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CKD biomarkers

Hayley Abbiss, Garth L Maker, Robert D Trengove
Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer, kidney transplantation and polycystic kidney diseases. Numerous studies have adopted a metabolomics approach to uncover new small molecule biomarkers of kidney diseases to improve specificity and sensitivity of diagnosis and to uncover biochemical mechanisms that may elucidate the cause and progression of these diseases...
February 14, 2019: Metabolites
Kevin Esmeijer, Johanna M Geleijnse, Johan W de Fijter, Daan Kromhout, Ellen K Hoogeveen
BACKGROUND: Post-myocardial infarction (MI) patients have a doubled rate of kidney function decline compared with the general population. We investigated the extent to which high intake of total, animal and plant protein are risk factors for accelerated kidney function decline in older stable post-MI patients. METHODS: We analysed 2255 post-MI patients (aged 60-80 years, 80% men) of the Alpha Omega Cohort. Dietary data were collected with a biomarker-validated 203-item food frequency questionnaire...
February 14, 2019: Nephrology, Dialysis, Transplantation
Yoojin M Kim, David J Polzin, Aaron Rendahl, Jennifer L Granick
BACKGROUND: Active kidney injury may play a role in chronic kidney disease (CKD) progression in dogs. Neutrophil gelatinase-associated lipocalin (NGAL), a novel tubular kidney injury biomarker, may help differentiate progressive CKD from stable CKD in dogs. OBJECTIVES: To determine if urinary NGAL : creatinine ratio (UNCR) differentiates stable and progressive CKD in dogs. We hypothesized that UNCR would be higher in dogs with progressive CKD versus stable CKD...
February 14, 2019: Journal of Veterinary Internal Medicine
Antonella Agodi, Martina Barchitta, Andrea Maugeri, Guido Basile, Matilde Zamboni, Giulia Bernardini, Daniela Corona, Massimiliano Veroux
The burden of chronic kidney disease is dramatically rising, making it a major public health concern worldwide. Kidney transplantation is now the best treatment for patients with end-stage renal disease. Although kidney transplantation may improve survival and quality of life, its long-term results are hampered by immune- and/or non-immune-mediated complications. Thus, the identification of transplanted patients with a higher risk of posttransplant complications has become a big challenge for public health...
2019: BioMed Research International
Casey M Rebholz, Zihe Zheng, Morgan E Grams, Lawrence J Appel, Mark J Sarnak, Lesley A Inker, Andrew S Levey, Josef Coresh
Background: Accurate assessment of dietary intake is essential, but self-report of dietary intake is prone to measurement error and bias. Discovering metabolic consequences of diets with lower compared with higher protein intake could elucidate new, objective biomarkers of protein intake. Objectives: The goal of this study was to identify serum metabolites associated with dietary protein intake. Methods: Metabolites were measured with the use of untargeted, reverse-phase ultra-performance liquid chromatography-tandem mass spectrometry quantification in serum specimens collected at the 12-mo follow-up visit in the Modification of Diet in Renal Disease (MDRD) Study from 482 participants in study A (glomerular filtration rate: 25-55 mL · min-1 · 1...
February 8, 2019: American Journal of Clinical Nutrition
Mohamed Abdelaziz El-Gamasy, Walid Ahmed El-Shehaby, Maaly M Mabrouk
Background: Cardiovascular morbidity (CVM) is the main etiology of mortality in children and adolescents with chronic kidney disease (CKD). CKD associated cardiovascular mortality is more common in children with diastolic cardiac dysfunction which was considered as an early indicator for death, while increased left ventricular mass (LVM) is a strong independent risk factor for these patients. Vitamin D deficiency was previously studied as one of the risk factors for CVM. Aim: The aim of the work was to investigate the relationship between biomarkers of mineral bone disorder including serum 25(OH) Vitamin D3 (25-OH D3), phosphorus and calcium × phosphorus (Ca×Po4) product with diastolic cardiac function and LVM in children and adolescents with CKD...
January 2019: Annals of Pediatric Cardiology
Chutimon Thanaboonnipat, Saikaew Sutayatram, Chollada Buranakarl, Nan Choisunirachon
BACKGROUND: Chronic kidney disease (CKD) is one of the most common diseases occurring in cats. It is characterized by renal fibrosis, which is strongly correlated with impairment of renal function. Since renal biopsy is not performed routinely in clinical practice, the non-invasive method of ultrasonographic shear-wave elastography (SWE) was used to determine renal parenchymal stiffness. Currently, urinary procollagen type III amino-terminal propeptide (uPIIINP) is a renal fibrosis biomarker in humans...
