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https://read.qxmd.com/read/30771459/leukotoxic-activity-of-fusobacterium-necrophorum-of-cattle-origin
#1
Deepti K Pillai, Raghavendra G Amachawadi, Giovanna Baca, Sanjeev Narayanan, T G Nagaraja
Fusobacterium necrophorum is a Gram negative, rod-shaped and aero tolerant anaerobe. In animals, it is an opportunistic pathogen frequently associated with necrotic infections, generally called necrobacillosis, such as calf diphtheria, foot rot and liver abscesses in cattle. Two subspecies exist: subsp. necrophorum and subsp. funduliforme. Among several virulence factors, leukotoxin (Lkt) is considered to be a major factor and a protective antigen. The objective of the study was to utilize BL3 cells and measure the release of lactic dehydrogenase to quantify Lkt activity of F...
February 13, 2019: Anaerobe
https://read.qxmd.com/read/30770742/social-determinants-and-cardiovascular-disease-mortality-in-panama-2012-2016
#2
Luis Quiel, Ilais Moreno Velásquez, Beatriz Gómez, Jorge Motta, Víctor Herrera-Ballesteros
BACKGROUND: The aims of this study were to determine the geographic and time variation of social determinants of health (SDH) and cardiovascular disease (CVD) mortality in Panama from 2012 to 2016, and to identify which of the SDH has the strongest correlation with a socioeconomic index (SEI). METHODS: We conducted an ecological study obtaining mortality from the National Mortality Register and socioeconomic variables derived from the National Household Survey (NHS)...
February 15, 2019: BMC Public Health
https://read.qxmd.com/read/30770220/lipid-control-and-associated-risk-factors-before-suffering-from-the-first-cardiovascular-event
#3
Pilar Ángeles Oriol Torón, Teresa Badía Farré, Amparo Romaguera Lliso
OBJECTIVE: To ascertain the degree of lipidic control before the first cardiovascular accident in population attended during 2013 at Primary Care. To analyze the distribution of these events depending on control intervals of cholesterol LDL (LDL-chol), cholesterol HDL (HDL-chol) and triglycerides (TG). METHOD: A multicentric cross-sectional, descriptive study on above 18-year-old people attended at the centres of the Primari Care Service (PCS) Baix Llobregat Nord, who had suffered a first cardiac or cerebral ischemic attack from 01/01/2013 to 31/12/2013...
February 12, 2019: Clínica e Investigación en Arteriosclerosis
https://read.qxmd.com/read/30770109/self-reported-functional-health-status-following-interrupted-aortic-arch-repair-a-congenital-heart-surgeons-society-study
#4
Anusha Jegatheeswaran, Marshall L Jacobs, Christopher A Caldarone, Paul M Kirshbom, William G Williams, Eugene H Blackstone, William M DeCampli, Kim F Duncan, Linda M Lambert, Henry L Walters, Christo I Tchervenkov, Brian W McCrindle
OBJECTIVES: Improved survival after congenital heart surgery has led to interest in functional health status. We sought to identify factors associated with self-reported functional health status in adolescents and young adults with repaired interrupted aortic arch. METHODS: Follow-up of survivors (aged 13-24 years) from a 1987 to 1997 inception cohort of neonates included completion of functional health status questionnaires (Child Health Questionnaire-CF87 [age <18 years, n = 51] or the Short Form [SF]-36 [age ≥18 years, n = 66]) and another about 22q11 deletion syndrome (22q11DS) features (n = 141)...
January 11, 2019: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30770034/pilot-testing-a-robot-for-reducing-pain-in-hospitalized-preterm-infants
#5
Nicholas Williams, Karon MacLean, Ling Guan, Jean Paul Collet, Liisa Holsti
Optimizing neurodevelopment is a key goal of neonatal occupational therapy. In preterm infants, repeated procedural pain is associated with adverse effects on neurodevelopment long term. Calmer is a robot designed to reduce infant pain. The objective of this study was to examine the effects of Calmer on heart rate variability (HRV) during routine blood collection in preterm infants. In a randomized controlled pilot trial, 10 infants were assigned to either standard care ( n = 5, facilitated tucking [FT]) or Calmer treatment ( n = 5)...
