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REVIEW
Antoinette Wannes Daou, Carolyn Wallace, Mitzi Barker, Teresa Ambrosino, Christopher Towe, David L S Morales, Kathryn A Wikenheiser-Brokamp, Don Hayes, Gregory Burg
Pediatric lung transplantation represents a treatment option for children with advanced lung disease or pulmonary vascular disorders who are deemed an appropriate candidate. Pediatric flexible bronchoscopy is an important and evolving field that is highly relevant in the pediatric lung transplant population. It is thus important to advance our knowledge to better understand how care for children after lung transplant can be maximally optimized using pediatric bronchoscopy. Our goals are to continually improve procedural skills when performing bronchoscopy and to decrease the complication rate while acquiring adequate samples for diagnostic evaluation...
June 2024: Pediatric Transplantation
#2
JOURNAL ARTICLE
Siew Eng Choon, Peter van de Kerkhof, Johann E Gudjonsson, Claudia de la Cruz, Jonathan Barker, Akimichi Morita, Ricardo Romiti, Azura Mohd Affandi, Pravit Asawanonda, Arthur David Burden, César Gonzalez, Slaheddine Marrakchi, Mohammad Rafiqul Mowla, Yukari Okubo, Hazel H Oon, Tadashi Terui, Tsen-Fang Tsai, Kristina Callis-Duffin, Hideki Fujita, Seong Jin Jo, Joseph Merola, Ulrich Mrowietz, Lluïs Puig, Diamant Thaçi, Margarita Velásquez, Matthias Augustine, Mahira El Sayed, Alexander A Navarini, Andrew Pink, Jörg Prinz, Hamida Turki, Renata Magalhães, Francesca Capon, Hervé Bachelez
IMPORTANCE: Generalized pustular psoriasis (GPP) lacks internationally accepted definitions and diagnostic criteria, impeding timely diagnosis and treatment and hindering cross-regional clinical and epidemiological study comparisons. OBJECTIVE: To develop an international consensus definition and diagnostic criteria for GPP using the modified Delphi method. EVIDENCE REVIEW: The rarity of GPP presents a challenge in acquiring comprehensive published clinical data necessary for developing standardized definition and criteria...
May 1, 2024: JAMA Dermatology
#3
JOURNAL ARTICLE
Jamie Anderson, Jack S Benton, Junyan Ye, Ellie Barker, Vanessa G Macintyre, Jack Wilkinson, James Rothwell, Matthew Dennis, David P French
There is little robust evidence of how sustainable park interventions impact on physical activity and other behaviours important for wellbeing. This controlled natural experimental study aimed to examine the effects of co-designing a sustainable park intervention, in a deprived UK urban area, on walking and other wellbeing behaviours. Behaviour observations were conducted at two intervention sites and two matched comparison sites (n = 4,783). Walking observations (primary outcome), wellbeing behaviours (vigorous, sedentary, social and take notice activities) and demographic characteristics were assessed at pre-intervention, and post-intervention (3 and 15 months)...
April 21, 2024: Environment International
#4
JOURNAL ARTICLE
John C Thomas, Wei Chen, Yihuang Xiong, Bradford A Barker, Junze Zhou, Weiru Chen, Antonio Rossi, Nolan Kelly, Zhuohang Yu, Da Zhou, Shalini Kumari, Edward S Barnard, Joshua A Robinson, Mauricio Terrones, Adam Schwartzberg, D Frank Ogletree, Eli Rotenberg, Marcus M Noack, Sinéad Griffin, Archana Raja, David A Strubbe, Gian-Marco Rignanese, Alexander Weber-Bargioni, Geoffroy Hautier
Point defects in two-dimensional materials are of key interest for quantum information science. However, the parameter space of possible defects is immense, making the identification of high-performance quantum defects very challenging. Here, we perform high-throughput (HT) first-principles computational screening to search for promising quantum defects within WS2 , which present localized levels in the band gap that can lead to bright optical transitions in the visible or telecom regime. Our computed database spans more than 700 charged defects formed through substitution on the tungsten or sulfur site...
