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cytokine antipsychotic

Marcelo Soares Fernandes, Fernanda Barbisan, Verônica Farina Azzolin, Pedro Antônio Schmidt do Prado-Lima, Cibele Ferreira Teixeira, Ivo Emílio da Cruz Jung, Charles Elias Assmann, Rogerio Tomasi Riffel, Marta Maria Medeiros Frescura Duarte, Ednea Maia Aguiar-Ribeiro, Ivana Beatrice Mânica da Cruz
BACKGROUND: Olanzapine (OLZ) is a second-generation antipsychotic drug used for treatment of schizophrenia, bipolar disorder, and other neuropsychiatric conditions. Undesirable side effects of OLZ include metabolic alterations associated with chronic oxidative-inflammation events. It is possible that lithium (Li), a mood modulator that exhibits anti-inflammatory properties may attenuate OLZ-induced oxi-inflammatory effects. METHODOLOGY: To test this hypothesis we activated RAW 264...
2019: PloS One
Oliver D Robertson, Nieves G Coronado, Rickinder Sethi, Michael Berk, Seetal Dodd
AIM: Neuropsychiatric disorders including depression, bipolar and schizophrenia frequently exhibit a neuroprogressive course from prodrome to chronicity. There are a range of agents exhibiting capacity to attenuate biological mechanisms associated with neuroprogression. This review will update the evidence for putative neuroprotective agents including clinical efficacy, mechanisms of action and limitations in current assessment tools, and identify novel agents with neuroprotective potential...
January 28, 2019: Early Intervention in Psychiatry
Emanuela Martinuzzi, Susana Barbosa, Douglas Daoudlarian, Wafa Bel Haj Ali, Cyprien Gilet, Lionel Fillatre, Olfa Khalfallah, Réjane Troudet, Stéphane Jamain, Guillaume Fond, Iris Sommer, Stefan Leucht, Paola Dazzan, Philip McGuire, Celso Arango, Covadonga M Diaz-Caneja, Wolfgang Fleischhacker, Dan Rujescu, Birte Glenthøj, Inge Winter, René Sylvain Kahn, Robert Yolken, Shon Lewis, Richard Drake, Laetitia Davidovic, Marion Leboyer, Nicolas Glaichenhaus
Early response to first-line antipsychotic treatments is strongly associated with positive long-term symptomatic and functional outcome in psychosis. Unfortunately, attempts to identify reliable predictors of treatment response in first-episode psychosis (FEP) patients have not yet been successful. One reason for this could be that FEP patients are highly heterogeneous in terms of symptom expression and underlying disease biological mechanisms, thereby impeding the identification of one-size-fits-all predictors of treatment response...
January 17, 2019: Translational Psychiatry
Mariane Nunes Noto, Michael Maes, Sandra Odebrecht Vargas Nunes, Vanessa Kiyomi Ota, Ana C Rossaneis, Waldiceu A Verri, Quirino Cordeiro, Sintia Iole Belangero, Ary Gadelha, Rodrigo Affonseca Bressan, Cristiano Noto
Psychotic disorders are accompanied by activation of the immune inflammatory response system (IRS). The compensatory immune-regulatory system (CIRS) is a regulatory immune response that is induced by the IRS but exerts negative feedback through increased levels of anti-inflammatory cytokines such as interleukin (IL)-4, IL-13 and IL-10. This study aims to examine the IRS and CIRS components, including macrophagic M1, T-helper (Th)-1, Th-2, Th-17 and T-regulatory (Treg) phenotypes, in antipsychotic-naïve first episode psychosis (AN-FEP) before and after risperidone treatment...
December 26, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Thiago Duarte, Fernanda Barbisan, Beatriz Sadigurski Nunes da Cunha, Verônica Farina Azzolin, Bárbara Osmarin Turra, Marta Maria Medeiros Frescura Duarte, Ivo Emilio da Cruz Jung, Euler Esteves Ribeiro, Pedro Antônio do Prado-Lima, Ivana Beatrice Mânica da Cruz
Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could attenuate peripheral inflammatory and oxidative stress potentially triggered ZIP. This is the case of guaraná xanthine-catechin chemical matrix (XC-Mix) that presents caffeine, theobromine, and catechin...
December 14, 2018: Inflammation
Raghunath Singh, Yashika Bansal, Bikash Medhi, Anurag Kuhad
Atypical antipsychotics (AAPs) are the drug of choice in the management of mental illnesses by virtue of their advantage over typical antipsychotics i.e. least tendency of producing extrapyramidal motor symptoms (EPS) or pseudoparkinsonism. Despite the clinical efficacy, AAPs produces troublesome adverse effects, particularly hyperphagia, hyperglycemia, dyslipidemia weight gain, diabetes mellitus, insulin resistance and QT prolongation which further develops metabolic and cardiac complications with subsequent reduction in life expectancy, poor patient compliance, and sudden death...
