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https://read.qxmd.com/read/30771025/non-occlusive-intestinal-ischemia-in-the-ascending-colon-and-rectum-a-pediatric-case-occurring-during-encephalitis-treatment
#1
Noboru Oyachi, Takaki Emura, Fuminori Numano, Tomoko Tando, Tomohiro Saito, Yusuke Goto
BACKGROUND: Non-occlusive mesenteric ischemia (NOMI) is a rare and severe pathological condition that can cause intestinal necrosis without mechanical obstruction of the mesenteric artery. NOMI often develops during the treatment of severe disease in elderly patients and mostly occurs in the intestine supplied by the superior mesenteric artery (SMA). We experienced a 12-year-old patient with NOMI that was segmentally localized in the ascending colon and rectum during encephalitis treatment...
February 15, 2019: Surgical Case Reports
https://read.qxmd.com/read/30763774/g1p-8-rotavirus-in-children-with-severe-diarrhea-in-the-post-vaccine-introduction-era-in-brazil-evidence-of-reassortments-and-structural-modifications-of-the-antigenic-vp7-and-vp4-regions
#2
F S Santos, E C Sousa Junior, S F S Guerra, P S Lobo, E T Penha Junior, A B F Lima, C B G Vinente, E H N Chagas, M C A Justino, A C Linhares, J Matthijnssens, L S Soares, J D P Mascarenhas
Worldwide rotaviruses A (RVA) are responsible for approximately 215,000 deaths annually among children aged <5 years. RVA G1P[8] remains associated with >50% of gastroenteritis cases in this age group. The aim of this study was to assess the genetic variability of G1P[8] strains detected in children with severe diarrhea in Belém, Pará, Brazil, during the post-rotavirus vaccine introduction era. Phylogenetic analysis clustered the VP4 and VP7 genes of 40 samples selected between 2009 and 2011 into lineages found to be different from the Rotarix® vaccine strain...
February 11, 2019: Infection, Genetics and Evolution
https://read.qxmd.com/read/30742566/dynamo-a-phase-ii-study-of-duvelisib-ipi-145-in-patients-with-refractory-indolent-non-hodgkin-lymphoma
#3
Ian W Flinn, Carole B Miller, Kirit M Ardeshna, Scott Tetreault, Sarit E Assouline, Jiri Mayer, Michele Merli, Scott D Lunin, Andrew R Pettitt, Zoltan Nagy, Olivier Tournilhac, Karem-Etienne Abou-Nassar, Michael Crump, Eric D Jacobsen, Sven de Vos, Virginia M Kelly, Weiliang Shi, Lori Steelman, NgocDiep Le, David T Weaver, Stephanie Lustgarten, Nina D Wagner-Johnston, Pier Luigi Zinzani
PURPOSE: Indolent non-Hodgkin lymphoma (iNHL) remains largely incurable and often requires multiple lines of treatment after becoming refractory to standard therapies. Duvelisib was approved by the Food and Drug Administration for relapsed or refractory (RR) chronic lymphocytic leukemia or small lymphocytic lymphoma (SLL) and RR follicular lymphoma (FL) after two or more prior systemic therapies. On the basis of the activity of duvelisib, a first-in-class oral dual inhibitor of phosphoinositide 3-kinase-δ,-γ, in RR iNHL in a phase I study, the safety and efficacy of duvelisib monotherapy was evaluated in iNHL refractory to rituximab and either chemotherapy or radioimmunotherapy...
February 11, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://read.qxmd.com/read/30740733/results-from-a-78-week-single-arm-open-label-phase-2-study-to-evaluate-ux007-in-pediatric-and-adult-patients-with-severe-long-chain-fatty-acid-oxidation-disorders-lc-faod
#4
Jerry Vockley, Barbara Burton, Gerard T Berry, Nicola Longo, John Phillips, Amarilis Sanchez-Valle, Pranoot Tanpaiboon, Stephanie Grunewald, Elaine Murphy, Alexandra Bowden, Wencong Chen, Chao-Yin Chen, Jason Cataldo, Deborah Marsden, Emil Kakkis
Long-chain fatty acid oxidation disorders (LC-FAOD) are rare disorders characterized by acute crises of energy metabolism and severe energy deficiency that may present with cardiomyopathy, hypoglycemia, and/or rhabdomyolysis, which can lead to frequent hospitalizations and early death. An open-label Phase 2 study evaluated the efficacy of UX007, an investigational odd-carbon medium-chain triglyceride, in 29 subjects with severe LC-FAOD. UX007 was administered over 78 weeks at a target dose of 25-35% total daily caloric intake (mean 27...
