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Genitourinary malignancies

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https://read.qxmd.com/read/30979478/malakoplakia-in-thoracic-transplant-recipients
#1
R J Lane, R Kradin, D Xia, C A Buchan, S Turbett, C N Kotton, M K Mansour
Malakoplakia is a rare granulomatous disease characterized by the presence of Michaelis-Gutmann bodies on histopathologic analysis. Lesions manifest in a wide range of organs with cutaneous, gastrointestinal, and genitourinary systems being most common, and often result in significant comorbidities owing largely to misdiagnoses and the similar appearance to malignancy or granulomatous processes. Most patients are immunocompromised, including the solid-organ transplant population. Among organ recipients, malakoplakia is most commonly seen in renal transplantation, and only rarely reported in thoracic organ recipients...
April 2019: Transplantation Proceedings
https://read.qxmd.com/read/30976567/prediction-tools-in-non-muscle-invasive-bladder-cancer
#2
REVIEW
Stefania Zamboni, Marco Moschini, Claudio Simeone, Alessandro Antonelli, Agostino Mattei, Philipp Baumeister, Evanguelos Xylinas, Oliver W Hakenberg, Atiqullah Aziz
Non-muscle invasive bladder cancer (BCa) is the second most common genitourinary malignancy, burdened by high rates of recurrence and progression. Urologist are encouraged to stratify patients on the bases of recurrence and progression risks in order to define the best therapeutic approach and follow-up scheme. For these reasons, the aim of the present non-systematic review was to assess the literature on prediction tools in non-muscle invasive BCa. Currently, the most widely used tools remain the European Organization for Research and Treatment of Cancer (EORTC) and the Club Urologico Espanol de Tratamiento Oncologico (CUETO) risk tables, which are based on clinicopathologic features...
February 2019: Translational Andrology and Urology
https://read.qxmd.com/read/30971548/diagnostic-utility-of-gata3-immunohistochemical-expression-in-urothelial-carcinoma
#3
Harshita Agarwal, Suresh Babu, Chanchal Rana, Madhu Kumar, Atin Singhai, Shiv Narayan Shankhwar, Vishwajeet Singh, Rahul Janak Sinha
Aims: This study aims to explore the utility of GATA binding protein 3, a zinc finger transcription factor, expression in genitourinary carcinoma, especially urothelial carcinoma. Settings and Design: It is a prospective study where 74 consecutive cases of urothelial carcinoma along with 10 cases each of prostatic adenocarcinoma (PC) and conventional clear cell renal cell carcinoma were included between August 2016 and January 2017. Methods and Materials: All the cases were histopathologically evaluated and immunohistochemically stained for GATA binding protein 3...
April 2019: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/30971543/evaluation-of-lymph-node-ratio-and-morphologic-patterns-of-nodal-reactive-hyperplasia-in-primary-organ-malignancy
#4
Shinde V Sweety, Ashwini Sardar Narayankar
Background: Lymph node ratio (LNR) in cancer staging is the ratio of nodal metastases (LNM) to total nodes harvested (LNH). Reactive nodal hyperplasia can exhibit morphological patterns I to VI. Aims: To measure LNR and evaluate it with tumor stage, tumor grade, LN reactive patterns, and LN size. Setting and Design: Retrospective, observational study of 100 cancer resections including breast, gastrointestinal (GIT), genitourinary (GUT), and head, face, neck, and thyroid (HFNT)...
April 2019: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/30963589/anastomosing-hemangioma-of-the-nasal-cavity
#5
Zheng-Yi Huang, Chien-Chin Chen, Bipin Thingujam
Anastomosing hemangioma (AH) is an uncommon benign vascular neoplasm first described in the genitourinary tract. Symptomatically and histologically mimicking malignant angiosarcoma, a few rare cases have been described in the nonrenal genitourinary tract. Here, we report a 37-year-old man with a nasal AH and epistaxis. To the best of our knowledge, this is the first case of AH reported in the nasal cavity. Awareness of this entity in the nasal cavity can be helpful in diagnosis and distinction from angiosarcoma...
