Keywords fluids and electrolytes in chi...

fluids and electrolytes in children
Cheuk C Au, Kam L Hon, Alexander K C Leung, Alcy R Torres
BACKGROUND: Infectious encephalitis is a serious and challenging condition to manage. This overview summarizes the current literature regarding the etiology, clinical manifestations, diagnosis, management and recent patents of acute childhood infectious encephalitis. METHODS: We used PubMed Clinical Queries and keywords of "encephalitis" AND "childhood" as a search engine, and patents were searched using the key term "encephalitis" in google...
November 24, 2020: Recent Patents on Inflammation & Allergy Drug Discovery
Xiao-Sheng Hao, Jian-Min Liang, Xue-Mei Wu, Yun-Peng Hao, Jiang-Tao Wang, Song-Yan Liu
BACKGROUND: Benign convulsions with mild gastroenteritis (BCWG) is a common condition in children in Asia and is generally not associated with pH or electrolyte imbalances. When BCWG is diagnosed, a lumbar puncture is usually recommended to rule out potential intracranial infections. This study examined the clinical characteristics of BCWG and evaluated the necessity of lumbar puncture. METHODS: Medical records of children admitted to the First Hospital of Jilin University with BCWG between January 2018 and May 2019 were reviewed and analyzed...
November 10, 2020: BMC Pediatrics
GÜl Hatİce Erkol Tuncer, Mesİha Ekİm, Emel Okulu, Begum Atasay, Tanil Kendİrlİ
BACKGROUND AND AIM: Continuous renal replacement therapy (CRRT) has significant benefits in the treatment of critically ill children. The objective of this study is to describe the treatment indications, methods, demographics and outcome of the patients, who received CRRT in our pediatric intensive care unit and neonatal care unit and according to these results we also aim to make improvements in our unit-based interventions. MATERIAL AND METHODS: In this single-centered study, we retrospectively evaluated medical charts of the patients admitted to our intensive care units and received CRRT between February 2010 and November 2015...
November 11, 2020: Turkish Journal of Medical Sciences
Mingkun Yu, Xuejing Jin, Changhao Liang, Fanlong Bu, Deng Pan, Qian He, Yang Ming, Paul Little, Hongbo Du, Shibing Liang, Ruixue Hu, Chengze Li, Yanhong Jessika Hu, Huijuan Cao, Jianping Liu, Yutong Fei
Background: Diarrhea is a ubiquitous digestive system disease, leading to loss of fluid and electrolytes, and may be life-threatening, especially in children and adults who are immunosuppressed or malnourished. Berberine has a broad-spectrum antibiotic activity and is very widely used to treat diarrhea in China. No systematic review has been carried out to evaluate the evidence presented in clinical trials. The aim of this study was to assess the effectiveness and safety of berberine in diarrhea treatment among children and adults...
2020: Therapeutic Advances in Gastroenterology
Saara Lehtiranta, Minna Honkila, Merja Kallio, Niko Paalanne, Outi Peltoniemi, Tytti Pokka, Marjo Renko, Terhi Tapiainen
Importance: The use of isotonic fluid therapy is currently recommended in children, but there is limited evidence of optimal fluid therapy in acutely ill children. Objective: To evaluate the risk for electrolyte disorders, including hyponatremia, hypernatremia, and hypokalemia, and the risk of fluid retention in acutely ill children receiving commercially available plasmalike isotonic fluid therapy. Design, Setting, and Participants: This unblinded, randomized clinical pragmatic trial was conducted at the pediatric emergency department of Oulu University Hospital, Finland, from October 3, 2016, through April 15, 2019...
October 26, 2020: JAMA Pediatrics
Udmila Podracká, Mária Chocholová
Chloride ions are involved in regulating cell volume, secreting body fluids and maintaining acid-base balance. Hypo/hyperchloraemia in neonates and infants is an emergent situation requiring careful differential diagnosis to detect a cause of the condition. The rare causes of severe hypochloremia include congenital chloridorhea (CLD), characterized by profound bulky diarrhea, high chloride concentration in stool, and severe metabolic alkalosis. CLD is a rare autosomal recessive disease caused by the mutation of the SLC26A3 gene located on chromosome 7q31, which encodes the transmembrane protein in intestinal cells...
2020: Vnitr̆ní Lékar̆ství
Adrienne G DePorre, Matthew Hall, Henry T Puls, Ashley Daly, James C Gay, Jessica L Bettenhausen, Jessica L Markham
OBJECTIVES: To assess hospital-level variation in laboratory testing and intravenous fluid (IVF) use and examine the association between these interventions and hospitalization outcomes among infants admitted with neonatal hyperbilirubinemia. METHODS: We performed a retrospective multicenter study of infants aged 2 to 7 days hospitalized with a primary diagnosis of hyperbilirubinemia from December 1, 2016, to June 30, 2018, using the Pediatric Health Information System...
