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Fat mass associated gene

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https://read.qxmd.com/read/30778226/protein-coding-variants-implicate-novel-genes-related-to-lipid-homeostasis-contributing-to-body-fat-distribution
#1
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie C Y Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Böger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul I W de Bakker, Simon de Denus, Renée de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dörr, Fotios Drenos, Marie-Pierre Dubé, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna M M Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon L R Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Krämer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian'an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas G D Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Müller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O'Connell, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John R B Perry, Tune H Pers, Ailith Ewing, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin M A Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Vuckovic, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, Fernando Rivadeneira, Ingrid B Borecki, J Andrew Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltán Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth J F Loos, Kari E North, Cecilia M Lindgren
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF <5%) coding novel variants...
February 18, 2019: Nature Genetics
https://read.qxmd.com/read/30767572/fat-mass-and-obesity-associated-fto-and-leptin-receptor-lepr-gene-polymorphisms-in-egyptian-obese-subjects
#2
Ehab M M Ali, Thoria Diab, Afaf Elsaid, Hamada A Abd El Daim, Rami M Elshazli, Ahmad Settin
BACKGROUND: Several studies addressed the contribution of fat mass and obesity-associated (FTO) and leptin receptor (LEPR) polymorphisms for the susceptibility to obesity among different ethnic subjects. The main purpose of this work is to evaluate the association of these polymorph\isms with obesity among Egyptian subjects. SUBJECTS AND METHODS: This case-control study was carried out on 110 unrelated obese Egyptian subjects who were compared with 122 controls...
February 15, 2019: Archives of Physiology and Biochemistry
https://read.qxmd.com/read/30766816/the-role-of-circulating-microrna-in-the-regulation-of-beta-cell-function-and-insulin-resistance-among-indians-with-type-2-diabetes
#3
S Sucharita, V Ashwini, J S Prabhu, S T Avadhany, V Ayyar, G Bantwal
Background: Circulating microRNA (miRNA/miR) levels are emerging out as markers of tissue level changes; however, their role in type 2 diabetes (T2D) needs to be explored. The study aimed to compare the circulating levels of the miRNA (miR9, miR30d, miR1, miR133a, miR29a, miR143) between T2D and gender matched controls and also to evaluate the strength of association between circulating miRNAs and beta cell function/insulin resistance among Indians with T2D. Subjects and Methods: Thirty T2D (25-60 years) and their gender matched controls ( n = 30) were recruited...
November 2018: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/30764585/the-interaction-between-genetic-polymorphisms-in-fto-and-tcf7l2-genes-and-dietary-intake-with-regard-to-body-mass-and-composition-an-exploratory-study
#4
Lara Nasreddine, Reem Akika, Aurelie Mailhac, Hani Tamim, Nathalie Khoueiry Zgheib
In contrast to the large number of genetic studies on obesity, there has been significantly less nutrigenetics investigation of the interaction between diet and single nucleotide polymorphisms (SNPs) in obesity, especially within Eastern Mediterranean populations. The aim of this study was to evaluate the potential interactions between three candidate SNPs, namely, rs1558902 and rs9939609 in the fat mass and obesity ( FTO) gene and the rs7903146 variant of the Transcription factor 7 like 2 ( TCF7L2) gene, and macronutrient intake with regard to obesity, body fat, and muscle composition...
February 5, 2019: Journal of Personalized Medicine
https://read.qxmd.com/read/30759834/eating-behaviours-and-food-cravings-influence-of-age-sex-bmi-and-fto-genotype
#5
Hanan M Abdella, Hameida O El Farssi, David R Broom, Dawn A Hadden, Caroline F Dalton
Previous studies indicate that eating behaviours and food cravings are associated with increased BMI and obesity. However, the interaction between these behaviours and other variables such as age, sex, BMI and genetics is complex. This study aimed to investigate the relationships between eating behaviours and food cravings, and to examine the influence of age, sex, body mass index (BMI) and fat mass and obesity-associated ( FTO ) genotype on these relationships. A total of 475 participants (252 female, 223 male, BMI: 25...
February 12, 2019: Nutrients
https://read.qxmd.com/read/30758089/insulin-action-is-severely-impaired-in-adipocytes-of-apparently-healthy-overweight-and-obese-subjects
#6
Mikael Rydén, Paul Petrus, Daniel P Andersson, Gema Medina-Gómez, Elia Escasany, Patricia Corrales Cordón, Ingrid Dahlman, Agné Kulyté, Peter Arner
OBJECTIVE: Many overweight/obese subjects appear metabolically healthy with normal in vivo insulin sensitivity. Still, they have increased long-term risk of developing type 2 diabetes. We hypothesized that adipose tissue dysfunction involving decreased insulin action in adipocytes is present in apparently healthy overweight/obese subjects. DESIGN/METHODS: Subjects with normal metabolic health according to Adult Treatment Panel-III or Framingham risk score criteria were subdivided into 67 lean, 32 overweight and 37 obese according to body mass index...
