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Rachel Jeitziner, Mathieu Carrière, Jacques Rougemont, Steve Oudot, Kathryn Hess, Cathrin Brisken
Motivation: Unbiased clustering methods are needed to analyze growing numbers of complex data sets. Currently available clustering methods often depend on parameters that are set by the user, they lack stability, and are not applicable to small data sets. To overcome these shortcomings we used topological data analysis, an emerging field of mathematics that can discerns additional feature and discover hidden insights on data sets and has a wide application range. Results: We have developed a topology-based clustering method called Two-Tier Mapper (TTMap) for enhanced analysis of global gene expression datasets...
February 7, 2019: Bioinformatics
Marc McDowell, Kara Nitti, Erik Kulstad, Michael Cirone, Riddhi Shah, Daniel Rochford, Richard Walsh, Kathleen Hesse
OBJECTIVES: Our objective was to compare outcomes of discharge disposition, need for additional medications, and restraint use for patients who received inhaled loxapine compared with patients receiving traditional antipsychotic drugs in the emergency department (ED). METHODS: A retrospective chart review was conducted on all patients who presented to the ED with agitation and received antipsychotic therapy, including loxapine, ziprasidone, or haloperidol from December 1, 2014, through October 31, 2016...
February 8, 2019: Clinical Neuropharmacology
Lisa M Hess, Amy M DeLozier, Fanni Natanegara, Xiaofei Wang, Victoria Soldatenkova, Alan Brnabic, Stephen L Able, Jacqueline Brown
Background: The objectives of this systematic review and meta-analysis were to compare the survival, toxicity, and quality of life of patients treated with necitumumab in combination with gemcitabine and cisplatin. These agents were investigated in published randomized controlled trials (RCTs) of patients with squamous non-small cell lung cancer (NSCLC) in the first-line setting. Methods: The systematic review was executed on January 27, 2015, and updated on August 21, 2016, using a pre-specified search strategy...
December 2018: Journal of Thoracic Disease
Bridgette A Sisson, Jasmina Uvalic, Kevin Kelly, Pavalan Selvam, Andrew N Hesse, Guruprasad Ananda, Harshpreet Chandok, Daniel Bergeron, Lauren Holinka, Honey V Reddi
The standard of care in oncology has been genomic profiling of tumor tissue biopsies for the treatment and management of disease, which can prove to be quite challenging in terms of cost, invasiveness of procedure, and potential risk for the patient. As the number of available drugs in oncology continues to increase, so too does the demand for technologies and testing applications that can identify genomic alterations targetable by these new therapies. Liquid biopsies that use a blood draw from the diseased patient may offset the many disadvantages of the invasive procedure...
2019: Biomarker Insights
Justin G Wilkes, Jessica L Evans, B Stephen Prato, Steven A Hess, Dougald C MacGillivary, Timothy L Fitzgerald
BACKGROUND: Frailty in the surgical patient has been associated with increased morbidity, mortality, and failure-to-rescue. However, there is little understanding of the economic impact of frailty. STUDY DESIGN: A prospective database of elective surgery patients at an academic medical center was utilized to create a modified version of the Risk Analysis Index, a validated frailty index. This included 10,257 patients undergoing elective surgery from 2016-2017. Patients were classified as not frail (RAI = 0), somewhat frail (RAI = 1-10), or significantly frail (RAI > 10)...
February 8, 2019: Journal of the American College of Surgeons
Neda M Bassir Kazeruni, Stanislav Tsitkov, Henry Hess
This protocol describes how to create kinesin-powered molecular shuttles with a weak and reversible attachment of the kinesins to the surface. In contrast to previous protocols, in this system, microtubules recruit kinesin motor proteins from solution and place them on a surface. The kinesins will, in turn, facilitate the gliding of the microtubules along the surface before desorbing back into the bulk solution, thus being available to be recruited again. This continuous assembly and disassembly leads to striking dynamic behavior in the system, such as the formation of temporary kinesin trails by gliding microtubules...
January 26, 2019: Journal of Visualized Experiments: JoVE
Sveva Auletta, Michela Varani, Rika Horvat, Filippo Galli, Alberto Signore, Søren Hess
BACKGROUND: Bacterial infections are still one of the main factors associated with mortality worldwide. Many radiopharmaceuticals were developed for bacterial imaging, both with single photon emission computed tomography (SPECT) and positron emission tomography (PET) isotopes. This review focuses on PET radiopharmaceuticals, performing a systematic literature review of published studies between 2005 and 2018. METHODS: A systematic review of published studies between 2005 and 2018 was performed...
