Francesca Ulbar, Ida Villanova, Raffaella Giancola, Stefano Baldoni, Francesco Guardalupi, Bianca Fabi, Paola Olioso, Anita Capone, Rosaria Sola, Sara Ciardelli, Beatrice Del Papa, Antonello Brattelli, Ilda Ricciardi, Stefano Taricani, Giulia Sabbatinelli, Ornella Iuliani, Cecilia Passeri, Paolo Sportoletti, Stella Santarone, Antonio Pierini, Giuseppe Calabrese, Franca Falzetti, Tiziana Bonfini, Patrizia Accorsi, Loredana Ruggeri, Massimo Fabrizio Martelli, Andrea Velardi, Mauro Di Ianni
In the setting of T cell-depleted, full-haplotype mismatched transplantation, adoptive immunotherapy with regulatory T cells (Tregs) and conventional T cells (Tcons) can prevent graft-versus-host disease (GVHD) and improve post-transplantation immunologic reconstitution and is associated with a powerful graft-versus-leukemia effect. To improve the purity and the quantity of the infused Tregs, good manufacturing practices (GMP)-compatible expansion protocols are needed. Here we expanded Tregs using an automated, clinical-grade protocol...
December 2020: Biology of Blood and Marrow Transplantation