keyword
https://read.qxmd.com/read/38546940/effect-of-a-single-small-volume-fluid-bolus-with-balanced-or-un-balanced-fluids-on-chloride-and-acid-base-status-a-prospective-randomized-pilot-study-the-flures-trial
#1
JOURNAL ARTICLE
M Raes, J A Kellum, R Colman, S Wallaert, M Crivits, F Viaene, M Hemeryck, D Benoit, J Poelaert, E Hoste
OBJECTIVE: To compare the short-term effects on acid base, electrolyte status and urine output of a single fluid bolus of saline to that of the balanced solution Plasmalyte® in critically ill patients. METHODS: Prospective, randomized, controlled trial. Adult patients (≥ 18 years) admitted to the ICU receiving a fluid bolus were randomized to receive 1 L of saline (NaCl 0.9%, Baxter) or a balanced fluid [Plasmalyte® (Baxter)]. Blood samples and urine output were collected just before (T0), just after (T1), 2 h after (T2) (only for urinary output) and three hours after termination of the fluid bolus (T4)...
March 28, 2024: Journal of Nephrology
https://read.qxmd.com/read/38546318/a-case-of-perforating-folliculitis-in-a-peritoneal-dialysis-patient
#2
JOURNAL ARTICLE
Glenn Goodwin, Katherine L O'Neil, Megan Dekok, Moshe Bengio, Philip O Scumpia, Abhishek Roka, Alexander J Scumpia
CASE PRESENTATION: A 30-year-old male with a past medical history of hypertension and renal failure on peritoneal dialysis presented to the emergency department with a chief complaint of a rash on his anterior trunk for the prior three weeks. Dermatological examination revealed multiple, discrete folliculocentric, erythematous, and hyperpigmented papules, with scattered adjacent angulated erosions. DISCUSSION: Perforating folliculitis is a rare and often difficult to diagnose skin condition classically seen in patients with chronic renal disease or underlying immunodeficiency...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546300/aortic-thrombus-with-bilateral-renal-infarcts-a-case-report
#3
JOURNAL ARTICLE
Lev Libet
INTRODUCTION: The presence of a hypercoagulable state predisposes to venous and arterial thrombi. While the relationship between protein C and S deficiencies with venous thrombus formation is clear, the relationship to arterial thrombi formation is less common. Thromboembolic disease of the renal arteries may result in renal infarction. The development of simultaneous bilateral renal infarction is rare and can lead to significant morbidity and mortality. CASE REPORT: This is a case of a 48-year-old male with known protein C deficiency who presented to the emergency department with sudden onset abdominal pain...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546145/effect-of-two-different-peritoneal-dialysis-modalities-on-wound-infection-in-peritoneal-dialysis-patients-a-meta-analysis
#4
JOURNAL ARTICLE
Li Tang, Qijun Cheng, Yonghong Qing, Jie Yu, Xiaoping Yan, Changbin Liao
Peritoneal dialysis(PD) is one of the most efficient methods in end-stage kidney disease, and it is very important for PD to perform well. No research has been conducted to evaluate the effect of various types of PD catheters on the prognosis of post-operative wound complications. While recent meta-analyses are in favour of straight tubing, there is still uncertainty as to whether direct or coiled PD is beneficial. The purpose of this meta-analysis was to compare the efficacy of direct and coiled PD catheters on the incidence of post-operative wound infection, bleeding and peritonitis...
April 2024: International Wound Journal
https://read.qxmd.com/read/38546133/urine-tricarboxylic-acid-cycle-metabolites-and-risk-of-end-stage-kidney-disease-in-patients-with-type-2-diabetes
#5
JOURNAL ARTICLE
Jian-Jun Liu, Sylvia Liu, Huili Zheng, Janus Lee, Resham L Gurung, Clara Chan, Lye Siang Lee, Keven Ang, Jianhong Ching, Jean-Paul Kovalik, Subramaniam Tavintharan, Chee Fang Sum, Kumar Sharma, Thomas M Coffman, Su Chi Lim
CONTEXT: Metabolites in tricarboxylic acid (TCA) pathway have pleiotropic functions. OBJECTIVE: To study the association between urine TCA cycle metabolites and the risk for chronic kidney disease (CKD) progression in individuals with type 2 diabetes. DESIGN, SETTING AND PARTICIPANTS: A prospective study in a discovery (n = 1826) and a validation (n = 1235) cohort of type 2 diabetes in a regional hospital and a primary care facility...
