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Keywords long noncoding RNA and parkins...

long noncoding RNA and parkinson disease

https://read.qxmd.com/read/34755654/the-long-noncoding-rna-gas5-potentiates-neuronal-injury-in-parkinson-s-disease-by-binding-to-microrna-150-to-regulate-fosl1-expression
#21
JOURNAL ARTICLE
Jianjun Ma, Wenhua Sun, Siyuan Chen, Zhidong Wang, Jinhua Zheng, Xiaoxue Shi, Mingjian Li, Dongsheng Li, Qi Gu
Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) have been the focus of recent studies of neurodegenerative disorders, including Parkinson's disease (PD). However, the specific mechanism of action of growth arrest-specific 5 (GAS5) in PD has not yet been characterized. First, the GSE8030 and GSE16658 datasets were analyzed to obtain differentially expressed genes (DEGs), followed by the development of a PD mouse model. The effects of shRNA targeting fos-like antigen-1 (shFosl1) and microRNA (miR)-150 agomiR on PD mouse behavior and neuronal injury were evaluated in vitro and in vivo...
January 2022: Experimental Neurology
https://read.qxmd.com/read/34607512/long-noncoding-rna-sry-box-transcription-factor-2-overlapping-transcript-participates-in-parkinson-s-disease-by-regulating-the-microrna-942-5p-nuclear-apoptosis-inducing-factor-1-axis
#22
JOURNAL ARTICLE
Yabi Guo, Yanyang Liu, Hong Wang, Peijun Liu
Parkinson's disease (PD) is a neurodegenerative disorder. Studies have shown that long noncoding RNA SRY-box transcription factor 2 overlapping transcript (lncRNA SOX2-OT) is highly expressed in PD patients, but its specific functions and mechanisms require further research. To address this gap, this study utilized an in vitro PD cell model induced by 1-methyl-4-phenylpyridinium (MPP+ ). Cell viability, apoptosis, lactate dehydrogenase (LDH) activity, inflammatory factor secretion, and oxidative stress indicators were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-dipheyltetrazolium bromide assay, LDH assay, flow cytometry, enzyme linked immunosorbent assay (ELISA), and corresponding kits, respectively...
December 2021: Bioengineered
https://read.qxmd.com/read/34536521/integrative-analysis-of-potential-biomarkers-and-immune-cell-infiltration-in-parkinson-s-disease
#23
JOURNAL ARTICLE
Xiaopeng Chen, Wei Cao, Yuansu Zhuang, Siyuan Chen, Xuezhong Li
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disease in the elderly population. However, there are no reliable diagnostic biomarkers for PD, and the pathogenesis of PD still needs further study. The aim of the current study was to identify potential biomarkers and explore the pathogenesis of PD. METHODS: We conducted an integrative analysis of messenger RNA (mRNA), microRNA (miRNA), and long noncoding RNA (lncRNA) expression profiles of PD using data from the Gene Expression Omnibus (GEO)...
December 2021: Brain Research Bulletin
https://read.qxmd.com/read/34511122/lncrna-hoxa-as2-regulates-microglial-polarization-via-recruitment-of-prc2-and-epigenetic-modification-of-pgc-1%C3%AE-expression
#24
JOURNAL ARTICLE
Xiaodong Yang, Yi Zhang, Yimeng Chen, Xiaoqin He, Yiwei Qian, Shaoqing Xu, Chao Gao, Chengjun Mo, Shengdi Chen, Qin Xiao
BACKGROUND: Microglia-mediated neuroinflammation plays an important role in Parkinson's disease (PD), and it exerts proinflammatory or anti-inflammatory effects depending on the M1/M2 polarization phenotype. Hence, promoting microglia toward the anti-inflammatory M2 phenotype is a potential therapeutic approach for PD. Long noncoding RNAs (lncRNAs) are crucial in the progression of neurodegenerative diseases, but little is known about their role in microglial polarization in PD. METHODS: In our study, we profiled the expression of lncRNAs in the peripheral blood mononuclear cells (PBMCs) of PD patients using a microarray...
September 12, 2021: Journal of Neuroinflammation
https://read.qxmd.com/read/34508910/long-noncoding-rna-neat1-knockdown-ameliorates-1-methyl-4-phenylpyridine-induced-cell-injury-through-microrna-519a-3p-sp1-axis-in-parkinson-disease
#25
JOURNAL ARTICLE
Shuihua Wang, Qinli Wen, Bohai Xiong, Li Zhang, Xiaoli Yu, Xiaochun Ouyang
BACKGROUND: Parkinson disease is a neurodegenerative disease and is characterized by resting tremor, dementia, and gait disorder. Previous studies have indicated that long noncoding RNA participates in the regulation of the pathogenesis of Parkinson disease. The study aimed to reveal the effects of long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) on 1-methyl-4-phenylpyridine (MPP+ )-induced human neuroblastoma cell injury and the underlying mechanism. METHODS: The expressions of NEAT1, microRNA (miR)-519a-3p, and transcription factor specific protein 1 (SP1) were detected by quantitative real-time polymerase chain reaction...
