Venkata R Latha Gullapudi, Kelly White, Jill Stewart, Paul Stewart, Mohammed T Eldehni, Maarten W Taal, Nicholas M Selby
BACKGROUND: Higher beat-to-beat blood pressure (BP) variation during haemodialysis (HD) has been shown to be associated with elevated cardiac damage markers and white matter ischaemic changes in the brain suggesting relevance to end-organ perfusion. We aimed to characterize individual patterns of BP variation and associated haemodynamic responses to HD. METHODS: Fifty participants underwent continuous non-invasive haemodynamic monitoring during HD and BP variation were assessed using extrema point (EP) frequency analysis...
July 22, 2021: Blood Purification
Pablo E Pergola, Diogo Belo, Paul Crawford, Moustafa Moustafa, Wenli Luo, Alexander Goldfarb-Rumyantzev, Youssef M K Farag
INTRODUCTION: Ferric citrate (FC) is indicated as an oral iron replacement for iron deficiency anemia in adult patients with chronic kidney disease (CKD) not on dialysis. The recommended starting dose is one 1-g tablet three times daily (TID). This study investigated long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD (NDD-CKD). METHODS: In this phase 4, randomized, open-label, multicenter study, patients with anemia with NDD-CKD (estimated glomerular filtration rate, ≥20 mL/min and <60 mL/min) were randomized 1:1 to one FC tablet (1-g equivalent to 210 mg ferric iron) TID (3 g/day) or 2 tablets twice daily (BID; 4 g/day)...
July 22, 2021: American Journal of Nephrology
James B Wetmore, Heng Yan, Yi Peng, David T Gilbertson, Charles A Herzog
INTRODUCTION: While severe hyperkalemia is commonly encountered, its manifestation in hospitalized patients and related outcomes are unclear. We aimed to examine development of hyperkalemia in hospitalized patients and associated outcomes. METHODS: Data from a county hospital electronic health record were used to assess all inpatient admissions, 2012-2016, for non-dialysis-dependent patients with ≥1 K value for development of hyperkalemia. Unadjusted odds ratios (ORs) were calculated for associations of the maximum K value with in-hospital mortality and adjusted ORs were calculated for death associated with hyperkalemia...
July 19, 2021: American Heart Journal
Anna A Bonenkamp, Tiny Hoekstra, Marc H Hemmelder, Anita van Eck van der Sluijs, Alferso C Abrahams, Frans J van Ittersum, Brigit C van Jaarsveld
BACKGROUND: Although the number of patients with end stage kidney disease is growing, the number of patients that perform dialysis at home has decreased during the past two decades. The aim of this study is to explore time trends in the use of home dialysis in the Netherlands. METHODS: Dialysis episodes of patients who started dialysis treatment were studied using Dutch registry data (RENINE). The uptake of home dialysis between 1997 through 2016 was evaluated in time periods of 5 years...
July 22, 2021: European Journal of Clinical Investigation
Seok Hui Kang, A Young Kim, Jun Young Do
BACKGROUND: Few studies have considered optimal adjusted lean mass indices for prediction of clinical outcomes in peritoneal dialysis (PD) patients. We aimed to evaluate clinical variables using various adjusted indices in PD patients. METHODS: Total 528 incident PD patients were included. Lean mass was measured using dual energy X-ray absorptiometry. Appendicular lean mass (ALM) was calculated using the sum for both upper and lower extremities. Each ALM index was calculated using ALM per body weight (ALM/BW), height squared (ALM/Ht2), or body mass index (ALM/BMI)...
2021: PloS One
Tarek Abdel Latif Ghonimi, Mohamad Mahmood Alkad, Essa Abdulla Abuhelaiqa, Muftah M Othman, Musab Ahmed Elgaali, Rania Abdelaziz M Ibrahim, Shajahan M Joseph, Hassan Ali Al-Malki, Abdullah Ibrahim Hamad
CONTEXT: Patients on maintenance dialysis are more susceptible to COVID-19 and its severe form. We studied the mortality and associated risks of COVID-19 infection in dialysis patients in the state of Qatar. METHODS: This was an observational, analytical, retrospective, nationwide study. We included all adult patients on maintenance dialysis therapy who tested positive for COVID-19 (PCR assay of the nasopharyngeal swab) during the period from February 1, 2020, to July 19, 2020...