October 2020: Hospital Pediatrics
Thomas Langer, Veronica D'Oria, Giulia C I Spolidoro, Giovanna Chidini, Stefano Scalia Catenacci, Tiziana Marchesi, Marta Guerrini, Andrea Cislaghi, Carlo Agostoni, Antonio Pesenti, Edoardo Calderini
BACKGROUND: Fluid therapy is a cornerstone of pediatric intensive care medicine. We aimed at quantifying the load of water, sodium and chloride due to different fluid indications in our pediatric intensive care unit (PICU). We were particularly interested in the role of fluid creep, i.e. fluid administered mainly as the vehicle for drugs, and the association between sodium load and water balance. METHODS: Critically ill children aged ≤3 years and invasively ventilated for ≥48 h between 2016 and 2019 in a single tertiary center PICU were retrospectively enrolled...
September 5, 2020: BMC Pediatrics
Hiba Hasan Khaddour, Diana Zaher, Triak Kassem, Ahmad Hasan
BACKGROUND: Pemphigus vulgaris is an autoimmune disorder that involves intraepithelial blistering and sores of the skin and mucous membranes. The average age of onset is between 50 and 70 years. Pemphigus rarely occurs in children. It correlates with the level of circulating autoantibodies; therapeutic plasma exchange is hypothesized to remove pathogenic autoantibodies, and this is necessary in refractory severe cases. CASE PRESENTATION: A 14-year-old Asian girl came to our hospital with blisters and erosions all over her body and in the oral mucosa...
July 19, 2020: Journal of Medical Case Reports
Cheng Cai, Gang Qiu, Wenchao Hong, Yunlin Shen, Xiaohui Gong
BACKGROUND: Sepsis is the leading cause of acute kidney injury (AKI) in the neonatal intensive care unit (NICU). The aim of the study is to explore the efficacy and security of continuous renal replacement therapy (CRRT) in the treatment of neonatal sepsis-related AKI. METHOD: Totally12 sepsis-related AKI neonates treated with CRRT were hospitalized in the NICU of Shanghai Children's Hospital between November 2012 and November 2019, and the clinical data of these 12 cases were retrospectively analyzed...
July 18, 2020: BMC Nephrology
Li Ding, Huawei Wang, Haifeng Geng, Ningxun Cui, Fengxia Huang, Xueping Zhu, Xiaoli Zhu
Objective: To identify postnatal risk factors for bronchopulmonary dysplasia (BPD) development in preterm infants with gestational age ≤32 weeks. Methods: Seventy-two preterm infants(30 with BPD and 42 non-BPD controls) admitted in the neonatal intensive care unit (NICU) of the Children's Hospital of Soochow University during 2017 were enrolled in this prospective longitudinal study. Perinatal clinical data, a neonatal critical illness score (NCIS), different soluble B7-H3(sB7-H3), and interleukin-18 (IL-18) levels by days after birth were collected...
2020: Frontiers in Pediatrics
L Peremans, D Declercq, S Vande Velde, R De Bruyne, M Van Winckel, J Vande Walle, S Van Biervliet
Most episodes of vomiting, reduced intake and diarrhoea in children can be evaluated and treated without additional tests. However, when the degree of clinical dehydration is not in line with the patient's medical history, other diagnoses should be suspected. In the presence of a hyponatraemic hypochloraemic metabolic alkalosis, cystic fibrosis (CF) should be included in the differential diagnosis, especially if there is failure to thrive even in the absence of respiratory symptoms. Furthermore, young patients diagnosed with CF have a higher risk for an acute electrolyte decompensation caused by increased salt and fluid losses...
April 2020: Acta Gastro-enterologica Belgica
Timothy Nduhukire, Daniel Atwine, Luwaga Rachel, Joseph E Byonanebye
BACKGROUND: Severe acute malnutrition (SAM) affects about 13 million under-five children (U5), with an estimated one million dying every year. In this study we aimed at determining the in hospital mortality and its associated factors among U5s admitted with SAM. METHODS: This was a prospective cohort study of children 6 months to 5 years with SAM admitted at Mbarara Regional Referral Hospital (MRRH) between June and August 2015. Care-takers were interviewed to collect socio-demographic and clinical information...
