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Non-healing wounds treatments

Gonzalo Hernández, Víctor Paredes, Rosa María López-Pintor, Amado de Andrés, Juan Carlos de Vicente, Mariano Sanz
OBJECTIVES: The aim of this clinical study was to evaluate long-term outcomes of implant therapy in a cohort of immunosuppressed renal transplant patients compared with a matched control group. MATERIAL AND METHODS: Pharmacologically immunosuppressed renal transplant patients received dental implant treatment between 2001 and 2011. Periodontal, clinical and radiographic parameters were prospectively measured with a mean follow-up of 116.8 months (range from 84 to 192 months)...
April 13, 2019: Clinical Oral Implants Research
Thomas Coutant, Claire Vergneau-Grosset, Stéphane Lair
Topical treatment for wound management in fish is challenging due to their aquatic life. The objective of the present study was to assess the effect of a topical gel containing misoprostol and phenytoin on the healing of skin wounds in brook trout. Four 16 x 8 mm full-thickness wounds were created in each trout. Fish were randomly assigned either to the misoprostol/phenytoin group (14 fish) or to the control untreated group (five fish). In fish from the misoprostol/phenytoin group, two randomly selected wounds were topically treated with a misoprostol/phenytoin gel while the other two wounds were left without topical treatment...
April 12, 2019: Journal of Aquatic Animal Health
A Di Martino, R Papalia, E Albo, L Diaz, L Denaro, V Denaro
Postoperative infections after spinal surgery are a challenging issue, difficult to diagnose and treat, that requires prolonged medical therapy and even surgery. In this paper, we aim to review the current standards in the diagnosis and treatment of post-procedural Spondylodiscitis (SD). We performed a review of the available literature focusing on diagnostic and therapeutic standards of post-procedural SD, both after minimally invasive procedures and open surgery. Spinal infections can occur in less invasive procedures with an incidence ranging from 0...
April 2019: European Review for Medical and Pharmacological Sciences
Faiza Sharif, Sabiniano Roman, Anila Asif, Giulia Gigliobianco, Sarah Ghafoor, Muhammad Tariq, Saadat Anwer Siddiqui, Farrukh Mahmood, Nawshad Muhammad, Ihtesham Ur Rehman, Sheila MacNeil
An oronasal fistula is a passage between the oral and nasal cavity. Currently, surgical procedures use mucosal flaps or collagen grafts to make a barrier between oral and nasal cavities. Our aim was to develop a cell-free synthetic repair material for closure of nasal fistulas. We surface functionalized electrospun polyurethane (PU) and poly-L-lactic acid (PLLA) and composite polymer (PU-PLLA) membranes with acrylic acid through plasma polymerization. Membranes were treated in a layer-by-layer approach to develop highly charged electrostatic layer which could bind heparin as a pro-angiogenic glycosaminoglycan...
April 11, 2019: Journal of Tissue Engineering and Regenerative Medicine
Rilei Jiang, Cheng Hu, Qian Li, Ziyu Cheng, Ling Gu, Hongxiao Li, Yuanyuan Guo, Qirui Li, Yueyang Lu, Ke Li, Meijuan Chen, Xu Zhang
BACKGROUND: As most lung cancer patients present with invasive, metastatic disease, it is vital to investigate anti-metastatic treatments for non-small cell lung cancer (NSCLC). Houttuynia cordata is commonly used as a Chinese anticancer medicine in the clinic, and sodium new houttuyfonate (SNH), a main compound of this herb, has long been found to have antibiotic effects, although its anticancer effects have not been investigated. Here, we tried to address this lack of research from the perspective of the competing endogenous RNA (ceRNA) theory...
April 11, 2019: Journal of Experimental & Clinical Cancer Research: CR
Matteo Coen, Chloé Alberto, Gilles Éperon, Abdessalam Cherkaoui, Jacques Schrenzel
Diphtheria is reappearing in a typical cutaneous form where pre-existing skin lesions (wounds or insect bites) become pustular and turn into painful non-healing ulcers. This form is more common among migrants and disadvantaged populations. Lesions can be caused by strains of toxigenic and non-toxigenic Corynebacteria and among them the famous Corynebacterium diphtheriae. In this paper we review diphtheria's clinical presentations and pathogenesis, as well as methods of diagnosis, treatment and prevention.
April 10, 2019: Revue Médicale Suisse
F J Álvaro-Afonso, Y García-Álvarez, J L Lázaro-Martínez, D Kakagia, N Papanas
Diabetic foot ulcers (DFUs) are one of the major complications of diabetes, representing a leading cause of hospitalisation and non-traumatic lower limb amputations. Multidisciplinary management, patient education, glucose control, debridement, off-loading, infection control, and adequate perfusion are the mainstays of standard care. Despite all these, at least 30% of DFUs fail to heal within 20 weeks. Therefore, dermoepidermal skin substitutes (DSS) have been used as a new therapeutic adjunct for DFUs. This brief review outlines the recent advances in DSS for the treatment of DFUs...
