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Neonate and hypoglycemia

Jian Zhang, Guang-Hui Liu, Yu-Wei Zhao, Hui-Qin Wang, Shuang-Gen Mao, Guo-Shun Mao, Kang-Ming Xi, Li-Li Wang, Chuan-Long Zhang, Cheng-Ju Gao, Dao-Dan Huang
OBJECTIVE: To investigate the risk factors for brain injury in preterm infants by a multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China. METHODS: Preterm infants who were hospitalized in the department of neonatology in 9 hospitals of Anhui Neonatal Collaboration Network between January 2016 and January 2017 were enrolled as subjects. The data of maternal pregnancy and clinical data of preterm infants were collected, and the logistic regression model was used to analyze the risk factors for brain injury in preterm infants...
February 2019: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Ching Shan Wan, Sally Abell, Rosalie Aroni, Alison Nankervis, Jacqueline Boyle, Helena Teede
BACKGROUND: Gestational diabetes mellitus (GDM) prevalence is increasing worldwide. Ethnic differences in risk factors and perinatal outcomes are clinically important. Chinese women constitute around 10% of the world's population, and are an increasing migrant population, yet their prevalence, risk factors and outcomes of GDM are insufficiently explored. METHODS: A retrospective study of a large pregnancy dataset comparing GDM prevalence, risk factors and perinatal outcomes between immigrant ethnic Chinese women and Australian-born Caucasian women was conducted using logistic regression...
February 18, 2019: Journal of Diabetes
Sarah G Običan, Linda Odibo, Methodius G Tuuli, Alejandro Rodriguez, Anthony O Odibo
OBJECTIVE: To test the hypothesis that third-trimester uterine artery Doppler (UAD) predicts adverse pregnancy and neonatal outcomes in a high-risk population. STUDY DESIGN: This is a nested case control study of women with singleton gestations referred for a fetal growth ultrasound between 24 and 36 weeks. Third-trimester UAD was performed if estimated fetal weight (Hadlock's chart) was <20th percentile as these patients were considered high risk for poor pregnancy outcomes...
February 13, 2019: Journal of Maternal-fetal & Neonatal Medicine
Kostas Iakovou, Kleopatra Schulpis
Parents had already taken information about galactosemia from web medical pages because they were asked for a second blood sample from their infant suspected for the disease. All enzyme types of this disorder are diagnosed by neonatal screening perinatally and treated with a galactose (GAL) free diet. The most frequent information about the disease was mental retardation (100%), eye cataracts (100%) liver dysfunction (90.5%), speech delay (76.1%), hypoglycemia (69.0%), seizures (31.0), etc. Most clinical and laboratory information about galactosemia taken from the Internet was correct for the classical type of the disorder...
February 12, 2019: Reviews on Environmental Health
J Lawrence Merritt, Marie Norris, Shibani Kanungo
Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism due to disruption of either mitochondrial β-oxidation or the fatty acid transport using the carnitine transport pathway. The presentation of a FAOD will depend upon the specific disorder, but common elements may be seen, and ultimately require a similar treatment. Initial presentations of the FAODs in the neonatal period with severe symptoms include cardiomyopathy, while during infancy and childhood liver dysfunction and hypoketotic hypoglycemia are common...
December 2018: Annals of Translational Medicine
Clara Gobé, Maëva Elzaiat, Nicolas Meunier, Marjolaine André, Eli Sellem, Patrice Congar, Luc Jouneau, Aurélie Allais-Bonnet, Ikrame Naciri, Bruno Passet, Eric Pailhoux, Maëlle Pannetier
Gonad differentiation is a crucial step conditioning the future fertility of individuals and most of the master genes involved in this process have been investigated in detail. However, transcriptomic analyses of developing gonads from different animal models have revealed that hundreds of genes present sexually dimorphic expression patterns. DMXL2 was one of these genes and its function in mammalian gonads was unknown. We therefore investigated the phenotypes of total and gonad-specific Dmxl2 knockout mouse lines...
