Xiaoyang Zhou, Pingping Dong, Jianneng Pan, Hua Wang, Zhaojun Xu, Bixin Chen
PURPOSE: This network meta-analysis aims to compare the efficacy and safety of various renal replacement therapy (RRT) modalities in critically ill patients with acute kidney injury (AKI). MATERIALS AND METHODS: We searched the electronic databases for randomized controlled trials (RCTs) comparing different RRT modalities, including continuous RRT, intermittent RRT, hybrid RRT, and peritoneal dialysis (PD), in critically ill patients with AKI through July 26, 2020...
March 25, 2021: Journal of Critical Care
Thiago Reis, Siddiq Anwar, Francisco de Assis da Rocha Neves, Claudio Ronco
In the past decade, a new class of hemodialysis (HD) membranes (high retention onset class) became available for clinical use. The high cutoff (HCO) and the medium cutoff (MCO) membranes have wider pores and more uniformity in pore size, allowing an increased clearance of uremic toxins. Owing to the mechanism of backfiltration/internal filtration, middle molecules are dragged by the convective forces, and no substitution solution is needed. The HCO dialyzer is applied in septic patients with acute kidney injury requiring continuous kidney replacement therapy...
April 9, 2021: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Inah Maria D Pecly, Rafael B Azevedo, Elizabeth S Muxfeldt, Bruna G Botelho, Gabriela G Albuquerque, Pedro Henrique P Diniz, Rodrigo Silva, Cibele I S Rodrigues
Kidney impairment in hospitalized patients with SARS-CoV-2 infection is associated with increased in-hospital mortality and worse clinical evolution, raising concerns towards patients with chronic kidney disease (CKD). From a pathophysiological perspective, COVID-19 is characterized by an overproduction of inflammatory cytokines (IL-6, TNF-alpha), causing systemic inflammation and hypercoagulability, and multiple organ dysfunction syndrome. Emerging data postulate that CKD under conservative treatment or renal replacement therapy (RRT) is an important risk factor for disease severity and higher in-hospital mortality amongst patients with COVID-19...
April 9, 2021: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Thomas J Wilkinson, Katherine Memory, Courtney J Lightfoot, Jared Palmer, Alice C Smith
BACKGROUND: Patient activation describes the knowledge, skills and confidence in managing one's own health. Promoting patient activation is being prioritized to reduce costs and adverse outcomes such as cardiovascular disease (CVD). The increasing prevalence of chronic kidney disease (CKD) presents a need to understand the characteristics that influence patient activation and the effect on health outcomes. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: Patients with non-dialysis CKD recruited from 14 sites (general nephrology and primary care) in England, UK...
April 9, 2021: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
Nazanin Falconer, Ahmad Abdel-Hafez, Ian A Scott, Sven Marxen, Stephen Canaris, Michael Barras
AIM: To identify and critically appraise studies of prediction models, developed using machine learning (ML) methods, for determining the optimal dosing of unfractionated heparin (UFH). METHODS: Embase, PubMed, CINAHL, Web of Science, International Pharmaceutical Abstracts and IEEE Xplore databases were searched from inception to 31 January 2020 to identify relevant studies using key search terms synonymous with artificial intelligence or ML, 'prediction', 'dose', 'activated partial thromboplastin time (aPTT)' and 'UFH...
April 9, 2021: British Journal of Clinical Pharmacology
Jessica L Stahl, Russell S Whelan, Jordan M Symons
BACKGROUND: Current guidelines for initiation of kidney replacement do not include specific recommendations for prescription parameters and monitoring. CASE OUTLINE: A 16-year-old girl presented with kidney failure with creatinine of 19.8 mg/dL and BUN of 211 mg/dL. She initiated continuous kidney replacement therapy (CKRT) with clearance of 1,300 mL/min/1.73 m2 which was increased to 1,950 mL/min/1.73 m2 at 17 h of stable therapy. COMPLICATIONS: At 31 h of therapy, she developed generalized seizure activity...
April 9, 2021: Pediatric Nephrology
Caroline M Hsu, Haris Murad, Kathleen Neuendorf, Tianming Gao, Jesse D Schold, Fahad Saeed
BACKGROUND: The majority of dialysis patients receive aggressive burdensome treatment near the end of life. Currently, we lack interventions to improve end-of-life care (EoLC) for these patients. We examined the association of palliative care consultation with improving EoLC for critically ill patients with end-stage renal disease (ESRD) who received cardiopulmonary resuscitation (CPR). MATERIALS AND METHODS: In this retrospective study, we included patients with ESRD admitted to a large academic center who received CPR either prior to or during their hospital stay...