February 15, 2019: OTJR: Occupation, Participation and Health
https://read.qxmd.com/read/30769812/computational-psychometrics-using-psychophysiological-measures-for-the-assessment-of-acute-mental-stress
#6
Pietro Cipresso, Desirée Colombo, Giuseppe Riva
The goal of this study was to provide reliable quantitative analyses of psycho-physiological measures during acute mental stress. Acute, time-limited stressors are used extensively as experimental stimuli in psychophysiological research. In particular, the Stroop Color Word Task and the Arithmetical Task have been widely used in several settings as effective mental stressors. We collected psychophysiological data on blood volume pulse, thoracic respiration, and skin conductance from 60 participants at rest and during stressful situations...
February 14, 2019: Sensors
https://read.qxmd.com/read/30768569/a-systematic-review-for-variables-to-be-collected-in-a-transplant-database-for-improving-risk-prediction
#7
Jehad Almasri, Mouaffaa Tello, Raed Benkhadra, Allison S Morrow, Bashar Hasan, Wigdan Farah, Neri Alvarez Villalobos, Khaled Mohammed, Jay-Sheree P Allen, Larry J Prokop, Zhen Wang, Bertram L Kasiske, Ajay K Israni, Mohammad Hassan Murad
BACKGROUND: This systematic review was commissioned to identify new variables associated with transplant outcomes that are not currently collected by the Organ Procurement and Transplantation Network (OPTN). METHODS: We identified 81 unique studies including 1,193,410 patients with median follow-up of 36 months posttransplant, reporting 108 unique risk factors. RESULTS: Most risk factors (104) were recipient-related; few (4) were donor-related...
February 6, 2019: Transplantation
https://read.qxmd.com/read/30768409/underlying-psychophysiology-of-dysregulation-resting-heart-rate-and-heart-rate-reactivity-in-relation-to-childhood-dysregulation
#8
Marike H F Deutz, Steven Woltering, Helen Vossen, Maja Deković, Anneloes L van Baar, Peter Prinzie
OBJECTIVE: High co-occurrence of externalizing and internalizing problems may underlie inconsistent findings regarding the relation between heart rate and psychopathology. In this study, heart rate measures are examined in relation to a general dysregulation profile, studied from both a variable- and person-centered approach. METHOD: The sample (N = 182) consisted of 8-12-year-old children referred for externalizing behaviors and typically-developing children (Mage = 9...
October 30, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/30768364/obesogenic-diet-in-aging-mice-disrupts-gut-microbe-composition-and-alters-neutrophil-lymphocyte-ratio-leading-to-inflamed-milieu-in-acute-heart-failure
#9
Vasundhara Kain, William Van Der Pol, Nithya Mariappan, Aftab Ahmad, Peter Eipers, Deanna L Gibson, Cecile Gladine, Claire Vigor, Thierry Durand, Casey Morrow, Ganesh V Halade
Calorie-dense obesogenic diet (OBD) is a prime risk factor for cardiovascular disease in aging. However, increasing age coupled with changes in the diet can affect the interaction of intestinal microbiota influencing the immune system, which can lead to chronic inflammation. How age and calorie-enriched OBD interact with microbial flora and impact leukocyte profiling is currently under investigated. Here, we tested the interorgan hypothesis to determine whether OBD in young and aging mice alters the gut microbe composition and the splenic leukocyte profile in acute heart failure (HF)...
February 15, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/30768193/association-between-self-rated-health-coronary-artery-calcium-scores-and-atherosclerotic-cardiovascular-disease-risk-the-multi-ethnic-study-of-atherosclerosis-mesa
#10
Olusola A Orimoloye, Mohammadhassan Mirbolouk, S M Iftekhar Uddin, Zeina A Dardari, Michael D Miedema, Mouaz H Al-Mallah, Joseph Yeboah, Ron Blankstein, Khurram Nasir, Michael J Blaha
Importance: The interplay of self-rated health (SRH), coronary artery calcium (CAC) scores, and cardiovascular risk is poorly described. Objectives: To assess the degree of correlation between SRH and CAC, to determine whether these measures are complementary for risk prediction, and to assess the incremental value of the addition of SRH to established risk tools. Design, Setting, and Participants: The Multi-Ethnic Study of Atherosclerosis (MESA) is a large population-based prospective cohort study of adults aged 45 to 84 years who were recruited from 6 US communities...
February 1, 2019: JAMA network open
https://read.qxmd.com/read/30767951/-the-nursing-led-in-patient-unit-a-descriptive-study-of-nursing-care-delivered
#11
Valentina Zeffiro, Gianfranco Sanson, Luigia Carboni, Anna Malatesta, Ercole Vellone, Rosaria Alvaro, Fabio D'Agostino
Chronic diseases require continuous healthcare that is not fully guaranteed by the Italian Health System which is more oriented towards acute care. In the Lazio region (city of Palombara Sabina), a Nursing-Led in-patient unit is present with the aim to care for patients affected by chronic diseases. The aim of this study was to describe the type of healthcare delivered by this unit. A descriptive-comparative design was used. All 290 patients admitted to the Nursing-Led Unit, during 2014 and 2015 participated in the study...
