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Janina Enderle, Annika Dorn, Natalja Beying, Oliver Trapp, Holger Puchta
Although DNA-protein crosslinks (DPCs) represent a severe threat to the genome integrity, only recently main mechanisms of DPC repair were elucidated in humans and yeast. Here we define the pathways for DPC repair in plants. Using CRISPR/Cas9, we could show that only one of two homologues of the universal repair proteases SPRTN/WSS1 (WSS1A) is essential for DPC repair in Arabidopsis. WSS1A defective lines exhibit developmental defects and are hypersensitive to camptothecin (CPT) and cis-platin. Interestingly, the CRISPR/Cas9 mutants of the tyrosyl-DNA phosphodiesterase 1 (TDP1) are insensitive to CPT, and only the wss1A tdp1 double mutant reveals a higher sensitivity than the wss1A single mutant...
February 13, 2019: Plant Cell
Anahit Babayan, Miray Erbey, Deniz Kumral, Janis D Reinelt, Andrea M F Reiter, Josefin Röbbig, H Lina Schaare, Marie Uhlig, Alfred Anwander, Pierre-Louis Bazin, Annette Horstmann, Leonie Lampe, Vadim V Nikulin, Hadas Okon-Singer, Sven Preusser, André Pampel, Christiane S Rohr, Julia Sacher, Angelika Thöne-Otto, Sabrina Trapp, Till Nierhaus, Denise Altmann, Katrin Arelin, Maria Blöchl, Edith Bongartz, Patric Breig, Elena Cesnaite, Sufang Chen, Roberto Cozatl, Saskia Czerwonatis, Gabriele Dambrauskaite, Maria Dreyer, Jessica Enders, Melina Engelhardt, Marie Michele Fischer, Norman Forschack, Johannes Golchert, Laura Golz, C Alexandrina Guran, Susanna Hedrich, Nicole Hentschel, Daria I Hoffmann, Julia M Huntenburg, Rebecca Jost, Anna Kosatschek, Stella Kunzendorf, Hannah Lammers, Mark E Lauckner, Keyvan Mahjoory, Ahmad S Kanaan, Natacha Mendes, Ramona Menger, Enzo Morino, Karina Näthe, Jennifer Neubauer, Handan Noyan, Sabine Oligschläger, Patricia Panczyszyn-Trzewik, Dorothee Poehlchen, Nadine Putzke, Sabrina Roski, Marie-Catherine Schaller, Anja Schieferbein, Benito Schlaak, Robert Schmidt, Krzysztof J Gorgolewski, Hanna Maria Schmidt, Anne Schrimpf, Sylvia Stasch, Maria Voss, Annett Wiedemann, Daniel S Margulies, Michael Gaebler, Arno Villringer
We present a publicly available dataset of 227 healthy participants comprising a young (N=153, 25.1±3.1 years, range 20-35 years, 45 female) and an elderly group (N=74, 67.6±4.7 years, range 59-77 years, 37 female) acquired cross-sectionally in Leipzig, Germany, between 2013 and 2015 to study mind-body-emotion interactions. During a two-day assessment, participants completed MRI at 3 Tesla (resting-state fMRI, quantitative T1 (MP2RAGE), T2-weighted, FLAIR, SWI/QSM, DWI) and a 62-channel EEG experiment at rest...
February 12, 2019: Scientific Data
Elaine Sarapio, Samir Khal De Souza, Everton Lopes Vogt, Débora Santos Rocha, Rafael Bandeira Fabres, Marcia Trapp, Roselis S M Da Silva
In this study we determined the effect of fed and fasting (48 h) states on the expression of stanniocalcin-1 (Stc1) and stanniocalcin-2 (Stc2) in rat brown adipose tissue (BAT), as well as the in vitro effects of human stanniocalcin 1 and 2 (hSTC-1 and hSTC-2) hormones on lipid and glucose metabolism. In addition, lactate, glycogen levels and hexokinase (HK) activity were determined. In fasting Stc2 expression increased markedly. The targets of action of hSTC-1 and hSTC-2 were glucose uptake and oxidation as well as glycogen storage, controlling the energetic metabolism in BAT...
February 7, 2019: Molecular and Cellular Endocrinology
Jamie Trapp
No abstract text is available yet for this article.
February 8, 2019: Australasian Physical & Engineering Sciences in Medicine
Ulrich Gergs, Theresa Trapp, Hasan Bushnaq, Andreas Simm, Rolf-Edgar Silber, Joachim Neumann
Heart failure and aging of the heart show many similarities regarding hemodynamic and biochemical parameters. There is evidence that heart failure in experimental animals and humans is accompanied and possibly exacerbated by increased activity of protein phosphatase (PP) 1 and/or 2A. Here, we wanted to study the age-dependent protein expression of major members of the protein phosphatase family in human hearts. Right atrial samples were obtained during bypass surgery. Patients ( n =60) were suffering from chronic coronary artery disease (CCS 2-3; New York Heart Association (NYHA) stage 1-3)...