February 11, 2019: BMC Veterinary Research
William R Zhang, Chirag R Parikh
The current unidimensional paradigm of kidney disease detection is incompatible with the complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has largely focused on glomerular filtration, while assessment of kidney tubular health has notably been absent. Following insult, the kidney tubular cells undergo a cascade of cellular responses that result in the production and accumulation of low-molecular-weight proteins in the urine and systemic circulation. Modern advancements in molecular analysis and proteomics have allowed the identification and quantification of these proteins as biomarkers for assessing and characterizing kidney diseases...
February 10, 2019: Annual Review of Physiology
Katarzyna Taranta-Janusz, Anna Moczulska, Hanna Nosek, Joanna Michaluk-Skutnik, Mark Klukowski, Anna Wasilewska
PURPOSE: We aimed at evaluating urinary levels of procollagen III aminoterminal propeptide (PIIINP) and β-catenin and the relationship between these markers and clinical and laboratory variables in children with a solitary functioning kidney (SFK). PATIENTS AND METHODS: The study group consisted of 98 (M/F: 62/36) children with an SFK with a median age of 8 years. An age-matched control group contained 54 healthy peers. Urinary levels of procollagen III aminoterminal propeptide and β-catenin were measured using a commercially available immunoassay kit...
February 6, 2019: Advances in Medical Sciences
Shengyuan Luo, Josef Coresh, Adrienne Tin, Casey M Rebholz, Lawrence J Appel, Jingsha Chen, Ramachandran S Vasan, Amanda H Anderson, Harold I Feldman, Paul L Kimmel, Sushrut S Waikar, Anna Köttgen, Anne M Evans, Andrew S Levey, Lesley A Inker, Mark J Sarnak, Morgan Erika Grams
BACKGROUND AND OBJECTIVES: Data are scarce on blood metabolite associations with proteinuria, a strong risk factor for adverse kidney outcomes. We sought to investigate associations of proteinuria with serum metabolites identified using untargeted profiling in populations with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using stored serum samples from the African American Study of Kidney Disease and Hypertension (AASK; n =962) and the Modification of Diet in Renal Disease (MDRD) study ( n =620), two rigorously conducted clinical trials with per-protocol measures of 24-hour proteinuria and GFR, we evaluated cross-sectional associations between urine protein-to-creatinine ratio and 637 known, nondrug metabolites, adjusting for key clinical covariables...
February 7, 2019: Clinical Journal of the American Society of Nephrology: CJASN
Siyun Xiang, Qiman Jin, Fangyi Xu, Ying Yao, Wangqun Liang, Xuezhi Zuo, Ting Ye, Chenjiang Ying
The present study aims to assess arsenic accumulation and explore its association with renal function and biomarkers of CVD risk in chronic kidney disease patients receiving continuous ambulatory peritoneal dialysis (CAPD). The serum was collected from 87 CAPD patients and 26 healthy subjects between 2015 and 2016. The arsenic concentration was measured by inductively coupled plasma mass spectrometer. Clinical variables related to CVD risk were determined with automatic biochemical analyzer. Serum arsenic was higher in CAPD patients as compared to healthy volunteers...
March 2019: Journal of Trace Elements in Medicine and Biology
Ferah Armutcu, Kadir Demircan, Umran Yildirim, Mehmet Namuslu, Murat Yagmurca, Hüseyin Tu Gbreve Rul Celik
AIM: Renal fibrosis is a common cause of renal dysfunction with chronic kidney diseases. This process is characterized by excessive production of extracellular matrix (ECM) or inhibition of ECM degradation. ADAMTS proteinases, which are widely presented in mammals, have very critical roles in ECM remodeling. We aimed to study the role of ADAMTS proteinases and some of the ECM markers in the pathogenesis of renal fibrosis, and to investigate the effects of hypoxia upon these biomarkers...
February 4, 2019: Nephrology
Jonas Björk, Ulf Nyman, Ulla Berg, Pierre Delanaye, Laurence Dubourg, Karolien Goffin, Anders Grubb, Magnus Hansson, Karin Littmann, Kajsa Åsling-Monemi, Arend Bökenkamp, Hans Pottel
BACKGROUND: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from several European medical centres. METHODS: Three thousand four hundred eight measurements of GFR (mGFR) using plasma clearance of exogenous substances were performed in 2218 children aged 2-17 years...
February 4, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Etty Kruzel-Davila, Jasmin Divers, Gregory B Russell, Zipi Kra-Oz, Moran Szwarcwort Cohen, Carl D Langefeld, Lijun Ma, Douglas S Lyles, Pamela J Hicks, Karl L Skorecki, Barry I Freedman
Purpose: African Americans who shed JC polyoma virus (JCV) in their urine have reduced rates of non-diabetic chronic kidney disease (CKD). The present study assessed associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus. Methods: African Americans with diabetic kidney disease and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative polymerase chain reaction...
