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Randomized Controlled Trial Supplement

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https://read.qxmd.com/read/30759442/the-effects-of-probiotics-on-symptoms-of-depression-protocol-for-a-double-blind-randomized-placebo-controlled-trial
#1
Caroline J K Wallace, Jane A Foster, Claudio N Soares, Roumen V Milev
BACKGROUND: A growing body of evidence has linked mental health outcomes to the gut microbiome. This has led to the investigation of the GI tract as a target for novel treatments and interventions for depression, including probiotic supplementation. Our recent pilot study provided the first evidence of probiotics improving symptoms of depression in treatment-naive depressed patients. To further support and expand upon this evidence, data from the pilot study were used to plan a 16-week, double-blind, randomized, placebo-controlled trial to assess the effects of probiotics on depression...
February 13, 2019: Neuropsychobiology
https://read.qxmd.com/read/30759117/multiple-micronutrient-supplementation-using-spirulina-platensis-and-infant-growth-morbidity-and-motor-development-evidence-from-a-randomized-trial-in-zambia
#2
Kazuya Masuda, Maureen Chitundu
In developing countries, micronutrient deficiency in infants is associated with growth faltering, morbidity, and delayed motor development. One of the potentially low-cost and sustainable solutions is to use locally producible food for the home fortification of complementary foods. This study aimed to test the hypothesis that locally producible spirulina platensis supplementation would achieve the following: 1) increase infant physical growth, 2) reduce morbidity, and 3) improve motor development. We randomly assigned 501 Zambian infants into the control group or the spirulina group...
2019: PloS One
https://read.qxmd.com/read/30758695/the-effects-of-coenzyme-q10-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-in-among-coronary-artery-disease-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#3
REVIEW
Mohammad Vahid Jorat, Reza Tabrizi, Fariba Kolahdooz, Maryam Akbari, Maryamalsadat Salami, Seyed Taghi Heydari, Zatollah Asemi
OBJECTIVE: Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD. METHODS: The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018...
February 13, 2019: Inflammopharmacology
https://read.qxmd.com/read/30758295/evaluation-of-mothers-perceptions-of-a-technology-based-supportive-educational-parenting-program-part-2-qualitative-study
#4
Shefaly Shorey, Esperanza Debby Ng
BACKGROUND: Transitioning into parenthood can be stressful as parents struggle to cope with new parenting responsibilities. Although perinatal care in hospitals aims to improve parental outcomes, there is a general consensus that it is suboptimal and insufficient. Therefore, many studies have designed intervention methods to supplement support for parents during this stressful period. However, studies often focus on parental outcomes as indicators of their interventions' success and effectiveness...
February 13, 2019: Journal of Medical Internet Research
https://read.qxmd.com/read/30755776/effects-of-laser-acupuncture-on-delayed-onset-muscle-soreness-of-the-biceps-brachii-muscle-a-randomized-controlled-trial
#5
Wen-Dien Chang, Jih-Huah Wu, Nai-Jen Chang, Chia-Lun Lee, Shuya Chen
Objectives: The aim of this study was to explore the effects of laser acupuncture on improvement of recovery and muscle performance in delayed muscle soreness (DOMS) when applied before exercise. Methods: This randomized, blinded, and controlled study included healthy participants (n = 40) who were randomized into laser acupuncture and placebo groups. Laser acupuncture was applied to the Tianquan (PC2) and Chihtseh acupoints (LU5) at a dose of 36 J and energy density of 9...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30753625/maternal-infant-supplementation-with-small-quantity-lipid-based-nutrient-supplements-does-not-affect-child-blood-pressure-at-4-6-y-in-ghana-follow-up-of-a-randomized-trial
#6
Sika M Kumordzie, Seth Adu-Afarwuah, Rebecca R Young, Brietta M Oaks, Solace M Tamakloe, Maku E Ocansey, Harriet Okronipa, Elizabeth L Prado, Kathryn G Dewey
Background: In the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, prenatal small-quantity lipid-based nutrient supplements (LNSs) had a positive effect on birth weight. Birth weight may be inversely related to blood pressure (BP) later in life. Objectives: We examined the effect of the intervention on BP at 4-6 y of age, and maternal and child factors related to BP. Methods: The iLiNS-DYAD-Ghana study was a partially double-blind, randomized controlled trial which assigned women (n = 1320) ≤20 weeks of gestation to daily supplementation with: 1) iron and folic acid during pregnancy and 200 mg Ca for 6 mo postpartum , 2) multiple micronutrients during pregnancy and postpartum, or 3) LNSs during pregnancy and postpartum plus LNSs for infants from 6 to 18 mo of age...