February 8, 2019: PLoS Genetics
Katheryn Grand, Christina Gonzalez-Gandolfi, Amanda M Ackermann, Deema Aljeaid, Emma Bedoukian, Lynne M Bird, Diva D De Leon, Jullianne Diaz, Robert J Hopkin, Sejal P Kadakia, Beth Keena, Karen O Klein, Ian Krantz, Eyby Leon, Katherine Lord, Carey McDougall, Livija Medne, Cara M Skraban, Charles A Stanley, Jennifer Tarpinian, Elaine Zackai, Matthew A Deardorff, Jennifer M Kalish
Sotos syndrome is an overgrowth syndrome characterized by distinctive facial features and intellectual disability caused by haploinsufficiency of the NSD1 gene. Genotype-phenotype correlations have been observed, with major anomalies seen more frequently in patients with 5q35 deletions than those with point mutations in NSD1. Though endocrine features have rarely been described, transient hyperinsulinemic hypoglycemia (HI) of the neonatal period has been reported as an uncommon presentation of Sotos syndrome...
February 4, 2019: American Journal of Medical Genetics. Part A
Abdullah M Al Alawi, Anna Nordenström, Henrik Falhammar
PURPOSE: 3β-hydroxysteroid dehydrogenase type 2 deficiency (3βHSD2D) is a very rare variant of congenital adrenal hyperplasia (CAH) causing less than 0.5% of all CAH. The aim was to review the literature. METHODS: PubMed was searched for relevant articles. RESULTS: 3βHSD2D is caused by HSD3B2 gene mutations and characterized by impaired steroid synthesis in the gonads and the adrenal glands and subsequent increased dehydroepiandrosterone (DHEA) concentrations...
February 4, 2019: Endocrine
Silvia Hoirisch-Clapauch, Antonio E Nardi
Autism spectrum disorders (ASD) are characterized by disconnectivity due to disordered neuronal migration, and by neuronal mitochondrial dysfunction. Different pathways involved in neuronal migration are affected by intrauterine hyperglycemia and hyperinsulinemia, while prolonged neonatal hypoglycemia may cause mitochondrial dysfunction. Our hypothesis was that conditions leading to intrauterine hyperglycemia or neonatal hypoglycemia would influence ASD pathogenesis. In this study, we identified risk factors for ASD by searching PubMed with the MeSH terms "autism spectrum disorder" and "risk factors"...
January 31, 2019: Translational Psychiatry
Anais Melin, Charles Brossard, Mireille Castanet, Soumeya Bekri, Abdellah Tebani
No abstract text is available yet for this article.
February 2019: Clinical Chemistry
Johanna Stark, Burkhard Simma, Anya Blassnig-Ezeh
BACKGROUND: Temporary low plasma glucose concentrations are common in healthy newborns. Although there is no uniform definition of neonatal hypoglycemia, there is a consensus in the current literature that plasma glucose concentrations should be measured in infants at risk. Known risk groups for transient neonatal hypoglycemia include infants of diabetic mothers (IDM), large (LGA) or small (SGA) for gestational age and late preterm (LPT) infants. OBJECTIVES: The aim of this retrospective trial was to determine the incidence of hypoglycemia and the impact of the application of a 2011 revised guideline in respect of additional feeding or i...
January 27, 2019: Journal of Maternal-fetal & Neonatal Medicine
Indranil Balki, Heet Sheth, Amy Shafey, Cynthia Maxwell, Derek Stephens, Vibhuti Shah
OBJECTIVE: With maternal obesity rates and twin pregnancies on the rise, the aim of this study was to assess the impact of pre-pregnancy or first trimester BMI on short-term neonatal morbidities in twins admitted to a level I unit. METHODS: This retrospective single-centre cohort study was conducted on twins born between January 1, 2010 and December 31, 2013 and admitted to the level I unit at Mount Sinai Hospital in Toronto, Ontario. Twin pairs were categorized according to maternal BMI: underweight (<18...
January 24, 2019: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Jacques Beltrand, Amandine Baptiste, Kanetee Busiah, Naim Bouazza, Cecile Godot, Adeline Boucheron, Zoubir Djerada, Claire Gozalo, Marianne Berdugo, Jean-Marc Tréluyer, Caroline Elie, Michel Polak
BACKGROUND: Results of genetic have led to off-label glibenclamide treatment in patients with neonatal diabetes due to potassium channel mutations. No pediatric form of glibenclamide was available. Glibenclamide was designated an orphan drug designation for neonatal diabetes and a suspension was developed. As a part of the pediatric plan investigation, we assessed its acceptability, efficiency and safety. METHODS: In this Phase II, prospective, non-randomized, single-center study, patient received glibenclamide tablets for 1 month then the suspension for 3 months...