April 26, 2024: Nature Communications
#5
JOURNAL ARTICLE
Xin Sun, Eddie Wai Chi Chan, Qun Chen, Nigel Kirby, Jingwen Yang, Jitendra P Mata, Richard L Kingston, David Barker, Laura Domigan, Jadranka Travas-Sejdic
As transient electronics continue to advance, the demand for new materials has given rise to the exploration of conducting polymer (CP)-based electronic materials. The big challenge lies in balancing conductivity while introducing controlled degradable properties into CP-based transient materials. In response to this, we present in this work a concept of using conducting polymers attached to an enzymatically biodegradable biopolymer to create transient polymer electronics materials. Specifically, poly(3-hexyl thiophene) (P3HT) is covalently grafted onto biopolymer gelatin, affording graft copolymer gelatin- graft -poly(3-hexyl thiophene) (termed Gel- g -P3HT)...
April 26, 2024: ACS Applied Materials & Interfaces
#6
JOURNAL ARTICLE
Timothy R Aksamit, Nicholas Locantore, Doreen Addrizzo-Harris, Juzar Ali, Alan Barker, Ashwin Basavaraj, Megan Behrman, Amanda E Brunton, Sarah Chalmers, Radmila Choate, Nathan C Dean, Angela DiMango, David Fraulino, Margaret M Johnson, Nicole C Lapinel, Diego J Maselli, Pamela J McShane, Mark L Metersky, Bruce E Miller, Edward T Naureckas, Anne E O'Donnell, Kenneth N Olivier, Elly Prusinowski, Marcos I Restrepo, Christopher J Richards, Gloria Rhyne, Andreas Schmid, George M Solomon, Ruth Tal-Singer, Byron Thomashow, Gregory Tino, Kevin Tsui, Sumith Abraham Varghese, Heather E Warren, Kevin Winthrop, Beth Shoshanna Zha
RATIONALE: Nontuberculous mycobacteria (NTM) are prevalent among patients with bronchiectasis. However, the long-term natural history of patients with NTM and bronchiectasis is not well described. OBJECTIVE: To assess the impact of NTM on 5-year clinical outcomes and mortality in patients with bronchiectasis. METHODS: Patients in the United States Bronchiectasis and Nontuberculous Mycobacteria Research Registry with ≥5 years of follow-up were eligible...
April 26, 2024: American Journal of Respiratory and Critical Care Medicine
#7
JOURNAL ARTICLE
Shaun Rees, Tayla Rees, Michelle van Rensburg, Christopher Walker, Lisa Pilkington, David Barker
Marine bromopyrrole alkaloids are a diverse family of natural products with a large array of biological applications. The mukanadin family is a group of molecules consisting of seven members (mukanadin A - G) that possess a range of biological activities. Inhibition of serotonergic signaling has been demonstrated by mukanadin B derivatives, presenting this chemical scaffold as a candidate for further SAR exploration. A library of thirteen novel mukanadin B and D derivatives with structural variation targeted at the pyrrole ring, central linker and hydantoin ring, were synthesized...
April 25, 2024: ChemMedChem
#8
JOURNAL ARTICLE
Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, David Barker, Mohd Hafiz Arzmi, Nurunajah Ab Ghani, Nurulfazlina Edayah Rasol
Phytochemical investigation of the leaves of Knema intermedia has led to the isolation of a new furofuran lignan, intermedianin 1 together with five known lignans, α-cubebin 2 , β-cubebin 3 , bicubebin A 4 , bicubebin B 5 , and bicubebin C 6 . The characterisation and structural elucidation of the isolated compounds were established by extensive spectroscopic data analysis and comparison with literature data. The antifungal activity was tested using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm...
April 24, 2024: Natural Product Research
#9
JOURNAL ARTICLE
Henry T W Blest, Alexander Redmond, Jed Avissar, Jake Barker, Anne Bridgeman, Gerissa Fowler, Lise Chauveau, Jonny Hertzog, Iolanda Vendrell, Roman Fischer, Marie B Iversen, Lichen Jing, David M Koelle, Søren R Paludan, Benedikt M Kessler, Colin M Crump, Jan Rehwinkel
DNA sensing is important for antiviral immunity. The DNA sensor cGAS synthesizes 2'3'-cyclic GMP-AMP (cGAMP), a second messenger that activates STING, which induces innate immunity. cGAMP not only activates STING in the cell where it is produced but cGAMP also transfers to other cells. Transporters, channels, and pores (including SLC19A1, SLC46A2, P2X7, ABCC1, and volume-regulated anion channels (VRACs)) release cGAMP into the extracellular space and/or import cGAMP. We report that infection with multiple human viruses depletes some of these cGAMP conduits...
