keyword
https://read.qxmd.com/read/38505087/mebendazole-induces-apoptosis-and-inhibits-migration-via-the-reactive-oxygen-species-mediated-stat3-signaling-downregulation-in-non-small-cell-lung-cancer
#21
JOURNAL ARTICLE
Zhipan Liang, Qiuyun Chen, Liuying Pan, Xiaowei She, Tengfei Chen
BACKGROUND: The incidence and mortality of non-small cell lung cancer (NSCLC) are extremely high. Previous research has confirmed that the signal transducer and activator of the transcription 3 (STAT3) protein critically participate in the tumorigenesis of NSCLC. Mebendazole (MBZ) has exerts a larger number of pharmacological activities and has anticancer effects in lung cancer, but its mechanism of action remains unclear. This study thus aimed to clarify the impacts of MBZ on NSCLC cell...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38505066/promotion-of-non-small-cell-lung-cancer-tumor-growth-by-fhl2-via-inducing-angiogenesis-and-vascular-permeability
#22
JOURNAL ARTICLE
Tengfei Chen, Jun Chen, Qiuyun Chen, Zhipan Liang, Liuying Pan, Jun Zhao, Xiaowei She
BACKGROUND: Antiangiogenetic therapy is one of the effective strategies for non-small cell lung cancer (NSCLC) treatment. Four-and-a-half LIM-domain protein 2 ( FHL2 ) serves as a key function in cell growth and metastasis of multiple cancers, but the role of FHL2 in NSCLC angiogenesis has not been intensely examined. METHODS: FHL2 expression in NSCLC tissues and cell lines and its correlation with patients prognosis were investigated by using The Cancer Genome Atlas (TCGA) database and quantitative polymerase chain reaction (qPCR)...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38502290/poor-short-term-outcomes-for-prognostic-high-risk-patients-with-chronic-limb-threatening-ischemia-undergoing-endovascular-therapy
#23
JOURNAL ARTICLE
Tatsuro Takei, Takashi Kajiya, Norihiko Ohura, Natsuko Tomimura, Takuro Kamiyama, Toshiko Ninomiya, Junichiro Takaoka, Nobuhiko Atsuchi
BACKGROUND: The prognosis of chronic limb-threatening ischemia (CLTI) is poor, with an expected life expectancy of 2 or more years, which significantly influences treatment decisions. However, death may occur at the early stages of treatment for wound healing, and aggressive treatment may limit the quality of life of such patients. In patients with CLTI undergoing endovascular therapy (EVT), the Wound, Ischemia, and foot Infection (WIfI) clinical stage, male sex, older age, non-ambulatory status, low body mass index, and dialysis have been reported as predictors of mortality risk...
March 19, 2024: CVIR Endovascular
https://read.qxmd.com/read/38499647/hippo-pathway-in-non-small-cell-lung-cancer-mechanisms-potential-targets-and-biomarkers
#24
REVIEW
Hongge Liang, Yan Xu, Jing Zhao, Minjiang Chen, Mengzhao Wang
Lung cancer is the primary contributor to cancer-related deaths globally, and non-small cell lung cancer (NSCLC) constitutes around 85% of all lung cancer cases. Recently, the emergence of targeted therapy and immunotherapy revolutionized the treatment of NSCLC and greatly improved patients' survival. However, drug resistance is inevitable, and extensive research has demonstrated that the Hippo pathway plays a crucial role in the development of drug resistance in NSCLC. The Hippo pathway is a highly conserved signaling pathway that is essential for various biological processes, including organ development, maintenance of epithelial balance, tissue regeneration, wound healing, and immune regulation...
March 18, 2024: Cancer Gene Therapy
https://read.qxmd.com/read/38495496/unveiling-the-stat3-acc1-axis-a-key-driver-of-lipid-metabolism-and-tumor-progression-in-non-small-cell-lung-cancer
#25
JOURNAL ARTICLE
Hong Zhai, Tiansheng Zheng, Lihong Fan
Background and Objective: Lung cancer is a prevalent global malignancy, and investigating the metabolic reprogramming of tumor cells has significant therapeutic implications. This study aims to explore the molecular mechanism driving the progression of non-small cell lung cancer (NSCLC), with a specific emphasis on the STAT3-ACC1-FAS axis involved in fatty acid synthesis. Methods: The levels of Signal transducer and activator of transcription 3 (STAT3) and acetyl-CoA carboxylase 1 (ACC1) were determined in mouse NSCLC specimens and cell lines using Western blot and qPCR methods...
