Henry Chen, Claire J Ang, Molly Crowder, William M Brieher, Steven R Blanke
Cytolethal distending toxins (CDTs) are intracellular-acting bacterial genotoxins generated by a diverse group of mucocutaneous human pathogens. CDTs must successfully bind to the plasma membrane of host cells in order to exert their modulatory effects. Maximal toxin activity requires all three toxin subunits, CdtA, CdtB, and CdtC, which, based primarily on high-resolution structural data, are believed to preassemble into a tripartite complex necessary for toxin activity. However, biologically active toxin has not been experimentally demonstrated to require assembly of the three subunits into a heterotrimer...
2023: Frontiers in Cellular and Infection Microbiology
Bo-Yu Cheng, Ting-Yun Lin, Szu-Chun Hung
OBJECTIVES: Patients who are undergoing dialysis due to end-stage kidney disease are susceptible to greater coronavirus disease 2019 (COVID-19) complications. While vaccination is seen as the most effective tactic against COVID-19, the dialysis population usually has impaired immune responses to vaccination. Owing to the global vaccine supply shortage in the early phase of the COVID-19 pandemic, hemodialysis patients in Taiwan were administered homologous ChAdOx1 nCoV-19/ChAdOx1 nCoV-19 at 12-week intervals, with a third booster shot of mRNA-1273 given 12 weeks after the second dose...
2023: Tzu chi medical journal
Jean-Paul Cristol, Alain R Thierry, Anne-Sophie Bargnoux, Marion Morena-Carrere, Bernard Canaud
Despite significant progress in dialysis modalities, intermittent renal replacement therapy remains an "unphysiological" treatment that imperfectly corrects uremic disorders and may lead to low-grade chronic inflammation, neutrophil activation, and oxidative stress due to repetitive blood/membrane interactions contributing to the "remaining uremic syndrome" and cardiovascular disease burden of hemodialysis patients. Understanding dialysis bioincompatibility pathways still remains a clinical and biochemical challenge...
2023: Frontiers in Medicine
Amber B Paulus, Jered M Wendte, Brandy Vinson
RATIONALE & OBJECTIVE: Despite many studies suggesting beneficial innovations for patients, few make it into clinical practice. This study aims to enhance patient care by facilitating effective dissemination of patient-centered outcomes research to health care workers in outpatient dialysis facilities, aided by the Patient-Centered Outcomes Research Institute's (PCORI) dissemination and implementation framework. STUDY DESIGN: Dissemination and implementation project...
December 2023: Kidney medicine
Silvi Shah, Goni Katz-Greenberg, Priyanka Gudsoorkar, Prema Vyas, Sunshine Barhorst, Prasoon Verma, Meredith Pensak
RATIONALE & OBJECTIVE: Pregnancy in females with kidney disease is not uncommon and is associated with adverse maternal and fetal outcomes. The use of contraception in females with chronic kidney disease remains low. We sought to describe the perspectives of female patients with advanced chronic kidney disease on the use of contraception. STUDY DESIGN: Qualitative study. SETTING & PARTICIPANTS: We conducted 5 focus group interviews involving 16 adult female patients with advanced chronic kidney disease (n = 3 nondialysis nontransplant chronic kidney disease, n = 9 kidney transplant, and n = 4 kidney failure receiving dialysis) in the United States, following which thematic saturation was reached...
December 2023: Kidney medicine
Krystell Oviedo Flores, Tanja Stamm, Seth L Alper, Valentin Ritschl, Andreas Vychytil
BACKGROUND: The global COVID-19 pandemic transformed healthcare services in ways that have impacted individual physical and psychological health. The substantial health challenges routinely faced by dialysis-dependent patients with advanced kidney disease have increased considerably during the ongoing COVID-19 pandemic but remain inadequately investigated. We therefore decided to analyze and compare the perspectives of dialysis patients on their own needs and challenges during the COVID-19 pandemic with those of their professional healthcare providers through interviews with both groups...
2023: Frontiers in Psychology
Tetyana Okan, Kulbir Ghuman, Faiza Chaudhary, Kaushik Doshi, Usman Shoaib
Calcific uremic arteriolopathy, or calciphylaxis, is a highly morbid, life-threatening syndrome of microvascular calcification leading to progressive skin necrosis. It affects 1-4% of the population with end-stage renal disease (ESRD) and is rarely seen in other conditions. The one-year mortality rate is 80% for patients with ulcerations. There is no evidence-based treatment, and the response to therapy is poor; thus, it creates a serious therapeutic challenge for clinicians. Our aim is to discuss a diagnostic approach and management of calciphylaxis and to raise awareness about this condition among the medical community...