April 22, 2024: Cell Reports
#10
JOURNAL ARTICLE
Michael Baria, Reshma George, Tyler Barker, David Flanigan, Christopher Kaeding, Robert Magnussen
OBJECTIVE: Body mass index (BMI) is known to contribute to outcomes for patients with knee OA. Furthermore, BMI influences the protein expression of orthobiologic treatments like platelet-rich plasma (PRP) and microfragmented adipose tissue (MFAT). We performed a secondary analysis of the association of BMI with PROs for patients with knee OA who received either PRP or MFAT injections. METHODS: Seventy-one patients with knee OA were randomized to receive a single ultrasound-guided injection of PRP or MFAT...
April 1, 2024: American Journal of Physical Medicine & Rehabilitation
#11
JOURNAL ARTICLE
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Alvaro Curiel-Garcia, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert H Vonderheide, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Broad-spectrum RAS inhibition holds the potential to benefit roughly a quarter of human cancer patients whose tumors are driven by RAS mutations1,2 . RMC-7977 is a highly selective inhibitor of the active GTP-bound forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants (RAS(ON) multi-selective)3 . As >90% of human pancreatic ductal adenocarcinoma (PDAC) cases are driven by activating mutations in KRAS4 , we assessed the therapeutic potential of the RAS(ON) multi-selective inhibitor RMC-7977 in a comprehensive range of PDAC models...
April 8, 2024: Nature
#12
JOURNAL ARTICLE
Jennifer Wardle, John McKenzie, Martin Barker, David F R P Burslem, Donald Gray
Participation in urban agriculture conducted through community gardens and allotments is known for its benefits to physical and mental health. Due to the recognition of these benefits, which include reduction of stress, depression and anxiety, such participation is increasingly being prescribed as a non-medical health intervention. Community gardens have the added advantage of immersion into a community, without the often-long waiting lists and level of commitment involved in allotment tenancies. What has not been explored is the demanding nature of the commitment required by volunteer coordinators, and ironically, the negative effects it can have on their wellbeing...
May 3, 2024: Local Environment
#13
REVIEW
Richard K Wyse, Tom Isaacs, Roger A Barker, Mark R Cookson, Ted M Dawson, David Devos, David T Dexter, Joy Duffen, Howard Federoff, Brian Fiske, Thomas Foltynie, Susan Fox, J Timothy Greenamyre, Karl Kieburtz, Jeffrey H Kordower, Dimitri Krainc, Helen Matthews, Darren J Moore, Leah Mursaleen, Michael A Schwarzschild, Simon R W Stott, David Sulzer, Per Svenningsson, Caroline M Tanner, Camille Carroll, David K Simon, Patrik Brundin
In 2011, the UK medical research charity Cure Parkinson's set up the international Linked Clinical Trials (iLCT) committee to help expedite the clinical testing of potentially disease modifying therapies for Parkinson's disease (PD). The first committee meeting was held at the Van Andel Institute in Grand Rapids, Michigan in 2012. This group of PD experts has subsequently met annually to assess and prioritize agents that may slow the progression of this neurodegenerative condition, using a systematic approach based on preclinical, epidemiological and, where possible, clinical data...
April 5, 2024: Journal of Parkinson's Disease
#14
Julie Leonard-Duke, Samuel M J Agro, David J Csordas, Anthony C Bruce, Taylor G Eggertsen, Tara N Tavakol, Thomas H Barker, Catherine A Bonham, Jeffery J Saucerman, Lakeshia J Taite, Shayn M Peirce
Investigating the molecular, cellular, and tissue-level changes caused by disease, and the effects of pharmacological treatments across these biological scales, necessitates the use of multiscale computational modeling in combination with experimentation. Many diseases dynamically alter the tissue microenvironment in ways that trigger microvascular network remodeling, which leads to the expansion or regression of microvessel networks. When microvessels undergo remodeling in idiopathic pulmonary fibrosis (IPF), functional gas exchange is impaired due to loss of alveolar structures and lung function declines...
March 22, 2024: bioRxiv
#15
JOURNAL ARTICLE
Delsa Pulickal Joseph, Urawadee Rajchakit, Lisa I Pilkington, Vijayalekshmi Sarojini, David Barker
Surface functionalisation of natural materials to develop sustainable and environmentally friendly antimicrobial fibres has received great research interest in recent years. Herein, chitosan covalent conjugation via aryl-diazonium based chemistry onto Phormium tenax fibres (PTF) and hemp hurds (HH) was investigated. PTF are fibres derived from Harakeke/New Zealand flax, an indigenous and abundant plant source of leaf fibres, which served as an important 19th century export commodity of New Zealand. HH are obtained as a by-product from the hemp (Cannabis sativa) industry and find applications as traditional construction material, animal bedding, chemical absorbent, insulation, fireboard etc...