December 2021: World Neurosurgery
https://read.qxmd.com/read/34472490/hottip-downregulation-reduces-neuronal-damage-and-microglial-activation-in-parkinson-s-disease-cell-and-mouse-models
#26
JOURNAL ARTICLE
Peng Lun, Tao Ji, De-Hong Wan, Xia Liu, Xiao-Dong Chen, Shuai Yu, Peng Sun
HOXA transcript at the distal tip (HOTTIP), a newly identified long noncoding RNA, has been shown to exhibit anti-inflammatory effects and inhibit oxygen-glucose deprivation-induced neuronal apoptosis. However, its role in Parkinson's disease (PD) remains unclear. 1-Methyl-4-phenylpyridium (MPP+ ) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were used to establish PD models in SH-SY5Y and BV2 cells and in C57BL/6 male mice, respectively. In vitro, after HOTTIP knockdown by sh-HOTTIP transfection, HOTTIP and FOXO1 overexpression promoted SH-SY5Y apoptosis, BV2 microglial activation, proinflammatory cytokine expression, and nuclear factor kappa-B and NACHT, LRR and PYD domains-containing protein 3 inflammasome activation...
April 2022: Neural Regeneration Research
https://read.qxmd.com/read/34421536/long-noncoding-rnas-in-neurodegenerative-diseases-pathogenesis-and-potential-implications-as-clinical-biomarkers
#27
JOURNAL ARTICLE
Meng Zhang, Ping He, Zhigang Bian
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are progressive and ultimately fatal. NDD onset is influenced by several factors including heredity and environmental cues. Long noncoding RNAs (lncRNAs) are a class of noncoding RNA molecules with: (i) lengths greater than 200 nucleotides, (ii) diverse biological functions, and (iii) highly conserved structures. They directly interact with molecules such as proteins and microRNAs and subsequently regulate the expression of their targets at the genetic, transcriptional, and post-transcriptional levels...
2021: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/34369042/downregulation-of-long-noncoding-rna-snhg7-protects-against-inflammation-and-apoptosis-in-parkinson-s-disease-model-by-targeting-the-mir-425-5p-traf5-nf-%C3%AE%C2%BAb-axis
#28
JOURNAL ARTICLE
Haiquan Zhang, Zhiyong Wang, Keqi Hu, Handong Liu
Accumulated evidence has manifested that long noncoding RNA (lncRNA) is involved in the progress of Parkinson's disease (PD). SNHG7, a novel lncRNA, has been found to be involved in tumorigenesis. However, SNHG7 expression and its functional effects on PD remain uncharted. Rotenone (Rot) was adopted to construct PD models in Sprague-Dawley (SD) rats and SH-SY5Y cells, respectively. The expression levels of caspase 3, tyrosine hydroxylase (TH), ionized calcium-binding adapter molecule 1 (Iba1) in SD rat striatum were measured via immunohistochemistry and western blot...
October 2021: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/33911864/long-noncoding-rna-snhg1-knockdown-ameliorates-apoptosis-oxidative-stress-and-inflammation-in-models-of-parkinson-s-disease-by-inhibiting-the-mir-125b-5p-mapk1-axis
#29
JOURNAL ARTICLE
Xiao Xiao, Zhiwen Tan, Min Jia, Xiaoli Zhou, Kemei Wu, Yanbing Ding, Wenjing Li
BACKGROUND: Parkinson's disease (PD) is a prevalent neurodegenerative disease. Long noncoding RNA small molecule RNA host gene 1 (SNHG1) has been reported to play critical roles in Parkinson's disease (PD) progression. The study aimed to further elucidate the mechanism of SNHG1 in PD pathogenesis. METHODS: The levels of SNHG1, miR-125b-5p and mitogen-activated protein kinase 1 (MAPK1) were determined by quantitative real-time polymerase chain reaction (qRT-PCR) or Western blot...
2021: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/33643816/long-non-coding-rnas-from-disease-code-to-drug-role
#30
REVIEW
Yuanyuan Chen, Zhaojun Li, Xiaoguang Chen, Sen Zhang
Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively participate in crucial physiological processes such as metabolism and immunity, and are closely related to the occurrence and development of tumors, cardiovascular diseases, nervous system disorders, nephropathy, and other diseases. The application of lncRNAs as biomarkers or intervention targets can provide new insights into the diagnosis and treatment of diseases. This paper has focused on the emerging research into lncRNAs as pharmacological targets and has reviewed the transition of lncRNAs from the role of disease coding to acting as drug candidates, including the current status and progress in preclinical research...