January 2019: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/30733919/adenovirus-pneumonia-treated-with-cidofovir-in-an-immunocompetent-high-school-senior
#5
Hee-Young Yoon, Hyun-Hae Cho, Yon Ju Ryu
Most adenovirus infections are self-limiting in immunocompetent individuals. Here, we report a case of adenovirus pneumonia in a 17-year-old immunocompetent male. He was admitted to our emergency room complaining of a febrile sense, cough, and diarrhea for four days. Crackles in the left lung and a high fever (40.7 °C) were revealed. Initial chest X-ray and computed tomography images showed consolidation in the left lung. We immediately started empirical antibiotic treatment, but his clinical symptoms and pneumonic consolidation in radiography had not improved by hospital day three...
2019: Respiratory Medicine Case Reports
https://read.qxmd.com/read/30722841/differentiating-acute-food-protein-induced-enterocolitis-syndrome-from-its-mimics-a-comparison-of-clinical-features-and-routine-laboratory-biomarkers
#6
Eric Lee, Elizabeth H Barnes, Sam Mehr, Dianne E Campbell
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is frequently misdiagnosed and subject to diagnostic delay. Profuse vomiting, the cardinal feature of acute FPIES, may occur in more common pediatric disorders such as gastroenteritis and sepsis. OBJECTIVES: We sought to determine differentiating features at acute presentation between FPIES, gastroenteritis, and sepsis in young children presenting to an emergency department (ED) with profuse vomiting...
February 2019: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/30677817/leukocytoclastic-vasculitis-with-late-onset-henoch-sch%C3%A3-nlein-purpura-after-trifluridine-tipiracil-treatment
#7
Alexander B Aria, Leon Chen, William F Glass, Amit Lahoti, Susan Y Chon
Trifluridine/tipiracil has been approved for the treatment of refractory metastatic colorectal cancer. Adverse effects of this drug combination include leukopenia, neutropenia, fatigue, diarrhea, and vomiting. We present a case of trifluridine/tipiracil-induced leukocytoclastic vasculitis (LCV) with late-onset Henoch-Schönlein purpura (HSP) in a 42-year-old man with metastatic appendiceal cancer. The patient's biopsy-proven LCV developed one month after he began trifluridine/tipiracil treatment and resolved after discontinuation of the drug...
October 15, 2018: Dermatology Online Journal
https://read.qxmd.com/read/30677534/genetic-evolution-analysis-and-pathogenicity-assessment-of-porcine-epidemic-diarrhea-virus-strains-circulating-in-part-of-china-during-2011-2017
#8
Pengfei Chen, Kang Wang, Yixuan Hou, Huichun Li, Xianbin Li, Lingxue Yu, Yifeng Jiang, Fei Gao, Wu Tong, Hai Yu, Zhibiao Yang, Guangzhi Tong, Yanjun Zhou
In recent years, the outbreaks of porcine epidemic diarrhea (PED) caused by the highly virulent porcine epidemic diarrhea virus (PEDV) variants occurred frequently in China, resulting in severe economic impacts to the pork industry. In this study, we selected and analyzed the genetic evolution of 15 PEDV representative strains that were identified in fecal samples of diarrheic piglets in 10 provinces and cities during 2011-2017. The phylogenetic analysis indicated that all the 15 PEDV isolates clustered into G2 genotype associated with the current circulating strains...
January 21, 2019: Infection, Genetics and Evolution
https://read.qxmd.com/read/30665434/a-decade-of-antiretroviral-therapy-in-uganda-what-are-the-emerging-causes-of-death
#9
Agnes N Kiragga, Frank Mubiru, Andrew D Kambugu, Moses R Kamya, Barbara Castelnuovo
BACKGROUND: The roll out of antiretroviral therapy (ART) in Sub-Saharan Africa led to a decrease in mortality. Few studies have documented the causes of deaths among patients on long term antiretroviral therapy in Sub-Saharan Africa. Our objective was to describe the causes of death among patients on long term ART in Sub-Saharan Africa. METHODS: We used data from a prospective cohort of ART naïve patients receiving care and treatment at the Infectious Diseases Institute in Kampala, Uganda...