2021: PloS One
Rumei Luan, Geng Tian, Hong Zhang, Xiaolei Shi, Jicui Li, Rui Zhang, Xuehong Lu
BACKGROUND: There are arguments for individualized treatments and the necessity of non-invasive biomarkers for patients with IgA nephropathy (IgAN) according to gender, but the rationale remains unclear. We aimed to investigate the relationship between urine exosomal circular RNA (circRNA) levels, related genes, clinical features, and renal pathological features in IgA nephropathy patients of different genders. METHODS: Clinicopathological data from patients of different genders from a multicenter cohort were retrospectively analyzed...
July 22, 2021: Journal of Nephrology
Enver Yuksel, Emre Aydin
INTRODUCTION: We aimed to investigate the relationship between Vitamin D level and quality of life in patients undergoing peritoneal dialysis as renal replacement therapy. METHODS: 50 peritoneal dialysis patients aged between 18 and 73 years were included in this study. KDQOL-36 questionnaire was applied to rate the quality of life of the patients. This questionnaire consisted of 36 questions divided into five subscales. The patients were divided into two groups according to serum vitamin D levels...
July 22, 2021: International Urology and Nephrology
John G Rizk, Jose G Lazo, David Quan, Steven Gabardi, Youssef Rizk, Elani Streja, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
Hyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-transplant hyperkalemia in recipients with a well-functioning graft...
July 22, 2021: Reviews in Endocrine & Metabolic Disorders
Anne-Catherine Schuepfer, Guido Schuepfer, Jacqueline Mauch
Tunnelled hemodialysis catheters are well accepted and widely used devices to provide vascular access for dialysis in patients when an arteriovenous shunt is not feasible or dysfunctional. In the literature complications after implantation are well documented but fatal or near-fatal events during implantation are seldom reported. In this article 3 such cases from a single tertiary center over a period of more than 10 years are presented and discussed. The (near) fatal complications occurred despite experienced surgeons and the use of ultrasound and fluoroscopy during implantation...
July 22, 2021: Der Anaesthesist
Tomoyuki Kawada
No abstract text is available yet for this article.
July 22, 2021: Seminars in Dialysis
Andrew Evans, Binh Nguyen, George Nassar
A patient with a 6-year-old left upper arm brachial cephalic AVF presented with symptoms of hemodialysis access-induced distal ischemia (HAIDI). Physical exam findings showed a well-developed AVF, but compression of the AVF aggravated arm pain and induced diffuse erythema of the left upper extremity. Angiographic evaluation disclosed the presence of a large axillary artery vascular malformation (AVM) as well as distal forearm hypo-perfusion. We elected to publish this case report to describe the interesting physical exam findings related to the AVM, and discuss HAIDI treatment options that are peculiar to this case...
July 22, 2021: Seminars in Dialysis
Aisha Sethi, Mahmood Ahmad, Tayyaba Huma, Waqas Ahmad
To prepare glutaraldehyde-based cross-linked medium molecular weight chitosan nanoparticles encapsulated with 5-Fluorouracil (5-FU), to overcome dosing frequency as well as reducing acute oral toxicity and poor bioavailability of the drug. Medium molecular weight chitosan nanoparticles (MMWCH-NPs) were prepared by reverse micelles method based on glutaraldehyde (GA) cross-linking and optimized by the process as well as formulation variables like a various drug to polymer ratio, cross-linker volumes, varying stirring speeds (rpm), different time of rotation/stirring, respectively and their effects on the mean particles size distribution and entrapment efficiency %EE and %LC of NPs...
December 2021: Drug Delivery
Athanasia Mitropoulou, Hendrik Lehmann, Evelyn M Heier, Matthias Schneider, Esther Hassdenteufel
A 4-year-old female Boxer was referred for renal replacement therapy 2 days after observed grape ingestion. An 11-French dual-lumen dialysis catheter was placed into the right jugular vein and continuous renal replacement therapy was initiated for 66 h. Afterwards the patient received enoxaparin subcutaneously as a thromboprophylaxis. Four hours after removal of the dialysis catheter the patient developed severe dyspnea with hypercapnia and signs of hemorrhagic shock. Bedside ultrasound and X-rays of the thorax revealed a soft tissue opacity dorsally of the trachea, located in the mediastinum...