2024: Journal of Cancer
https://read.qxmd.com/read/38495113/myofibroblasts-reside-in-the-middle-dermis-of-the-keloids-but-do-not-predict-the-response-to-injection-therapies-a-double-blinded-randomized-controlled-trial
#26
JOURNAL ARTICLE
Tuomas Komulainen, Patrik Daymond, Kristiina E Hietanen, Ilkka S Kaartinen, Tero A H Järvinen
INTRODUCTION: Keloids form as a pathological response to skin wound healing, and their etiopathology is poorly understood. Myofibroblasts, which are cells transformed from normal fibroblasts, are believed to contribute to pathological scar formation in wounds. METHODS: We carried out a double-blinded randomized controlled trial (RCT) comparing the efficacy of intralesional 5-fluorouracil (5-FU) and triamcinolone (TAC) injections in treating keloids. A total of 43 patients with 50 keloids were treated with either intralesional TAC or 5-FU injections, and their clinical response was evaluated...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38494195/the-clinical-value-of-intelligent-wound-measurement-devices-in-patients-with-chronic-wounds-a-scoping-review
#27
JOURNAL ARTICLE
Yujie Wu, Liping Wu, Mingfeng Yu
Chronic wounds are common in clinical practice, with long treatment cycle and high treatment cost. Changes in wound area can well predict the effectiveness of treatment and the possibility of healing. Therefore, continuous wound monitoring and evaluation are particularly important. Traditional manual wound measurement tends to overestimate wound area. Recently, various intelligent wound measurement devices have been introduced into clinical practice. This review aims to summarise the reliability, validity, types and measurement principles of different intelligent wound measurement devices, so as to analyse the clinical value and application prospect...
March 2024: International Wound Journal
https://read.qxmd.com/read/38493151/gli1-mediated-tumor-cell-derived-bfgf-promotes-tumor-angiogenesis-and-pericyte-coverage-in-non-small-cell-lung-cancer
#28
JOURNAL ARTICLE
Xueping Lei, Zhan Li, Manting Huang, Lijuan Huang, Yong Huang, Sha Lv, Weisong Zhang, Zhuowen Chen, Yuanyu Ke, Songpei Li, Jingfei Chen, Xiangyu Yang, Qiudi Deng, Junshan Liu, Xiyong Yu
BACKGROUND: Tumor angiogenesis inhibitors have been applied for non-small cell lung cancer (NSCLC) therapy. However, the drug resistance hinders their further development. Intercellular crosstalk between lung cancer cells and vascular cells was crucial for anti-angiogenenic resistance (AAD). However, the understanding of this crosstalk is still rudimentary. Our previous study showed that Glioma-associated oncogene 1 (Gli1) is a driver of NSCLC metastasis, but its role in lung cancer cell-vascular cell crosstalk remains unclear...
March 16, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38481753/risk-factors-for-burn-contractures-in-a-lower-income-country-four-illustrative-cases
#29
JOURNAL ARTICLE
RuthAnn Fanstone, Mohammad Rabiul Karim Khan
INTRODUCTION: Burns are most prevalent in low- and middle-income countries but the risk factors for burn contractures in these settings are poorly understood. There is some evidence from low- and middle-income country studies to suggest that non-medical factors such as socio-economic and health system issues may be as, or possibly more, important than biomedical factors in the development of post-burn contractures. METHODS: Four cases are presented to illustrate the impact of non-biomedical factors on contracture outcomes in a low-income setting...
2024: Scars, Burns & Healing
https://read.qxmd.com/read/38473413/pancreatic-cancer-treatment-targeting-the-hgf-c-met-pathway-the-mek-inhibitor-trametinib
#30
REVIEW
Junyeol Kim, Tae Seung Lee, Myeong Hwan Lee, In Rae Cho, Ji Kon Ryu, Yong-Tae Kim, Sang Hyub Lee, Woo Hyun Paik
Pancreatic cancer is characterized by fibrosis/desmoplasia in the tumor microenvironment, which is primarily mediated by pancreatic stellate cells and cancer-associated fibroblasts. HGF/c-MET signaling, which is instrumental in embryonic development and wound healing, is also implicated for its mitogenic and motogenic properties. In pancreatic cancer, this pathway, along with its downstream signaling pathways, is associated with disease progression, prognosis, metastasis, chemoresistance, and other tumor-related factors...