October 2023: Curēus
Franziska Marquard, Claudia Langebrake, Dietlinde Janson, Maida Mahmud, Adrin Dadkhah, Nicolaus Kröger, Francis Ayuk
Acute kidney injury and chronic kidney disease is common in multiple myeloma. Fludarabine which is part of lymphodepletion before CAR-T cell therapy is renally eliminated and its use is not recommended for patients with severe renal impairment defined as a glomerular filtration rate below 30ml/min/1.73m2 . We administered fludarabine to a 58-year-old female patient with myeloma-associated severe renal impairment as part of lymphodepletion before Idecabtagen vicleucel infusion. Fludarabine was administered in reduced dose (15mg/m2 ) and cyclophosphamide with a dose of 300mg/m2 followed by hemodialysis over six hours using a larger filter (FX-100)...
2023: Frontiers in Oncology
Angela R Schneider, Pietro Ravani, Kathryn M King-Shier, Robert R Quinn, Jennifer M MacRae, Shannan Love, Matthew J Oliver, Swapnil Hiremath, Matthew T James, Mia Ortiz, Braden R Manns, Meghan J Elliott
BACKGROUND: Updates to the Kidney Disease Outcomes Quality Initiative Clinical Practice Guideline for Vascular Access emphasize the "right access, in the right patient, at the right time, for the right reasons." Although this implies a collaborative approach, little is known about how patients, their caregivers, and health care providers engage in vascular access (VA) decision-making. OBJECTIVE: To explore how the perspectives of patients receiving hemodialysis, their caregivers, and hemodialysis care team align and diverge in relation to VA selection...
2023: Canadian Journal of Kidney Health and Disease
Jaya K Sharma, Sono Khan, Tristin Wilson, Nathan Pilkey, Sanjana Kapuria, Angélique Roy, Michael A Adams, Rachel M Holden
BACKGROUND: Type 2 diabetes (T2D) and kidney disease are risk factors for vitamin D deficiency. Native forms of vitamin D have a lower risk of hypercalcemia than calcitriol, the active hormone. The enzyme responsible for activating native vitamin D is now known to be expressed throughout the body; therefore, native vitamin D may have clinically relevant effects in many body systems. OBJECTIVE: The objective of this systematic review was to examine the effect of native vitamin D supplementation on clinical outcomes and surrogate laboratory measures in patients with T2D and diabetic kidney disease (DKD)...
2023: Canadian Journal of Kidney Health and Disease
(no author information available yet)
No abstract text is available yet for this article.
November 30, 2023: Nephrology, Dialysis, Transplantation
Joonhyuk Lee, Seetharam C Chadalavada, Anish Ghodadra, Arafat Ali, Elsa M Arribas, Leonid Chepelev, Ciprian N Ionita, Prashanth Ravi, Justin R Ryan, Lumarie Santiago, Nicole Wake, Adnan M Sheikh, Frank J Rybicki, David H Ballard
BACKGROUND: Medical three-dimensional (3D) printing has demonstrated utility and value in anatomic models for vascular conditions. A writing group composed of the Radiological Society of North America (RSNA) Special Interest Group on 3D Printing (3DPSIG) provides appropriateness recommendations for vascular 3D printing indications. METHODS: A structured literature search was conducted to identify all relevant articles using 3D printing technology associated with vascular indications...
November 30, 2023: 3D Printing in Medicine
Juan Carlos Ramirez-Sandoval, Lluvia Marino, Gabriel Cojuc-Konigsberg, Estefania Reul-Linares, Nathalie Desire Pichardo-Cabrera, Cristino Cruz, Elisa Naomi Hernández-Paredes, Nathan Berman-Parks, Vanessa Vidal-Ruíz, Jonathan Mauricio Estrada-Linares, Alfredo Adolfo Reza-Albarrán, Ricardo Correa-Rotter, Luis Eduardo Morales-Buenrostro
BACKGROUND: Hypercalcemia is highly prevalent in kidney transplant recipients with hyperparathyroidism. However, its long-term impact on graft function is uncertain. METHODS: We conducted a prospective cohort study investigating adverse graft outcomes associated with persistent hypercalcemia (free calcium > 5.2 mg/dL in ≥ 80% of measures) and inappropriately elevated intact parathyroid hormone (> 30 pg/mL) in kidney transplant recipients...