February 11, 2019: Journal of Nutrition
https://read.qxmd.com/read/30753501/evaluation-of-active-dried-yeast-in-the-diets-of-feedlot-steers-ii-effects-on-rumen-ph-and-liver-health-of-feedlot-steers
#7
Whitney Lynn Crossland, Caitlyn M Cagle, Jason E Sawyer, Todd R Callaway, Luis Orlindo Tedeschi
The objective of this trial was to determine the benefits of supplementing active dried yeast (ADY; 3 × 1010 CFU/d of Saccharomyces cerevisiae) in diets of growing and finishing steers on ruminal pH and liver health, and evaluate the relationship of these variables with performance traits. Growing beef steers (n = 120) were blocked by weight (i.e., heavy and light) and allocated to 1 of 4 pens in an automated feed intake monitoring system. Steers were fed either control (CON; no ADY) or ADY supplemented in 4 sequential diets: grower diet from days 0 to 70, 2 step up diets (STEP1 and STEP2) for 7 d each, and finishing diet from days 85 to 164...
February 7, 2019: Journal of Animal Science
https://read.qxmd.com/read/30747970/interventions-to-prevent-perinatal-depression-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#8
Elizabeth O'Connor, Caitlyn A Senger, Michelle L Henninger, Erin Coppola, Bradley N Gaynes
Importance: Depression during pregnancy and the postpartum period is relatively common and can have adverse effects on both mother and child. Objective: To systematically review benefits and harms of primary care-relevant interventions to prevent perinatal depression, a major or minor depressive episode during pregnancy or up to 1 year after childbirth, to inform the US Preventive Services Task Force. Data Sources: MEDLINE, PubMED (for publisher-supplied records only), PsycINFO, and the Cochrane Central Register of Controlled Trials; surveillance through December 5, 2018...
February 12, 2019: JAMA: the Journal of the American Medical Association
https://read.qxmd.com/read/30746344/effect-of-eicosapentaenoic-acid-supplementation-on-paraoxonase-2-gene-expression-in-patients-with-type-2-diabetes-mellitus-a-randomized-double-blind-clinical-trial
#9
Mohammad Hassan Golzari, Mohammad Hassan Javanbakht, Ehsan Ghaedi, Hamed Mohammadi, Mahmoud Djalali
Type 2 diabetes mellitus (T2DM) is recognized as one of the most prevalent metabolic diseases, and it is mostly associated with oxidative stress, atherosclerosis and dyslipidemia. Paraoxonase 2 (PON2) due to its antioxidant properties may play a role in the atherosclerosis development. Although long-chain omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) have been shown to reduce the risk of cardiovascular disease, the exact mechanism of action is still unknown. Our goal in this study was to determine the effect of EPA administration on gene expression of PON2 in patients with T2DM...
January 2019: Clinical Nutrition Research
https://read.qxmd.com/read/30746213/first-line-treatment-of-patients-with-advanced-or-metastatic-squamous-non-small-cell-lung-cancer-systematic-review-and-network-meta-analysis
#10
Lisa M Hess, Amy M DeLozier, Fanni Natanegara, Xiaofei Wang, Victoria Soldatenkova, Alan Brnabic, Stephen L Able, Jacqueline Brown
Background: The objectives of this systematic review and meta-analysis were to compare the survival, toxicity, and quality of life of patients treated with necitumumab in combination with gemcitabine and cisplatin. These agents were investigated in published randomized controlled trials (RCTs) of patients with squamous non-small cell lung cancer (NSCLC) in the first-line setting. Methods: The systematic review was executed on January 27, 2015, and updated on August 21, 2016, using a pre-specified search strategy...