January 30, 2019: Journal of Clinical Endocrinology and Metabolism
A V Smirnov, M Khasun, I G Kayukov, O V Galkina, V G Sipovski, M M Parastaeva, E O Bogdanova
AIM: To assess the significance of the serum uromodulin (Tamm-Horsfall protein - THP) concentration (Sumo) as an early biomarker of tubular atrophy (TA) and interstitial renal fibrosis (IF) in patients with glomerulopathies. MATERIALS AND METHODS: 84 patients with glomerulopathy and 11 practically healthy persons (control) were examined. Uromodulin concentrations in serum and urine (Uumo) were measured, renal excretion of this protein and the estimated glomerular filtration rate (eGFR) were established...
June 20, 2018: Terapevticheskiĭ Arkhiv
Liza Grosman-Rimon, Sarah Genevieve Hui, Danit Freedman, Gabby Elbaz-Greener, David Cherney, Vivek Rao
BACKGROUND/AIMS: Renal dysfunction or renal failure is a common complication in left ventricular assist device (LVAD) recipients and is associated with reduced survival. To date, serum creatinine and glomerular filtration rate (GFR) are used for the evaluation of kidney function. However, serum creatinine and GFR have limitations. The objective of our study is to assess the levels of kidney biomarkers in LVAD recipients compared to heart failure patients and healthy controls and to examine their association with conventional clinical biomarkers...
January 30, 2019: Cardiorenal Medicine
Boris L Zybailov, Galina V Glazko, Yasir Rahmatallah, Dmitri S Andreyev, Taylor McElroy, Oleg Karaduta, Stephanie D Byrum, Lisa Orr, Alan J Tackett, Samuel G Mackintosh, Ricky D Edmondson, Dorothy A Kieffer, R J Martin, Sean H Adams, Nosratola D Vaziri, John M Arthur
BACKGROUND: Resistant starch is a prebiotic metabolized by the gut bacteria. It has been shown to attenuate chronic kidney disease (CKD) progression in rats. Previous studies employed taxonomic analysis using 16S rRNA sequencing and untargeted metabolomics profiling. Here we expand these studies by metaproteomics, gaining new insight into the host-microbiome interaction. METHODS: Differences between cecum contents in CKD rats fed a diet containing resistant starch with those fed a diet containing digestible starch were examined by comparative metaproteomics analysis...
2019: PloS One
Tadashi Toyama, Brendon L Neuen, Min Jun, Toshiaki Ohkuma, Bruce Neal, Meg Jardine, Hiddo L Heerspink, Muh Geot Wong, Toshiharu Ninomiya, Takashi Wada, Vlado Perkovic
AIM: The use of sodium glucose co-transporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) has been limited, primarily because glycemic efficacy is dependent on kidney function. We performed a systematic review and meta-analysis to assess the efficacy and safety of SGLT2 inhibitors in patients with T2DM and CKD, defined as estimated glomerular filtration rate (eGFR) <60mL/min/1.73m2 . MATERIALS AND METHODS: We searched MEDLINE, EMBASE and the Cochrane Library to August 7, 2018, as well as the websites of the United States, European, and Japanese regulatory authorities to July 27, 2018 for data from randomized controlled trials of SGLT2 inhibitors that included reporting of effects on biomarkers, cardiovascular, renal, or safety outcomes in individuals with T2DM and CKD...
January 29, 2019: Diabetes, Obesity & Metabolism
K S Bezerra de Carvalho, R F V Vasco, M R Custodio, V Jorgetti, R M A Moysés, R M Elias
Although chronic kidney disease is associated with other bone disorders, osteoporosis can be found in this context, and it is defined based on bone mineral density (BMD), measured by dual-energy X-ray absorptiometry. As CKD progresses, the percentage of normal BMD decreases, whereas that of osteopenia/osteoporosis increases, mostly due to hip involvement, particularly in patients with reduced renal function. INTRODUCTION: Osteoporosis is a highly prevalent disease in patients with chronic kidney disease (CKD)...
January 28, 2019: Osteoporosis International
Andrew J MacDonald, Mitra K Nadim, François Durand, Constantine J Karvellas
PURPOSE OF REVIEW: Acute kidney injury (AKI) in cirrhosis consists of varying phenotypes, with hepatorenal syndrome (HRS) representing a single entity. Prompt recognition and diagnosis of AKI cause identifies appropriate therapeutic measures. This review provides an overview of AKI definitions, highlights challenges in quantifying renal impairment in cirrhosis, lists novel diagnostic AKI biomarkers, and summarizes transplantation implications. RECENT FINDINGS: Biomarkers (neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, interleukin-18, and liver-type fatty acid-binding protein) may assist in the identification of underlying acute tubular necrosis...
January 22, 2019: Current Opinion in Critical Care
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