Jefferson A Proaño-Zamudio, Dias Argandykov, Anthony Gebran, Angela Renne, Charudutt N Paranjape, Stephanie J Maroney, Louisa Onyewadume, Haytham M A Kaafarani, David R King, George C Velmahos, John O Hwabejire
INTRODUCTION: Elderly patients are frequently presenting with emergency surgical conditions. The open abdomen technique is widely used in abdominal emergencies needing rapid control of intrabdominal contamination. However, specific predictors of mortality identifying candidates for comfort care are understudied. METHODS: The 2013-2017 the American College of Surgeons-National Surgical Quality Improvement Program database was queried for emergent laparotomies performed in geriatric patients with sepsis or septic shock in whom fascial closure was delayed...
March 16, 2023: Journal of Surgical Research
Peter J Apel, Brian A Cripe, Mark W Schmitt, Noah J Orfield, Alicia J Lozano, Alexandra L Hanlon, Anthony E Capito
PURPOSE: Digital amputation is a commonly performed procedure for infection and necrosis in patients with diabetes, peripheral vascular disease (PVD), and on dialysis. There is a lack of data regarding prognosis for revision amputation and mortality following digital amputation in these patients. METHODS: All digital amputations over 10-year period (2008-2018) at a single center were reviewed. There were 484 amputations in 360 patients, among which 358 were performed for trauma (reference sample) and 126 for infection or necrosis (sample of interest)...
March 15, 2023: Journal of Hand Surgery
Brian Lewis, Daniel Brooks, Christopher Dion, Courtney Schwebach
A 53-year-old man died following a reported ingestion of 80 g of his metformin tablets resulting in severe, refractory shock and metformin-associated lactic acidosis. His peak serum metformin concentration was 53 μg/mL (therapeutic range 1-2 μg/mL), peak lactic acid concentration was 49.7 mmol/L, and arterial pH nadir was 7.06. He died despite vasopressors and renal replacement therapy [RRT; both intermittent hemodialysis (IHD) and continuous venovenous hemodiafiltration (CVVHDF)]. Serial metformin concentrations during CVVHDF suggested a half-life of 33-h...
March 2, 2023: American Journal of Emergency Medicine
Serhan Tuğlular, Valerie Luyckx, Raymond Vanholder, Andrej Skoberne, Andrzej Wiecek, İonut Nistor, Ewa Pawlowicz-Szlarska, Rukshana Shroff, Dymtro Ivanov, Kai-Uwe Eckardt, Edita Noruisiene, Daniel Gallego, Olena Loboda, Mehmet S Sever
People living with kidney disease are among the most vulnerable groups at the time of natural or man-made disasters. In addition to their unpredictable course, armed-conflicts impose a major threat given disruption of infrastructure, sanitation, access to food, water, and medical care. The ongoing war in Ukraine has once more demonstrated the importance of preparedness, organization, coordination and solidarity during disasters. People living with kidney disease face serious challenges given their dependence on life-saving treatment, irrespective of whether they remain in the war zone, or are displaced internally or externally...
March 17, 2023: Nephrology, Dialysis, Transplantation
Ashlee Stutsrim, Lucas Hunter, Cullen McCarthy, Zachary German, Timothy Craven, Donna Keith, Gabriela Velazquez-Ramirez, Matthew Edwards
INTRODUCTION: The purpose of this study is to provide an updated description of demographics, technical details and clinical outcomes of 101 consecutive branch renal artery repairs in 98 patients using cold perfusion. METHODS: Single institution, retrospective analysis branch renal artery reconstructions performed between 1987 and 2019. RESULTS: Patients were predominantly Caucasian (80.6%) women (74.5%) with mean age of 46.8 ± 15.3 years...
March 15, 2023: Journal of Vascular Surgery
Cuneyt Köksoy, Kimberly Rebello, Susan Y Green, Hiruni S Amarasekara, Marc R Moon, Scott A LeMaire, Joseph S Coselli
OBJECTIVE: We aimed to identify outcomes and factors that independently associate with early mortality after open repair of Crawford extent IV thoracoabdominal aortic aneurysms (TAAAs), defined as aneurysms confined to the segment below the diaphragm. METHODS: This retrospective analysis included 721 extent IV TAAA repairs performed in our institution from 1986 to 2021. Indications for repair were aneurysm without dissection in 627 cases (87.0%) and aortic dissection in 94 (13...