January 26, 2019: Pediatric Diabetes
Caroline Stekelenburg, Karine Gerster, Jean-Louis Blouin, Mariarosaria Lang-Muritano, Michel Guipponi, Federico Santoni, Valerie M Schwitzgebel
OBJECTIVE: When diabetes is associated with congenital malformations, without autoimmune antibodies, a genetic cause is suspected. Here, we aimed to identify a defective gene that led to diabetes. RESEARCH DESIGN AND METHODS: We performed an exome analysis of an index case and his healthy parents. RESULTS: The child presented with childhood-onset diabetes, congenital hypopituitarism, cardiac malformation, and anal atresia. A DNA analysis revealed a heterozygous de novo pathogenic variant in the developmental transcription factor, forkhead box A2 (FOXA2)...
January 26, 2019: Pediatric Diabetes
Ohad Gluck, Michal Kovo, Daniel Tairy, Giulia Barda, Jacob Bar, Eran Weiner
OBJECTIVE: To study the association between bloody amniotic fluid (BAF) during labor and adverse pregnancy outcomes. STUDY DESIGN: In the last 10 years we have implemented an institutional protocol that mandates obstetricians/midwives to report their subjective impression of the color of amniotic fluid (clear, meconium stained, bloody) during labor. The medical records, and neonatal charts of all singleton deliveries ≥ 370/7 weeks between 2008-2018 were reviewed...
January 17, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jennifer L Barkin, Julie M Stausmire, Minda N Te, Alicia Pazik-Huckaby, Marta Serati, Massimiliano Buoli, Roberta S Harding, Cynthia A Bruss, Kari L Stausmire
OBJECTIVE: Factors associated with maternal functioning in biological mothers whose infants were admitted to a Neonatal Intensive Care Unit (NICU) were identified as measured by a modified version of the Barkin Index of Maternal Functioning. MATERIALS AND METHODS: This multivariable regression analysis explored sociodemographic and clinical data from 146 mother-infant dyads admitted to a Level III NICU between February 2015 and May 2016. Eligible dyads included: (1) adult biological mothers with singleton infants discharged home alive after NICU admission meeting criteria and (2) infants discharged home alive from the NICU with adult, biological mothers after a minimum 6-day admission...
January 25, 2019: Journal of Women's Health
Lisa M Scheid, L Steven Brown, Christopher Clark, Charles R Rosenfeld
OBJECTIVES: Determine sources of error in electronically extracted data from electronic health records. STUDY DESIGN: Categorical and continuous variables related to early-onset neonatal hypoglycemia were preselected and electronically extracted from records of 100 randomly selected neonates within 3479 births with laboratory-proven early-onset hypoglycemia. Extraction language was written by an information technologist and data validated by blinded manual chart review...
January 24, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
Priyadarshani Giri, Furong Hu, Edmund F La Gamma, Bistra B Nankova
BACKGROUND: Gut microbiota plays an important role during early development via bidirectional gut-brain signaling. Catecholamines provide a survival advantage allowing adaptation to common postnatal stressors. We aimed to explore the potential link between gut microbiota/gut-derived metabolites and sympathoadrenal stress responsivity. METHODS: The effect of insulin-induced hypoglycemia was compared in mice with (control, adapted control) and without microbiome (germ-free, GF)...
January 14, 2019: Pediatric Research
Ladan Younesi, Mostafa Ghadamzadeh, Ghazaleh Amjad, Zeinab Safarpour Lima
Intrauterine growth restriction is associated with a significant increase in morbidity and perinatal mortality, and increases the likelihood of fetal death, asphyxia, meconium aspiration, hypoglycemia, and neonatal hypothermia. The aim of this study was to determine aortic isthmus flow difference by using color doppler sonography in Intrauterine growth restriction and normal fetuses. The data presented were obtained from 30 mothers, who referred to the radiology department of Akbarabadi Hospital of Tehran with a diagnosis of intrauterine growth restriction...
November 2, 2018: European Journal of Translational Myology
Annabel C M Sheehan, Mark P Umstad, Stephen Cole, Thomas J Cade
It has been suggested that the risk of adverse perinatal outcomes in twin pregnancies is exacerbated by concomitant gestational diabetes mellitus (GDM). This study aimed to assess the risk incurred by twin pregnancy and by a diagnosis of GDM, separately, on the development of poor perinatal outcomes. A retrospective cohort study was conducted on all pregnant women at a tertiary center between 2016 and 2017. The impact of GDM and twin pregnancies on perinatal outcomes - birth weight above the 90th centile for gestational age, cesarean delivery, clinical neonatal hypoglycemia, and premature delivery (before 37 weeks' gestation) - was assessed using univariate and multivariate analyses...
January 21, 2019: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
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