February 13, 2019: Journal of Internal Medicine
https://read.qxmd.com/read/30754064/association-of-the-pnpla2-scd1-and-leptin-expression-with-fat-distribution-in-liver-and-adipose-tissue-from-obese-subjects
#7
Lucía De la Cruz-Color, Zamira Helena Hernández-Nazará, Montserrat Maldonado-González, Eliseo Navarro-Muñíz, José Alfredo Domínguez-Rosales, José Rodrigo Torres-Baranda, Elizabeth Del Carmen Ruelas-Cinco, Sandra Margarita Ramírez-Meza, Bertha Ruíz-Madrigal
The expansion of adipose tissue is regulated by insulin and leptin through SREBP-1c, up-regulating lipogenesis in tissues by SCD1 enzyme, while ATGL enzyme is key in lipolysis. THE RESEARCH OBJECTIVE WAS TO EVALUATE THE EXPRESSION OF SREBF1, SCD1, PNPLA2, AND LEP GENES IN HEPATIC-ADIPOSE TISSUE, AND RELATED THEM WITH THE INCREMENT AND DISTRIBUTION OF FAT DEPOTS OF INDIVIDUALS WITHOUT INSULIN RESISTANCE.: Thirty-eight subjects undergoing elective cholecystectomy with liver and adipose tissue biopsies (subcutaneous-omental) are included...
February 12, 2019: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/30737047/haptoglobin-phenotype-influences-the-effectiveness-of-diet-induced-weight-loss-in-middle-age-abdominally-obese-women-with-metabolic-abnormalities
#8
Kelvin Yohanes Tang, Shih-Yi Huang, Tsai-Mu Cheng, Chyi-Huey Bai, Jung-Su Chang
BACKGROUND & AIMS: Haptoglobin (Hp) is associated with risks of obesity and cardiometabolic dysfunction; however, the role of the Hp phenotype in diet-induced weight loss remains to be elucidated. This study investigated whether the Hp phenotype contributes to inter-individual variations in body weight reduction as well as changes in the metabolic profile. METHODS: Secondary data analysis from a randomized controlled trial. In total, 151 abdominally obese Taiwanese women with ≥2 metabolic components were randomized to each of four dietary programs [calorie restriction (CR), calorie restriction plus fish oil supplementation (CRF), calorie restricted meal replacement (CRMR), and calorie restricted meal replacement with fish oil supplementation (CRMRF)] for 12 weeks...
January 26, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/30717975/the-novel-adipokine-ctrp5-is-a-negative-regulator-of-white-adipose-tissue-browning
#9
Caijun Rao, Dandan Huang, Xiaoxiang Mao, Ru Chen, Dan Huang, Kai Huang
The browning of white adipose tissue predominantly emerges as an adaptation to environmental cues, such as cold exposure. The enhanced browning of adipose tissue results in improved energy and glucose homeostasis and reduced fat mass and body weight, which is greatly beneficial for the treatment of obesity and other metabolic diseases. C1q/TNF-related protein 5 (CTRP5) is a novel adipokine associated with a variety of endocrine and metabolic diseases; however, whether it can regulate the metabolism of adipose tissue itself remains unknown...
February 1, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30711402/mir-132-3p-is-a-positive-regulator-of-alpha-cell-mass-and-is-downregulated-in-obese-hyperglycemic-mice
#10
Rodolphe Dusaulcy, Sandra Handgraaf, Florian Visentin, Christian Vesin, Jacques Philippe, Yvan Gosmain
OBJECTIVE: Diabetes is a complex disease implicating several organs and cell types. Within the islets, dysregulation occurs in both alpha- and beta-cells, leading to defects of insulin secretion and increased glucagon secretion. Dysregulation of alpha-cells is associated with transcriptome changes. We hypothesized that microRNAs (miRNAs) which are negative regulators of mRNA stability and translation could be involved in alpha-cell alterations or adaptations during type 2 diabetes. METHODS: miRNA microarray analyses were performed on pure alpha- and beta-cells from high-fat diet fed obese hyperglycemic mice and low-fat diet fed controls...