March 28, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38545743/a-meta-analysis-of-risk-factors-for-acute-kidney-injury-in-pneumonia-effectiveness-of-nursing-interventions
#6
REVIEW
Liangjuan Yuan, Arshad Mehmood, Lei Meng
INTRODUCTION: The spread of coronavirus disease 2019 (COVID-19) worldwide since November 2019 is of interest to understand its impact on various organs. COVID-19 patients experience a higher incidence of acute kidney injury (AKI) compared with non-COVID-19 patients. METHODS: A systematic literature search was conducted that covered the period from November 1, 2019 to February 28, 2021. RESULTS: The analysis incorporated a comprehensive review of 19 studies of 21 362 patients...
March 28, 2024: Therapeutic Apheresis and Dialysis
https://read.qxmd.com/read/38545310/the-effectiveness-of-acceptance-and-commitment-therapy-on-clinical-symptoms-and-treatment-adherence-in-dialysis-patients
#7
JOURNAL ARTICLE
Amir Hossein Sadeghi, Seyyed Ali Ahmadi, Abbas Ghodrati-Torbati
BACKGROUND: Clinical symptoms and treatment adherence are one of the most important problems in dialysis patients. Psychological treatments can be effective in reducing the problems of these patients. Therefore, this study aimed at investigating the effectiveness of acceptance and commitment therapy (ACT) on clinical symptoms and treatment adherence in these patients. MATERIALS AND METHOD: This study was a quasi-experimental study with the experimental and control groups in the dialysis clinic of Torbat-e Heydarieh City in 2012...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38544335/the-safety-of-a-low-protein-diet-in-older-adults-with-advanced-chronic-kidney-disease
#8
JOURNAL ARTICLE
Karin Windahl, Nicholas C Chesnaye, Gerd Faxén Irving, Peter Stenvinkel, Tora Almquist, Maarit Korkeila Lidén, Christiane Drechsler, Maciej Szymczak, Magdalena Krajewska, Esther de Rooij, Claudia Torino, Gaetana Porto, Fergus J Caskey, Christoph Wanner, Kitty J Jager, Friedo W Dekker, Marie Evans
BACKGROUND: A low protein diet (LPD) is recommended to patients with advanced chronic kidney disease (CKD), whereas geriatric guidelines recommend a higher amount of protein. The aim of this study was to evaluate the safety of LPD treatment in older adults with advanced CKD. METHODS: The EQUAL study is a prospective, observational study, including patients ≥65 years, incident estimated glomerular filtration rate <20 ml/min/1.73m², in six European countries with follow-up up till six years...
March 27, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38544324/prevalence-and-characteristics-of-genetic-disease-in-adult-kidney-stone-formers
#9
JOURNAL ARTICLE
Manuel A Anderegg, Eric G Olinger, Matteo Bargagli, Rob Geraghty, Lea Taylor, Alexander Nater, Rémy Bruggmann, John A Sayer, Bruno Vogt, André Schaller, Daniel G Fuster
BACKGROUND: Molecular mechanisms of kidney stone formation remain unknown in most patients. Previous studies showed high a heritability of nephrolithiasis, but data on prevalence and characteristics of genetic disease in unselected adults with nephrolithiasis are lacking. This study was conducted to fill this important knowledge gap. METHODS: We performed whole exome sequencing in 787 participants of the Bern Kidney Stone Registry, an unselected cohort of adults with ≥ 1 past kidney stone episode (KSF), and 114 non-stone-forming individuals (NKSF)...
March 27, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38544321/structural-adaptation-to-hyperfiltration-defines-ckd-versus-healthy-aging
#10
JOURNAL ARTICLE
Aleksandar Denic, Andrew D Rule
No abstract text is available yet for this article.