2021: Frontiers in Veterinary Science
Danielle E Fox, Robert R Quinn, Paul E Ronksley, Tyrone G Harrison, Hude Quan, David Bigam, A M James Shapiro, Rachel Jeong, Ngan N Lam
Background: Simultaneous kidney-pancreas transplantation (SPK) has benefits for patients with kidney failure and type I diabetes mellitus, but is associated with greater perioperative risk compared with kidney-alone transplantation. Postoperative care settings for SPK recipients vary across Canada and may have implications for patient outcomes and hospital resource use. Objective: To compare outcomes following SPK transplantation between patients receiving postoperative care in the intensive care unit (ICU) compared with the ward...
2021: Canadian Journal of Kidney Health and Disease
Neema W Minja, Huda Akrabi, Karen Yeates, Kajiru Gad Kilonzo
Background: Acute kidney injury (AKI) is a recognized complication in critically ill patients. The epidemiology of AKI varies worldwide, depending on the diagnostic criteria used and the setting. The International Society of Nephrology has called for a reduction in preventable deaths from AKI to zero by the year 2025. It is suspected that the majority of AKI cases are in limited-resource countries, but the true burden of AKI in these settings remains unknown. Objective: We aimed to determine, using standardized KDIGO (Kidney Disease Improving Global Outcomes) criteria, the prevalence of AKI, associated factors, and clinical characteristics of adult (≥18 years) patients admitted to intensive care units (ICUs) at a tertiary hospital in Tanzania...
2021: Canadian Journal of Kidney Health and Disease
Tyler Pitre, Angela Hong Tian Dong, Aaron Jones, Jessica Kapralik, Sonya Cui, Jasmine Mah, Wryan Helmeczi, Johnny Su, Vivek Patel, Zaka Zia, Michael Mallender, Xinxin Tang, Cooper Webb, Nivedh Patro, Mats Junek, MyLinh Duong, Terence Ho, Marla K Beauchamp, Andrew P Costa, Rebecca Kruisselbrink, Jennifer L Y Tsang, Michael Walsh
Background: The incidence of acute kidney injury (AKI) in patients with COVID-19 and its association with mortality and disease severity is understudied in the Canadian population. Objective: To determine the incidence of AKI in a cohort of patients with COVID-19 admitted to medicine and intensive care unit (ICU) wards, its association with in-hospital mortality, and disease severity. Our aim was to stratify these outcomes by out-of-hospital AKI and in-hospital AKI...
2021: Canadian Journal of Kidney Health and Disease
Ying Hang, Hao Yan, He Zhang, Zhenyuan Li, Wei Fang
Objectives: We designed this prospective observational study to clarify the associations between dialysate IL-6, a marker of ongoing peritoneal inflammation, Tie2, an important factor in angiogenesis in the peritoneum, and a high peritoneal solute transport rate (PSTR) in patients undergoing peritoneal dialysis (PD) and to investigate their outcome predictive roles. Methods: A total of 60 stable continuous ambulatory peritoneal dialysis (CAPD) patients from a single center in China were analyzed in this prospective study...
July 2021: Pakistan Journal of Medical Sciences Quarterly
Chen-Li Zhang, De-Qiong Xie, Li-Na Ao, Lei Zhu
Objective: This study aims to compare the clinical application value of high-flux dialysis with low-flux dialysis in patients without significantly improved renal function after cervical cancer and obstructive renal failure catheterisation. Methods: This prospective randomised study was conducted from January 2018 to December 2019. Eighty cervical cancer patients with obstructive renal failure who showed no significant renal function improvement after catheterisation were randomised into two groups (n = 40 in each group) in the Second People's Hospital of Yibin City...
July 2021: Pakistan Journal of Medical Sciences Quarterly
Nupur Gupta, Brent Miller
No abstract text is available yet for this article.
July 21, 2021: Clinical Journal of the American Society of Nephrology: CJASN
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