January 18, 2019: Molecular Metabolism
https://read.qxmd.com/read/30690068/adipocyte-mterf4-regulates-non-shivering-adaptive-thermogenesis-and-sympathetic-dependent-glucose-homeostasis
#11
Anna Castillo, Maria Vilà, Inés Pedriza, Rosario Pardo, Yolanda Cámara, Edgar Martín, Daniel Beiroa, Javier Torres-Torronteras, Marta Oteo, Miguel A Morcillo, Ramon Martí, Rafael Simó, Rubén Nogueiras, Josep A Villena
In humans, low brown adipose tissue (BAT) mass and activity have been associated with increased adiposity and fasting glucose levels, suggesting that defective BAT-dependent thermogenesis could contribute to the development of obesity and/or type 2 diabetes. The thermogenic function of BAT relies on a vast network of mitochondria exclusively equipped with UCP1. Mitochondrial biogenesis is exquisitely regulated by a well-defined network of transcription factors that coordinate the expression of nuclear genes required for the formation of functional mitochondria...
January 25, 2019: Biochimica et biophysica acta. Molecular basis of disease
https://read.qxmd.com/read/30689684/the-nematode-caenorhabditis-elegans-as-a-model-organism-to-study-metabolic-effects-of-%C3%AF-3-polyunsaturated-fatty-acids-in-obesity
#12
Amal Bouyanfif, Shasika Jayarathne, Iurii Koboziev, Naima Moustaid-Moussa
Obesity is a complex disease that is influenced by several factors, such as diet, physical activity, developmental stage, age, genes, and their interactions with the environment. Obesity develops as a result of expansion of fat mass when the intake of energy, stored as triglycerides, exceeds its expenditure. Approximately 40% of the US population suffers from obesity, which represents a worldwide public health problem associated with chronic low-grade adipose tissue and systemic inflammation (sterile inflammation), in part due to adipose tissue expansion...
January 1, 2019: Advances in Nutrition
https://read.qxmd.com/read/30686248/intron-specific-single-nucleotide-polymorphisms-of-fat-mass-and-obesity-associated-gene-in-obese-and-overweight-individuals-of-the-indian-adult-population-a-pilot-study
#13
Aakash Reddy, Katari Venkatesh, Sayani Sahu, Pallavi Sinha Roy, Konkona Datta, Pearlin, L Vinod Kumar Reddy, Erfath Thanjeem Begum Moghal, Madhubanti Mullick, Gundu H R Rao, Dwaipayan Sen
BACKGROUND: The Fat mass and obesity-associated gene (FTO) and its involvement in weight gain and obesity is well-known. However, there are no reports published on Indian population regarding the relation between single nucleotide polymorphisms (SNPs) in its intronic region and obesity. The aim of this pilot study was to evaluate the frequency and association of SNPs in intron-1 of the FTO gene in obese and overweight Indian adults. METHODS: This study group consisted of 80 adults, aged 23...
November 26, 2018: Current Diabetes Reviews
https://read.qxmd.com/read/30672377/body-composition-and-s-klotho-plasma-levels-in-middle-aged-adults-a-cross-sectional-study
#14
Francisco J Amaro-Gahete, Alejandro De-la-O, Lucas Jurado-Fasoli, Andrea Espuch-Oliver, Tomás de Haro, Ángel Gutiérrez, Jonatan R Ruiz, Manuel J Castillo
The α-Klotho gene was identified as a possible "ageing-suppressor" agent that extends lifespan when overexpressed. However, little is known about the association of the body composition with the secreted protein form of the α-Klotho gene (S-Klotho). Therefore, the aim of this study was to analyse the association of body composition including lean and fat mass as well as bone mineral density (BMD) with S-Klotho plasma levels in middle-aged sedentary adults. A total of 74 (39 women) middle-aged sedentary adults (53...
January 23, 2019: Rejuvenation Research
https://read.qxmd.com/read/30671185/evaluation-of-fto-rs9939609-and-mc4r-rs17782313-polymorphisms-as-prognostic-biomarkers-of-obesity-a-population-based-cross-sectional-study
#15
Mina Mozafarizadeh, Mohsen Mohammadi, Soha Sadeghi, Morteza Hadizadeh, Tayebe Talebzade, Massoud Houshmand
Objectives: Obesity is a significant risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer. Obesity usually results from a combination of causes and contributing factors, including genetics and lifestyle choices. Many studies have shown an association of single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated ( FTO ) and the melanocortin-4 receptor ( MC4R ) genes with body mass index (BMI). Therefore, recognizing the main genes and their relevant genetic variants will aid prediction of obesity risk...