January 21, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30654269/emerging-and-re-emerging-coronaviruses-in-pigs
#10
REVIEW
Qiuhong Wang, Anastasia N Vlasova, Scott P Kenney, Linda J Saif
Porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome-coronavirus (SADS-CoV) are emerging/reemerging coronaviruses (CoVs). They cause acute gastroenteritis in neonatal piglets. Sequence analyses suggest that PEDV and SADS-CoV may have originated from bat CoVs and PDCoV from a sparrow CoV, reaffirming the interspecies transmission of CoVs. The clinical signs and pathogenesis of the three viruses are similar. Necrosis of infected intestinal epithelial cells occurs, causing villous atrophy that results in malabsorptive diarrhea...
January 14, 2019: Current Opinion in Virology
https://read.qxmd.com/read/30638863/safety-and-efficacy-of-monoclonal-antibody-vis410-in-adults-with-uncomplicated-influenza-a-infection-results-from-a-randomized-double-blind-phase-2-placebo-controlled-study
#11
Ellie Hershberger, Susan Sloan, Kristin Narayan, Catherine A Hay, Patrick Smith, Frank Engler, Rienk Jeeninga, Saskia Smits, Jose Trevejo, Zach Shriver, David Oldach
BACKGROUND: VIS410, a broadly neutralizing monoclonal antibody that binds the hemagglutinin stem of influenza A viruses, was safe and efficacious in a human H1N1 virus challenge study. This study evaluated the safety and tolerability of VIS410 in non-hospitalized adult patients with uncomplicated influenza A. METHODS: Patients 18 to 65 years of age with symptom onset within 72 h were randomized 1:1:1 to receive a single intravenous infusion of VIS410 4000 mg, 2000 mg, or placebo...
January 9, 2019: EBioMedicine
https://read.qxmd.com/read/30638036/brigatinib-novel-alk-inhibitor-for-non-small-cell-lung-cancer
#12
Sara A Spencer, Angela C Riley, Adia Matthew, Anthony J Di Pasqua
OBJECTIVE: We review here the pharmacology, pharmacokinetics, efficacy, safety, dosage and administration, potential drug-drug interactions and place in therapy of brigatinib for abnormal anaplastic lymphoma kinase (ALK) specific non-small-cell lung cancer (NSCLC). DATA SOURCES: A literature search using PubMed was conducted using the terms brigatinib and ALK positive NSCLC from January 2013 to November 2018. STUDY SELECTION AND DATA EXTRACTION: All English-language articles evaluating brigatinib were analyzed for this review...
January 13, 2019: Annals of Pharmacotherapy
https://read.qxmd.com/read/30634958/pathogenicity-and-immunogenicity-of-attenuated-porcine-epidemic-diarrhea-virus-pc22a-strain-in-conventional-weaned-pigs
#13
Chun-Ming Lin, Shristi Ghimire, Yixuan Hou, Patricia Boley, Stephanie N Langel, Anastasia N Vlasova, Linda J Saif, Qiuhong Wang
BACKGROUND: Porcine epidemic diarrhea virus (PEDV) causes diarrhea in all ages of pigs with 50-100% mortality rates in neonatal piglets. In the United States, inactivated and subunit PEDV vaccines for pregnant sows are available, but fail to induce sufficient protection in neonatal piglets farrowed from PEDV naïve sows. A safe and efficacious live attenuated vaccine that can prime mucosal immune responses is urgently needed. In this study, we evaluated the safety and efficacy of two attenuated PEDV vaccine candidates, the emerging non-S INDEL PEDV strain PC22A at the 100th cell culture passage level - Clone no...
January 11, 2019: BMC Veterinary Research
https://read.qxmd.com/read/30634396/bats-and-coronaviruses
#14
REVIEW
Arinjay Banerjee, Kirsten Kulcsar, Vikram Misra, Matthew Frieman, Karen Mossman
Bats are speculated to be reservoirs of several emerging viruses including coronaviruses (CoVs) that cause serious disease in humans and agricultural animals. These include CoVs that cause severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), porcine epidemic diarrhea (PED) and severe acute diarrhea syndrome (SADS). Bats that are naturally infected or experimentally infected do not demonstrate clinical signs of disease. These observations have allowed researchers to speculate that bats are the likely reservoirs or ancestral hosts for several CoVs...
January 9, 2019: Viruses
https://read.qxmd.com/read/30630990/the-emergence-of-non-communicable-disease-in-indonesia
#15
Dyah Purnamasari
Based on data from the Indonesian Ministry of Health Information Center, the estimated population of Indonesia in 2016 was approximately 258,704,986 people, consisted of 129,988,690 men and 128,716,296 women. This number of Indonesian population represents young population since the proportion of population aged 0-14 years is more than that aged >14 years. Meanwhile, the proportion of population aged 50 years and above is significantly reduced, which is thought to be due to high mortality rate in the middle-aged population...