February 2021: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/33505213/lncrna-snhg14-plays-a-role-in-sepsis-induced-acute-kidney-injury-by-regulating-mir-93
#31
JOURNAL ARTICLE
Chuanchuan Shi, Yuqian Zhao, Qi Li, Jianguo Li
Acute kidney injury (AKI) is a common organ injury in sepsis, which leads to poor prognosis. Long noncoding RNA (lncRNA) small nucleolus RNA host gene 14 (SNHG14) was recognized to induce cell injury in LPS-induced acute lung injury and Parkinson's disease. We want to investigate the functions and mechanisms of SNHG14 in sepsis-induced AKI. Increased expression of SNHG14 was observed in LPS-induced HK-2 cells, and this was due to the activation of the TLR4/NF- κ B pathway. In vitro studies showed that SNHG14 was involved in the oxidative stress, inflammation, and apoptosis of LPS-induced HK-2 cells...
2021: Mediators of Inflammation
https://read.qxmd.com/read/33464446/silencing-of-uca1-protects-against-mpp-induced-cytotoxicity-in-sk-n-sh-cells-via-modulating-kctd20-expression-by-sponging-mir-423-5p
#32
JOURNAL ARTICLE
Yanhua Zheng, Junpeng Liu, Jiajun Zhuang, Xiaoyan Dong, Miao Yu, Zhihui Li
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. Long noncoding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) has been implicated in PD development. Nevertheless, little insight has been gained on the mechanisms of UCA1 in PD pathogenesis. The levels of UCA1, miR-423-5p and potassium channel tetramerization domain containing 20 (KCTD20) were assessed by qRT-PCR and western blot. Cell viability was gauged by the CCK-8 assay, and cell apoptosis was detected by flow cytometry...
January 19, 2021: Neurochemical Research
https://read.qxmd.com/read/33445654/single-cell-profiling-of-coding-and-noncoding-genes-in-human-dopamine-neuron-differentiation
#33
JOURNAL ARTICLE
Fredrik Nilsson, Petter Storm, Edoardo Sozzi, David Hidalgo Gil, Marcella Birtele, Yogita Sharma, Malin Parmar, Alessandro Fiorenzano
Dopaminergic (DA) neurons derived from human pluripotent stem cells (hPSCs) represent a renewable and available source of cells useful for understanding development, developing disease models, and stem-cell therapies for Parkinson's disease (PD). To assess the utility of stem cell cultures as an in vitro model system of human DA neurogenesis, we performed high-throughput transcriptional profiling of ~20,000 ventral midbrain (VM)-patterned stem cells at different stages of maturation using droplet-based single-cell RNA sequencing (scRNAseq)...
January 12, 2021: Cells
https://read.qxmd.com/read/33208053/linc00943-knockdown-attenuates-mpp-induced-neuronal-damage-via-mir-15b-5p-rab3ip-axis-in-sk-n-sh-cells
#34
JOURNAL ARTICLE
Chunming Meng, Jing Gao, Qingyuan Ma, Qian Sun, Tiantian Qiao
OBJECTIVES: Parkinson's disease (PD) is a neurodegenerative problem correlated with neuronal damage. Long noncoding RNAs (lncRNAs) are implicated in neuronal damage in PD development. This research aims to analyze the function and mechanism of LINC00943 in 1-methyl-4-phenylpyridinium (MPP+ )-caused neuronal injury. METHODS: MPP+ -challenged SK-N-SH cells served as a PD-like model of neuronal damage. LINC00943, microRNA-15b-5p (miR-15b-5p) and RAB3A interacting protein (RAB3IP) abundances were examined via quantitative reverse transcription polymerase chain reaction or western blot...
November 19, 2020: Neurological Research
https://read.qxmd.com/read/32953727/adncr-modulates-neural-stem-cell-differentiation-and-proliferation-through-the-regulation-of-tcf3-expression
#35
JOURNAL ARTICLE
Ling Long, Chao Zeng, Honglei Chen, Taicheng Zhou, Lili Wu, Xiaodong Cai
Background: Neural stem cells (NSCs) are undifferentiated precursor cells that have the ability to self-renew and proliferate and have the capacity to become either glia (oligodendrocytes and astrocytes) or neurons. NSCs can act as beneficial adjuncts for many neurological disorders, such as cerebral infarction, spinal cord injuries, Alzheimer's disease, and Parkinson's disease. Long noncoding RNAs (lncRNAs) play essential roles during cell differentiation, proliferation, and metabolism...