February 6, 2019: Journal of Clinical Medicine
Antje Steinbrink, Sina Zotzmann, Sarah Cunze, Sven Klimpel
Aedes koreicus, a mosquito species originating from Japan, China, Korea, and parts of Russia, has been sporadically found in Europe since 2008. It is suspected to be a vector of a variety of viruses and nematodes. In Germany, one individual was found in 2015 in the city of Augsburg, situated in the federal state of Bavaria. Based on morphological and molecular species identification, this study reports a new finding of Ae. koreicus, about 370 km northwest from Augsburg. The sampling point is located in the city of Wiesbaden, in the federal state of Hesse, where four individuals were found over a period of 2 months in 2017...
February 8, 2019: Parasitology Research
Priscila Hess Lopes, Mário T Murakami, Fernanda C V Portaro, Kerly Fernanda Mesquita Pasqualoto, Carmen van den Berg, Denise V Tambourgi
Loxosceles spiders' venoms consist of a mixture of proteins, including the sphingomyelinases D (SMases D), which are the main toxic components responsible for local and systemic effects in human envenomation. Herein, based on the structural information of SMase D from Loxosceles laeta spider venom and virtual docking-based screening approach, three benzene sulphonate compounds (named 1, 5 and 6) were identified as potential Loxosceles SMase D inhibitors. All compounds inhibited the hydrolysis of the sphingomyelin substrate by both recombinant and native SMases D...
December 2019: Journal of Enzyme Inhibition and Medicinal Chemistry
Vivek Subbiah, Peter Meade Anderson, Kalevi Kairemo, Kenneth R Hess, Winston W Huh, Vinod Ravi, Najat C Daw, Neeta Somaiah, Joseph A Ludwig, Robert S Benjamin, Sant P Chawla, David S Hong, Funda Meric-Bernstam, Gregory Ravizzini, Eugenie S Kleinerman, Homer A Macapinlac, Eric M Rohren
PURPOSE: The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (223 RaCl2 ) can be safely administered to patients with osteosarcoma and that early signals of response or resistance can be assessed by quantitative and qualitative correlative imaging studies and biomarkers. EXPERIMENTAL DESIGN: A 3+3 phase I, dose-escalation trial of 223 RaCl2 (50, 75, and 100 kBq/kg) was designed in recurrent/metastatic osteosarcoma patients aged ≥15 years...
February 7, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
J Hesse-Macabata, B Morgner, S Morgenstern, M O Grimm, P Elsner, U C Hipler, C Wiegand
BACKGROUND: Superficial cutaneous infection caused by the zoophilic dermatophyte Trichophyton benhamiae is often associated with a highly inflammatory immune response. As non-professional immune cells, epidermal keratinocytes and dermal fibroblasts contribute to the first line of defence by producing pro-inflammatory cytokines and antimicrobial peptides (AMP). OBJECTIVE: Purpose of this study was to gain a deeper understanding of the pathogenesis and the fungal-host interaction as not much is known about the innate immune response of these cutaneous cells against T...
February 5, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
K Hoenes, M Hess, P Vatter, B Spellerberg, M Hessling
Photoinactivation of bacteria with visible light has been reported in numerous studies. Radiation around 405 nm is absorbed by endogenous porphyrins and generates reactive oxygen species that destroy bacteria from within. Blue light in the spectral range of 450-470 nm also exhibits an antibacterial effect, but it is weaker than 405 nm radiation, and the photosensitizers involved have not been clarified yet, even though flavins and porphyrins are possible candidates. There are significantly fewer photoinactivation studies on fungi...
December 23, 2018: European Journal of Microbiology & Immunology
Friederike Bothe, Anne-Kathrin Deubel, Eliane Hesse, Benedict Lotz, Jürgen Groll, Carsten Werner, Wiltrud Richter, Sebastien Hagmann
Despite advances in cartilage repair strategies, treatment of focal chondral lesions remains an important challenge to prevent osteoarthritis. Articular cartilage is organized into several layers and lack of zonal organization of current grafts is held responsible for insufficient biomechanical and biochemical quality of repair-tissue. The aim was to develop a zonal approach for cartilage regeneration to determine whether the outcome can be improved compared to a non-zonal strategy. Hydrogel-filled polycaprolactone (PCL)-constructs with a chondrocyte-seeded upper-layer deemed to induce hyaline cartilage and a mesenchymal stromal cell (MSC)-containing bottom-layer deemed to induce calcified cartilage were compared to chondrocyte-based non-zonal grafts in a minipig model...
February 2, 2019: International Journal of Molecular Sciences
Cung Lian Sang, Michael Adams, Timm Hörmann, Marc Hesse, Mario Porrmann, Ulrich Rückert
The Two-Way Ranging (TWR) method is commonly used for measuring the distance between two wireless transceiver nodes, especially when clock synchronization between the two nodes is not available. For modeling the time-of-flight (TOF) error between two wireless transceiver nodes in TWR, the existing error model, described in the IEEE 802.15.4-2011 standard, is solely based on clock drift. However, it is inadequate for in-depth comparative analysis between different TWR methods. In this paper, we propose a novel TOF Error Estimation Model (TEEM) for TWR methods...