December 7, 2018: European Journal of Pharmacology
Outi Mantere, Kalevi Trontti, Judit García-González, Ingrid Balcells, Suvi Saarnio, Teemu Mäntylä, Maija Lindgren, Tuula Kieseppä, Tuukka Raij, Jarno K Honkanen, Outi Vaarala, Iiris Hovatta, Jaana Suvisaari
Previous studies suggest immunological alterations in patients with first-episode psychosis (FEP). Some studies show that antipsychotic compounds may cause immunomodulatory effects. To evaluate the immunological changes and the possible immunomodulatory effects in FEP, we recruited patients with FEP (n = 67) and matched controls (n = 38), aged 18-40 years, from the catchment area of the Helsinki University Hospital and the City of Helsinki, Finland. Fasting peripheral blood samples were collected between 8 and 10 a...
November 10, 2018: Journal of Psychiatric Research
Toby Pillinger, Emanuele F Osimo, Stefan Brugger, Valeria Mondelli, Robert A McCutcheon, Oliver D Howes
Immune parameters are elevated in psychosis, but it is unclear whether alterations are homogenous across patients or heterogeneity exists, consistent with the hypothesis that immune alterations are specific to a subgroup of patients. To address this, we examine whether antipsychotic-naïve first-episode psychosis patients exhibit greater variability in blood cytokines, C-reactive protein, and white cell counts compared with controls, and if group mean differences persist after adjusting for skewed data and potential confounds...
November 8, 2018: Schizophrenia Bulletin
Chia-Hui Chen, Song-Kun Shyue, Chiao-Po Hsu, Tzong-Shyuan Lee
BACKGROUND/AIMS: Olanzapine, an atypical antipsychotic drug, has therapeutic effects for schizophrenia. However, clinical reports indicate that patients taking atypical antipsychotic drugs are at high risk of metabolic syndrome with unclear mechanisms. We investigated the effect of olanzapine on atherosclerosis and the mechanisms in apolipoprotein E-null (apoE-/-) mice. METHODS: ApoE-/- mice were used as in vivo models. Western blot analysis was used to evaluate protein expression...
2018: Cellular Physiology and Biochemistry
Xiaohua Chen, Zhenzhen Xiong, Zhixiong Li, Yali Yang, Zhanying Zheng, Yonghong Li, Yan Xie, Zhe Li
The pathophysiology of schizophrenia may involve increased production of inflammatory cytokines by activated microglia. Minocycline can inhibit activated microglia and may improve secondary negative symptoms and/or cognitive functions when used as adjuvant to antipsychotics. Effects on minocycline on primary and enduring negative symptoms in deficit schizophrenia (DS) are unknown. We present a male patient with a 3-year history of DS. He was treated for 12 weeks with risperidone at a maximal dose of 6 mg per day, then for 10 weeks with olanzapine at 20 mg per day...
2018: Neuropsychiatric Disease and Treatment
Andreza B Sonego, Douglas S Prado, Gabriel T Vale, Julia E Sepulveda-Diaz, Thiago M Cunha, Carlos R Tirapelli, Elaine A Del Bel, Rita Raisman-Vozari, Francisco S Guimarães
The chronic use of drugs that reduce the dopaminergic neurotransmission can cause a hyperkinetic movement disorder called tardive dyskinesia (TD). The pathophysiology of this disorder is not entirely understood but could involve oxidative and neuroinflammatory mechanisms. Cannabidiol (CBD), the major non-psychotomimetic compound present in Cannabis sativa plant, could be a possible therapeutic alternative for TD. This phytocannabinoid shows antioxidant, anti-inflammatory and antipsychotic properties and decreases the acute motor effects of classical antipsychotics...
September 11, 2018: Brain, Behavior, and Immunity
Britta Stapel, Irina Sieve, Christine S Falk, Stefan Bleich, Denise Hilfiker-Kleiner, Kai G Kahl
Schizophrenia and major depression are associated with alterations in peripheral inflammatory markers, and anti-inflammatory therapy has been proposed as a promising add-on approach in the pharmacologic treatment of both disorders. Second-generation atypical antipsychotics are currently first-line drugs in the treatment of schizophrenia and are also used as augmentation strategies in treatment-resistant major depression. Furthermore, these drugs have been reported to exhibit distinct metabolic side effects and to influence inflammatory processes...
October 2018: Journal of Psychiatric Research
Apiwan Rosena, Thongchai Koobkokkruad, Waleewan Eaknai, Phichaporn Bunwatcharaphansakun, Rawiwan Maniratanachote, Sasitorn Aueviriyavit
Bombyx mori silk extracts, derived from the cocoon degumming process of draw and dye silk in the textile industry, are mainly composed of sericin protein. To add value to the Thai silk extracts, and hence the silk industry, a simple enrichment process was recently developed and the enriched silk extracts were then applied in nano-cosmeceutical products and nano-delivery systems. In this study, the protective effect of Thai silk extracts from three different strains of Bombyx mori on the drug-induced phototoxicity was evaluated in vitro using chlorpromazine (CPZ), a commonly used antipsychotic drug, as a representative phototoxic drug...