November 30, 2023: Journal of Nephrology
Jie Zhao, Mei Wang, Qing Yu, Yi Yang, Bin Zhang, Sanhua Zhan
BACKGROUND: The current investigation sought to conduct a real-world analysis of adverse events (AEs) associated with selexipag by utilizing data from the Food and Drug Administration Adverse Event Reporting System (FAERS). METHODS: The Reporting Odds Ratios (ROR) and the Medicines Healthcare Products Regulatory Agency (MHRA) method were employed to assess the potential associations between selexipag and AEs. Case reports of adverse drug reaction (ADR) related to selexipag were systematically sourced from PubMed, Embase, and Web of Science databases...
November 30, 2023: Expert Opinion on Drug Safety
Nanbo Zhu, Hong Xu, Tyra Lagerberg, Kristina Johnell, Juan Jesús Carrero, Zheng Chang
BACKGROUND: Depression is prevalent in patients with CKD and is related to poor prognosis. Despite the widespread use of antidepressants in the CKD population, their safety remains unclear. METHODS: We identified adults with CKD stages G3-5 (eGFR <60 ml/min per 1.73 m2 not treated with dialysis) and incident depression diagnosis during 2007-2019 from the Stockholm Creatinine Measurements project. Using the target trial emulation framework, we compared the following treatment strategies: (1) initiating versus not initiating antidepressants, (2) initiating mirtazapine versus selective serotonin reuptake inhibitors (SSRIs), and (3) initiating SSRIs with a lower dose versus a standard dose...
December 1, 2023: Clinical Journal of the American Society of Nephrology: CJASN
David W Johnson, Kai Ming Chow, Philip Kam-Tao Li
No abstract text is available yet for this article.
November 29, 2023: Peritoneal Dialysis International
Sasa Nie, Qingtao Zhang, Rong Chen, Li Lin, Zhenzhen Li, Yanli Sun, Jing Huang, Zhe Feng, Xueying Cao, Kun Ye, Li Tang, Jianhui Zhou, Guangyan Cai, Xiangmei Chen
INTRODUCTION: Peritoneal dialysis (PD)-related peritonitis is a serious complication of PD. Improving the diagnostic rate of peritonitis pathogens may substantially benefit peritonitis patients. METHODS: The study was conducted in the People's Liberation Army (PLA) General Hospital from 1 June 2021 to 31 May 2022. Information about peritonitis, culture and metagenomic next-generation sequencing (mNGS) results and so on were collected. Patients were divided into antibiotic-use and antibiotic-free groups...
2023: Renal Failure
C Y Goh, R Visvanathan, C T Leong, L S Hooi, C C Ch'ng, S Y Yee, K A Abd Manaf, L Mushahar, K W Goh, Y F Liew, A B Manocha, L M Ong
INTRODUCTION: The incidence of acute kidney injury (AKI) among hospitalised patients has not been well studied in Malaysia. MATERIALS AND METHODS: We conducted a prospective, multicentre study in seven hospitals in West Malaysia. All the adults admitted in March 2017 fulfilling Kidney Disease Improving Global Outcomes (KDIGO) criteria for AKI were included. RESULTS: Of the 34,204 patients screened, 2,457 developed AKI (7.18%), 13.1% of which occurred in intensive care unit (ICU)...
November 2023: Medical Journal of Malaysia
Yangkai Xu, Jiawen Huang, Xiaodong Fan, Zhichao Wang, Jiangyong Lou, Xiaoming Liu, Guobin Weng
OBJECTIVE: To assess the feasibility and safety of three-dimensional (3D) laparoscopic nephrectomy in combination with bench surgery and autotransplantation for treating highly complex renal tumors. MATERIALS AND METHODS: The clinical data of six patients with highly complex renal cell carcinoma were collected. All patients underwent 3D laparoscopic nephrectomy in combination with bench surgery and autotransplantation by the same surgeons, two of them had previously undergone laparoscopic partial nephrectomy for contralateral renal cancer...
November 29, 2023: World Journal of Surgical Oncology
Junhui Li, Zhi Wang, Qiannan Zhang, Huiping Zhang, Yuxin Shen, Qi Zhang, Guihua Jian, Dongsheng Cheng, Niansong Wang
BACKGROUND: Disability in activities of daily living (ADL) significantly increases the risk of mortality among patients undergoing hemodialysis. Malnutrition and decreased exercise capacity are closely correlated with ADL disability. Phase angle (PhA) has been proposed as a measure of nutritional status and exercise capacity. This study aims to investigate the prevalence of ADL disability in hemodialysis patients and its association with PhA. METHODS: A prospective, observational study was conducted, involving hemodialysis patients treated between November 2019 and January 2020 in an affiliated hospital of Chinese university...
November 29, 2023: BMC Nephrology
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