March 15, 2023: Journal of Thoracic and Cardiovascular Surgery
Ebun L Bamgboye, Manjusha Yadla, Guillermo Garcia-Garcia, Vincent Boima, Privilage D Makanda-Charambira, Mignon I McCulloch, Dwomoa Adu
In the absence of malignancy or other severe comorbidity, kidney transplantation offers better survival rates and quality of life than dialysis. Despite this survival advantage, many lower- and upper-middle-income countries do not offer adequate kidney transplant services. This is particularly troubling because end-stage kidney disease often is more common in these countries than in high-income countries and overall is less costly in the life of a patient. We describe the contrasting levels of provision of kidney transplantation in Mexico, India, Nigeria, Ghana, and Zimbabwe, and kidney transplant services for children in Africa...
March 15, 2023: Seminars in Nephrology
Victor Pope, Varunaavee Sivashanmugathas, Dirusha Moodley, Lakshman Gunaratnam, Lillian Barra
BACKGROUND: End-stage kidney disease (ESKD) is associated with poor prognosis in patients with anti-neutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This study summarizes the existing evidence regarding outcomes in AAV patients with ESKD on renal replacement therapy. METHODS: Searches of the MEDLINE and Embase databases were performed from inception until December 2021. Any study reporting outcomes after ESKD in patients with AAV on haemodialysis or peritoneal dialysis was included...
March 11, 2023: Seminars in Arthritis and Rheumatism
Michael Eder, Lisabeth Pimenov, Georg A Böhmig, Barbara Kornek, Lisa Göschl, Gregor Bond, Matthias G Vossen, Winfried F Pickl, Monika Breuer, Irene Görzer, Nicolas Kozakowski, Hermann Laferl, Stefan Winkler
No abstract text is available yet for this article.
March 17, 2023: Journal of Nephrology
Hang Fang, Qiankun Zhang, Lie Jin
β-2 microglobulin, a light chain in the major histocompatibility complex Class 1 molecule, is associated with mortality in dialysis or uremic patients. Current evidence on the relationship between beta-2-microglobulin (B2M) and mortality in the general and non-chronic kidney disease (CKD) population are limited and controversial. Data from the nutrition and health examination survey database and the nutrition and health examination survey linked mortality file were used. In total, 10,388 adults who had complete data for B2M were included...
March 17, 2023: Medicine (Baltimore)
Takamasa Miyauchi, Hiroki Nishiwaki, Aya Mizukami, Masahiko Yazawa
INTRODUCTION: This systematic review and meta-analysis examined the relationship between hyponatremia and worse outcomes in patients undergoing maintenance hemodialysis. METHODS: The MEDLINE, EMBASE, CENTRAL, and Web of Science databases were used to search for relevant articles. The target population was patients on maintenance hemodialysis (those undergoing hemodialysis for ≥60 days). The defined outcomes were death, cardiovascular disease, cognitive decline, and falls...
March 16, 2023: Seminars in Dialysis
Giuseppina Spartà, Karine Hadaya, Luc Paunier, Eric Girardin, Ernst Leumann
BACKGROUND: Kidney transplantation in children in 1970 was considered by many to be unethical, as long-term survival was minimal. It was therefore risky at the time to offer transplantation to a child. CASE DIAGNOSIS/TREATMENT: A 6-year-old boy with kidney failure due to haemolytic uraemic syndrome received 4 months of intermittent peritoneal dialysis followed by 6 months of haemodialysis until at 6 years and 10 months, he underwent bilateral nephrectomy and received a kidney transplant from a deceased 18-year-old donor...
March 16, 2023: Pediatric Nephrology
Peter Nourse, Mignon McCulloch, Ashton Coetzee, Tim Bunchman, Stefano Picca, Jody Rusch, Andre Brooks, Hilton Heydenrych, Brenda Morrow
BACKGROUND: Our previously demonstrated continuous flow peritoneal dialysis (CFPD) technique in children with acute kidney injury (AKI), although effective, was manpower heavy and expensive due to the high-volume pumps required. The aim of this study was to develop and test a novel gravity-driven CFPD technique in children using readily available, inexpensive equipment and to compare this technique to conventional PD. METHODS: After development and initial in vitro testing, a randomised crossover clinical trial was conducted in 15 children with AKI requiring dialysis...