July 2018: Igiene e Sanità Pubblica
https://read.qxmd.com/read/30767904/the-current-state-of-mobile-phone-apps-for-monitoring-heart-rate-heart-rate-variability-and-atrial-fibrillation-narrative-review
#12
REVIEW
Ka Hou Christien Li, Francesca Anne White, Timothy Tipoe, Tong Liu, Martin Cs Wong, Aaron Jesuthasan, Adrian Baranchuk, Gary Tse, Bryan P Yan
BACKGROUND: Mobile phone apps capable of monitoring arrhythmias and heart rate (HR) are increasingly used for screening, diagnosis, and monitoring of HR and rhythm disorders such as atrial fibrillation (AF). These apps involve either the use of (1) photoplethysmographic recording or (2) a handheld external electrocardiographic recording device attached to the mobile phone or wristband. OBJECTIVE: This review seeks to explore the current state of mobile phone apps in cardiac rhythmology while highlighting shortcomings for further research...
February 15, 2019: JMIR MHealth and UHealth
https://read.qxmd.com/read/30767398/nocturnal-ventricular-arrhythmias-are-associated-with-severity-of-cardiovascular-autonomic-neuropathy-in-type-2-diabetes
#13
Chuhui Chen, Weimin Wang, Wen Zhou, Jiewen Jin, Wei Chen, Dalong Zhu, Yan Bi
BACKGROUND: Cardiovascular autonomic neuropathy (CAN) is a risk factor for arrhythmias and adverse cardiovascular events, but the relation between the severity of CAN progression and nocturnal arrhythmias needs to be furthermore clarified. The following study aims to evaluate the association between nocturnal arrhythmias and severity of CAN in patients with type 2 diabetes. METHODS: 219 type 2 diabetes patients were recruited from January 2017 to May 2018. Subjects were classified into no CAN (NCAN), early CAN (ECAN), definite CAN (DCAN) or advanced CAN (ACAN) according to cardiovascular autonomic reflex tests (CARTs)...
February 15, 2019: Journal of Diabetes
https://read.qxmd.com/read/30767143/the-different-response-of-cardiomyocytes-and-cardiac-fibroblasts-to-mitochondria-inhibition-and-the-underlying-role-of-stat3
#14
Jing Zhao, Jin-Lai Gao, Jun-Xue Zhu, Hai-Bin Zhu, Xuan Peng, Man Jiang, Yao Fu, Juan Xu, Xi-Hai Mao, Nan Hu, Ming-Hui Ma, De-Li Dong
Cardiomyocyte loss and cardiac fibrosis are the main characteristics of cardiac ischemia and heart failure, and mitochondrial function of cardiomyocytes is impaired in cardiac ischemia and heart failure, so the aim of this study is to identify fate variability of cardiomyocytes and cardiac fibroblasts with mitochondria inhibition and explore the underlying mechanism. The mitochondrial respiratory function was measured by using Oxygraph-2k high-resolution respirometry. The STAT3 expression and activity were evaluated by western blot...
February 14, 2019: Basic Research in Cardiology
https://read.qxmd.com/read/30766559/prevalence-of-autonomic-dysfunction-among-pre-dialysis-chronic-kidney-disease-patients-in-a-tertiary-hospital-south-east-nigeria
#15
Obinna Onodugo, Ejikeme Arodiwe, Julius Okoye, Birinus Ezeala, Nkiru Onodugo, Ifeoma Ulasi, Chinwuba Ijoma
Background: Autonomic dysfunction (AD) has been recognized as an important contributor to the poor outcome in chronic kidney disease (CKD) patients. Several studies have reported abnormalities in heart rate variability (HRV) among these patients. Objectives: To determine the prevalence of Autonomic Dysfunction (AD) in pre-dialysis Chronic Kidney Disease (CKD) patients in a tertiary hospital in South East Nigeria. Methods: A cross sectional study of eighty chronic kidney disease patients attending the renal unit out-patient in the University of Nigeria Teaching Hospital (UNTH) Enugu was carried out...
