Sripal Bangalore, David J Maron, Sean M O'Brien, Jerome L Fleg, Evgeny I Kretov, Carlo Briguori, Upendra Kaul, Harmony R Reynolds, Tomasz Mazurek, Mandeep S Sidhu, Jeffrey S Berger, Roy O Mathew, Olga Bockeria, Samuel Broderick, Radoslaw Pracon, Charles A Herzog, Zhen Huang, Gregg W Stone, William E Boden, Jonathan D Newman, Ziad A Ali, Daniel B Mark, John A Spertus, Karen P Alexander, Bernard R Chaitman, Glenn M Chertow, Judith S Hochman
BACKGROUND: Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease. METHODS: We randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia on stress testing to be treated with an initial invasive strategy consisting of coronary angiography and revascularization (if appropriate) added to medical therapy or an initial conservative strategy consisting of medical therapy alone and angiography reserved for those in whom medical therapy had failed...
March 30, 2020: New England Journal of Medicine
John A Spertus, Philip G Jones, David J Maron, Daniel B Mark, Sean M O'Brien, Jerome L Fleg, Harmony R Reynolds, Gregg W Stone, Mandeep S Sidhu, Bernard R Chaitman, Glenn M Chertow, Judith S Hochman, Sripal Bangalore
BACKGROUND: In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of <30 ml per minute per 1...
March 30, 2020: New England Journal of Medicine
Arjan van der Tol, Vianda S Stel, Kitty J Jager, Norbert Lameire, Rachael L Morton, Wim Van Biesen, Raymond Vanholder
BACKGROUND: We compare reimbursement for haemodialysis (HD) and peritoneal dialysis (PD) in European countries to assess the impact on government healthcare budgets. We discuss strategies to reduce costs by promoting sustainable dialysis and kidney transplantation. METHODS: This was a cross-sectional survey among nephrologists conducted online July-December 2016. European countries were categorized by tertiles of gross domestic product per capita (GDP). Reimbursement data were matched to kidney replacement therapy (KRT) data...
March 30, 2020: Nephrology, Dialysis, Transplantation
Grecia Marrufo, Erin Murphy Colligan, Brighita Negrusa, Darin Ullman, Joe Messana, Anand Shah, Tom Duvall, Richard A Hirth
Importance: Medicare beneficiaries with end-stage renal disease (ESRD) are a medically complex group accounting for less than 1% of the Medicare population but more than 7% of Medicare fee-for-service payments. Objective: To evaluate the association of the Comprehensive End-Stage Renal Disease Care (CEC) model with Medicare payments, health care use, and quality of care. Design, Setting, and Participants: In this economic evaluation, a difference-in-differences design estimated the change in outcomes for 73 094 Medicare fee-for-service beneficiaries aligned to CEC dialysis facilities between the baseline (from January 2014 to March 2015) and intervention periods (from October 2015 to December 2017) relative to 60 464 beneficiaries at matched dialysis facilities...
March 30, 2020: JAMA Internal Medicine
Carlucci Gualberto Ventura, Felício Lopes Roque, Itanilton Queiroz de Sousa, Renata Desordi Lobo, Claudio Luders
INTRODUCTION: Chronic hemodialysis (HD) patients are considered to be at high risk for infection. Here, we describe the clinical outcomes of chronic HD patients with influenza A (H1N1) infection and the strategies adopted to control an outbreak of influenza A in a dialysis unit. METHODS: Among a total of 62 chronic HD patients, H1N1 infection was identified in 12 (19.4%). Of the 32 staff members, four (12.5%) were found to be infected with the H1N1 virus. Outcomes included symptoms at presentation, comorbidities, occurrence of hypoxemia, hospital admission, and clinical evaluation...
March 23, 2020: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Kyriakos Atmatzidis, Farbod Alimohammadi, Daniel R Strongin, Rouzbeh Tehrani
The use of nanomaterials has transformed fields such as medicine and electronics. However, aggregation of nanomaterials in aqueous solutions, difficult recovery of spent nano-adsorbents from reactors, and a tremendous pressure loss caused by nano-adsorbents in adsorption columns have prevented the wide-scale use of nano-adsorbents in industrial applications for water purification. An over-reliance on traditional adsorption media for fluid purification practices has slowed innovation in this field. This study serves as a proof of concept for a new approach in utilizing nano-adsorbents in water treatment...
March 24, 2020: ACS Omega
Geertje J Dreyer, Johan W de Fijter
Worldwide over 40% of patients receiving renal replacement therapy (RRT) are aged 65 years or older, a number that is still increasing. Renal transplantation is the preferred RRT, providing substantial survival benefit over those remaining on dialysis, including the elderly. Only 3% of patients aged 65 years or older accepted on the waiting list actually received a kidney transplant offer within the Eurotransplant allocation region. To increase the chance for elderly to receive a timely kidney transplant, the Eurotransplant Senior Program was introduced...