January 2019: Oman Medical Journal
https://read.qxmd.com/read/30670438/arylacetamide-deacetylase-aadac-gene-polymorphism-and-hiv-infection-affect-the-exposure-of-rifapentine-a-population-pharmacokinetics-analysis
#16
Jose Francis, Simbarashe P Zvada, Paolo Denti, Mark Hatherill, Salome Charalambous, Stanley Mungofa, Rodney Dawson, Susan Dorman, Nikhil Gupte, Lubbe Wiesner, Amina Jindani, Thomas S Harrison, Adeniyi Olagunju, Deirdre Egan, Andrew Owen, Helen M McIlleron
Rifapentine is a rifamycin used to treat tuberculosis. As for rifampicin, plasma exposures of rifapentine are associated with treatment response. While concomitant food intake and HIV infection explain part of the pharmacokinetic variability associated with rifapentine, few studies have evaluated the contribution of genetic polymorphisms. We evaluated the effects of functionally significant polymorphisms of the genes encoding OATP1B1, PXR, CAR, and AADAC on rifapentine exposure. Two studies evaluating novel regimens amongst Southern African patients with drug-susceptible pulmonary tuberculosis were included in this analysis...
January 22, 2019: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/30667079/increased-central-adiposity-and-decreased-subcutaneous-adipose-tissue-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-are-associated-with-deterioration-in-glucose-tolerance-a-longitudinal-cohort-study
#17
Rachel K Crowley, Conor P Woods, Beverly A Hughes, Joanna Gray, Theresa McCarthy, Angela E Taylor, Laura L Gathercole, Cedric Hl Shackleton, Nicola Crabtree, Wiebke Arlt, Paul M Stewart, Jeremy W Tomlinson
OBJECTIVE & CONTEXT: Increasing adiposity, aging and tissue-specific regeneration of cortisol through the activity of 11β-hydroxysteroid dehydrogenase type 1 have been associated with deterioration in glucose tolerance. We undertook a longitudinal, prospective clinical study to determine if alterations in local glucocorticoid metabolism track with changes in glucose tolerance. DESIGN, PATIENTS, MEASUREMENTS: 65 overweight/obese individuals (mean age 50.3±7...
January 22, 2019: Clinical Endocrinology
https://read.qxmd.com/read/30666042/deletion-polymorphism-of-angiotensin-converting-enzyme-gene-is-associated-with-low-muscle-mass-in-elderly-people-in-jakarta-indonesia
#18
Maria Dara Novi Handayani, Ahmad Hamim Sadewa, Arta Farmawati, Wasilah Rochmah
Decline in muscle mass due to aging is a growing public health problem as it contributes to a decreased capacity for independent living among elderly people. A clear understanding of genetic factors is important, as it is known that angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism affects muscle mass, although the findings are frequently heterogeneous. This study was conducted to determine the association between ACE I/D polymorphism and muscle mass in elderly people. A total of 130 elderly people were recruited from nursing homes in Jakarta...
November 12, 2018: Kobe Journal of Medical Sciences
https://read.qxmd.com/read/30661688/therapeutic-and-preventive-effects-of-exercise-on-cardiometabolic-parameters-in-aging-and-obese-rats
#19
Raildo da Silva Coqueiro, Telma de Jesus Soares, Rafael Pereira, Thiago Macêdo Lopes Correia, Danila Souza Oliveira Coqueiro, Márcio Vasconcelos Oliveira, Lucas Miranda Marques, Cloud Kennedy Couto de Sá, Amélia Cristina Mendes de Magalhães
BACKGROUND AND AIMS: Aging, obesity and sedentarism are among the most important predictors of cardiometabolic diseases. Aiming to reduce the impact of the combination of these three factors, we tested the therapeutic and preventive effects of exercise in aging and obese rats on the following cardiometabolic disease risk parameters: body fat, blood pressure, blood lipids, and glycemic homeostasis. METHODS: Eighteen male Wistar rats (initial age = 4 months, and final age = 14 months) were randomly distributed into three aging and obese groups: sedentary, therapeutic exercise and preventive exercise...
February 2019: Clinical Nutrition ESPEN
https://read.qxmd.com/read/30661330/hepatoprotective-and-anti-obesity-effects-of-korean-blue-honeysuckle-extracts-in-high-fat-diet-fed-mice
#20
Yoon-Seok Chun, Se-Kwang Ku, Jong-Kyu Kim, Sok Park, In-Ho Cho, Nam-Ju Lee
PURPOSE: This study aimed to study the protective effects and mechanism of Blue Honeysuckle (BH) extracts (Berries of Lonicera caerulea L.) on non-alcoholic fatty liver disease (NAFLD) and obesity risk factors in a high fat-diet (HFD) model. METHODS: Animals adapted to HFD were selected after 1 week of adaption period and divided into 6 groups (8 mice in each group; 40 HFD-fed mice and 8 normal fat pellet diet (NFD)-fed mice). After the end of 12 weeks of continuous oral administrations of 3 different dosages of BH extract, 400, 200 and 100 mg/kg, or metformin 250 mg/kg, dissolved in a volume of 10 mL/kg distilled water, the hepatoprotective, hypolipidemic, hypoglycemic, nephroprotective, and anti-obesity effects were analyzed...
December 31, 2018: Journal of Exercise Nutrition & Biochemistry
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