August 2020: Annals of Translational Medicine
https://read.qxmd.com/read/32899172/noncoding-rnas-and-midbrain-da-neurons-novel-molecular-mechanisms-and-therapeutic-targets-in-health-and-disease
#36
REVIEW
Emilia Pascale, Giuseppina Divisato, Renata Palladino, Margherita Auriemma, Edward Faustine Ngalya, Massimiliano Caiazzo
Midbrain dopamine neurons have crucial functions in motor and emotional control and their degeneration leads to several neurological dysfunctions such as Parkinson's disease, addiction, depression, schizophrenia, and others. Despite advances in the understanding of specific altered proteins and coding genes, little is known about cumulative changes in the transcriptional landscape of noncoding genes in midbrain dopamine neurons. Noncoding RNAs-specifically microRNAs and long noncoding RNAs-are emerging as crucial post-transcriptional regulators of gene expression in the brain...
September 3, 2020: Biomolecules
https://read.qxmd.com/read/32617144/role-of-long-noncoding-rnas-in-parkinson-s-disease-putative-biomarkers-and-therapeutic-targets
#37
REVIEW
Qiankun Lv, Ziyu Wang, Zhen Zhong, Wei Huang
Parkinson's disease (PD) is a neurodegenerative disease characterized by bradykinesia, rigidity, and tremor. Age is the main risk factor. Long noncoding RNAs (lncRNAs) are novel RNA molecules of more than 200 nucleotides in length. They may be involved in the regulation of many pathological processes of PD. PD has a variety of pathophysiological mechanisms, including alpha-synuclein aggregate, mitochondrial dysfunction, oxidative stress, calcium homeostasis, axonal transport, and neuroinflammation. Among these, the impacts of lncRNAs on the pathogenesis and progression of PD need to be highlighted...
2020: Parkinson's Disease
https://read.qxmd.com/read/32470877/long-noncoding-rna-gas5-promotes-microglial-inflammatory-response-in-parkinson-s-disease-by-regulating-nlrp3-pathway-through-sponging-mir-223-3p
#38
JOURNAL ARTICLE
Wei Xu, Ling Zhang, Yu Geng, Ye Liu, Ning Zhang
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Neuroinflammation induced by microglia plays an important role in the pathogenesis of PD. Long noncoding RNA GAS5 was showed to have significant effects on regulating inflammatory response. Here, we aim to investigate the effects of GAS5 on the inflammatory response of PD, and the underlying mechanism. An in vivo model of PD was established in C57BL/6 mice by rotenone and an in vitro cell model was conducted on microglia by lipopolysaccharide (LPS)...
May 26, 2020: International Immunopharmacology
https://read.qxmd.com/read/32442477/long-noncoding-rna-neat1-knockdown-inhibits-mpp-induced-apoptosis-in%C3%AF-ammation-and-cytotoxicity-in-sk-n-sh-cells-by-regulating-mir-212-5p-rab3ip-axis
#39
JOURNAL ARTICLE
Ruiguang Liu, Fenlin Li, Weijie Zhao
BACKGROUND: Some long non-coding RNAs (lncRNAs) have been suggested to play critical roles in Parkinson's disease (PD) pathogenesis, including nuclear enriched abundant transcript 1 (NEAT1). The purpose of this study was to further elucidate the molecular mechanism of NEAT1 in PD. METHODS: The expression levels of NEAT1, miR-212-5p and RAB3A-interacting protein (RAB3IP) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Cell viability and apoptosis were evaluated by Cell Counting Kit-8 (CCK-8) assay and flow cytometry analysis, respectively...
May 19, 2020: Neuroscience Letters
https://read.qxmd.com/read/32236821/long-noncoding-rna-pou3f3-and-%C3%AE-synuclein-in-plasma-l1cam-exosomes-combined-with-%C3%AE-glucocerebrosidase-activity-potential-predictors-of-parkinson-s-disease
#40
JOURNAL ARTICLE
Jing Zou, Yue Guo, Lei Wei, Fang Yu, Bo Yu, Anding Xu
Long noncoding RNAs (lncRNAs) are implicated in the autophagic-lysosomal pathway (ALP) and are closely linked to Parkinson's disease (PD) pathology. β-Glucocerebrosidase (GCase) has also been reported to be correlated with α-synuclein (α-syn) proteostasis. However, lncRNAs and α-syn in neural-derived L1CAM exosomes and GCase activity in the plasma of PD patients have not been studied. This study used an ultrasensitive methodology, fluorescence nanoparticle tracking analysis (NTA), to measure plasma L1CAM exosomes and Quanterix Simoa to measure α-syn concentrations in L1CAM exosomes...
March 31, 2020: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
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