April 8, 2019: Current Vascular Pharmacology
Tianze Liu, Lizi Jin, Wenjing Lu, Hairun Gan, Zhidong Lin, Miao Chen, Jiani Liu, Fan Zhang, Siyang Wang, Hongyu Zhang, Wuguo Deng, Hongtao Chen
BACKGROUND: Recent Clinical trials of administration of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in combination with standard first-line chemotherapy have failed to improve survival in patients with advanced NSCLC, However, the sequential treatment with EGFR-TKIs and chemotherapy is expected to improve survival of NSCLC. The aim of this study is to test the antiproliferative effect of pemetrexed combined with icotinib in different sequences on non-small cell lung cancer (NSCLC) cell lines to determine the optimal combination schedule, and subsequently elaborated the potential mechanisms...
April 5, 2019: Journal of Experimental & Clinical Cancer Research: CR
Silvio Wuschko, Alfred Gugerell, Monika Chabicovsky, Helmut Hofbauer, Maria Laggner, Michael Erb, Tobias Ostler, Anja Peterbauer, Susanne Suessner, Svitlana Demyanets, Jost Leuschner, Bernhard Moser, Michael Mildner, Hendrik J Ankersmit
A cell-free approach using secretomes derived from stem cells or peripheral blood mononuclear cells is an active area of regenerative medicine that holds promise for therapies. Regulatory authorities classify these secretomes as biological medicinal products, and non- clinical safety assessment thus falls under the scope of ICH S6. A secretome of stressed peripheral blood mononuclear cells (APOSEC) was successfully tested in a toxicology program, supporting clinical use of the new drug candidate. Here, to allow for topical, dermal treatment of patients with diabetic foot ulcer, several non-clinical safety studies were performed...
April 3, 2019: Scientific Reports
Elena Yu Zakirova, Dmitry V Shalimov, Ekaterina E Garanina, Margarita N Zhuravleva, Catrin S Rutland, Albert A Rizvanov
Objectives: Large full-thickness skin defects represent a serious veterinary problem. Methods: We have developed novel bioactive 3D-matrixes based on fibrin glue Tissucol (Baxter), containing the combination of the adenoviral constructs with genes vascular endothelial growth factor 165 (VEGF165) and fibroblast growth factor two (FGF2; construct Ad5-VEGF165 + Ad5-FGF2) or multipotent mesenchymal stem cells, genetically modified with these constructs. Results: In vitro studies confirmed the biosynthesis of VEGF165 and FGF2 mRNA in the transduced cells...
2019: Frontiers in Veterinary Science
Wen-Hui Gao, Hong-Ye Gao, Yue-Tong Li, Ping-Ping Huang
INTRODUCTION AND OBJECTIVE: Transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) has been shown to be effective in treating critical limb ischemia (CLI). However, the mechanism of MSCs-mediated improvements, especially on the immune-inflammatory aspects of this disease, is still unknown. In this study, we investigated the changes in T-lymphocyte subpopulations and inflammatory mediators (such as IL-6, IL-10 and TNF-α) in PBMCs from CLI patients after UC-MSCs treatment and correlation between inflammatory mediators and EPCs...
March 26, 2019: Medicina Clínica
Kayo Okamoto, Kumiko Matsumoto, Norichika Iga, Seiji Komatsu
Treatment of empyema is very challenging. The use of negative pressure wound therapy (NPWT), and NPWT with instillation and dwell time (NPWTi-d) for wound closure have attracted attention. However, they are both limited to use after open-window thoracostomy (OWT) performed to control infection. In some patients with poor general conditions, who cannot undergo surgery, no treatment for empyema is available. Therefore, we devised a new treatment for such patients with NPWTi-d without OWT (non-OWT NPWTi-d). Here we present the cases of two patients with refractory empyema after intrathoracic irrigation and drainage, who underwent non-OWT NPWTi-d using the fistula of the thoracic drain...
July 2019: Respirology Case Reports
Kyoung In Jung, Jung Eun Woo, Chan Kee Park
A hypertensive phase frequently develops in the early postoperative period after glaucoma shunt operations. Anti-glaucoma eye drop use is essential when postoperative intraocular pressure (IOP) is not controlled. We investigated whether the use of early topical anti-glaucoma medication affects wound healing following glaucoma tube surgery. Eyes were randomly assigned to receive topical aqueous suppressant (timolol-dorzolamide fixed combination), prostaglandin (PG) analogue (travoprost), or normal saline (control group)...
