hospitalizations involve risks and costs. Clinical prediction rules using biomarkers beyond the white blood cell count (WBC) may accurately identify febrile infants at low risk for SBIs. Objective: To derive and validate a prediction rule to identify febrile infants 60 days and younger at low risk for SBIs...
February 18, 2019: JAMA Pediatrics
Maxime Lussier, Stéphane Adam, Belkacem Chikhaoui, Charles Consel, Mathieu Gagnon, Brigitte Gilbert, Sylvain Giroux, Manon Guay, Carol Hudon, Hélène Imbeault, Francis Langlois, Joel Macoir, Hélène Pigot, Lise Talbot, Nathalie Bier
BACKGROUND: Functional assessment is of paramount importance when mild cognitive impairment is suspected, but common assessment tools such as questionnaires lack sensitivity. An alternative and innovative approach consists in using sensor technology in smart apartments during scenario-based assessments of instrumental activities of daily living (IADL). However, studies that investigate this approach are scarce and the technology used is not always transposable in healthcare settings. OBJECTIVE: To explore whether simple and wireless technology used in two different smart environments could add value to performance and rater-based measures of IADL when it comes to predicting mild cognitive impairment (MCI) in older adults...
February 11, 2019: Journal of Alzheimer's Disease: JAD
Louis Perol, Eric Grignano, Adrien Contejean, Lauris Gastaud, Marielle Legoff, Patricia Franchi, Bénédicte Deau-Fischer, Lise Willems, Didier Bouscary, Jerome Tamburini
No abstract text is available yet for this article.
February 18, 2019: Leukemia & Lymphoma
Lise G Bjerregaard, Kasper Adelborg, Jennifer L Baker
Childhood obesity adversely affects the structure and function of the cardiovascular system, but the relationship between excessive weight gain during childhood and adult cardiovascular disease (CVD) is not fully understood. This review summarizes evidence for associations of change in body mass index (BMI) from childhood onwards with CVD outcomes. We found that excessive gain in BMI from childhood onwards was consistently associated with the presence of CVD risk factors, with increased risks of coronary heart disease, and there were suggestions of associations with stroke, atrial fibrillation and heart failure, but a lack of evidence precludes firm conclusions...
February 5, 2019: Trends in Cardiovascular Medicine
David M Shahian, David F Torchiana, Daniel T Engelman, Thoralf M Sundt, Richard S D'Agostino, Ann F Lovett, Matthew J Cioffi, James D Rawn, Vladimir Birjiniuk, Robert H Habib, Sharon-Lise T Normand
OBJECTIVES: Beginning in 2002, all 14 Massachusetts nonfederal cardiac surgery programs submitted Society of Thoracic Surgeons (STS) National Database data to the Massachusetts Data Analysis Center for mandatory state-based analysis and reporting, and to STS for nationally benchmarked analyses. We sought to determine whether longitudinal prevalences and trends in risk factors and observed and expected mortality differed between Massachusetts and the nation. METHODS: We analyzed 2003 to 2014 expected (STS predicted risk of operative [in-hospital + 30-day] mortality), observed, and risk-standardized isolated coronary artery bypass graft mortality using Massachusetts STS data (N = 39,400 cases) and national STS data (N = 1,815,234 cases)...
December 31, 2018: Journal of Thoracic and Cardiovascular Surgery
Mathias J Holmberg, Ari Moskowitz, Sebastian Wiberg, Anne V Grossestreuer, Tuyen Yankama, Lise Witten, Sarah M Perman, Michael W Donnino, Lars W Andersen
AIM: To determine whether the removal of atropine from the 2010 ACLS guidelines for non-shockable cardiac arrests was associated with a change in survival. METHODS: Using the Get With The Guidelines®-Resuscitation registry, we included adults with an index in-hospital cardiac arrest between 2006 and 2015. The primary outcome was survival to hospital discharge. Secondary outcomes included return of spontaneous circulation and favorable functional outcome. An interrupted time-series analysis was used to compare survival before (pre-guidelines) and after (post-guidelines) introduction of the 2010 guidelines...