December 2018: African Health Sciences
https://read.qxmd.com/read/30766489/chronic-low-level-vagus-nerve-stimulation-improves-long-term-survival-in-salt-sensitive-hypertensive-rats
#16
Elizabeth M Annoni, Dusty Van Helden, Yugene Guo, Brett Levac, Imad Libbus, Bruce H KenKnight, John W Osborn, Elena G Tolkacheva
Chronic hypertension (HTN) affects more than 1 billion people worldwide, and is associated with an increased risk of cardiovascular disease. Despite decades of promising research, effective treatment of HTN remains challenging. This work investigates vagus nerve stimulation (VNS) as a novel, device-based therapy for HTN treatment, and specifically evaluates its effects on long-term survival and HTN-associated adverse effects. HTN was induced in Dahl salt-sensitive rats using a high-salt diet, and the rats were randomly divided into two groups: VNS ( n = 9) and Sham ( n = 8), which were implanted with functional or non-functional VNS stimulators, respectively...
2019: Frontiers in Physiology
https://read.qxmd.com/read/30765686/psychobiological-factors-of-resilience-and-depression-in-late-life
#17
Kelsey T Laird, Beatrix Krause, Cynthia Funes, Helen Lavretsky
In contrast to traditional perspectives of resilience as a stable, trait-like characteristic, resilience is now recognized as a multidimentional, dynamic capacity influenced by life-long interactions between internal and environmental resources. We review psychosocial and neurobiological factors associated with resilience to late-life depression (LLD). Recent research has identified both psychosocial characteristics associated with elevated LLD risk (e.g., insecure attachment, neuroticism) and psychosocial processes that may be useful intervention targets (e...
February 14, 2019: Translational Psychiatry
https://read.qxmd.com/read/30765403/salmanticor-study-rationale-and-design-of-a-population-based-study-to-identify-structural-heart-disease-abnormalities-a-spatial-and-machine-learning-analysis
#18
Jose Ignacio Melero-Alegria, Manuel Cascon, Alfonso Romero, Pedro Pablo Vara, Manuel Barreiro-Perez, Victor Vicente-Palacios, Fernando Perez-Escanilla, Jesus Hernandez-Hernandez, Beatriz Garde, Sara Cascon, Ana Martin-Garcia, Elena Diaz-Pelaez, Jose Maria de Dios, Aitor Uribarri, Javier Jimenez-Candil, Ignacio Cruz-Gonzalez, Baltasara Blazquez, Jose Manuel Hernandez, Clara Sanchez-Pablo, Inmaculada Santolino, Maria Concepcion Ledesma, Paz Muriel, P Ignacio Dorado-Diaz, Pedro L Sanchez
INTRODUCTION: This study aims to obtain data on the prevalence and incidence of structural heart disease in a population setting and, to analyse and present those data on the application of spatial and machine learning methods that, although known to geography and statistics, need to become used for healthcare research and for political commitment to obtain resources and support effective public health programme implementation. METHODS AND ANALYSIS: We will perform a cross-sectional survey of randomly selected residents of Salamanca (Spain)...
February 13, 2019: BMJ Open
https://read.qxmd.com/read/30765277/heart-rate-variability-in-patients-presenting-with-neurally-mediated-syncope-in-an-emergency-department
#19
Hikaru Akizuki, Naoyuki Hashiguchi
BACKGROUND: Neurally mediated syncope (NMS) is a disorder of autonomic nervous system (ANS) regulation. Orthostatic stress is one of the most common causative factors seen in clinical practice. Analysis of heart rate variability (HRV) is a non-invasive method that is used to assess ANS regulation. In this study, we investigated the pathophysiology of NMS using HRV in our emergency department. METHODS: The subjects were 19 patients (age 25.8 ± 6.2 years old) who presented with NMS and 20 healthy individuals (age 26...
February 6, 2019: American Journal of Emergency Medicine
https://read.qxmd.com/read/30763851/temperature-variability-and-hospitalization-for-ischaemic-heart-disease-in-brazil-a-nationwide-case-crossover-study-during-2000-2015
#20
Qi Zhao, Shanshan Li, Micheline S Z S Coelho, Paulo H N Saldiva, Kejia Hu, Rachel R Huxley, Michael J Abramson, Yuming Guo
BACKGROUND: Previous studies have suggested a potential relationship between temperature variability (TV) and ischaemic heart disease (IHD) but the nature and strength differ between studies. We quantify the association between TV and risk of hospitalization for IHD across Brazilian regions and examine how the relationship varies across important population subgroups. METHODS: Data on hospitalization for IHD and meteorological parameters were collected from 1814 cities during 2000-2015...
February 5, 2019: Science of the Total Environment
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