Midori Hasegawa, Jin Iwasaki, Satoshi Sugiyama, Takuma Ishihara, Yoshihiro Yamamoto, Hiroaki Asada, Shigehisa Koide, Hiroki Hayashi, Kazuo Takahashi, Daijo Inaguma, Yukio Yuzawa, Naotake Tsuboi
INTRODUCTION: Degenerative aortic valve stenosis (AS) is a chronic progressive disease that resembles atherosclerosis development. Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is reportedly associated with accelerated atherosclerosis. This study aimed to examine the development of AS in patients with myeloperoxidase-AAV (MPO-AAV) with renal involvement at more than 1 year after the onset of vasculitis. METHODS: We performed a retrospective review of clinical records of MPO-AAV patients with renal involvement without AS at the onset of vasculitis who were treated in three hospitals and three dialysis clinics...
2021: PloS One
S A Martynov, A S Severina, I I Larina, M S Shamhalova, S V Arzumanov, A V Pinchuk, M V Shestakova
Kidney transplantation is unique method of renal replacement therapy, allowing to improve quality and duration of life for patients with diabetes mellitus type 1 (DM1) and end-stage renal disease (ESRD) on dialysis therapy. Recently using of innovation technologies for diabetes management and modern immunosuppression enable achieving better results of posttransplant rehabilitation for patients with DM1, especially if kidney transplantation is performed early after initiation of dialysis. Detailed examination of patient with DM1 before potential kidney transplantation is very important to reduce of early and late postoperative complications...
December 20, 2020: Problemy E̊ndokrinologii
Federico Marin, Simone Fezzi, Alessia Gambaro, Francesco Ederle, Gianluca Castaldi, Maddalena Widmann, Concetta Gangemi, Valeria Ferrero, Gabriele Pesarini, Michele Pighi, Flavio L Ribichini
AIMS: To evaluate the safety and efficacy of catheter-based radiofrequency renal sympathetic denervation (RSD) in a daily practice population of patients with uncontrolled resistant hypertension, on top of medical therapy. METHODS: Consecutive unselected patients with uncontrolled resistant hypertension undergoing RSD were enrolled. Office and ambulatory blood pressure (BP) measurements were collected at baseline and 3, 6 and 12 months after RSD. Efficacy was assessed even in patients with an estimated glomerular filtration rate (eGFR) below 45 mL/min/1...
January 22, 2021: Journal of Nephrology
Irene Faravelli, Daniele Velardo, Manuel Alfredo Podestà, Claudio Ponticelli
A large number of neurological disorders can affect renal transplant recipients, potentially leading to disabling or life-threatening complications. Prevention, early diagnosis and appropriate management of these conditions are critical to avoid irreversible lesions. A pivotal role in the pathogenesis of common post-transplant neurological disorders is played by immunosuppressive therapy. The most frequently administered regimen consists of triple immunosuppression, which comprises a calcineurin inhibitor (CNI), a purine synthesis inhibitor and glucocorticoids...
January 22, 2021: Journal of Nephrology
Pablo V Uceda, Julio Peralta Rodriguez, Hernán Vela, Adelina Lozano Miranda, Luis Vega Salvatierra, Robert Feldtman, Sam S Ahn
The health care system in Peru treats 15,000 dialysis patients annually. Approximately 45% of patients receive therapy using catheters. The incidence of catheter-induced superior vena cava (SVC) occlusion is increasing along with its associated significant morbidity and vascular access dysfunction. One of the unusual manifestations of this complication is bleeding "downhill" esophageal varices caused by reversal of blood flow through esophageal veins around the obstruction to the right atrium. Herein is presented the case of an 18-year-old woman on hemodialysis complicated by SVC occlusion and bleeding esophageal varices who underwent successful endovascular recanalization of the SVC...
January 22, 2021: Journal of Endovascular Therapy
Tanusree Sengupta, Tilen Koklic, Barry R Lentz, Rinku Majumder
Cell membranes have important functions in many steps of the blood coagulation cascade, including the activation of factor X (FX) by the factor VIIa (FVIIa)-tissue factor (TF) complex (extrinsic Xase). FVIIa shares structural similarity with factor IXa (FIXa) and FXa. FIXa and FXa are regulated by binding to phosphatidylserine (PS)-containing membranes via their γ-carboxy-glutamic acid (Gla) and epidermal growth-factor (EGF) domains.  Although FVIIa also has a Gla-rich region, its affinity for PS-containing membranes is much lower compared to that of FIXa and FXa...
