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https://read.qxmd.com/read/30784925/upregulation-of-mmp-9-and-camkii-prompts-cardiac-electrophysiological-changes-that-predispose-denervated-transplanted-hearts-to-arrhythmogenesis-after-prolonged-cold-ischemic-storage
#1
WeiChao Li, Hong Gao, Ju Gao, ZiJun Wang
BACKGROUND: Although the importance of the potential mechanisms of arrhythmogenesis, including cardiac electrophysiology dysfunction and gap junction electrical uncoupling by Cx43 degradation under pathological conditions, has been widely and thoroughly established, the correlations between these mechanisms and biomarkers of cold ischemic insult have not yet been confirmed. Limited evidence suggests that these biomarkers are significantly associated with cardiac dysrhythmia. Thus, in this study, we analyzed such correlations in denervated transplanted hearts...
February 20, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://read.qxmd.com/read/30778907/a-rare-variation-of-the-hemiazygos-vein-draining-into-the-persistent-left-superior-vena-cava
#2
Fengxia Liu, Abudureyimujiang Ruze, Siyiti Amuti, Shuiquan Wang, Shenguo Chen, Adilijiang Yiming, Kun Xiong
During an educational dissection of a 72-year-old Chinese male cadaver, the hemiazygos vein (HAV) coursing the left side that drains into the persistent left superior vena cava was observed. The HAV was formed at the junction of the 9th to 11th right posterior intercostal veins, right subcostal vein, 5th to 11th left posterior intercostal veins, and left subcostal vein; it then ascended posteriorly to the thoracic aorta. After collecting the accessory hemiazygos vein, it crossed over the aorta and the pedicle of the left lung via the hemiazygos arch, then converged with a communicative branch (vein of Marshall) that emerged from the left brachiocephalic vein to form the persistent left superior vena cava and entered the pericardium at the level of the sixth thoracic vertebra...
February 18, 2019: Anatomical Science International
https://read.qxmd.com/read/30746688/profiles-analysis-reveals-circular-rnas-involving-zebrafish-physiological-development
#3
Heng Liu, Yin Hu, Jing Yin, Xiang-Yun Yan, Wen-Juan Chen, Cheng-Yao Jiang, Xiao-Shan Hu, Xing-Yun Wang, Jin-Gai Zhu, Zhang-Bin Yu, Shu-Ping Han
Recent studies have found that known functions of circular RNAs (circRNAs) include sequestration of microRNAs (miRNAs) or proteins, modulation of transcription and interference with splicing, and even translation to produce polypeptides. The zebrafish model is also demonstrably similar to humans in many studies. To explore the changes in circRNAs during embryonic development and to further research the mechanism of action of circRNAs in development-related diseases, Zebrafish embryos at the blastula period, gastrula period, segmentation period, throat stage, and incubation period were collected...
February 11, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30715268/bicuspid-aortic-valve-behaviour-in-elite-athletes
#4
Araceli Boraita, Francisco Morales-Acuna, Manuel Marina-Breysse, María-Eugenia Heras, Alicia Canda, María-Eugenia Fuentes, Antonio Chacón, Leonel Diaz-Gonzalez, Manuel Rabadan, Begoña Parra Laca, Leopoldo Pérez de Isla, José Tuñón
Aims: To determine the prevalence and characteristics of bicuspid aortic valve (BAV) among elite athletes and to analyse the effect of long-term exercise training on their aortas. Methods and results: Consecutive BAV and tricuspid aortic valve (TAV) elite athletes from a population of 5136 athletes evaluated at the Sports Medicine Center of the Spanish National Sports Council were identified using echocardiography. A total of 41 BAV elite athletes were matched with 41 TAV elite athletes, and 41 BAV non-athletic patients from three Spanish tertiary hospitals...
January 31, 2019: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/30707595/modulating-cardiac-conduction-during-metabolic-ischemia-with-perfusate-sodium-and-calcium-in-guinea-pig-hearts
#5
Sharon Ann George, Gregory Hoeker, Patrick Calhoun, Michael Entz, Tristan B Raisch, David Ryan King, Momina Khan, Chandra E Baker, Robert G Gourdie, James W Smyth, Morten Schak Nielsen, Steven Poelzing
INTRODUCTION: We previously demonstrated that altering extracellular sodium (Nao ) and calcium (Cao ) can modulate a form of electrical communication between cardiomyocytes, termed ephaptic coupling, especially during loss of gap junction coupling. We hypothesized that altering Nao and Cao modulates conduction velocity (CV) and arrhythmic burden during ischemia. METHODS: Electrophysiology was quantified by optically mapping Langendorff-perfused guinea pig ventricles with modified Nao (147 or 155mM) and Cao (1...