April 8, 2019: Laryngoscope
https://read.qxmd.com/read/30958692/anastomosing-hemangioma-short-review-of-a-benign-mimicker-of-angiosarcoma
#6
Eleni Lappa, Elias Drakos
Anastomosing hemangioma is a rare neoplastic vascular lesion, histologically mimicking angiosarcoma. It is predominantly composed of irregularly anastomosing sinusoidal-like spaces lined by endothelial cells with minimal atypia, a frequently hobnail morphology, and minimally invasive margins. Since its original description in the genitourinary system, an increasing number of anastomosing hemangiomas have been reported, localized deep in the body in various organs, always with similar histologic features. It is more frequently asymptomatic, often discovered incidentally by imaging studies, owing to coexisting benign or malignant tumors...
April 8, 2019: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/30929848/combining-immunotherapy-with-radiotherapy-for-the-treatment-of-genitourinary-malignancies
#7
REVIEW
Abhishek A Solanki, Alberto Bossi, Jason A Efstathiou, Derrick Lock, Michele Mondini, Rishab Ramapriyan, James Welsh, Josephine Kang
CONTEXT: Immunotherapy drugs, particularly checkpoint inhibitors, have recently been approved by the Food and Drug Administration for various malignancies. Preclinical and early clinical data show that combining these agents with radiotherapy may produce an even more potent antitumor effect in the treatment of cancer. OBJECTIVE: To describe the rationale, available data, and emerging data on the use of combined immunotherapy and radiation therapy in the setting of genitourinary (GU) malignancies...
February 2019: European Urology Oncology
https://read.qxmd.com/read/30914802/mif-family-proteins-in-genitourinary-cancer-tumorigenic-roles-and-therapeutic-potential
#8
REVIEW
Justin C Penticuff, Benjamin L Woolbright, Thais M Sielecki, Scott J Weir, John A Taylor
Genitourinary cancers encompass some of the most common solid tumours and have high rates of morbidity and mortality. Inflammation is associated with enhanced tumorigenesis, and a number of pro-inflammatory mediators, such as macrophage migration inhibitory factor (MIF), also promote tumorigenesis. Studies of the role of MIF (which largely functions via the type II transmembrane receptor CD74) in prostate, bladder and kidney cancers suggest that it is a pro-tumorigenic factor in genitourinary malignancy. Inhibiting MIF activity in cell culture and in preclinical animal models of genitourinary cancers reduces the phenotypic hallmarks of cancer, such as proliferation, angiogenesis and tumour aggressiveness, by downregulating signalling pathways such as those regulated by extracellular signal-regulated kinase (ERK), protein kinase B and p53, and MIF may also reverse immunosuppression...
March 26, 2019: Nature Reviews. Urology
https://read.qxmd.com/read/30907629/testicular-pain-as-an-atypical-presentation-of-sarcoidosis
#9
F Chierigo, H M Alnajjar, A Haider, M Walkden, T Shaikh, A Muneer
Sarcoidosis is a systemic granulomatous disease, with genitourinary tract involvement being very rare (0.2% of all sarcoidosis cases). Genitourinary sarcoidosis may present with a scrotal mass with or without testicular pain, often mimicking epididymo-orchitis or malignancy. Only 8 cases of genitourinary sarcoidosis have been reported in the literature in the last 14 years. We describe the case of a 25-year-old man who was referred with testicular pain. Scrotal ultrasonography demonstrated multiple bilateral hypoechoic testicular lesions that were of similar size and distributed unusually throughout the testicular parenchyma...