March 5, 2024: Cancers
https://read.qxmd.com/read/38464338/influence-of-zika-virus-on-the-cytotoxicity-cell-adhesion-apoptosis-and-inflammatory-markers-of-glioblastoma-cells
#31
JOURNAL ARTICLE
Daniel Rodrigo Marinowic, Gabriele Goulart Zanirati, Pamella Nunes Azevedo, Ângela Zanatta, Ismael Plentz, Allan Marinho Alcará, Fernanda Bueno Morrone, Thamiris Becker Scheffel, Angélica Regina Cappellari, Paulo Michel Roehe, Ana Paula Muterle Varela, Denise Cantarelli Machado, Fabiana Spillari Viola, Jaderson Costa Da Costa
Glioblastoma (GBM) is one of the most common types of brain tumor in adults. Despite the availability of treatments for this disease, GBM remains one of the most lethal and difficult types of tumors to treat, and thus, a majority of patients die within 2 years of diagnosis. Infection with Zika virus (ZIKV) inhibits cell proliferation and induces apoptosis, particularly in developing neuronal cells, and thus could potentially be considered an alternative for GBM treatment. In the present study, two GBM cell lines (U-138 and U-251) were infected with ZIKV at different multiplicities of infection (0...
April 2024: Oncology Letters
https://read.qxmd.com/read/38463859/keratin-as-an-effective-coating-material-for-in-vitro-stem-cell-culture-induced-differentiation-and-wound-healing-assays
#32
JOURNAL ARTICLE
Hina F Bhat, Nuzhat Amin, Zarka Nasir, Saba Nazir, Zuhaib F Bhat, Abrar A Malik, Nazir A Ganai, S Mudasir Andrabi, Riaz A Shah, Rana Muhammad Aadil, Asif H Sofi, Gholamreza Abdi
The utilization of stem cells in tissue engineering holds great promise as efficient tools for tissue regeneration and in treating numerous musculoskeletal diseases. However, several limiting factors, such as precise delivery and control of differentiation of these stem cells as well as mimicking the microenvironment required to modulate stem cell behaviour in-vivo , have given rise to an urgent need for the development of new biomaterials which could be tailored to enhance cell renewal and/or direct cell fates...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38463193/the-mechanism-of-pyroptosis-and-its-application-prospect-in-diabetic-wound-healing
#33
REVIEW
Abdullah Al Mamun, Chuxiao Shao, Peiwu Geng, Shuanghu Wang, Jian Xiao
Pyroptosis defines a form of pro-inflammatory-dependent programmed cell death triggered by gasdermin proteins, which creates cytoplasmic pores and promotes the activation and accumulation of immune cells by releasing several pro-inflammatory mediators and immunogenic substances upon cell rupture. Pyroptosis comprises canonical (mediated by Caspase-1) and non-canonical (mediated by Caspase-4/5/11) molecular signaling pathways. Numerous studies have explored the contributory roles of inflammasome and pyroptosis in the progression of multiple pathological conditions such as tumors, nerve injury, inflammatory diseases and metabolic disorders...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38454046/successful-topical-treatment-of-human-biofilms-using-multiple-antibiotic-elution-from-a-collagen-rich-hydrogel
#34
JOURNAL ARTICLE
Ayushi D Sharma, Evan H Jarman, Krutika Kuppalli, Matthew J Murphy, Michael T Longaker, Geoffrey Gurtner, Paige M Fox
Chronic non-healing wounds significantly strain modern healthcare systems, affecting 1-2% of the population in developed countries with costs ranging between $28.1 and $96.8 billion annually. Additionally, it has been established that chronic wounds resulting from comorbidities, such as peripheral vascular disease and diabetes mellitus, tend to be polymicrobial in nature. Treatment of polymicrobial chronic wounds with oral and IV antibiotics can result in antimicrobial resistance, leading to more difficult-to-treat wounds...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38449936/utilization-of-split-thickness-skin-graft-as-a-treatment-option-following-mohs-micrographic-surgery
#35
Luis J Borda, Courtny S Cushman, Thomas W Chu
Split-thickness skin grafting (STSG) is a frontline treatment for challenging surgical wounds, including diabetic foot ulcers, venous leg ulcers, and post-surgical defects. This study explores the use of STSG employing the pinch graft technique for hard-to-heal surgical wounds following Mohs micrographic surgery (MMS). An 83-year-old patient with a non-improving post-MMS defect on the left lower leg underwent STSG from the right inner thigh using the pinch graft technique. The grafts were secured with a mesh dressing, adhesive strips, and compression bandaging...