March 16, 2023: Pediatric Nephrology
Christian Combe, Sébastien Rubin
No abstract text is available yet for this article.
March 16, 2023: Nephrology, Dialysis, Transplantation
Waranya Rattanavipapong, Chittawan Poonsiri, Wanrudee Isaranuwatchai, Sopon Iamsirithaworn, Jutarat Apakupakul, Chaninan Sonthichai, Rungrueng Kitphati, Yot Teerawattananon
BACKGROUND AND AIMS: The introduction of Coronavirus disease 2019 (COVID-19) vaccines urged all Thais to seek prevention of serious illness and death from COVID-19. However, immunocompromised individuals might not be able to achieve an efficient immune response from these vaccines. This study aimed to evaluate the cost-effectiveness and budget impact of introducing Evusheld (tixagevimab plus cilgavimab) for three patient groups-organ transplant, autoimmune disease, and dialysis patients, from the Thai government perspective...
March 16, 2023: Applied Health Economics and Health Policy
Kelsey Muir, Ahad Firoz, Mohammed A Kashem, Norihisa Shigemura, Yoshiya Toyoda
There is an established association between red blood cell (RBC) transfusion and increased mortality and morbidity in cardiac surgery; however, there is little data demonstrating the influence of blood transfusion while awaiting lung transplantation. Therefore, our study compared the impact of pretransplant RBC transfusion on patient survival and post-transplantation adverse events. Adult lung transplant patient data were extracted retrospectively using the United Network for Organ Sharing thoracic database...
March 16, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Pei-Hua He, Li-Chang Liu, Xing-Fu Zhou, Jun-Jie Xu, Wei-Hong Hong, Li-Chun Wang, Su-Jun Liu, Jia-Hao Zeng
BACKGROUND: IgG4-related disease (IgG4-RD) is a chronic fibrotic disease mediated by immunity recognized by clinicians in recent years. When the kidney is involved, it is called IgG4-related kidney disease (IgG4-RKD). IgG4-related tubulointerstitial nephritis (IgG4-TIN) is a representative manifestation of IgG4-RKD. IgG4-TIN can cause obstructive nephropathy complicated by retroperitoneal fibrosis (RPF). Cases of IgG4-TIN complicated with RPF are rare. Glucocorticoids are the first-line therapeutic medication for IgG4-RD and can significantly improve renal function...
March 6, 2023: World Journal of Clinical Cases
Renata Sledge, Beatrice P Concepcion, Beth Witten, Kristi Klicko, Dori Schatell
RATIONALE & OBJECTIVE: Patients with kidney failure who have used multiple treatment modalities are a unique source of information for how different options may best fit their values. We aimed to understand how people interpret their health and kidney failure treatment experience to inform providers who facilitate shared decision-making conversations. STUDY DESIGN: This qualitative, interpretive phenomenological study explores how patients with kidney failure interpret health throughout their treatment trajectory...
April 2023: Kidney medicine
Yanli Wang, Yuxiang Bai, Jingjing Dong, Jialin Liu, Zhengyu Jin
Highly branched α-glucan (HBAG) proved to be a promising material as an osmotic agent in peritoneal dialysis solutions. However, high resistance of HBAG to amylolytic enzymes might be a potential drawback for peritoneal dialysis due to its high degree of branching (20-30 %). To address this issue, we designed a small-clustered α-glucan (SCAG) with a relatively low molecular weight (Mw) and limited branching. Structural characteristics revealed that SCAG was successfully synthesized by modifying waxy rice starch (WRS) using sequential maltogenic α-amylase (MA) and starch branching enzyme (BE)...
June 15, 2023: Carbohydrate Polymers
Jorge Correia, Bernardo Teixeira, Gonçalo Mendes, Avelino Fraga, Miguel Silva-Ramos
INTRODUCTION: Kidney transplantation requires immunosuppression, traditionally regarded as a risk factor for progression in all malignancies. Based on the Cincinnati Registry, a waiting period before transplantation is therefore mandatory. However, recent evidence suggests this increased risk is restricted to particular tumors, whereas others like renal cell carcinoma (RCC) are not negatively affected. We aimed to compare oncological outcomes of RCC in native kidneys of end-stage renal disease (ESRD) patients, according to their transplantation or dialysis status...
March 15, 2023: Archivio Italiano di Urologia, Andrologia
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