2020: Frontiers in Immunology
Elena Rodríguez-Sánchez, José Alberto Navarro-García, Jennifer Aceves-Ripoll, Judith Abarca-Zabalía, Andrea Susmozas-Sánchez, Teresa Bada-Bosch, Eduardo Hernández, Evangelina Mérida-Herrero, Amado Andrés, Manuel Praga, Mario Fernández-Ruiz, José María Aguado, Julián Segura, Luis Miguel Ruilope, Gema Ruiz-Hurtado
Renal replacement therapy (RRT) is complicated by a chronic state of inflammation and a high mortality risk. However, different RRT modalities can have a selective impact on markers of inflammation and oxidative stress. We evaluated the levels of active matrix metalloproteinase (MMP)-9 in patients undergoing two types of dialysis (high-flux dialysis (HFD) and on-line hemodiafiltration (OL-HDF)) and in kidney transplantation (KT) recipients. Active MMP-9 was measured by zymography and ELISA before (pre-) and after (post-) one dialysis session, and at baseline and follow-up (7 and 14 days, and 1, 3, 6, and 12 months) after KT...
March 26, 2020: Biomolecules
Juan D Echeverri, Maria J Alhajj, Nicolle Montero, Cristhian J Yarce, Alvaro Barrera-Ocampo, Constain H Salamanca
In the past decade, pharmaceutical nanotechnology has proven to be a promising alternative for improving the physicochemical and biopharmaceutical features for conventional pharmaceutical drug formulations. The goal of this study was to develop, characterize, and evaluate the in vitro and in vivo release of the model drug carbamazepine (CBZ) from two emulsified formulations with different droplet sizes (coarse and nanometric). Briefly, oil-in-water emulsions were developed using (i) Sacha inchi oil, ultrapure water, TweenTM 80, and SpanTM 80 as surfactants, (ii) methyl-paraben and propyl-paraben as preservatives, and (iii) CBZ as a nonpolar model drug...
March 26, 2020: Pharmaceuticals
Go Aoki, Aiko Sawazaki, Kazuo Notsumata, Yasuyuki Ushiogi, Kazuhiro Okafuji, Daishu Toya
A 78-year-old man was hospitalized because of rapid progression of chronic renal failure and diagnosed with multiple myeloma (MM) IgG-λ type ISS-III R-ISS-II with complex karyotype including t(14;19). Even after receiving bortezomib-based regimens, his renal failure progressed. He became dependent on dialysis, which was required three times a week. After introducing the daratumumab (DARA)-based regimen, his renal function improved, the frequency of dialysis decreased to twice a week, and the free light chain (FLC) ratio also improved...
2020: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Sandra Ortega Ugalde, Kerstin Wallraven, Alexander Speer, Wilbert Bitter, Tom N Grossmann, Jan N M Commandeur
Tuberculosis (TB) is a globally significant infective disease that is caused by a single infectious agent, Mycobacterium tuberculosis (Mtb). Because of the rise in the number of multidrug-resistant (MDR) TB strains, identification of alternative drug targets for the development of drugs with different mechanism of actions is desired. CYP121A1, one of the twenty cytochrome P450 enzymes encoded in the Mtb genome, was previously shown to be essential for bacterial growth. This enzyme catalyzes the intramolecular C-C crosslinking reaction of the cyclopeptide cyclo(L-tyr-L-tyr) (cYY) yielding the metabolite mycocyclosin...
March 26, 2020: Biochemical Pharmacology
Ko Chiba, Ryoichi Suetoshi, Dorian Cretin, Tatsuo Arai, Takeshi Kawajiri, Akira Okayama, Shotaro Tsuji, Narihiro Okazaki, Makoto Osaki, Kosei Yoh
INTRODUCTION: The objectives of this study were to identify what is reflected in cortical speed of sound (cSOS) measured by a cortical quantitative ultrasound (cortical QUS) device we have developed, and to investigate cSOS measurements in healthy individuals and dialysis patients. METHODS: The cSOS and the SOS were measured by cortical QUS and conventional QUS in 20 volunteers, and the correlations between these measurements and areal bone mineral density measured by dual-energy X-ray absorptiometry and bone microstructural parameters on high-resolution peripheral quantitative computed tomography were analyzed...
February 18, 2020: Journal of Clinical Densitometry
Dayana Bitencourt Dias, Marcela Lara Mendes, Jacqueline Teixeira Caramori, Pâmela Falbo Dos Reis, Daniela Ponce
BACKGROUND: Few studies have evaluated the viability and outcomes between peritoneal dialysis (PD) and haemodialysis (HD) in urgent-start renal replacement therapy (RRT). This study aimed to compare infectious and mechanical complications related to urgent-start PD and HD. Secondary outcomes were to identify risk factors for complications and mortality related to urgent-start dialysis. METHODS: A quasi-experimental study with incident patients receiving PD and HD in a Brazilian university hospital, between July 2014 and December 2017...