January 22, 2021: Bioscience Reports
Domenico Giannese, Alessandro Puntoni, Adamasco Cupisti, Riccardo Morganti, Enrico Varricchio, Claudia D'Alessandro, Claudia Mannucci, Piera Serio, Maria Francesca Egidi
BACKGROUND: Dry weight assessment in hemodialysis (HD) remains a challenge. The aim of the study was to investigate the prevalence of subclinical pulmonary congestion using lung ultrasound (LUS) in maintenance HD patients with no clinical or bioimpedance signs of hyperhydration. The correlation between B-lines Score (BLS) and brain natriuretic peptide (BNP) was also evaluated. METHODS: Twenty-four HD patients underwent LUS and BNP dosage at the end of the mid-week HD session, monthly for 6 months ...
January 21, 2021: BMC Nephrology
Fang-Yu Wang, Zhuan Cui, Chun-Yan Su, Tao Wang, Wen Tang
BACKGROUND: As kidney disease progresses, patients often experience a variety of symptoms. There are very few studies reporting spectrum of predialysis patients' symptoms in peritoneal dialysis (PD) patients. Furthermore, the clinical significance of predialysis patients' symptoms for PD patients' prognosis remains unknown. METHODS: In this retrospective cohort study, patients who started PD during 1 January 2006 to 31 January 2018 were included. Patients' predialysis symptoms and clinical parameters were obtained...
December 2021: Renal Failure
Keishi Yamasaki, Akito Kawai, Keiki Sakurama, Nagiko Udo, Yuta Yoshino, Yuki Saito, Kenji Tsukigawa, Koji Nishi, Masaki Otagiri
Benzbromarone has been used for the treatment of gout for more than 30 years. Although it shows a high level of binding to plasma proteins (>99%), our knowledge of this binding is not sufficiently extensive to permit us to understand its pharmacokinetics and pharmacodynamics. To address this issue in more detail, we characterized the binding of benzbromarone to human serum albumin (HSA), the most abundant protein in plasma. Equilibrium dialysis and circular dichroism findings indicated that benzbromarone binds strongly to one primary as well as to multiple secondary sites on HSA and that the bromine atoms of benzbromarone play important roles in this high affinity binding...
January 21, 2021: Molecular Pharmaceutics
Tae Ryom Oh, Su Hyun Song, Hong Sang Choi, Chang Seong Kim, Seung Hyeok Han, Kyung Pyo Kang, Young Joo Kwon, Soo Wan Kim, Seong Kwon Ma, Eun Hui Bae
Immunoglobin A (IgA) nephropathy causes chronic kidney disease worldwide. Therefore, identifying risk factors associated with the progression of IgA nephropathy is crucial. Anemia is a common complication of chronic kidney disease; however, few studies have investigated the effect of serum hemoglobin on the renal prognosis of IgA nephropathy. This study aimed to determine the effect of serum hemoglobin on the progression of IgA nephropathy. We retrospectively analyzed 4326 patients with biopsy-proven IgA nephropathy...
January 19, 2021: Journal of Clinical Medicine
Vincenzo Losappio, Barbara Infante, Serena Leo, Dario Troise, Martina Calvaruso, Piercarla Vitale, Stefania Renzi, Giovanni Stallone, Giuseppe Castellano
Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement therapies (RRT) have shown the long-term impact of conservative therapies for advanced CKD and the consequences of the uremic milieu, with a frail clinical condition that impacts not only their survival but also limits their access to transplantation. This process, referred to as "inflammaging," might be reversible with a tailored approach, such as RRT accompanied by specific nutritional support...
January 18, 2021: Nutrients
Hina Mushtaq, Arshid Jehangir, Shabir Ahmad Ganai, Saleem Farooq, Bashir Ahmad Ganai, Ruqeya Nazir
A novel temperature stable alkaline protease yielding bacteria was isolated from the soils of Dachigam National Park, which is known to be inhabited by a wide variety of endemic plant and animal species of Western Himalaya. This high-potential protease producing isolate was characterized and identified as Bacillus amyloliquefaciens strain HM48 by morphological, Gram's staining and biochemical techniques followed by molecular characterization using 16S rRNA approach. The extracellular protease of B. amyloliquefaciens HM48 was purified by precipitating with ammonium sulfate (80%), followed by dialysis and Gel filtration chromatography increasing its purity by 5...
January 18, 2021: Biomolecules
Koyo Nishimura, Koki Ogawa, Maho Kawaguchi, Shintaro Fumoto, Hidefumi Mukai, Shigeru Kawakami
Gene therapy is expected to be used for the treatment of peritoneal fibrosis, which is a serious problem associated with long-term peritoneal dialysis. Hepatocyte growth factor (HGF) is a well-known anti-fibrotic gene. We developed an ultrasound and nanobubble-mediated (sonoporation) gene transfection system, which selectively targets peritoneal tissues. Thus, we attempted to treat peritoneal fibrosis by sonoporation-based human HGF (hHGF) gene transfection in mice. To prepare a model of peritoneal fibrosis, mice were intraperitoneally injected with chlorhexidine digluconate...