March 27, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38544153/the-feasibility-of-semi-continuous-and-multi-frequency-thoracic-bioimpedance-measurements-by-a-wearable-device-during-fluid-changes-in-hemodialysis-patients
#11
JOURNAL ARTICLE
Melanie K Schoutteten, Lucas Lindeboom, Hélène De Cannière, Zoë Pieters, Liesbeth Bruckers, Astrid D H Brys, Patrick van der Heijden, Bart De Moor, Jacques Peeters, Chris Van Hoof, Willemijn Groenendaal, Jeroen P Kooman, Pieter M Vandervoort
Repeated single-point measurements of thoracic bioimpedance at a single (low) frequency are strongly related to fluid changes during hemodialysis. Extension to semi-continuous measurements may provide longitudinal details in the time pattern of the bioimpedance signal, and multi-frequency measurements may add in-depth information on the distribution between intra- and extracellular fluid. This study aimed to investigate the feasibility of semi-continuous multi-frequency thoracic bioimpedance measurements by a wearable device in hemodialysis patients...
March 15, 2024: Sensors
https://read.qxmd.com/read/38543898/antibody-response-after-3-dose-booster-against-sars-cov-2-mrna-vaccine-in-kidney-transplant-recipients
#12
JOURNAL ARTICLE
Domenico Tripodi, Roberto Dominici, Davide Sacco, Gennaro Santorelli, Rodolfo Rivera, Sandro Acquaviva, Marino Marchisio, Paolo Brambilla, Graziana Battini, Valerio Leoni
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in kidney transplant recipients (KTRs). Current vaccine strategies for KTRs seem to be unable to provide effective protection against coronavirus disease 2019 (COVID-19), and the occurrence of severe disease in some vaccinated KTRs suggested a lack of immunity. We initially analyzed the antibody response in a group of 32 kidney transplant recipients (KTRs) followed at the nephrology and dialysis unit of the Hospital Pio XI of Desio, ASST-Brianza, Italy...
March 1, 2024: Vaccines
https://read.qxmd.com/read/38543218/ivermectin-loaded-mesoporous-silica-and-polymeric-nanocapsules-impact-on-drug-loading-in-vitro-solubility-enhancement-and-release-performance
#13
JOURNAL ARTICLE
Maiara Callegaro Velho, Nadine Lysyk Funk, Monique Deon, Edilson Valmir Benvenutti, Silvio Buchner, Ruth Hinrichs, Diogo André Pilger, Ruy Carlos Ruver Beck
Ivermectin (IVM), a widely used drug for parasitic infections, faces formulation and application challenges due to its poor water solubility and limited bioavailability. Pondering the impact of IVM's high partition coefficient value (log P) on its drug release performance, it is relevant to explore whether IVM nanoencapsulation in organic or inorganic nanoparticles would afford comparable enhanced aqueous solubility. To date, the use of inorganic nanoparticles remains an unexplored approach for delivering IVM...
February 26, 2024: Pharmaceutics
https://read.qxmd.com/read/38543007/structural-characterization-and-immunoenhancing-properties-of-polysaccharide-cptm-p1-from-taxus-media
#14
JOURNAL ARTICLE
Jiangtao Fan, Xiong Huang, Mengke Dou, Shuqin Tang, Gang Wang, Yijun Fan, Aoxue Luo, Gang Wang, Yong Wang
Polysaccharides extracted from Taxus media hrough an aqueous method were further refined by removing proteins via the Sevag technique and purified by dialysis. The separation of these polysaccharides was accomplished using a DEAE-cellulose chromatog-raphy column, yielding two distinct fractions, named CPTM-P1 and CPTM-P2. Notably, CPTM-P1 emerged as the primary polysaccharide component within Taxus media . Consequently, a comprehensive analysis focusing exclusively on CPTM-P1 was undertaken. The molecular weight of CPTM-P1 was established through gel permeation chromatography (GPC), and its monosaccharide composition was deciphered using HPLC-MS...