March 30, 2020: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Jian Wang, Xiao-Sheng Li, Feng-Xia Zhang, Run-Xiu Wang, Feng Cao, Xian-Hu Tang, Xiao-Qing Chen, Bo Hong
A simple, noninvasive method for removing peritoneal dialysis (PD) catheters, called the "pull technique," has become popular in recent years. Physicians still worry, however, about the range of its application and possible complications such as infection of the retained cuff and breakage. We, therefore, applied this technique in patients and enriched its administration for removing PD catheters. Altogether, 24 PD catheter removals in 24 patients were reviewed during the period from July 2018 to October 2019 in our hospital...
March 30, 2020: Peritoneal Dialysis International
Ryosuke Fukuda, Mio Saito, Shiori Shibukawa, Ayumi Sumino, Minoru Nakano, Tatsuya Murakami
High-density lipoprotein (HDL) is a naturally occurring composite of lipids and lipid-binding proteins. The cholate dialysis method, first reported by Jonas in 1969, is the most widely used approach for reconstituting discoidal HDL (dHDL) in test tubes with phospholipids and the most dominant protein, Apolipoprotein A-1 (apoA-I). Here, we show that a dHDL-relevant complex can also be prepared by gently mixing 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and apoA-I or its mutants in ethanol/H2O solutions containing urea in the order of a few molar, and then incubating the mixture at the gel-liquid crystalline phase transition temperature in test tubes...
March 30, 2020: Biochemistry
Joanna Krajewska Wojciechowska, Wojciech Krajewski, Tomasz Zatoński
PURPOSE: Otorhinolaryngological abnormalities are common complications of chronic kidney disease (CKD) and its treatment. The main aim of this study was to provide a brief and precise review of the current knowledge regarding CKD and its treatment-related influence on head and neck organs. METHODS: The Medline and Web of Science databases were searched using the terms "chronic kidney disease", "kidney transplantation", "immunosuppression", "dialysis" in conjunction with "otorhinolaryngological manifestation"...
March 28, 2020: European Archives of Oto-rhino-laryngology
Antoney J Ferrey, Grace Choi, Ramy M Hanna, Yongen Chang, Ekamol Tantisattamo, Kaushik Ivaturi, Elisa Park, Lawrence Nguyen, Brian Wang, Sam Tonthat, Connie M Rhee, Uttam Reddy, Wei Ling Lau, Susan S Huang, Shruti Gohil, Alpesh N Amin, Lanny Hsieh, Timmy T Cheng, Richard A Lee, Kamyar Kalantar-Zadeh
Novel coronavirus disease 2019 (COVID-19) is a highly infectious, rapidly spreading viral disease with an alarming case fatality rate up to 5%. The risk factors for severe presentations are concentrated in patients with chronic kidney disease, particularly patients with end-stage renal disease (ESRD) who are dialysis dependent. We report the first US case of a 56-year-old nondiabetic male with ESRD secondary to IgA nephropathy undergoing thrice-weekly maintenance hemodialysis for 3 years, who developed COVID-19 infection...
March 28, 2020: American Journal of Nephrology
Dian Fu, Bo Yang, Jing Xu, Zhiguo Mao, Chenchen Zhou, Cheng Xue
Since December 2019, the epidemic of coronavirus disease 2019 (COVID-19) has spread very rapidly in China and worldwide. In this article, we report on a 75-year-old man infected with 2019 novel coronavirus who has end-stage kidney disease (ESKD). COVID-19 patients with ESKD need isolation dialysis, but most of them cannot be handled in time due to limited continuous renal replacement therapy (CRRT) machines. CRRT provided benefits for this patient by removing potentially damaging toxins and stabilizing his metabolic and hemodynamic status...
March 27, 2020: Nephron
Suzanne Watnick, Elizabeth McNamara
No abstract text is available yet for this article.
March 28, 2020: Clinical Journal of the American Society of Nephrology: CJASN
Qinglian Wang, Liang Xu, Xianzheng Zhang, Dan Liu, Rong Wang
Inflammation and fibrosis in peritoneal mesothelial cells caused by long-term peritoneal dialysis (PD) are the main reasons why patients withdraw from peritoneal dialysis treatment. However, the related mechanism is still unclear. In the current study, we revealed that the expression of EZH2 was positively related to EMT and fibrosis in an in vitro model using human peritoneal mesothelial cells (HPMCs) stimulated with high glucose. Moreover, EZH2 also exhibited a positive correlation with HIF-1α expression...
March 25, 2020: European Journal of Pharmacology
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