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plasmodium vivax malaria

Pranjal Gupta, Vasudev Guddattu, Kavitha Saravu
The association of hematological parameters especially platelet parameters with disease severity in malaria is poorly understood. We aimed to characterize the platelet parameters across Plasmodium falciparum and Plasmodium vivax malaria stratified by severity and to elucidate the potential role of platelet parameters to predict disease severity. Individuals > 18 years, of either gender with microscopically proven symptomatic malaria were prospectively enrolled between October 2014 and August 2016 in a tertiary center in Manipal, India...
April 9, 2019: Pathogens and Global Health
Saranath Lawpoolsri, Jetsumon Sattabongkot, Jeeraphat Sirichaisinthop, Liwang Cui, Kirakorn Kiattibutr, Nattawan Rachaphaew, Kritsana Suk-Uam, Amnat Khamsiriwatchara, Jaranit Kaewkungwal
BACKGROUND: In low malaria transmission areas, many people acquire multiple malaria infections within a single season. This study aimed to describe the pattern and epidemiological profile of malaria recurrence in a hypoendemic area of western Thailand and identify factors associated with having multiple malaria episodes. METHODS: An open cohort of 7000 residents in seven clusters along the Thai-Myanmar border was followed during a 6.5-year period (2011-mid 2017)...
April 8, 2019: Malaria Journal
Wang Nguitragool, Stephan Karl, Michael White, Cristian Koepfli, Ingrid Felger, Pratap Singhasivanon, Ivo Mueller, Jetsumon Sattabongkot
Over the past decades, the malaria burden in Thailand has substantially declined. Most infections now originate from the national border regions. In these areas, the prevalence of asymptomatic infections is still substantial and poses a challenge for the national malaria elimination program. To determine epidemiological parameters as well as risk factors for malaria infection in western Thailand, we carried out a cohort study in Kanchanaburi and Ratchaburi provinces on the Thailand-Myanmar border. Blood samples from 999 local participants were examined for malaria infection every 4 weeks between May 2013 and Jun 2014...
April 4, 2019: International Journal for Parasitology
Farhad Jahangiri, Nahid Jalallou, Mansour Ebrahimi
Plasmodium vivax, an intracellular protozoan, causes malaria which is characterized by fever, anemia, respiratory distress, liver and spleen enlargement. In spite of attempts to design an efficient vaccine, there is not a vaccine against P. vivax. Notable advances have recently achieved in the development of malaria vaccines targeting the surface antigens such as Apical Membrane Antigens (AMA)-1. AMA-1 is a micronemal protein synthesized during the erythrocyte-stage of Plasmodium species and plays a significant role in the invasion process of the parasite into host cells...
April 3, 2019: Infection, Genetics and Evolution
Cindy S Chu, Aung Pyae Phyo, Claudia Turner, Htun Htun Win, Naw Pet Poe, Widi Yotyingaphiram, Suradet Thinraow, Pornpimon Wilairisak, Rattanaporn Raksapraidee, Verena I Carrara, Moo Kho Paw, Jacher Wiladphaingern, Stéphane Proux, Germana Bancone, Kanlaya Sriprawat, Sue J Lee, Atthanee Jeeyapant, James Watson, Joel Tarning, Mallika Imwong, François Nosten, Nicholas J White
BACKGROUND: Primaquine is necessary for the radical cure of Plasmodium vivax malaria, but the optimum duration of treatment and best partner drug are uncertain. A randomized controlled trial was performed to compare the tolerability and radical curative efficacy of 7-day versus 14-day high-dose primaquine regimens (total dose 7mg/kg) with either chloroquine or dihydroartemisinin-piperaquine. METHODS: Patients with uncomplicated P. vivax malaria on the Thailand-Myanmar border were randomized to either chloroquine (25mg base/kg) or dihydroartemisinin-piperaquine (dihydroartemisinin 7mg/kg and piperaquine 55mg/kg) plus primaquine, either 0...
August 24, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Maria Anice M Sallum, Jan E Conn, Eduardo S Bergo, Gabriel Z Laporta, Leonardo S M Chaves, Sara A Bickersmith, Tatiane M P de Oliveira, Elder Augusto G Figueira, Gilberto Moresco, Lêuda Olívêr, Claudio J Struchiner, Laith Yakob, Eduardo Massad
BACKGROUND: Brazilian malaria control programmes successfully reduced the incidence and mortality rates from 2005 to 2016. Since 2017, increased malaria has been reported across the Amazon. Few field studies focus on the primary malaria vector in high to moderate endemic areas, Nyssorhynchus darlingi, as the key entomological component of malaria risk, and on the metrics of Plasmodium vivax propagation in Amazonian rural communities. METHODS: Human landing catch collections were carried out in 36 houses of 26 communities in five municipalities in the Brazilian states of Acre, Amazonas and Rondônia states, with API (> 30)...