February 2024: Curēus
https://read.qxmd.com/read/38447479/no-difference-in-clinical-and-hospital-quality-outcomes-in-treatment-of-reverse-obliquity-intertrochanteric-hip-fractures-ao-ota-31-a3-based-on-cephalomedullary-nail-length
#36
JOURNAL ARTICLE
Sanjit R Konda, Lauren A Merrell, Garrett W Esper, Kester Gibbons, Rachel Ranson, Abhishek Ganta, Kenneth A Egol
INTRODUCTION: The purpose of this study was to evaluate outcomes following reverse obliquity (RO) intertrochanteric hip fractures based on the use of short cephalomedullary nails (CMNs) compared to long CMNs for fixation. METHODS: An IRB-approved prospectively collected hip fracture registry at an urban academic medical center was queried for all AO/OTA 31A3.1-3 reverse obliquity intertrochanteric (RO) fractures. One hundred and seventy patients with age > 55 years old and minimum 6-month follow-up were identified for analysis...
March 2, 2024: Injury
https://read.qxmd.com/read/38446155/which-surgical-technique-may-yield-the-best-results-in-large-infected-segmental-non-unions-of-the-tibial-shaft-a-scoping-review
#37
JOURNAL ARTICLE
Dena Akhoundzadeh, Frank W Bloemers, Michael H J Verhofstad, Linda J Schoonmade, Leo M G Geeraedts
PURPOSE: Infected nonunion of the tibia with a large segmental bone defect is a complex and challenging condition for the patient and surgeon. This scoping review was conducted to identify existing evidence and knowledge gaps regarding this clinical scenario. Secondly, the objective of this study was to search for a valid recommendation on the optimal treatment. METHODS: A comprehensive search was conducted in the bibliographic databases: PubMed, Embase.com, and Web of Science Core Collection...
March 6, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38443685/medication-related-osteonecrosis-of-the-jaw-evolving-research-for-multimodality-medical-management
#38
REVIEW
Ali Abdolrahmani, Joel B Epstein, Firoozeh Samim
PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating side effect of antiresorptive and antiangiogenic agents that can lead to progressive bone destruction in the maxillofacial region. Dental surgery, including tooth extractions, commonly trigger the onset of MRONJ. While guidelines suggest avoiding extraction when possible, complete avoidance is not always feasible, as necrosis can develop from dental and periodontal disease without dental procedures. The goal of this article is to provide an update review of current preventive and therapeutic approaches for MRONJ...
March 5, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38440257/improving-depression-like-behaviors-caused-by-diabetes-is-likely-to-offer-a-new-perspective-for-the-treatment-of-non-healing-chronic-wounds
#39
JOURNAL ARTICLE
Zhiqin Dong, Jijin Wu, Hanchen Cao, Jinqiang Lu
BACKGROUND: Three phases are often involved in the intricate process of wound healing: inflammatory exudation, cell proliferation, and tissue remodeling. It is challenging for wounds to heal if conditions like ischemia, persistent pressure, infection, repetitive trauma, or systemic or localized illnesses arise during the healing process. Chronic wounds are persistent injuries that do not follow the normal healing process and fail to progress through the stages of healing within a reasonable timeframe, like diabetic ulcers, vascular ulcers, pressure sores, and infectious wounds...
2024: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/38438404/the-influence-of-microbial-colonization-on-inflammatory-versus-pro-healing-trajectories-in-combat-extremity-wounds
#40
JOURNAL ARTICLE
Seth A Schobel, Eric R Gann, Desiree Unselt, Scott F Grey, Felipe A Lisboa, Meenu M Upadhyay, Michael Rouse, Simon Tallowin, Nicholas A Be, Xijun Zhang, Clifton L Dalgard, Matthew D Wilkerson, Milos Hauskrecht, Stephen F Badylak, Ruben Zamora, Yoram Vodovotz, Benjamin K Potter, Thomas A Davis, Eric A Elster
A combination of improved body armor, medical transportation, and treatment has led to the increased survival of warfighters from combat extremity injuries predominantly caused by blasts in modern conflicts. Despite advances, a high rate of complications such as wound infections, wound failure, amputations, and a decreased quality of life exist. To study the molecular underpinnings of wound failure, wound tissue biopsies from combat extremity injuries had RNA extracted and sequenced. Wounds were classified by colonization (colonized vs...
March 4, 2024: Scientific Reports
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