April 9, 2021: Clinical Nephrology
Hila Soetendorp, Orit Kliuk-Ben Bassat, Asaf Wasserman, Doron Schwartz, Rachila Bedbalayev, Inna Faukman, Ayelet Grupper
AIM: Infection is one of the drawbacks associated with peritoneal dialysis (PD) and is related to significant morbidity. After we experienced an increase in exit-site infection (ESI) rate, mostly derived from environmental and water-derived organisms, we hypothesized that preventing exit-site exposure to water and narrowing local antibiotics range will reduce colonization and subsequent infection. MATERIALS AND METHODS: In this study, we aimed to estimate PD-related infections after exit-site policy change in a prospective study cohort of 27 participants compared to a control group of 58 participants...
April 9, 2021: Clinical Nephrology
Panagiotis M Kitrou, Tobias Steinke, Rami El Hage, Pedro Ponce, Pierleone Lucatelli, Konstantinos Katsanos, Stavros Spiliopoulos, Alessio Spinelli, Theodosios Bisdas, Konstantinos Stavroulakis, Ounali Jaffer, Alexandros Mallios, Simone Zilahi de Gyurgyokai, Roberto Cancellieri, Raphael Coscas, Dimitrios Karnabatidis
INTRODUCTION: This was a European, multicenter, investigator-initiated and run, single-arm retrospective analysis to assess the safety and the clinical benefit of the use of paclitaxel-coated balloon (PCB) for the treatment of symptomatic central venous stenosis (CVS). MATERIALS AND METHODS: Eleven centers from 7 countries across Europe, submitted 86 cases performed during the period between October 2015 and June 2018. Minimum follow-up was 6 months. Patient baseline demographics and procedural details were collected...
April 9, 2021: Journal of Endovascular Therapy
Yuhang Fu, Xusheng Xie, Yongfeng Wang, Jian Liu, Zhaozhu Zheng, David Lee Kaplan, Xiaoqin Wang
Microalgae immobilized in hydrogels offer advantages over those cultured in suspension culture in terms of carbon fixation and oxygen emission. However, alginate as a commonly used hydrogel for microalgal immobilization encounters problems with mechanical strength and stability. To address this limitation, silk fibroin (silk) hydrogels prepared by ultrasonication were utilized to host microalgae when mixed with the presonicated protein solution prior to its gelation. The gelation time, stability, and light transmission of these silk gels were evaluated, and a silk concentration of 4% w/v and a gel thickness of 1 mm provided mechanical strength and stability during algal culture in comparison to alginate hydrogels...
April 9, 2021: ACS Biomaterials Science & Engineering
Daniela Gouveia, José Máximo, Nuno Costa, Soraia Moreira, Armando Abreu, Paulo Pinho, Jorge Casanova
OBJECTIVES: Our objective was to examine the results of ECMO post cardiotomy in Centro Hospitalar Universitário S. João (CHUSJ). METHODS: Between 2011 and 2019, 13 patients were cannulated for refractory cardiogenic shock post-cardiotomy; 8 (61,5%) male and 5 (38,5%) female. Patients under 18 years old were excluded. Data was collected from hospital archives concerning preoperative comorbidities, open-heart surgery procedure, dates of ECMO cannulation and decannulation, postoperative complications, hospital mortality and cause of death...
April 8, 2021: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Yan Zhou, Kevin Freeman, Vincent Setola, Danni Cao, Shane Kaski, Mary Jeanne Kreek, Lee-Yuan Liu-Chen
Nalfurafine has been used clinically in Japan for treatment of itch in kidney dialysis patients and in patients with chronic liver diseases. A one-year post-marketing study showed nalfurafine to be safe and efficacious without producing side effects of typical KOR agonists such as anhedonia and psychotomimesis. In this chapter, we summarize in vitro characterization and in vivo preclinical studies on nalfurafine. In vitro, nalfurafine is a highly potent and moderately selective KOR full agonist; however, whether it is a biased KOR agonist is a matter of debate...
April 9, 2021: Handbook of Experimental Pharmacology
Dan Luo, Wenbo Zhao, Zhiming Lin, Jianhao Wu, Hongchun Lin, Yongjie Li, Jun Song, Jun Zhang, Hui Peng
Gut microbiota alterations occur in end-stage renal disease (ESRD) patients with or without dialysis. However, it remains unclear whether changes in gut microbiota of dialysis ESRD patients result from dialysis or ESRD, or both. Similarly, there is a dearth of information on the relationship between gut microbiota and ESRD prognoses. We collected fecal samples and tracked clinical outcomes from 73 ESRD patients, including 33 pre-dialysis ESRD patients, 19 peritoneal dialysis (PD) patients, and 21 hemodialysis (HD) patients...