March 27, 2019: Scientific Reports
Ashlee MacDonald, James D Brodell, John L Daiss, Edward M Schwarz, Irvin Oh
Diabetic foot ulcers (DFU) contribute to 80% of lower extremity amputations. Although physicians currently rely on clinical signs along with non-specific biomarkers of infection, such as erythrocyte sedimentation rate and C-reactive protein, to diagnose and monitor DFU, there is no specific and sensitive measure available to monitor or prognosticate the success of foot salvage therapy (FST). To address this we performed a prospective, observational microbiome analysis to test the hypotheses that: (i) the initial microbiomes of healed versus non-healed DFU are distinct; (ii) the microbial load, diversity and presence of pathogenic organism of the DFU change in response to antibiotics treatment; and (iii) the changes in the DFU microbiome during treatment are prognostic of clinical outcome...
March 25, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Pau Bosch-Nicolau, Dolors Rodríguez-Pardo, Carles Pigrau, Ferran Pellisé, Sleiman Haddad, Mayli Lung, Benito Almirante
The study aims to determine whether 8 weeks of antibiotics is non-inferior to 12 weeks in patients with acute deep spinal implant infection (SII). In the retrospective study of all SII cases (2009-2016), patients aged ≥ 15 years with microbiologically confirmed SII treated with debridement and implant retention were included. Whenever possible, tailored antibiotic treatment was used: rifampin/linezolid in gram-positive and quinolones in gram-negative infection. Patients were divided into short treatment course (8 weeks, ST group) and extended treatment (12 weeks, ET group)...
March 23, 2019: European Journal of Clinical Microbiology & Infectious Diseases
Ravindra V Badhe, Sonali S Nipate
Millions of people die as a result of fatal injuries accounting for 9% of the total global annual deaths. Non fatal injuries generally result in variety of wounds. The normal wound healing process is slow and takes weeks to months, depending on the type of wound. In last two decades, electrotherapy called low-intensity currents (LIC) for the treatment became popular for faster wound healing, as well as in management of nonresponding and ulcerative wounds. It was reported that LIC mimics 'the current of injury' which is generated by body on wounding and helps in faster wound healing...
April 2019: Medical Hypotheses
Nalinrat Petpiroon, Narumol Bhummaphan, Sucharat Tungsukruthai, Tatchakorn Pinkhien, Arnatchai Maiuthed, Boonchoo Sritularak, Pithi Chanvorachote
BACKGROUND: A Lung cancer death account for approximately 1 in 5 of all cancer-related deaths and is particularly virulent due to its enhanced metastasis and resistance to chemotherapy. Chrysotobibenzyl has been reported to decrease cell metastasis, according to the results of an anchorage-independent growth assay; however, its underlying mechanism has not been investigated yet. PURPOSE: The aim of this study was to investigate the effect of chrysotobibenzyl on lung cancer cell migration and drug sensitization and its mechanism...
March 11, 2019: Phytomedicine
Nina Kosaric, Harriet Kiwanuka, Geoffrey Gurtner
Aberrant wound healing is a significant healthcare problem, posing a substantial burden on patients, their families, and the healthcare system. Existing treatment options remain only moderately effective and often fail to promote the closure of non-healing wounds in susceptible populations, such as aging and diabetic patients. Stem cell therapy has emerged as a promising treatment modality, with the potential to restore tissue to its pre-injured state. Of particular interest are mesenchymal stromal cells, which have been shown to accelerate wound healing by modulating the immune response and promoting angiogenesis...
March 22, 2019: Expert Opinion on Biological Therapy
V Umayangana Godakanda, Heyu Li, Laura Alquezar, Lixiang Zhao, Li-Min Zhu, Rohini de Silva, K M Nalin de Silva, Gareth R Williams
The management of pain and inflammation arising from wounds is essential in obtaining effective healing rates. The application of a wound dressing loaded with an anti-inflammatory drug would enable both issues to be ameliorated, and the aim of this work was to fabricate such a dressing by electrospinning. Fibers comprising ethyl cellulose (EC) and poly(vinyl pyrrolidone) (PVP) loaded with naproxen (Nap) were developed to be used in the early stages of wound care. A family of PVP/EC/Nap systems was prepared by varying the PVP: EC ratio...
May 1, 2019: International Journal of Pharmaceutics
Zunmeng Sang, Xuewen Jiang, Longfei Guo, Gang Yin
MicroRNAs (miRs) are small non‑coding RNA molecules that regulate gene expression at the post‑transcriptional level. Aberrant expression of miR‑9 has been reported to be involved in the tumorigenesis and progression of various malignancies. However, its role in prostate cancer (PC) has not been completely clarified. In the present study, miR‑9 expression was examined in different PC cell lines, patient tissues and a mouse model. Cell Counting Kit‑8 and BrdU immunofluorescence assays were performed to assess the effect of miR‑9 on the viability of PC cells, while Transwell and wound‑healing assays were utilized to evaluate the migration and invasion of PC cells expressing miR‑9...
March 21, 2019: Molecular Medicine Reports
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