February 1, 2019: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/30701711/gender-related-association-between-arterial-stiffness-and-aortic-root-geometry
#6
You Jeong Ki, Hack Lyoung Kim, Sohee Oh, Won Kyeong Jeon, Tae Min Rhee, Woo Hyun Lim, Jae Bin Seo, Sang Hyun Kim, Myung A Kim, Joo Hee Zo
BACKGROUND: The gender-related change in aortic morphology by arterial stiffness has not been well studied. This study was performed to investigate the association between brachial-ankle pulse wave velocity (baPWV) and aortic root size according to gender. METHODS: A total of 263 consecutive subjects (63.2 ± 10.6 years, 71.1% men) without overt cardiovascular disease who underwent both baPWV measurement and transthoracic echocardiography on the same day were retrospectively analyzed...
January 2019: Journal of cardiovascular imaging
https://read.qxmd.com/read/30698817/propagation-of-pericentral-necrosis-during-acetaminophen-induced-liver-injury-evidence-for-early-interhepatocyte-communication-and-information-exchange
#7
Ryan C Kennedy, Andrew K Smith, Glen E P Ropella, Mitchell R McGill, Hartmut Jaeschke, C Anthony Hunt
Acetaminophen (APAP) induced liver injury is clinically significant, and APAP overdose in mice often serves as a model for drug-induced liver injury in humans. By specifying that APAP metabolism, reactive metabolite formation, glutathione depletion, and mitigation of mitochondrial damage within individual hepatocytes are functions of intralobular location, an earlier virtual model mechanism provided the first concrete multi-attribute explanation for how and why early necrosis occurs close to the central vein (CV)...
January 29, 2019: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/30662232/junctional-rhythm-a-rare-sign-in-leptospirosis
#8
Rachana Warrier, Santosh Kumar Singh, Sarvinder Singh, Ajai Kumar Tentu, Nidhi Singh, Chinmaya Dash, Vani Singh
Leptospirosis is an important re-emerging infectious disease. Leptospirosis has been estimated to affect tens of millions of humans annually with a case fatality rate ranging from 5% to 25%; however, it is underreported due to the lack of clinical suspicion and barriers to diagnostic capacity. A 33-year-old healthy male presented with a history of fever of 2-day duration. His examination revealed icterus. His workup did not show any significant findings except for a mild transaminitis and a rise in serum creatinine by 0...
December 2018: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/30659271/glucagon-like-peptide-1-receptor-activation-alleviates-lipopolysaccharide-induced-acute-lung-injury-in-mice-via-maintenance-of-endothelial-barrier-function
#9
Jian Xu, Guihong Wei, Jingjing Wang, Jiali Zhu, Min Yu, Xiaoning Zeng, Hong Wang, Weiping Xie, Hui Kong
Glucagon-like peptide-1 (GLP-1), which is well known for regulating glucose homeostasis, exhibits multiple actions in cardiovascular disorders and renal injury. However, little is known about the effect of GLP-1 receptor (GLP-1R) activation on acute lung injury (ALI). In this study, we investigated the effect of GLP-1R on ALI and the potential underlying mechanisms with the selective agonist liraglutide. Our results show that GLP-1 levels decreased in serum, though they increased in bronchoalveolar lavage fluid (BALF) and lung tissue in a mouse model of lipopolysaccharide (LPS)-induced ALI...
January 18, 2019: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://read.qxmd.com/read/30621602/antiarrhythmic-effect-of-sevoflurane-as-an-additive-to-htk-solution-on-reperfusion-arrhythmias-induced-by-hypothermia-and-ischaemia-is-associated-with-the-phosphorylation-of-connexin-43-at-serine-368
#10
Wei Chao Li, Hong Gao, Ju Gao, Zi Jun Wang
BACKGROUND: Reperfusion ventricular arrhythmia (RA) associated with hypothermic ischaemic storage is increasingly recognized as a substantial contributor to adverse consequences after heart transplantation. Ischemia- or hypothermia-induced gap junction (GJ) remodelling is closely linked to RA. Reducing GJ remodelling contributes to RA attenuation and is important in heart transplantation. However, sevoflurane has an antiarrhythmic effect associated with the connexin 43 (Cx43) protein that has not yet been fully established...
January 8, 2019: BMC Anesthesiology
https://read.qxmd.com/read/30605053/extracellular-rna-a-potential-drug-target-for-alleviating-atherosclerosis-ischemia-reperfusion-injury-and-organ-transplantation
#11
Anna-Kristina Kluever, Elisabeth Deindl
Extracellular RNA (eRNA), composed of mainly rRNA e.g. released upon cell injury, has previously been shown to have three main detrimental functions in the context of cardiovascular disease: (1) to promote tissue edema by activating the VEGF signal transduction cascade, disrupting endothelial tight junctions and increasing intercellular permeability; (2) to induce thrombus formation by activating the contact phase system of intrinsic blood coagulation; and (3) to increase inflammation by stimulating leukocyte adhesion and transmigration and the mobilization of pro-inflammatory cytokines...
