Yu Soma, Miku Kato, Gaku Shimura, Manabu Kamio, Maki Iida
No abstract text is available yet for this article.
November 28, 2022: Journal of Nephrology
Daphne J Theodorou, Stavroula J Theodorou, Lampros K Bourantas, Thomas Tzimas
No abstract text is available yet for this article.
November 28, 2022: Journal of Nephrology
Sophia Heinrich, Thomas Austgen, Darko Castven, Moritz Hess, Christian Labenz, Martha Kirstein, Carolin Zimpel, Lena Stockhoff, Benjamin Maasoumy, Bernd Heinrich, Hans Heinrich Wedemeyer, Peter Robert Galle, Harald Binder, Marc Nguyen-Tat, Jens Uwe Marquardt
BACKGROUND AND AIMS: Hepatorenal syndrome is a major complication in patients with cirrhosis and associated with high mortality. Predictive biomarkers for therapy response are largely missing. Cytokeratin18-based cell death markers are significantly elevated in patients with complications of chronic liver disease, but the role of these markers in patients with HRS treated with vasoconstrictors and albumin is unknown. METHODS: We prospectively analyzed a total of 138 patients with HRS, liver cirrhosis without HRS and acute kidney injury treated at the University Medical Center Mainz between April 2013 and July 2018...
November 28, 2022: United European Gastroenterology Journal
Kunihiro Yamagata
No abstract text is available yet for this article.
November 28, 2022: Nephrology, Dialysis, Transplantation
Giovanni Gambaro, Lazaros Tzelves, Andreas Skolarikos, Mehmet Kanbay, Alberto Ortiz, Mario Cozzolino
No abstract text is available yet for this article.
November 28, 2022: Nephrology, Dialysis, Transplantation
Carla Burballa, Gerard Cantero-Recasens, Larisa Prikhodina, Francesca Lugani, Karlpeter Schlingmann, Petr V Ananin, Martine Besouw, Detlef Bockenhauer, Leire Madariaga, Aurelia Bertholet-Thomas, Francesca Taroni, Mattia Parolin, Peter Conlon, Dorella Delprete, Dominique Chauveau, Linda Koster-Kamphuis, Marc Fila, Andrea Pasini, Isabel Castro, Giacomo Colussi, Marta Gil, Barian Mohidin, Tanja Wlodkowski, Franz Schaefer, Gema Ariceta
BACKGROUND: Dent's disease type 1 (DD1) is a rare X-linked nephropathy caused by CLCN5 mutations, characterized by proximal tubule dysfunction, including low-molecular-weight proteinuria (LMWP), hypercalciuria, nephrolithiasis-nephrocalcinosis, progressive chronic kidney disease (CKD) and kidney failure (KF). Current management is symptomatic and does not prevent disease progression. Here we describe the contemporary DD1 picture across Europe to highlight its unmet needs. METHODS: A physician-based anonymous international e-survey supported by several European Nephrology Networks/Societies was conducted...
November 28, 2022: Nephrology, Dialysis, Transplantation
(no author information available yet)
No abstract text is available yet for this article.
November 28, 2022: Hemodialysis International
Wen-Yu Ho, Chieh-Li Yen, Cheng-Chia Lee, Yi-Ran Tu, Chao-Yu Chen, Ching-Chung Hsiao, Pao-Hsien Chu, Hsiang-Hao Hsu, Ya-Chun Tian, Chih-Hsiang Chang
BACKGROUND: Although a recent study reported that fibrates are associated with a low risk of cardiovascular (CV) death and can postpone the need for long-term hemodialysis in patients with advanced chronic kidney disease (CKD), little is known regarding whether the CV protective effects of fibrates extend to patients with end-stage renal disease (ESRD). The present study compared CV outcomes and mortality among patients with ESRD treated with fibrates, statins, neither, or their combination...
2022: Frontiers in Cardiovascular Medicine
Young Rong Kim, Ha-Jin Chun, Jung Yeon Heo, Jin Sae Yoo, Young Hwa Choi, Eun Jin Kim
BACKGROUND: Current guidelines for the therapeutic monitoring of vancomycin recommend dosing based on the area under the concentration-time curve (AUC) to achieve clinical efficacy while reducing nephrotoxicity. Although a wide range of nephrotoxicity thresholds have been reported, few studies have documented clinical outcomes based on AUC-guided vancomycin dosing in Korea. OBJECTIVE: The aim of the study was to evaluate whether a relationship exists between AUC and treatment outcomes in vancomycin treated patients in methicillin-resistant Staphylococcus aureus bacteremia...