2021: Frontiers in Cellular and Infection Microbiology
Eric D Weinhandl, James B Wetmore, Yi Peng, Jiannong Liu, David T Gilbertson, Kirsten L Johansen
BACKGROUND: Reports from around the world have indicated a fatality rate of patients with coronavirus disease 2019 (COVID-19) in the range of 20%-30% among patients with ESKD. Population-level effects of COVID-19 on patients with ESKD in the United States are uncertain. METHODS: We identified patients with ESKD from Centers for Medicare and Medicaid Services data during epidemiologic weeks 3-27 of 2017-2020 and corresponding weeks of 2017-2019, stratifying them by kidney replacement therapy...
April 8, 2021: Journal of the American Society of Nephrology: JASN
Takeo Furuya, Masashi Yamazaki, Tetsuharu Nemoto, Akihiko Okawa, Seiji Ohtori
BACKGROUND: Mayfield skull clamps are widely used and indispensable in current neurosurgery. Complications such as skull fractures or intracranial hematoma from using a Mayfield skull clamp have largely been reported in the pediatric population, are likely related to the relative thinness of the skull, such as in patients with hydrocephalus, and are extremely rare in adults. Here, we report a case of skull fracture and epidural hematoma caused by a Mayfield skull clamp used for posterior decompression surgery in an adult patient with chronic hemodialysis...
April 9, 2021: Journal of Medical Case Reports
Peter Bergin, Aoife Leggett, Chris R Cardwell, Jayne V Woodside, Ammarin Thakkinstian, Alexander P Maxwell, Gareth J McKay
BACKGROUND: Haemodialysis (HD) patients tend to have higher levels of oxidative stress (OS), associated with increased morbidity and premature mortality, compared to the general population. Levels of malondialdehyde (MDA), a biomarker of OS, are reduced by the antioxidant properties of vitamin E (VE) but outcomes from randomised control trials of VE supplementation on MDA in HD patients have been inconsistent. METHODS: We undertook a systematic review and meta-analysis of adult HD patients from VE supplementation studies with measures of MDA...
April 9, 2021: BMC Nephrology
Sihyung Park, Bong Soo Park, Yoo Jin Lee, Il Hwan Kim, Jin Han Park, Junghae Ko, Yang Wook Kim, Kang Min Park
BACKGROUND: Artificial intelligence (AI) has had a significant impact on our lives and plays many roles in various fields. By analyzing the past 30 years of AI trends in the field of nephrology, using a bibliography, we wanted to know the areas of interest and future direction of AI in research related to the kidney. METHODS: Using the Institute for Scientific Information Web of Knowledge database, we searched for articles published from 1990 to 2019 in January 2020 using the keywords AI; deep learning; machine learning; and kidney (or renal)...
April 9, 2021: Medicine (Baltimore)
Zülfünaz Özer, Sebahat Ateş
This study evaluates the effects of "laughter yoga" on the plasma beta-endorphin levels, pain levels and sleep quality of hemodialysis patients. It is a randomized controlled trial. The study was carried out between July and October 2018. A total of 68 patients receiving hemodialysis treatment at two different dialysis centers were included in the study. The duration of the laughter yoga was 30 min, and a total of 16 sessions were performed on a twice-weekly basis. The data were collected by using a socio-demographic information form, the Visual Analog Scale and the Pittsburgh Sleep Quality Index, and blood samples were collected to determine beta-endorphin levels...
April 2, 2021: Complementary Therapies in Clinical Practice
Benjamin J Pomy, Ethan S Rosenfeld, Salim Lala, K Benjamin Lee, Andrew D Sparks, Richard L Amdur, John J Ricotta, Anton N Sidawy, Robyn A Macsata, Bao-Ngoc Nguyen
TYPE OF RESEARCH: Retrospective NSQIP database review KEY FINDINGS:: Comparison of FEVAR vs OSR for juxtarenal abdominal aortic aneurysms in patients with renal disease showed similar 30-day mortality. However, FEVAR was associated with fewer renal and pulmonary complications compared to OSR. TAKE HOME MESSAGE: FEVAR is better for patients with chronic renal insufficiency due to decreased renal and pulmonary complications. Table of Contents Summary This retrospective NSQIP review evaluated 30-day outcomes between fenestrated endovascular aneurysm repair vs open surgical repair of juxta-renal aortic aneurysms (JAAA) in patients with chronic renal insufficiency...
April 5, 2021: Annals of Vascular Surgery
Kai Zhao, Joy Obayemi, Mary Ann C Lim, Grace Wang, Ali Naji
Renal artery aneurysms (RAA) are rare and challenging to repair. We present a case of a 48-year-old female with solitary right kidney who had complex aneurysms near the renal hilum. CT angiogram showed fibromuscular dysplasia (FMD) features of the renal artery and 2 saccular aneurysms measuring 2.3 cm and 1 cm. An additional small lower pole renal artery added to the complexity of the case. Ex-vivo aneurysm repair was performed after the kidney was removed and flushed with preservation solution. This was followed by auto-transplantation to the right external iliac vessels...
April 5, 2021: Annals of Vascular Surgery
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