January 2, 2019: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/30597676/morphological-and-pharmacological-characterization-of-the-porcine-popliteal-artery-a-novel-model-for-study-of-lower-limb-arterial-disease
#12
N E Frederick, R Mitchell, T W Hein, P Bagher
OBJECTIVE: This study was undertaken to characterize structural and pharmacological properties of the pig popliteal artery in order to develop a novel system for the examination of lower limb blood flow regulation in a variety of cardiovascular pathologies, such as diabetes-induced peripheral artery disease. METHODS: Popliteal arteries were isolated from streptozocin-induced diabetic pigs or age-matched saline-injected control pigs for morphological study using transmission electron microscopy and for examination of vasoreactivity to pharmacological agents using wire myography...
December 30, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30554012/fabrication-of-electrochemical-biosensor-composed-of-multi-functional-dna-structure-au-nanospike-on-micro-gap-pcb-system-for-detecting-troponin-i-in-human-serum
#13
Taek Lee, Yeonju Lee, Sun Yong Park, Keonyoung Hong, Younghun Kim, Chulhwan Park, Yong-Ho Chung, Min-Ho Lee, Junhong Min
Acute myocardial infarction (AMI) is one of the most serious diseases affecting human beings. In this study, in order to rapidly detect AMI disease, the authors fabricated a label-free electrochemical biosensor composed of a multi-functional DNA structure on Au nanospike (AuNS) with a fabricated Au micro-gap electrode which was incorporated with a PCB chip in order to detect cardiac troponin I (cTnI). As a bioprobe, the DNA 3 way-junction (3WJ) was introduced, because the DNA 3WJ has three arms for embodying the multi-functionality...
December 7, 2018: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/30553558/surgical-validation-of-functional-magnetic-resonance-urography-in-the-study-of-ureteropelvic-junction-obstruction-in-a-pediatric-cohort
#14
M C Y Wong, F Sertorio, M B Damasio, V Incarbone, F Beati, M Bodria, A Pistorio, G M Ghiggeri, G M Magnano, G Mattioli
INTRODUCTION: Ureteropelvic junction obstruction (UPJO) is one of the most common urological diseases in children. The etiology can be intrinsic, extrinsic (crossing vessel [CV] or adhesions), or mixed. To date, ultrasonography and scintigraphy are considered gold-standard imaging techniques for the study of UPJO. Functional magnetic resonance urography (fMRU) combines anatomical and functional information and has been recently evaluated for the detection of CVs in UPJO. OBJECTIVE: The objective of the study was to evaluate the concordance between fMRU and surgery in determining the etiology of UPJO and the presence of obstructing/non-obstructing CVs...
November 22, 2018: Journal of Pediatric Urology
https://read.qxmd.com/read/30496878/neulasta-regimen-for-the-hematopoietic-ars-effects-beyond-neutrophil-recovery
#15
Betre Legesse, Amandeep Kaur, Doreswamy Kenchegowda, Bernadette Hritzo, William E Culp, Maria Moroni
PURPOSE: Understanding the physiopathology underlying the Acute Radiation Syndrome (ARS) and the mechanism of action of drugs known to ameliorate ARS is expected to help identify novel countermeasure candidates and improve the outcome for victims exposed to radiation. G-CSF has been approved by the FDA for treatment of hematopoietic ARS (H-ARS) based on its ability to alleviate myelosuppression. Besides its role in hematopoiesis, G-CSF is known to protect the cardiovascular and neurological systems, to attenuate vascular injury and cardiac toxicity, to preserve gap junction function, and to modulate inflammation and oxidative stress...
November 26, 2018: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/30485657/the-relationship-between-serum-apelin-levels-and-aortic-dilatation-in-bicuspid-aortic-valve-patients
#16
Ersin Çagrı Şimşek, Selcen Yakar Tülüce, Kamil Tülüce, Sadık Volkan Emren, Serap Çuhadar, Cem Nazlı
OBJECTIVE: The bicuspid aortic valve (BAV) is the most common congenital heart disease. The process of aortic dilatation is not completely clear in patients with the BAV. Apelin is a peptide found at high levels in vascular endothelial cells which has a role in vascular regulation and cardiovascular function. The aim of this study was to determine the relationship between serum apelin levels and ascending aortic dilatation in adult patients with BAV. DESIGN: This cross-sectional study included 62 patients with isolated BAV and to an age, gender, and body mass index-matched control group of 58 healthy volunteers with tricuspid aortic valve...