February 13, 2019: Resuscitation
Lise Brogaard, Ole Kierkegaard, Lone Hvidman, Kristiane Roed Jensen, Peter Musaeus, Niels Uldbjerg, Tanja Manser
OBJECTIVE: Little is known about how teams' non-technical performance influences clinical performance in obstetric emergencies like postpartum haemorrhage. DESIGN: Video review - observational study. SETTING: A university hospital (5,000 deliveries) and a regional hospital (2,000 deliveries) in Denmark. POPULATION: Obstetric teams managing real-life postpartum haemorrhage. METHODS: We systematically assessed 99 video recordings of obstetric teams managing real-life major postpartum haemorrhage...
February 16, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
Arjun Majithia, Michael E Matheny, Jessica K Paulus, Danica Marinac-Dabic, Susan Robbins, Henry Ssemaganda, Kathleen Hewitt, Angelo Ponirakis, Nilsa Loyo-Berrios, Issam Moussa, Joseph Drozda, Sharon-Lise Normand, Frederic S Resnic
Background Current strategies for ensuring the postmarket safety of medical devices are limited by small sample size and reliance on voluntary reporting of adverse events. Prospective, active surveillance of clinical registries may provide early warnings in the postmarket evaluation of medical device safety but has not been demonstrated in national clinical data registries. Methods and Results The CathPCI DELTA (Data Extraction and Longitudinal Trend Analysis) study was designed to assess the feasibility of prospective, active safety surveillance of medical devices within a national cardiovascular registry...
February 2019: Circulation. Cardiovascular Quality and Outcomes
Lise Charuaud, Emilie Jardé, Anne Jaffrézic, Marine Liotaud, Quentin Goyat, Fabien Mercier, Barbara Le Bot
In intensive livestock areas, veterinary pharmaceutical residues (VPRs) can occur in water resources, but also in tap water because treatment processes are not designed to remove these contaminants. The main objective of this study is to assess the occurrence of VPRs in water resources and tap waters in Brittany. As several identical compounds are used in both veterinary and human medicine, a toolbox (stanols and pharmaceuticals) is used to help determine the origin of contamination in the case of mixed-use molecules...
January 24, 2019: Science of the Total Environment
Michiel T van Diepen, Rosamund Chapman, Nicola Douglass, Shireen Galant, Penny L Moore, Emmanuel Margolin, Phindile Ximba, Lynn Morris, Edward P Rybicki, Anna-Lise Williamson
A vaccine regimen that elicits broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine research. Here we assessed the immunogenicity of the CAP256SU envelope protein delivered by modified vaccinia virus Ankara (M) and DNA (D) vaccines in different prime/boost combinations followed by a soluble protein (P) boost. The envelope protein (Env) contained a flexible, glycine linker and I559P mutation. Trimer-specific bNAbs PGT145, PG16 and CAP256 VRC26_08 efficiently bound to the membrane-bound CAP256 envelope expressed on the surface of cells transfected or infected with the DNA and MVA vaccines respectively...
February 13, 2019: Journal of Virology
Marie-A Chaix, Annie Dore, François Marcotte, Azadeh Shohoudi, Fabien Labombarda, Lise-Andrée Mercier, Anna Proietti, Réda Ibrahim, Anita W Asgar, Blandine Mondésert, Nancy Poirier, Paul Khairy, François-Pierre Mongeon
BACKGROUND: Echocardiographic evaluation of the systemic right ventricle (sRV) remains challenging in patients with transposition of the great arteries (TGA) corrected by an atrial switch (AS) and with congenitally corrected TGA (ccTGA). The aim of this study was to determine the interobserver and intraobserver variability of echocardiographic parameters for sRV size and systolic function. METHODS: Six independent observers retrospectively interpreted 44 previously acquired echocardiograms (25 patients with TGA/AS and 19 patients with ccTGA)...
February 2019: Canadian Journal of Cardiology
Marie Beauséjour, Lise Goulet, Marjolaine Roy-Beaudry, Guy Grimard, Hubert Labelle
In absence of school scoliosis screening programs (SSSP) in Canada, this study examined the relationships between the lay person's perception of morbidity and the appropriateness of referral in orthopaedics. A cross-sectional study was conducted with all children consecutively referred in orthopaedics for suspected scoliosis. The 831 participants were classified as Appropriate, Late or Inappropriate referrals for the orthopaedic setting. Perceived morbidity was operationalized by: the scoliosis detection originator, the perceptions of the seriousness of the condition and urgency to consult a physician, the perception of the general health, as well as Visible Back Deformity, Self-image and Pain...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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