2020: PloS One
Aladine A Elsamadicy, Andrew B Koo, Wyatt B David, Adam J Kundishora, Christopher S Hong, Margot Sarkozy, Kristopher T Kahle, Michael DiLuna
PURPOSE: For young children and adolescents with Chiari malformation type I (CM-I), the determinants of extended length of hospital stay (LOS) after neurosurgical suboccipital decompression are obscure. Here, we investigate the impact of patient- and hospital-level risk factors on extended LOS following surgical decompression for CM-I in young children to adolescents. METHODS: The Kids' Inpatient Database year 2012 was queried. Pediatric CM-I patients (6-18 years) undergoing surgical decompression were identified...
June 9, 2020: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Aleisha M Nabower, Matt Hall, Jason Burrows, Amanda Dave, Ashley Deschamp, Chinenye R Dike, Joshua C Euteneuer, Teri Mauch, Russell McCulloh, Laura Ortmann, Kari Simonsen, Gwenn Skar, Jessica Snowden, Veronica Taylor, Jessica L Markham
OBJECTIVES: Assess trends in inpatient acute gastroenteritis (AGE) management across children's hospitals and identify elements of AGE management associated with resource use. METHODS: We examined inpatient stays for children 6 months to 18 years hospitalized with AGE from 2009 to 2018 using the Pediatric Health Information System database. We characterized demographics, hospital-level resource use (ie, medications, laboratories, and imaging), and outcomes (ie, cost per case, 14-day revisit rates, and length of stay [LOS])...
June 3, 2020: Hospital Pediatrics
D W Bearl, B Feingold, A Lorts, D N Rosenthal, F Zafar, J Conway, B A Elias, H P Tunuguntla, C Thurm, S M Amdani, N A Jaworski, J Godown
PURPOSE: There is a concerted effort to increase discharges of children on ventricular assist device (VAD) support. Optimizing this process represents a quality improvement target of Advanced Cardiac Therapies Improving Outcomes Network (ACTION). We sought to describe discharge and readmission frequency in children on VAD support using a multicenter administrative database. METHODS: All VAD-implanted patients aged 10-21 years at ACTION centers were identified from the Pediatric Health Information System database (2009-2018)...
April 2020: Journal of Heart and Lung Transplantation
Luz Castellanos, Marwa Tuffaha, Dorit Koren, Lynne L Levitsky
Diabetic ketoacidosis (DKA) is the end result of insulin deficiency in type 1 diabetes mellitus (T1D). Loss of insulin production leads to profound catabolism with increased gluconeogenesis, glycogenolysis, lipolysis, and muscle proteolysis causing hyperglycemia and osmotic diuresis. High levels of counter-regulatory hormones lead to enhanced ketogenesis and the release of 'ketone bodies' into the circulation, which dissociate to release hydrogen ions and cause an overwhelming acidosis. Dehydration, hyperglycemia, and ketoacidosis are the hallmarks of this condition...
August 2020: Paediatric Drugs
Robert Sümpelmann, Rolf Zander, Lars Witt
The composition and type of intravenous fluids during paediatric anaesthesia have been subjects of debates for decades. Errors in perioperative infusion therapy in children may lead to serious complications and a negative outcome. Therefore, in this review historical and recent developments and recommendations for perioperative fluid management in children are presented, based on physiology and focused on safety and efficacy. Recent studies showed that optimized preoperative fasting times and liberal clear fluid intake until 1 h improve patient comfort and metabolic and haemodynamic condition after induction of anaesthesia...
May 2020: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Vittoria Buccigrossi, Andrea Lo Vecchio, Eugenia Bruzzese, Carla Russo, Antonella Marano, Sara Terranova, Valentina Cioffi, Alfredo Guarino
Oral rehydration solutions (ORSs) is the key treatment of acute diarrhea in children, as it restores the electrolyte balance by stimulating the intestinal sodium/glucose transporter SGLT1 to induce fluid absorption. The World Health Organization (WHO) and The European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) proposed ORSs with different chemical compositions. The main agent of childhood acute gastroenteritis is rotavirus (RV). We evaluate the effects of ORS with different concentration of glucose and sodium on RV induced secretion...
May 8, 2020: Scientific Reports
Naile Tufan Pekkucuksen, Ayse Akcan Arikan, Sarah J Swartz, Poyyapakkam Srivaths, Joseph R Angelo
OBJECTIVES: Paralleling improved outcomes in critically ill patients, survival for pediatric acute kidney injury has improved. Continuous renal replacement therapy is the preferred modality to optimize fluid and electrolyte management as well as nutritional support for children developing acute kidney injury in the PICU. However, some patients remain too fragile for transition to intermittent renal replacement therapies and require continuous renal replacement therapy for a prolonged period...
June 2020: Pediatric Critical Care Medicine
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