2019: Advances in Medicine
Elena Cosimi, Nils Trapp, Marc-Olivier Ebert, Helma Wennemers
A combined experimental and computational approach provided insight into the nature and conformational dependence of long-range 4JHF couplings in α-fluoro amides. The dependence of 4JHF on substituents and the solvent was investigated. H-F coupling constants determined by NMR spectroscopy are in agreement with DFT calculations. NBO analysis revealed that a favourable nF→σNH* interaction correlates with the magnitude of 4JHF.
January 30, 2019: Chemical Communications: Chem Comm
Miriam Deniz, Amelie DeGregorio, Nikolaus DeGregorio, Inga Bekes, Peter Widschwendter, Fabienne Schochter, Kristina Ernst, Christoph Scholz, Emanuel Ca Bauer, Viktoria Aivazova-Fuchs, Tobias Weissenbacher, Bernd Kost, Julia Jueckstock, Ullrich Andergassen, Julia Steidl, Elisabeth Trapp, Peter A Fasching, Lothar Häberle, Matthias W Beckmann, Andreas Schneeweiss, Iris Schrader, Wolfgang Janni, Brigitte Rack, Thomas Wp Friedl
OBJECTIVES: In breast cancer, large tumor size, positive nodal stage and a triple-negative tumor subtype are associated with reduced survival, but the interactions between these prognostic factors are not well understood. MATERIAL AND METHODS: Here we re-evaluated the impact of tumor size, nodal stage and tumor subtype on disease-free survival (DFS), overall survival (OS), distant disease-free survival (DDFS) and breast cancer specific survival (BCSS) in a retrospective analysis using data from the adjuvant SUCCESS A trial...
December 20, 2018: Breast: Official Journal of the European Society of Mastology
Caroline Trapp
No abstract text is available yet for this article.
February 2019: American Journal of Nursing
R Borrows, A Scheer, P Cockwell, F Braun, I Anagnostopoulos, H Riess, H Zimmermann, R U Trappe
Post-transplant lymphoproliferative disease (PTLD) is a serious complication of solid organ transplantation. As early diagnosis remains challenging, we investigated the utility of serum-free light chain (FLC) and heavy chain/light chain pairs (HLC) as diagnostic biomarkers. Pre-treatment serum FLC and HLC levels were measured in 20 patients at their first diagnosis of B cell PTLD and in 14/20 patients during follow-up. Results were compared to serum FLC/HLC levels of 90 matched PTLD-free transplanted controls...
January 25, 2019: Annals of Hematology
Lukas Lenga, Franziska Trapp, Moritz H Albrecht, Julian L Wichmann, Addison A Johnson, Ibrahim Yel, Tommaso D'Angelo, Christian Booz, Thomas J Vogl, Simon S Martin
OBJECTIVES: To evaluate radiation exposure and image quality in matched patient cohorts for CT pulmonary angiography (CTPA) acquired in single- and dual-energy mode using second- and third-generation dual-source CT (DSCT) systems. METHODS: We retrospectively included 200 patients (mean age, 65.5 years ± 15.7 years) with suspected pulmonary embolism-equally divided into four study groups (n = 50) and matched by gender and body mass index. CTPA was performed with vendor-predefined second-generation (group A, 100-kV single-energy computed tomography (SECT); group B, 80/Sn140-kV dual-energy computed tomography (DECT)) or third-generation DSCT (group C, 100-kV SECT; group D, 90/Sn150-kV DECT) devices...
January 21, 2019: European Radiology
Theresa Lahousen, Michael D Linder, Uwe Gieler, Dirk Hofmeister, Eva M Trapp, Ada Borkenhagen, Hans-Peter Kapfhammer, Elmar Brähler
BACKGROUND: The most popular body modifications are tattoos and piercings and their prevalence has increased in recent years. The current study gathered statistics regarding tattoing, piercing and body-hair removal, differentiated by gender and attitude towards cosmetic surgery. METHODS: The study was based on 2512 individuals and was performed as a population based survey with the assistance of a demographic consulting company. In addition to sociodemographicquestions, specific issues concerning body modification were asked...
January 15, 2019: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Jannik M Trapp, Manuel Decker, Jörg Petschulat, Thomas Pertsch, Toufic G Jabbour
In this contribution, we investigate the use of holographic optical elements (HOEs) as progressive addition lenses (PALs). We design HOEs with high diffraction efficiency (DE) using the Fourier Modal Method (FMM) and optimize an optical system comprising two of these HOEs to fulfill the optical function of a 2 diopter (dpt) PAL. The resulting design is a holographic PAL (hPAL) exhibiting high DE and limited angular color error (CE) with a distribution of spherical power and astigmatism equivalent to its refractive counterpart...
December 10, 2018: Optics Express
Jianjun Duan, David G Lambright
GEFs play a key role in activation and membrane targeting of Rab GTPases. In this issue of Developmental Cell, Thomas et al. (2018) demonstrate how two TRAPP complexes with a common GEF core select distinct Rab substrates through a steric gating mechanism involving their hypervariable tails.