March 19, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542505/coupling-osmotic-efficacy-with-biocompatibility-in-peritoneal-dialysis-a-stiff-challenge
#15
REVIEW
Mario Bonomini, Valentina Masola, Maria Pia Monaco, Vittorio Sirolli, Lorenzo Di Liberato, Tommaso Prosdocimi, Arduino Arduini
Peritoneal dialysis (PD) is a home-based efficacious modality for the replacement of renal function in end-stage kidney failure patients, but it is still under-prescribed. A major limitation is the durability of the dialytic technique. Continuous exposure of the peritoneum to bioincompatible conventional glucose-based solutions is thought to be the main cause of the long-term morpho-functional peritoneal changes that eventually result in ultrafiltration failure. Poor PD solution biocompatibility is primarily related to the high glucose content, which is not only detrimental to the peritoneal membrane but has many potential metabolic side effects...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542300/age-related-changes-in-clinical-and-analytical-variables-in-chronic-hemodialyzed-patients
#16
JOURNAL ARTICLE
Luís Belo, Maria João Valente, Susana Rocha, Susana Coimbra, Cristina Catarino, Irina Lousa, Elsa Bronze-da-Rocha, Petronila Rocha-Pereira, Maria do Sameiro-Faria, José Gerardo Oliveira, José Madureira, João Carlos Fernandes, Vasco Miranda, José Pedro L Nunes, Alice Santos-Silva
Worldwide, the number of elderly individuals receiving chronic hemodialysis is rising. The aim of our study was to evaluate several clinical and analytical biomarkers in chronically dialyzed patients and analyze how they change with age. A cross-sectional study was performed by evaluating 289 end-stage renal disease patients undergoing dialysis. We evaluated the hemogram, adipokines, the lipid profile, and several markers related to inflammation, endothelial function/fibrinolysis, nutrition, iron metabolism, and cardiac and renal fibrosis...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542131/zeolitic-imidazole-framework-silica-nanocomposite-for-targeted-cancer-therapeutics-comparative-study-of-chemo-drug-cisplatin-cpt-and-green-platinum-gpt-efficacy
#17
JOURNAL ARTICLE
Hend Ghnaim Alotaibi, Eman Al-Abbad, Dana Almohazey, Vijaya Ravinayagam, Sultan Akhtar, Hatim Dafalla, B Rabindran Jermy
A chemo-drug such as cisplatin is effective for cancer treatment but remains non-specific, is susceptible to drug resistance, and induces several side effects on organ systems. Zeolitic imidazolate framework-8, a type of MOF, has gained attention, including as a drug delivery method for targeted cancer therapeutics. In this study, ZIF-8/Silica nanocomposite was synthesized using a one-pot hydrothermal technique using the Stober technique. We studied the effect of phyto-synthesized GPt and chemo-drug cisplatin CPt on ZIF-8/Silica for targeted efficacy of cancer therapy...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542094/septic-hyperinflammation-is-there-a-role-for-extracorporeal-blood-purification-techniques
#18
REVIEW
Dominik Jarczak, Stefan Kluge, Axel Nierhaus
This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis characterized by an uncontrolled immune response leading to multiorgan dysfunction. We provide an overview of sepsis, focusing on the dynamics of immune response, the involvement of neutrophils, and the role of the endothelium in the disease's progression. It evaluates the effectiveness of various blood purification methods, including high-cut-off membranes, high-volume hemofiltration, adsorption techniques, and albumin dialysis, in removing cytokines and endotoxin and improving hemodynamic stability...
March 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541968/renal-al-amyloidosis-updates-on-diagnosis-staging-and-management
#19
REVIEW
Areez Shafqat, Hassan Elmaleh, Ali Mushtaq, Zaina Firdous, Omer Ashruf, Debduti Mukhopadhyay, Maheen Ahmad, Mahnoor Ahmad, Shahzad Raza, Faiz Anwer
AL amyloidosis is caused by the excessive production of nonfunctional immunoglobulins, leading to the formation of amyloid fibrils that damage vital organs, especially the heart and kidneys. AL amyloidosis presents with non-specific symptoms such as fatigue, weight loss, numbness, pain, and nephrotic syndrome. Consequently, diagnosis is often delayed, and patients typically present with advanced disease at diagnosis. The Pavia renal staging model stratifies patients based on their likelihood of progressing to dialysis...
March 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541824/thrombotic-microangiopathy-as-a-life-threatening-complication-of-long-term-interferon-beta-therapy-for-multiple-sclerosis-clinical-phenotype-and-response-to-treatment-a-literature-review
#20
REVIEW
Marco Allinovi, Tommaso Mazzierli, Selene Laudicina, Luisa Pastò, Emilio Portaccio, Maria Pia Amato, Giorgio Trivioli
Thrombotic microangiopathy (TMA) has been observed in some patients receiving interferon beta (IFNβ) therapy for relapsing-remitting multiple sclerosis, but little is known about its clinical features and outcomes. We searched the literature to identify cases with IFNβ-related TMA and assessed their pattern of organ involvement, the presence of prodromal manifestations, the treatments used, and the outcomes. Thirty-five articles met the inclusion criteria, and data of 67 patients were collected...
March 11, 2024: Journal of Clinical Medicine
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