December 2018: Journal of Thoracic Disease
https://read.qxmd.com/read/30745578/elevated-blood-pressure-reduction-after-%C3%AE-lipoic-acid-supplementation-a-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
Virginia Boccardi, Mohsen Taghizadeh, Sina Amirjani, Sadegh Jafarnejad
The aim of the comprehensive meta-analysis was to systematically explore the reductive effect of α-lipoic acid (ALA) supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP). The related records were selected from PubMed, Scopus, EMBASE, Cochrane library, and Persian databases including SID and Magiran from earliest date 1980 until August 2018. The heterogeneities were assessed by I2 test (I2 < 50%) and χ2 test on Cochrane's Q statistic. Standardized mean difference (SMD) and their 95% confidence intervals (CIs) were estimated for change in SBP and DBP...
February 11, 2019: Journal of Human Hypertension
https://read.qxmd.com/read/30744880/a-randomised-controlled-trial-of-vitamin-d-and-omega-3-long-chain-polyunsaturated-fatty-acids-in-the-treatment-of-irritability-and-hyperactivity-among-children-with-autism-spectrum-disorder
#12
Hajar Mazahery, Cathryn A Conlon, Kathryn L Beck, Owen Mugridge, Marlena C Kruger, Welma Stonehouse, Carlos A Camargo, Barbara J Meyer, Beatrix Jones, Pamela R von Hurst
Irritability and hyperactivity are common in children with Autism Spectrum Disorder (ASD). Because pharmacological treatments may have adverse effects, and despite limited evidence, caregivers/parents often use dietary supplements such as vitamin D and omega-3 fatty acids to address these behavioural symptoms. As a secondary objective of the VIDOMA (Vitamin D and Omega-3 in ASD) trial, we evaluated the efficacy of vitamin D, omega-3 long chain polyunsaturated fatty acid [omega-3 LCPUFA; docosahexaenoic acid (DHA)], or both on irritability and hyperactivity...
March 2019: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/30744589/preventing-the-recurrence-of-depression-with-a-mediterranean-diet-supplemented-with-extra-virgin-olive-oil-the-predi-dep-trial-study-protocol
#13
A Sánchez-Villegas, B Cabrera-Suárez, P Molero, A González-Pinto, C Chiclana-Actis, C Cabrera, F Lahortiga-Ramos, M Florido-Rodríguez, P Vega-Pérez, R Vega-Pérez, J Pla, M J Calviño-Cabada, F Ortuño, S Navarro, Y Almeida, J L Hernández-Fleta
BACKGROUND: The role of dietary patterns in the prevention of unipolar depression has been analyzed in several epidemiological studies. The primary aims of this study are to determine the effectiveness of an extra-olive oil-enriched Mediterranean diet in reducing the recurrence of depression and improving the symptoms of this condition. METHODS: Multicenter, two-arm, parallel-group clinical trial. Arm 1, extra-virgin olive oil Mediterranean diet; Arm 2, control group without nutritional intervention...
February 11, 2019: BMC Psychiatry
https://read.qxmd.com/read/30744357/assessment-of-mulberry-leaf-as-a-potential-feed-supplement-for-animal-feeding-in-p-r-china
#14
Ming Cai, Lan Mu, Zong Li Wang, Jian Yong Liu, Tian Liang Liu, Metha Wanapat, Bi Zhi Huang
Objective: Mulberry (Morus alba L.) is a cultivated shrub grown widely in the sub-tropical and tropical areas. It has been shown that mulberry leaf contains high levels of protein while having polyphenols as phytonutrients. Therefore, it is important to conduct an experiment to assess potential toxic level from mulberry on behavior, blood hematological and coagulation parameter using Sprague Dawley rats. Methods: Both male and female Sprague-Dawley rats (SD rats) were given an intragastric administration of respective treatments of mulberry leaf intakes (control, low and high levels)...
January 4, 2019: Asian-Australasian Journal of Animal Sciences
https://read.qxmd.com/read/30741439/pep-up-enhanced-protein-energy-provision-via-the-enteral-route-feeding-protocol-in-surgical-patients-a-multicenter-pilot-randomized-controlled-trial
#15
D Dante Yeh, Luis Alfonso Ortiz, Jae Moo Lee, Jeffrey Chan, Katherine McKenzie, Brian Young, Lindsay Chetelat, Bryan Collier, Andrew Benson, Daren K Heyland
BACKGROUND: The Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol (PEP uP) has been shown to be feasible, safe, and effective in delivering significantly more energy/protein, though it has not been well studied in surgical/trauma patients. We hypothesized that PEP uP will effectively increase energy/protein delivery to critically ill surgical/trauma patients. METHODS: This multicenter, prospective, randomized pilot study included adult patients admitted to surgical service who were expected to require mechanical ventilation for >24 hours and intensive care unit (ICU) care for >72 hours...