January 7, 2019: Developmental Cell
Mark R Ams, Nils Trapp, Anatol Schwab, Jovana V Milić, François Diederich
Chalcogen bonding (CB) is the focus of increased attention for its applications in medicinal chemistry, materials science, and crystal engineering. However, the origin of sulfur's recognition properties remains controversial, and experimental evidence for supporting theories is still emerging. Here, a comprehensive evaluation of sulfur CB interactions is presented by investigating 2,1,3-benzothiadiazole X-ray crystallographic structures gathered from the Cambridge Structure Database (CSD), Protein Data Bank (PDB), and own laboratory findings...
January 2, 2019: Chemistry: a European Journal
Martin Christ, Katharina Isabel von Auenmueller, Michael Brand, Sofia Fessaras, Timo von den Benken, Hans-Joachim Trappe
BACKGROUND: In patients with supraventricular tachycardia, catheter ablation is an important treatment option. However, approximately one quarter of these patients remain symptomatic, so sustainable strategies for the treatment of those patients who do not benefit from the first catheter ablation are required. METHODS: In a series of redo procedures, we investigated the combined use of an electro-anatomic mapping system and an ablation catheter with mini-electrodes...
December 2018: Indian Heart Journal
Daiane Borba de Lima, Artur Trapp, Márcio Silveira Corrêa, Bruno Lima Giacobbo, Irani Iracema de Lima Argimon, Elke Bromberg
BACKGROUND: Contextual memory is susceptible to the effects of aging and its impairment compromises episodic memories and quality of life in older adults. OBJECTIVE: Compare the effects of cognitive support on incidental contextual memory free recall and recognition with a naturalistic experimental paradigm and explore the association of encoding strategies and physical activity on memory improvement. METHODS: Subjects (≥60 years, n = 52) were assigned to one of two encoding conditions for the contextual memory task: with or without an incidental associative instruction to encourage association of an item to its spatial context...
December 27, 2018: Aging & Mental Health
Safwan Aroua, Andrew N Lowell, Ankita Ray, Nils Trapp, W Bernd Schweizer, Marc-Olivier Ebert, Yoko Yamakoshi
A series of quinoxaline cavitands bearing pendant amide groups with various substituent sizes (Et, i Pr, t Bu) were synthesized, and their cavity size/structure were investigated by X-ray and NMR analyses. In the case of the Et or i Pr amide cavitand, the conformation of the molecule was in the vase form, while the bulky t Bu amide cavitand gave the kite conformation at room temperature. X-ray crystal structures of Et and i Pr cavitands clearly showed the intramolecular H-bondings to influence the conformation and the cavity sizes dependent on the bulkiness of functional groups...
December 19, 2018: Organic Letters
Adrien Lion, Evelyne Esnault, Emmanuel Kut, Vanaïque Guillory, Laetitia Trapp-Fragnet, Sébastien M Soubies, Nathalie Chanteloup, Alisson Niepceron, Rodrigo Guabiraba, Daniel Marc, Nicolas Eterradossi, Sascha Trapp, Pascale Quéré
It is well established that the endothelium plays a prominent role in the pathogenesis of various infectious diseases in mammals. However, little is known about the role of endothelial cells (EC) as targets for avian pathogens and their contribution to the pathogenesis of infectious diseases in galliform birds. First, we explored the innate immune response of primary chicken aortic endothelial cells (pchAEC) obtained from 18 day-old embryos to stimulation with pathogen-associated molecular patterns (PAMPs) or recombinant chicken interferons (type I, II and III IFNs)...
December 17, 2018: Avian Pathology: Journal of the W.V.P.A
Ann P Britton, Melissa Trapp, Suzana Sabaiduc, William Hsiao, Tomy Joseph, Helen Schwantje
Striped skunks (skunks) are susceptible to respiratory infection by influenza A viruses (IAV). As they are common synanthropes, maintenance of IAV in skunks could provide a source of infection for humans. We previously studied the nasal turbinates, lungs and faeces of 50 free-ranging skunks for the presence of IAV and identified two individuals with influenza A(H1N1)pdm09 infection during the 2009/2010 and 2013/2014 flu seasons. Subsequent to publication of that study, ferrets were shown to preferentially replicate and harbour A(H1N1)pdm09 in the soft palate, a site which had not been investigated in the skunks...
December 14, 2018: Zoonoses and Public Health
Florian Schöberl, Stephanie Irving, Cauchy Pradhan, Stanislavs Bardins, Christoph Trapp, Erich Schneider, Günter Kugler, Peter Bartenstein, Marianne Dieterich, Thomas Brandt, Andreas Zwergal
OBJECTIVE: To investigate long-term recovery of allocentric and egocentric spatial orientation as a sensitive marker for hippocampal and extrahippocampal network function in transient global amnesia (TGA). METHODS: A group of 18 patients with TGA performed an established real-space navigation paradigm, requiring allo- and egocentric spatial orientation abilities, 3 days (postacute stage) and 3 months (follow-up) after symptom onset. Visual exploration behavior and navigation strategy were documented by a gaze-controlled, head-fixed camera...
January 15, 2019: Neurology
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