November 28, 2018: Congenital Heart Disease
https://read.qxmd.com/read/30480084/age-related-changes-in-four-dimensional-cmr-derived-atrioventricular-junction-velocities-and-displacements-implications-for-the-identification-of-altered-annular-dynamics-for-ventricular-function-assessment
#17
Shuang Leng, Xiaodan Zhao, Angela S Koh, Lei Zhao, John C Allen, Ru-San Tan, Xiaohai Ma, Liang Zhong
Background: We determined the age-related changes in atrioventricular junction (AVJ) velocities and displacements by feature tracking cardiovascular magnetic resonance (FT-CMR) in a healthy community-based population. We also investigated the importance of age-matching for the identification of altered AVJ dynamics. Methods: FT-CMR was performed in 230 controls (18-78 years) and in two patient groups each consisting of 40 subjects (group 1: 23-55 years, group 2: 56-80 years)...
March 2019: IJC Heart & Vasculature
https://read.qxmd.com/read/30459711/the-usefulness-of-magnetic-resonance-imaging-of-the-cardiovascular-system-in-the-diagnostic-work-up-of-patients-with-turner-syndrome
#18
Monika Obara-Moszynska, Justyna Rajewska-Tabor, Szymon Rozmiarek, Katarzyna Karmelita-Katulska, Anna Kociemba, Barbara Rabska-Pietrzak, Magdalena Janus, Andrzej Siniawski, Bartlomiej Mrozinski, Agnieszka Graczyk-Szuster, Marek Niedziela, Malgorzata Pyda
Cardiovascular defects occur in 50% of patients with Turner syndrome (TS). The aim of the study was to estimate the usefulness of cardiac magnetic resonance imaging (CMR) and magnetic resonance angiography (angio-MR) as diagnostics in children and adolescents with TS. Forty-one females with TS, aged 13.9 ± 2.2 years, were studied. CMR was performed in 39 patients and angio-MR in 36. Echocardiography was performed in all patients. The most frequent anomalies diagnosed on CMR and angio-MR were as follows: elongation of the ascending aorta (AA) and aortic arch, present in 16 patients (45...
2018: Frontiers in Endocrinology
https://read.qxmd.com/read/30453253/plasmatic-and-chamber-specific-modulation-of-cardiac-micrornas-in-an-acute-model-of-dox-induced-cardiotoxicity
#19
Sonia Gioffré, Veronica Ricci, Chiara Vavassori, Clarissa Ruggeri, Mattia Chiesa, Ivana Alfieri, Silvia Zorzan, Marta Buzzetti, Giuseppina Milano, Alessandro Scopece, Laura Castiglioni, Luigi Sironi, Giulio Pompilio, Gualtiero I Colombo, Yuri D'Alessandra
BACKGROUND: Doxorubicin (DOX) is a chemotherapeutic drug limited in its usefulness by an adverse side effect, cardiotoxicity. The mechanisms leading to this detrimental occurrence are not completely clear, and lately many authors focused their attention on the possible role of microRNAs (miRNAs), small regulators of cardiovascular functions, in this phenomenon. Notably, these molecules recently emerged also as potential circulating biomarkers of several cardiac diseases. Thus, the aim of this study was the simultaneous investigation of circulating and cardiac tissue miRNAs expression upon DOX treatment in vivo...
November 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://read.qxmd.com/read/30448117/diagnostic-and-prognostic-utility-of-cardiac-magnetic-resonance-imaging-in-aortic-regurgitation
#20
Andreas A Kammerlander, Matthias Wiesinger, Franz Duca, Stefan Aschauer, Christina Binder, Caroline Zotter Tufaro, Christian Nitsche, Roza Badre-Eslam, Robert Schönbauer, Philipp Bartko, Dietrich Beitzke, Christian Loewe, Christian Hengstenberg, Diana Bonderman, Julia Mascherbauer
OBJECTIVES: This study investigated the diagnostic and prognostic value of cardiac magnetic resonance (CMR) imaging in chronic aortic regurgitation (AR). BACKGROUND: Accurate quantification of AR severity by echocardiography frequently remains difficult. CMR is recommended as the complementary method; however, its accuracy and prognostic utility remain unknown. METHODS: A total of 232 consecutive patients (34.5% were females 55.5 ± 19.8 years of age) with chronic AR (including 40 with moderate to severe and 44 with severe AR on echocardiography) underwent CMR within 4 weeks of echocardiography...
November 8, 2018: JACC. Cardiovascular Imaging
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