February 11, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/30740404/fatty-acid-oxidation-disorders
#16
REVIEW
J Lawrence Merritt, Marie Norris, Shibani Kanungo
Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism due to disruption of either mitochondrial β-oxidation or the fatty acid transport using the carnitine transport pathway. The presentation of a FAOD will depend upon the specific disorder, but common elements may be seen, and ultimately require a similar treatment. Initial presentations of the FAODs in the neonatal period with severe symptoms include cardiomyopathy, while during infancy and childhood liver dysfunction and hypoketotic hypoglycemia are common...
December 2018: Annals of Translational Medicine
https://read.qxmd.com/read/30739626/the-effects-of-magnesium-supplementation-on-carotid-intima-media-thickness-and-metabolic-profiles-in-diabetic-hemodialysis-patients-a-randomized-double-blind-placebo-controlled-trial
#17
Hamid Reza Talari, Mehrafrouz Zakizade, Alireza Soleiman, Fereshteh Bahmani, Amir Ghaderi, Naghmeh Mirhosseini, Masoumeh Eslahi, Mahtab Babadi, Mohammad Ali Mansournia, Zatollah Asemi
No abstract text is available yet for this article.
February 11, 2019: British Journal of Nutrition
https://read.qxmd.com/read/30739288/effects-of-a-simple-home-exercise-program-and-vitamin-d-supplementation-on-health-related-quality-of-life-after-a-hip-fracture-a-randomized-controlled-trial
#18
K Renerts, K Fischer, B Dawson-Hughes, E J Orav, G Freystaetter, H-P Simmen, H-C Pape, A Egli, R Theiler, H A Bischoff-Ferrari
PURPOSE: To test the effects of vitamin D intervention and a simple home exercise program (HE) on health-related quality of life (HRQL) in the first 12 months after hip fracture. METHODS: HRQL was reported in 173 acute hip fracture patients (mean age 84 years, 79% females, 77% community dwelling) who were enrolled in the 12-month 2 × 2 factorial Zurich Hip Fracture Trial. Pre-fracture HRQL was assessed at baseline (4.2 ± 2.2 days post-surgery) and then again at 6 and 12 months after hip fracture surgery by the EuroQol EQ-5D-3L index value (EQ-5D-3L questionnaire)...
February 9, 2019: Quality of Life Research
https://read.qxmd.com/read/30738684/supplementation-of-sodium-butyrate-to-postweaned-heifer-diets-effects-on-growth-performance-nutrient-digestibility-and-health
#19
E M Rice, K M Aragona, S C Moreland, P S Erickson
The objective of this study was to determine the effect of varying levels of sodium butyrate (SB) supplementation in feed on the growth, digestibility, and health of postweaned heifers. Forty Holstein dairy heifers with a mean age of 84 d and average body weight (BW) of 100.9 ± 11.2 kg were housed in a naturally ventilated freestall barn. Heifers were blocked by birth date and randomly assigned to 1 of 4 treatments in a completely randomized block design: (1) 100 g of soybean meal carrier (control), (2) 0...
February 6, 2019: Journal of Dairy Science
https://read.qxmd.com/read/30737643/vitamin-d-supplementation-for-the-improvement-of-vascular-function-in-patients-with-chronic-kidney-disease-a-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
Ding Dou, Bing Yang, Hongqiao Gan, Dengpiao Xie, Huangwei Lei, Naijing Ye
BACKGROUND: The efficacy of vitamin D on vascular function remains controversial in chronic kidney disease (CKD) patients. The aim of the present work was to perform a meta-analysis of randomized controlled trials to evaluate the efficacy of vitamin D on vascular function in CKD patients. METHODS: We searched Medline, the Cochrane Central Register of Controlled Trials, Embase, the Science Citation Index, and clinical trial registries for randomized controlled trials comparing vitamin D with a placebo in CKD patients...
February 8, 2019: International Urology and Nephrology
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