April 4, 2019: Malaria Journal
Lenore L Carias, Sebastien Dechavanne, Vanessa C Nicolete, Sokunthea Sreng, Seila Suon, Chanaki Amaratunga, Rick M Fairhurst, Celia Dechavanne, Samantha Barnes, Benoit Witkowski, Jean Popovici, Camille Roesch, Edwin Chen, Marcelo U Ferreira, Niraj H Tolia, John H Adams, Christopher L King
Plasmodium vivax invasion of reticulocytes relies on distinct receptor-ligand interactions between the parasite and host erythrocytes. Engagement of the highly polymorphic domain II of the P. vivax Duffy-binding protein (DBPII) with the erythrocyte's Duffy Ag receptor for chemokines (DARC) is essential. Some P. vivax -exposed individuals acquired Abs to DBPII that block DBPII-DARC interaction and inhibit P. vivax reticulocyte invasion, and Ab levels correlate with protection against P. vivax malaria. To better understand the functional characteristics and fine specificity of protective human Abs to DBPII, we sorted single DBPII-specific IgG+ memory B cells from three individuals with high blocking activity to DBPII...
April 3, 2019: Journal of Immunology
Naveed Abbas, Tanzila Saba, Amjad Rehman, Zahid Mehmood, Nadeem Javaid, Muhammad Tahir, Naseer Ullah Khan, Khawaja Tehseen Ahmed, Roaider Shah
Malaria is a serious worldwide disease, caused by a bite of a female Anopheles mosquito. The parasite transferred into complex life round in which it is grown and reproduces into the human body. The detection and recognition of Plasmodium species are possible and efficient through a process called staining (Giemsa). The staining process slightly colorizes the red blood cells (RBCs) but highlights Plasmodium parasites, white blood cells and artifacts. Giemsa stains nuclei, chromatin in blue tone and RBCs in pink color...
April 1, 2019: Microscopy Research and Technique
Mariko S Peterson, Chester J Joyner, Regina J Cordy, Jorge L Salinas, Deepa Machiah, Stacey A Lapp, Esmeralda V S Meyer, Sanjeev Gumber, Mary R Galinski
Background: Plasmodium vivax can cause severe malaria with multisystem organ dysfunction and death. Clinical reports suggest that parasite accumulation in tissues may contribute to pathogenesis and disease severity, but direct evidence is scarce. Methods: We present quantitative parasitological and histopathological analyses of tissue sections from a cohort of naive, mostly splenectomized Saimiri boliviensis infected with P vivax to define the relationship of tissue parasite load and histopathology...
March 2019: Open Forum Infectious Diseases
Alla Baranova, Vladimir Sergiev, Lola Morozova, Natalia Turbabina, Evgeny Morozov
Background: Imported cases of Plasmodium vivax malaria from western Africa are reported annually in the Russian Federation. Infected native African people moving from western Africa for different purposes (students, businessmen, specialists, etc.) or Russian citizens (tourists, diplomats, businessmen, etc.) incubate the pathogen until reaching their Russian destination. Methods: All imported and other confirmed malaria cases and the associated Plasmodium species recorded over the past twenty years throughout the Russian Federation were inventoried...
2019: Journal of Tropical Medicine
Subhashree Rout, Rajani Kanta Mahapatra
Plasmodium vivax (Pv) is the second most malaria causing pathogen among Plasmodium species. M18 aspartic aminopeptidase (M18AAP) protein is a single gene copy present in Plasmodium. This protein is functional at the terminal stage of hemoglobin degradation of host and completes the hydrolysis process which makes it an important target for new chemotherapeutics. No experimental and structural study on M18AAP protein of P. vivax is reported till today. This paper advocates the application of multiple computational approaches like protein model prediction, ligand-based 3D QSAR study, pharmacophore, structure-based virtual screening and molecular docking simulation for identification of potent lead molecules against the enzyme...
March 22, 2019: Bioorganic & Medicinal Chemistry
Hargobinder Kaur, Rakesh Sehgal, Sofia Rani
DARC is thought to act as a key invasion receptor in P. vivax malaria. It is known that the expression of DARC and susceptibility to P. vivax malaria is influenced by the presence of specific DARC genotypes. Studies have reported the low probability of P. vivax malaria in individuals carrying FyA allele due to the significantly reduced binding of the P. vivax duffy binding protein. No association of the allele frequency and severe vivax malaria epidemiology has been yet established in our country. In the present study, a high level of heterozygotes was observed with a statistically significant deviation from the H-W equilibrium in the group with complicated malaria; which is indicative of demographic disequilibrium...
March 27, 2019: Parasitology International
Migbaru Keffale, Girma Shumie, Sinknesh Wolde Behaksra, Wakweya Chali, Lotus L van den Hoogen, Elifaged Hailemeskel, Daniel Mekonnen, Menberework Chanyalew, Demekech Damte, Tiruwork Fanta, Temesgen Ashine, Sagni Chali, Kevin K A Tetteh, Dereje Dillu Birhanu, Taye T Balcha, Abraham Aseffa, Chris Drakeley, Tesfaye S Tessema, Haileeyesus Adamu, Teun Bousema, Endalamaw Gadisa, Fitsum G Tadesse
BACKGROUND: Following successful malaria control during the last decade, Ethiopia instituted a stepwise malaria elimination strategy in selected low-transmission areas. METHODS: Cross-sectional surveys were conducted in Babile district, Oromia, Ethiopia from July to November 2017 to evaluate malaria infection status using microscopy and nested polymerase chain reaction (nPCR) and serological markers of exposure targeting Plasmodium falciparum and Plasmodium vivax apical membrane antigen-1 (AMA-1)...