November 2018: Journal of Photochemistry and Photobiology. B, Biology
Mirza S Baig, Anjali Roy, Uzma Saqib, Sajjan Rajpoot, Mansi Srivastava, Adnan Naim, Dongfang Liu, Rohit Saluja, Syed M Faisal, Qiuwei Pan, Kati Turkowski, Gajanan N Darwhekar, Rajkumar Savai
Nuclear factor-kB (NF-kB) is a crucial transcription factor in the signal transduction cascade of the inflammatory signaling. Activation of NF-κB depends on the phosphorylation of IκBα by IκB kinase (IKKβ) followed by subsequent ubiquitination and degradation. This leads to the nuclear translocation of the p50- p65 subunits of NF-κB, and further triggers pro-inflammatory cytokine gene expression. Thus, in the need of a more effective therapy for the treatment of inflammatory diseases, specific inhibition of IKKβ represents a rational alternative strategy to the current therapies...
August 20, 2018: Scientific Reports
Mohammad Mahdi Eftekharian, Mir Davood Omrani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard
Schizophrenia is a chronic severe mental disorder in which immunologic imbalances have been reported. Some researchers have demonstrated dysregulation of cytokine levels in this mental disorder. Considering the possible role of cytokines in the pathogenesis or clinical course of schizophrenia, we assessed serum levels of IL-4, IL-10, IL-17A and IFN-γ in a homogenous sample of Iranian patients who were in remission under treatment with Clozapine compared with sex and age matched controls. There was a statistically significant difference in IL-4 levels between patients and healthy subjects (P= 0...
July 14, 2018: Human Antibodies
Hebatalla I Ahmed, Somaia A Abdel-Sattar, Heba S Zaky
There are increasing evidences supporting the involvement of oxidative stress and neuroinflammation in schizophrenia. Vinpocetine, a nootropic phosphodiesterase-1 inhibitor, was proven to possess anti-oxidant and anti-inflammatory potentials. This research aimed to reveal the likely protective features of vinpocetine against ketamine-induced schizophrenia-like deficits in rats. Additionally, the probable mechanisms contributing to this neuroprotection were also elucidated. Vinpocetine was given (20 mg/kg, i...
December 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
David W Volk, Annie E Moroco, Kaitlyn M Roman, Jessica R Edelson, David A Lewis
BACKGROUND: Transcript levels for cytokines and the viral restriction factor interferon-induced transmembrane protein are markedly higher in the prefrontal cortex in schizophrenia. These gene products are regulated by the nuclear factor-κB (NF-κB) transcriptional complex. NF-κB activity, which requires the formation of NF-κB family member heterodimers, is regulated by activation receptors, kinases, and inhibitors. Whether any of these factors are altered in schizophrenia is not known...
January 1, 2019: Biological Psychiatry
Bruno Romeo, Marine Brunet-Lecomte, Catherine Martelli, Amine Benyamina
Background: Immune system dysfunction is a hypothesis in the psychopathology of schizophrenia, but the impact of antipsychotic treatment within this system is not clear. The aim of this meta-analysis was to investigate the impact of antipsychotic treatment on cytokine levels in in vivo studies on schizophrenia. Methods: After a systematic database search, original data were extracted with the help of certain authors. Means and SDs were extracted to calculate standardized mean differences...
September 1, 2018: International Journal of Neuropsychopharmacology
Rigil K Yeung, Zheng-Hua Xiang, Shui-Ying Tsang, Rui Li, Timothy Y C Ho, Qi Li, Chok-King Hui, Pak-Chung Sham, Ming-Qi Qiao, Hong Xue
Intronic polymorphisms of the GABAA receptor β2 subunit gene (GABRB2) under adaptive evolution were associated with schizophrenia and reduced expression, especially of the long isoform which differs in electrophysiological properties from the short isoform. The present study was directed to examining the gene dosage effects of Gabrb2 in knockout mice of both heterozygous (HT) and homozygous (KO) genotypes with respect to possible schizophrenia-like and comorbid phenotypes. The KO mice, and HT mice to a lesser extent, were found to display prepulse inhibition (PPI) deficit, locomotor hyperactivity, stereotypy, sociability impairments, spatial-working and spatial-reference memory deficits, reduced depression and anxiety, and accelerated pentylenetetrazol (PTZ)-induced seizure...
July 17, 2018: Translational Psychiatry
María Juncal-Ruiz, Laura Riesco-Dávila, Víctor Ortiz-García de la Foz, Obdulia Martínez-Garcia, Mariluz Ramírez-Bonilla, Javier Gonzalo Ocejo-Viñals, Juan Carlos Leza, Marcos López-Hoyos, Benedicto Crespo-Facorro
INTRODUCTION: Evidence about the anti-inflammatory properties of antipsychotics has grown. However, no previous studies have compared the immunomodulatory effect of risperidone and aripiprazole. OBJECTIVES: The main aim of the present work is to compare the anti-inflammatory effect of risperidone and aripiprazole on a large array of serum cytokines at 3 months following the onset of treatment. METHODS: This is a prospective, randomized, open-label study...
June 22, 2018: Schizophrenia Research
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