January 18, 2021: Pharmaceutics
Ali Cansu Bozaci, Mesut Altan, Hakan Bahadir Haberal, Emrullah Söğütdelen, Fazil Tuncay Aki, İlhan Erkan
OBJECTIVE: To report our experience with ureterolysis for the management of retroperitoneal fibrosis. METHODS: The data of 25 patients who underwent ureterolysis due to primary retroperitoneal fibrosis between 2002 and 2017 were reviewed retrospectively. Initial symptoms, laterality, renal function status (initial/final), operation complications and serum creatinine levels (diagnosis/preoperative/6 months, 12 months postoperatively) were recorded. After surgery, patients were followed up by ultrasonography and serum creatinine levels...
January 21, 2021: International Journal of Urology: Official Journal of the Japanese Urological Association
Paul Voigt, Paul Kairys, Anne Voigt, Thomas Frese
BACKGROUND:  The majority of patients with non-dialysis chronic kidney disease are cared for by general practitioners. Especially for Germany, the evidence of this topic is still very low. The aim of the survey was to estimate the perceived frequency of non-dialysis chronic kidney disease in general practice, the use of diagnostics and therapy, used tools considering the professional background and experience of the responding general practitioners. METHODS:  A questionnaire was self-designed in the cooperation of several disciplines...
January 21, 2021: Deutsche Medizinische Wochenschrift
Ako Hanaoka, Toshihide Naganuma, Daijiro Kabata, Daichi Morii, Yoshiaki Takemoto, Junji Uchida, Ayumi Shintani
INTRODUCTION: In patients requiring both hemodialysis (HD) and apheresis, the 2 treatments can be performed simultaneously. At our hospital, selective plasma exchange (SePE) is often performed along with HD for removal of isoagglutinins before ABO-incompatible (ABOi) kidney transplantation. The 2 treatments can be completed within the HD schedule, which allows the treatment time to be shortened. This approach is also less stressful for patients because fewer punctures are required. In this study, we investigated the safety and efficacy of tandem HD and SePE...
January 21, 2021: Blood Purification
Atsushi Kainuma, Yuming Ning, Paul A Kurlansky, Kelly Axsom, Maryjane Farr, Gabriel Sayer, Nir Uriel, Matthew J Lewis, Marlon S Rosenbaum, David Kalfa, Damien J LaPar, Emile A Bacha, Hiroo Takayama, Yoshifumi Naka, Koji Takeda
BACKGROUND: Adult congenital heart disease (ACHD) patients who require orthotopic heart transplantation are surgically complex due to anatomical abnormalities and multiple prior surgeries. In this study, we investigated these patients outcomes using our institutional database. METHODS: ACHD patients who had prior intracardiac repair and subsequent heart transplant were included (2008-2018). Adult patients without ACHD were extracted as a control. A comparison of patients with functional single ventricular (SV) and biventricular (BV) hearts was performed...
January 21, 2021: Clinical Transplantation
Harmandeep Kaur, Andrew Advani
In the past few years there has been a rapid expansion of interest in the study of single cells, especially through the new techniques that involve single-cell RNA sequencing (scRNA-seq). Recently, these techniques have provided new insights into kidney health and disease, including insights into diabetic kidney disease (DKD). However, despite the interest and the technological advances, the study of individual cells in DKD is not a new concept. Many clinicians and researchers who work within the DKD space may be familiar with experimental techniques that actually involve the study of individual cells, but may be unfamiliar with newer scRNA-seq technology...
January 21, 2021: Journal of Nephrology
Namrata Krishnan
A comprehensive, hands-on hemodialysis curriculum during nephrology training is necessary for effective learning and optimal patient care. Traditional instructive approaches are unable to fully meet the needs of the digitally inclined learner and are limited by time constraints and increasing clinical workload. Internet based learning (E-learning) is becoming increasingly popular in medical education and nephrology and gaining even greater relevance in the COVID era. However, it presents technical challenges and may create an environment of social isolation...
January 21, 2021: Journal of Nephrology
Suraj D Serai, Meng Yin
Application of MRE for noninvasive evaluation of renal fibrosis has great potential for noninvasive assessment in patients with chronic kidney disease (CKD). CKD leads to severe complications, which require dialysis or kidney transplant and could even result in death. CKD in native kidneys and interstitial fibrosis in allograft kidneys are the two major kidney fibrotic pathologies where MRE may be clinically useful. Both these conditions can lead to extensive morbidity, mortality, and high health care costs...
2021: Methods in Molecular Biology
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