March 30, 2019: Transactions of the Royal Society of Tropical Medicine and Hygiene
Tsegaye Shamebo, Beyene Petros
OBJECTIVE: The study aimed to determine the prevalence of malaria in Halaba special district, Southern Ethiopia, from 2013 to 2017. RESULTS: Of a total 583,668 malaria suspected cases examined during the study period, 55,252 (9.5%) were microscopically confirmed to be positive for malaria, at the rate of 27,712 (50.2%) females and 27,540 (49.8%) males (P = 0.95). The highest prevalence of 8454 (15.3%) malaria cases were observed in Halaba health center, followed by Halaba district hospital, at 7290 (13...
March 29, 2019: BMC Research Notes
Yi Wan Quah, Andreea Waltmann, Stephan Karl, Michael T White, Ventis Vahi, Andrew Darcy, Freda Pitakaka, Maxine Whittaker, Daniel J Tisch, Alyssa Barry, Celine Barnadas, James Kazura, Ivo Mueller
BACKGROUND: Following the scale-up of intervention efforts, malaria burden has decreased dramatically in Solomon Islands (SI). Submicroscopic and asymptomatic Plasmodium vivax infections are now the major challenge for malaria elimination in this country. Since children have higher risk of contracting malaria, this study investigated the dynamics of Plasmodium spp. infections among children including the associated risk factors of residual P. vivax burden. METHODS: An observational cohort study was conducted among 860 children aged 0...
March 28, 2019: Malaria Journal
M Andreína Pacheco, Kristan A Schneider, Nora Céspedes, Sócrates Herrera, Myriam Arévalo-Herrera, Ananias A Escalante
BACKGROUND: Malaria remains endemic in several countries of South America with low to moderate transmission intensity. Regional human migration through underserved endemic areas may be responsible for significant parasite dispersion making the disease resilient to interventions. Thus, the genetic characterization of malarial parasites is an important tool to assess how endemic areas may connect via the movement of infected individuals. Here, four sites in geographically separated areas reporting 80% of the malaria morbidity in Colombia were studied...
March 28, 2019: PLoS Neglected Tropical Diseases
Alebachew Messele Kebede, Fitsum Girma Tadesse, Adey Desta Feleke, Lemu Golassa, Endalamaw Gadisa
BACKGROUND: Plasmodium vivax merozoite surface protein 3α (PvMSP3α) is a promising vaccine candidate which has shown strong association with immunogenicity and protectiveness. Its use is however complicated by evolutionary plasticity features which enhance immune evasion. Low complexity regions (LCRs) provide plasticity in surface proteins of Plasmodium species, but its implication in vaccine design remain unexplored. Here population genetic, comparative phylogenetic and structural biology analysis was performed on the gene encoding PvMSP3α...
March 27, 2019: BMC Structural Biology
Fatima Jahan, Nazma Habib Khan, Sobia Wahid, Zaki Ullah, Aisha Kausar, Naheed Ali
The present study was aimed at elucidation of malaria epidemiology and comparing performance of several diagnostic procedures in Bannu, a highly endemic district of Khyber Pakhtunkhwa, Pakistan. Dried blood spots were collected from patients suspected of malaria visiting a hospital and two private laboratories in district Bannu and processed for species-specific PCR (rRNA). Patients were also screened for malaria through microscopy and RDT. A well-structured questionnaire was used to collect patient information to assess risk factors for malaria...
March 21, 2019: Pathogens and Global Health
Li Ai-Hua, Wang Lin, Li Sha-Sha
OBJECTIVE: To analyze the epidemic situation and epidemiological characteristics of malaria in Zhenjiang City from 2004 to 2017, so as to provide the evidence for formulating the reasonable strategies and measures for malaria prevention and control. METHODS: The epidemiological data of malaria in Zhenjiang City from 2004 to 2017 were collected and analyzed for the epidemic situation, epidemiological characteristics, species of Plasmodium , blood test status for febrile patients...
November 15, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Xu Sui, Gu Ya-Ping, Cao Yuan-Yuan, Wang Wei-Ming, Tang Jian-Xia, Li Ju-Lin, Zhang Mei-Hua, Zhou Hua-Yun, Zhu Guo-Ding, Cao Jun
OBJECTIVE: To analyze the results of samples testing of Jiangsu Provincial Malaria Diagnostic Reference Laboratory in 2017, so as to provide the evidence for improving the malaria diagnostic performance in this province. METHODS: The samples of reported malaria cases in Jiangsu were collected by the provincial reference laboratory (PRL) in 2017. The microscopy and nucleic acid test were performed to confirm the infection of Plasmodium species of each case, while Plasmodium antigen tests (rapid diagnostic test, RDT) were performed as well...
November 27, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
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