2022: Current Therapeutic Research, Clinical and Experimental
Qimei Luo, Mi Liu, Yanhong Tan, Jinzhong Chen, Wei Zhang, Shaoxin Zhong, Jianyi Pan, Qingkun Zheng, Lewei Gong, Lijuan Su, Zhanjun Jia, Xianrui Dou
Inflammatory responses in the peritoneum contribute to peritoneal dialysis (PD)-associated peritoneal fibrosis. Results of our previous study showed that increased microsomal prostaglandin E synthase-1-mediated production of prostaglandin E2 (PGE2) contributed to peritoneal fibrosis. However, the role of its downstream receptor in the progression of peritoneal fibrosis has not been established. Here, we examined the role of PGE2 receptor 4 (EP4) in the development of peritoneal fibrosis. EP4 was significantly upregulated in peritoneal tissues of PD patients with ultrafiltration failure, along with the presence of an enhanced inflammatory response...
2022: Frontiers in Pharmacology
Masatomo Ogata, Shu Ushimaru, Rie Fujishima, Hirofumi Sumi, Kazuhiro Shiizaki, Naoto Tominaga
Preventing osteoporotic fractures is an issue requiring urgent attention to reduce mortality. However, unlike chronic kidney disease-mineral and bone disorder (CKD-MBD), osteoporosis is inadequately addressed in patients undergoing chronic dialysis. In fact, little is known about the proper use of anti-osteoporotic drugs for patients with CKD-MBD. A recent study showed that romosozumab, an anti-osteoporotic drug, increased bone mineral density in osteoporotic patients on hemodialysis without clinically significant adverse events...
December 2022: Bone Reports
Stephanie N Dixon, Kyla L Naylor, Seychelle Yohanna, Susan McKenzie, Dmitri Belenko, Peter G Blake, Candice Coghlan, Rebecca Cooper, Lori Elliott, Leah Getchell, Vincent Ki, Istvan Mucsi, Gihad Nesrallah, Rachel E Patzer, Justin Presseau, Marian Reich, Jessica M Sontrop, Darin Treleaven, Amy D Waterman, Jeffrey Zaltzman, Amit X Garg
BACKGROUND: Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) is a quality improvement intervention designed to enhance access to kidney transplantation and living kidney donation. We conducted a cluster-randomized clinical trial to evaluate the effect of the intervention versus usual care on completing key steps toward receiving a kidney transplant. OBJECTIVE: To prespecify the statistical analysis plan for the EnAKT LKD trial. DESIGN: The EnAKT LKD trial is a pragmatic, 2-arm, parallel-group, registry-based, open-label, cluster-randomized, superiority, clinical trial...
2022: Canadian Journal of Kidney Health and Disease
Nazanin Noori, Arti Sharma Parpia, Ron Wald, Marc B Goldstein
BACKGROUND: Online dialysis clearance monitors typically provide an accurate value for Kt. A value for V (total body water [TBW]) is required to calculate Kt/V, the measure of the adequacy of the delivered dialysis in hemodialysis (HD) patients. Using bioimpedance spectroscopy (BIS), we previously developed 2 sex-specific equations for the estimation of the TBW, which we have chosen to name the St Michael's Hospital (SMH) equations. OBJECTIVE: The objective of this study was to validate the SMH equations in a second distinct population of patients...
2022: Canadian Journal of Kidney Health and Disease
Marcelo Barreto Lopes, Márcia Tereza Silveira-Martins, Fernanda Albuquerque da Silva, Luciana Ferreira Silva, Maria Tereza Silva-Martins, Cácia M Matos, Angiolina C Kraychete, Keith C Norris, Sherman A James, Antonio Alberto Lopes
RATIONALE & OBJECTIVE: Studies in the United States and United Kingdom generally report better survival for Black than White patients undergoing maintenance hemodialysis, a finding not explained by differences in sociodemographics or comorbid conditions. It is not clear if such findings can be generalized to other countries. We investigated the association between race and mortality among a Black, White, and Mixed-Race sample of maintenance hemodialysis patients in Salvador, Brazil...