October 2018: Acta Medica Indonesiana
https://read.qxmd.com/read/30630118/disentangling-microbial-mediators-of-malnutrition-modeling-environmental-enteric-dysfunction
#16
REVIEW
Luther A Bartelt, David T Bolick, Richard L Guerrant
Environmental enteric dysfunction (EED, syn. environmental enteropathy (EE)) is a subclinical chronic intestinal disorder that is an emerging contributor to early childhood malnutrition. EED is common in resource-limited settings, and is postulated to consist of small intestinal injury, dysfunctional nutrient absorption, and chronic inflammation that results in impaired early child growth attainment. While there is emerging interest in the hypothetical potential for chemical toxins in the environmental 'exposome' to contribute to EED, the propensity of published data, and hence the focus of this review, implicates a critical role of environmental microbes...
January 7, 2019: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/30613162/safety-of-oral-methylnaltrexone-for-opioid-induced-constipation-in-patients-with-chronic-noncancer-pain
#17
Richard L Rauck, Neal E Slatkin, Nancy Stambler, Robert J Israel
Purpose: Oral methylnaltrexone was shown to be effective in treating opioid-induced constipation (OIC) in patients with chronic noncancer pain in a Phase III randomized controlled trial. This report provides a detailed safety analysis from that study. Methods: Adults (n=803) with chronic noncancer pain for ≥2 months and confirmed OIC while receiving opioid doses ≥50 mg morphine equivalent per day for ≥14 days were randomized 1:1:1:1 to oral methylnaltrexone (150, 300, or 450 mg) or placebo once daily for 4 weeks, followed by as-needed use for 8 weeks...
2019: Journal of Pain Research
https://read.qxmd.com/read/30613161/naldemedine-in-japanese-patients-with-opioid-induced-constipation-and-chronic-noncancer-pain-open-label-phase-iii-studies
#18
Yoji Saito, Takaaki Yokota, Masatsugu Arai, Yukio Tada, Masahiko Sumitani
Introduction: Naldemedine is a peripherally-acting µ-opioid-receptor antagonist, approved in Japan for opioid-induced constipation (OIC). In two open-label, single-arm, Phase III studies, we evaluated the safety and efficacy of naldemedine in Japanese patients with OIC receiving regular-use opioids (COMPOSE-6) or prolonged-release oxycodone (COMPOSE-7) for chronic noncancer pain. Methods: Eligible Japanese adults with OIC and chronic noncancer pain received once-daily oral naldemedine 0...
2019: Journal of Pain Research
https://read.qxmd.com/read/30599304/splenic-hematoma-may-present-as-large-bowel-obstruction-a-case-report
#19
Christine Kolwitz, Christopher Esposito, Caitlin Gauvin, Vinaya Gaduputi, Brian Chiong, Tagore Sunkara, Gerard A Baltazar
INTRODUCTION: Large bowel obstruction (LBO) warrants prompt evaluation and management. Although causes of LBO are most commonly intrinsic to the colon (e.g. malignancy, diverticular stricture, intussusception or volvulus), rare extrinsic etiologies exist. An extremely rare extrinsic etiology of LBO described only once, is compressive splenic hematoma. PRESENTATION OF CASE: A 64-year-old female presented to the emergency department complaining of two days of diffuse abdominal pain and distension, watery diarrhea and nausea subsequent to a mechanical fall to her left side...
November 22, 2018: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30598584/five-years-of-fecal-microbiota-transplantation-an-update-of-the-israeli-experience
#20
Sharon A Greenberg, Ilan Youngster, Nathaniel A Cohen, Dan M Livovsky, Jacob Strahilevitz, Eran Israeli, Ehud Melzer, Kalman Paz, Naomi Fliss-Isakov, Nitsan Maharshak
AIM: To evaluate and describe the efficacy of fecal microbiota transplantation (FMT) for Clostridium difficile infection (CDI) in a national Israeli cohort. METHODS: All patients who received FMT for recurrent (recurrence within 8 wk of the previous treatment) or refractory CDI from 2013 through 2017 in all the five medical centers in Israel currently performing FMT were included. Stool donors were screened according to the Israeli Ministry of Health guidelines...
December 21, 2018: World Journal of Gastroenterology: WJG
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