February 1, 2019: Sensors
Antje Giede-Jeppe, Jonathan Reichl, Maximilian I Sprügel, Hannes Lücking, Philip Hoelter, Ilker Y Eyüpoglu, Joji B Kuramatsu, Hagen B Huttner, Stefan T Gerner
OBJECTIVEStroke-associated immunosuppression and inflammation are increasingly recognized as factors triggering infections and thus potentially influencing outcome after stroke. Several studies have demonstrated that elevated neutrophil-to-lymphocyte ratio (NLR) is a significant predictor of adverse outcomes for patients with ischemic stroke or intracerebral hemorrhage. Thus far, in patients with subarachnoid hemorrhage the association between NLR and outcome is insufficiently established. The authors sought to investigate the association between NLR on admission and functional outcome in aneurysmal subarachnoid hemorrhage (aSAH)...
February 1, 2019: Journal of Neurosurgery
Allison E Wolfel, Samantha L Pederson, Allison M Cleymaet, Ann M Hess, Kate S Freeman
OBJECTIVE: To describe and compare normative anterior segment parameters between canine age groups using the Pentacam® HR Scheimpflug camera (Pentacam). ANIMALS STUDIED: Thirty-six sedated dogs (60 eyes) of varying ages and breeds were imaged with the Pentacam; only nondiseased anterior segments were included. PROCEDURES: Dogs were divided into three age groups: Group 1 (1-5 years), Group 2 (6-10 years), and Group 3 (11-15 years). Values assessed included central corneal thickness (CCT), anterior and posterior corneal elevation (ACE/PCE), anterior and posterior corneal curvature metrics, corneal volume (CV), anterior and posterior corneal astigmatism (AA/PA), anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA)...
February 4, 2019: Veterinary Ophthalmology
Lida Kanari, Srikanth Ramaswamy, Ying Shi, Sebastien Morand, Julie Meystre, Rodrigo Perin, Marwan Abdellah, Yun Wang, Kathryn Hess, Henry Markram
A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, which is based on expert analyses of neuronal morphologies. Even for neurons that are visually distinguishable, there is no common ground to consistently define morphological types. The objective classification of PCs can be achieved with methods from algebraic topology, and the dendritic arborization is sufficient for the reliable identification of distinct types of cortical PCs...
January 31, 2019: Cerebral Cortex
Clarisa R Krueger, Robert D Lewis, C Wayne McIlwraith, Michael D Major, Jeffrey E Brakenhoff, D Reese Hand, Aileen L Rowland, Ann M Hess, Samuel W Johnson, Eileen S Hackett
OBJECTIVE To determine effects of prosthetic laryngoplasty on return to racing, performance index, and career longevity in racing Quarter Horses with recurrent laryngeal neuropathy (RLN) and to evaluate performance variables for horses with RLN undergoing prosthetic laryngoplasty, compared with a control horse population. DESIGN Multicenter, retrospective cohort study. ANIMALS 162 racing Quarter Horses with RLN treated with prosthetic laryngoplasty (case horses) and 324 racing Quarter Horse without RLN (control horses)...
February 15, 2019: Journal of the American Veterinary Medical Association
Michael S Guss, Lindsay K Hess, Mark E Baratz
HYPOTHESIS: This study's purpose was to provide a reproducible way for surgeons to intraoperatively assess the elbow's lateral ulnar collateral ligament origin and determine whether there is posterolateral rotatory instability (PLRI) despite an intact common extensor origin (CEO). We hypothesized that we could re-create clinically relevant disruption of lateral supporting structures despite an intact CEO and illustrate progressive elbow PLRI. METHODS: The relationship of the lateral capsule to the capitellum articular surface was noted in 8 cadaveric upper extremities...
February 1, 2019: Journal of Shoulder and Elbow Surgery
John A Curiel, Gary D Slade, Thu-Mai L Christian, Sophia Lafferty-Hess, Thomas M Carsey, Anne E Sanders
OBJECTIVE: To explore health literacy as a marker of voter confusion in order to understand the basis for public opposition to community water fluoridation. DESIGN: A cross-sectional study. SETTING: Conducted in three large US cities of San Antonio, Texas (602 voting precincts); Wichita, Kansas (171 voting precincts); and Portland, Oregon (132 voting precincts). Precinct-level voting data were compiled from community water fluoridation referendums conducted in San Antonio in 2002, Wichita in 2012 and Portland in 2013...
February 1, 2019: BMJ Open
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