December 2022: Kidney medicine
Bojana Simunov, Anna Mrzljak, Zeljka Jurekovic, Snjezana Zidovec Lepej, Ana Bainrauch, Jadranka Pavicic Saric, Zeljka Hruskar, Leona Radmanic, Tatjana Vilibic-Cavlek
BACKGROUND: Parvovirus B19 (B19V) is associated with a wide range of clinical manifestations. The major presentation is erythema infectiosum. However, a persistent infection may cause pure red cell aplasia and chronic anemia in immunocompromized patients. The B19V seroprevalence varies with age and geographical location. AIM: To determine the B19V serological status and DNAemia in kidney, liver, and pancreas transplant candidates. METHODS: Patients who underwent kidney, liver, or simultaneous kidney and pancreas/liver transplantation between January 2021 and May 2022 were included in the study...
November 18, 2022: World Journal of Transplantation
Catherine R Mitchell, Carsten Hornig, Bernard Canaud
BACKGROUND: This systematic review was performed to identify recent published comparative evidence on the efficacy, effectiveness, and safety of expanded hemodialysis (HDx) versus high-flux HD and/or hemodiafiltration (HDF) for long-term outcomes in end-stage kidney disease. METHODS: Systematic literature review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Medline, Medline® Epub Ahead of Print, EconLit, Embase, and EBM reviews were searched to identify relevant publications from 2013 onwards...
November 27, 2022: Seminars in Dialysis
Mehran Hesaraki, Razieh Behzadmehr, Hamideh Goli, Hosein Rafiemanesh, Mahboobe Doostkami
Chronic kidney disease is a significant public health problem worldwide. However, the causes of chronic kidney disease in Iran are unclear. This systematic review and meta-analysis identified the causes of chronic kidney disease in the general population of Iran. International databases (PubMed, Web of Science, Scopus, and Google Scholar) and national databases (Scientific Information Database and Magiran) were searched for studies published until March 1, 2018. The quality of the studies was assessed using the checklist developed by Hoy et al...
November 24, 2022: Néphrologie & Thérapeutique
Eiichiro Kanda
The munber of chronic kidney disease (CKD) patients is increasing globally because kidney function is affected by aging and lifestyle habits. Malnutrition, muscle weakness, and a decline in activities of daily living (ADL) are often observed in elderly CKD patients and dialysis patients, and are related to their CKD prognosis and life prognoses. Chronic inflammation and atherosclerotic disease are associated with malnutrition. Because malnutrition and its related factors affect patients' prognoses, it is necessary to identify and treat patients with malnutrition at an early stage...
2022: Journal of Nutritional Science and Vitaminology
Corinne Guibergia, François Brazier, Gabriel Choukroun
Iron deficiency is very common in chronic kidney disease, even before the dialysis stage. It is an independent factor of morbidity and mortality in patients with non-dialysis chronic kidney disease. During chronic kidney disease, iron deficiency is defined by a transferrin saturation <20% and/or a serum ferritin <100 μg/L. In France, about half of non-dialysis chronic kidney disease patients have absolute iron deficiency (transferrin saturation <20% and serum ferritin <100 μg/L) and/or functional iron deficiency (transferrin saturation <20% and serum ferritin >100 μg/L)...
November 23, 2022: Néphrologie & Thérapeutique
Şükran Keskin Gözmen, Erkin Serdaroğlu, Nida Dinçel, Pınar Erturgut, Cemaliye Başaran, Fatma Devrim, Betül Pehlivan Zorlu, Özlem Dur, Orhan Deniz Kara, Ebru Bekiroğlu Yilmaz
INTRODUCTION: Peritoneal dialysis is the treatment of choice for end-stage renal disease. Peritoneal dialysis related peritonitis is of great importance for patient and technical survival. The aim of our study was to evaluate the accuracy and the correlation between the three methods (complete blood count, urinalysis device, urine dipstick test) and with the reference manual method (Thoma Cell Counter Chamber). MATERIALS AND METHODS: We retrospectively analyzed 167 peritoneal fluid samples taken from 25 patients receiving peritoneal dialysis treatment...
November 23, 2022: Néphrologie & Thérapeutique
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