March 19, 2024: International Journal of Biological Macromolecules
#16
JOURNAL ARTICLE
Teresa L Street, Nicholas D Sanderson, Leanne Barker, James Kavanagh, Kevin Cole, The GonFast Investigators Group, Martin Llewelyn, David W Eyre
Multi-drug-resistant Neisseria gonorrhoeae infection is a significant public health risk. Rapidly detecting N. gonorrhoeae and antimicrobial-resistant (AMR) determinants by metagenomic sequencing of urine is possible, although high levels of host DNA and overgrowth of contaminating species hamper sequencing and limit N. gonorrhoeae genome coverage. We performed Nanopore sequencing of nucleic acid amplification test-positive urine samples and culture-positive urethral swabs with and without probe-based target enrichment, using a custom SureSelect panel, to investigate whether selective enrichment of N...
March 2024: Microbial Genomics
#17
JOURNAL ARTICLE
Svenja Meissner, Shaun Rees, Linh Nguyen, Bronwen Connor, David Barker, Bruce Harland, Brad Raos, Darren Svirskis
Poloxamer-based hydrogels show promise to stabilise and sustain the delivery of growth factors in tissue engineering applications, such as following spinal cord injury. Typically, growth factors such as neurotrophin-3 (NT-3) degrade rapidly in solution. Similarly, poloxamer hydrogels also degrade readily and are, therefore, only capable of sustaining the release of a payload over a small number of days. In this study, we focused on optimising a hydrogel formulation, incorporating both poloxamer 188 and 407, for the sustained delivery of bioactive NT-3...
March 20, 2024: Biomater Adv
#18
JOURNAL ARTICLE
Michael Baria, Tyler Barker, Sushmitha Durgam, Angela Pedroza, David Flanigan, Liuqing Jia, Christopher Kaeding, Robert Magnussen
BACKGROUND: Platelet-rich plasma (PRP) is an effective treatment for knee osteoarthritis (OA). Microfragmented adipose tissue (MFAT) is another orthobiologic that holds promise, but data supporting its use are limited. Previous studies showed that MFAT created using the Lipogems device was equivalent to PRP created via noncommercial laboratory-based processes. PURPOSE: To perform a comparison of commercially available MFAT and PRP systems for treatment of knee OA...
March 2024: Orthopaedic Journal of Sports Medicine
#19
JOURNAL ARTICLE
Audrey Barker Plotkin, David A Orwig, Meghan Graham MacLean, Aaron M Ellison
Forest insect outbreaks cause large changes in ecosystem structure, composition, and function. Humans often respond to insect outbreaks by conducting salvage logging, which can amplify the immediate effects, but it is unclear whether logging will result in lasting differences in forest structure and dynamics when compared with forests affected only by insect outbreaks. We used 15 years of data from an experimental removal of Tsuga canadensis (L.) Carr. (Eastern hemlock), a foundation tree species within eastern North American forests, and contrasted the rate, magnitude, and persistence of response trajectories between girdling (emulating mortality from insect outbreak) and timber harvest treatments...
March 14, 2024: Ecological Applications
#20
JOURNAL ARTICLE
Nishal Govindji-Bhatt, Stephnie M Kennedy, Michael G Barker, Darren Kell, Duncan Henderson, Nicholas Goddard, Ana Yepes Garcia, Adam S Milner, Tom Willett, Ryan Griffiths, Peter Foster, William Kilgallon, Rachel Cant, Christopher G Knight, David Lewis, Richard Corbett, Habib Akbani, Graham Woodrow, Bhrigu Sood, Osasuyi Iyasere, Simon Davies, Junaid Qazi, Anand Vardhan, Laura Gillis, Martin Wilkie, Curtis B Dobson
INTRODUCTION: Peritoneal dialysis (PD)-related peritonitis (PDRP) is a common cause of transfer to hemodialysis, patient morbidity, and is a risk factor for mortality. Associated patient anxiety can deter selection of PD for renal replacement therapy. Diagnosis relies on hospital laboratory tests; however, this might be achieved earlier if such information was available at the point-of-care (POC), thereby significantly improving outcomes. The presence of culturable microbes and the concentration of leukocytes in effluent both aid peritonitis diagnosis, as specified in the International Society for Peritoneal Dialysis (ISPD) diagnostic guidelines...
March 2024: KI Reports
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