March 25, 2019: Annals of the Royal College of Surgeons of England
https://read.qxmd.com/read/30900626/spectrum-of-urogenital-tumors-in-males-in-sub-himalayan-region-an-institutional-experience
#10
Rakesh Panwar, Anchana Gulati, Rajni Kaushik, Vijay Kaushal, Pamposh Raina
Aims: The clinical presentation and frequency of urogenital tumors varies in different regions of the world. This study was undertaken to analyze the frequency, clinical presentation, and the histopathological spectrum of the various male urogenital tumors diagnosed over a period of 3 years in a tertiary care institute. Materials and Methods: Three-year data were collected from the histopathology laboratory, which included all the cases of male urogenital tumors which were diagnosed histopathologically between November 2012 and October 2015...
March 2019: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30872123/the-role-of-pd-l1-testing-in-advanced-genitourinary-malignancies
#11
Andrew W Hahn, Deepika Sirohi, Neeraj Agarwal
In accordance with US Food and Drug Administration recommendations, tumor PD-L1 expression should be assessed in all patients with platinum-ineligible metastatic urothelial carcinoma (mUC), and patients with low PD-L1 expression should not receive single-agent immune checkpoint inhibition treatment. By contrast, PD-L1 should not be tested in metastatic renal cell carcinoma and platinum-refractory mUC.
March 11, 2019: European Urology Focus
https://read.qxmd.com/read/30824360/myalgia-and-arthralgia-immune-related-adverse-events-iraes-in-patients-with-genitourinary-malignancies-treated-with-immune-checkpoint-inhibitors
#12
Moshe C Ornstein, Cassandra Calabrese, Laura S Wood, Elizabeth Kirchner, Pamela Profusek, Kimberly D Allman, Allison Martin, Apostolos Kontzias, Petros Grivas, Jorge A Garcia, Leonard H Calabrese, Brian I Rini
BACKGROUND: Myalgia and arthralgia immune-related adverse events (irAEs) in patients treated with checkpoint inhibitors (CPIs) present a clinical challenge. We describe the clinical characteristics and treatment of myalgia and arthralgia irAEs in CPI-treated patients with genitourinary (GU) malignancies. PATIENTS AND METHODS: Patients with GU malignancies who were treated with CPIs and developed myalgia and arthralgia irAEs that resulted in interruption or discontinuation of CPI therapy were reviewed...
February 7, 2019: Clinical Genitourinary Cancer
https://read.qxmd.com/read/30808538/renal-cyst-evolution-in-childhood-a-contemporary-observational-study
#13
C Rediger, L A Guerra, M A Keays, C Wayne, D Reddy, S Ksara, M P Leonard
INTRODUCTION: Children with renal cysts often undergo ultrasound (US) monitoring to identify malignant transformation or polycystic kidney disease (PKD). However, the utility of ongoing surveillance is uncertain. OBJECTIVE: The objective of this study was to assess the natural history of simple or minimally complex cysts and the proportion of progression to autosomal dominant polycystic kidney disease (ADPKD), autosomal recessive polycystic kidney disease (ARPKD), or malignancy...
February 1, 2019: Journal of Pediatric Urology
https://read.qxmd.com/read/30786173/genitourinary-cancer-patients-have-worse-baseline-semen-parameters-than-healthy-sperm-bankers
#14
R Xu, G M Centola, C Tanrikut
BACKGROUND: While the spermatotoxic properties of cancer treatments such as chemotherapy and radiation therapy are widely recognized, the effect of malignancy itself on male fertility is not clearly understood. OBJECTIVES: To determine whether malignancy is associated with diminished semen quality prior to spermatotoxic treatment among sperm bankers. MATERIALS AND METHODS: Retrospective database review of de-identified records was obtained for all episodes of sperm banking performed at a cryobank from January 2004 to May 2017 for one of the following reasons: 'future use' (e...
February 20, 2019: Andrology
https://read.qxmd.com/read/30772359/updates-on-the-management-of-rare-genitourinary-malignancies-where-do-we-stand
#15
EDITORIAL
Philippe E Spiess
No abstract text is available yet for this article.
February 13, 2019: European Urology Focus
https://read.qxmd.com/read/30763745/pneumatosis-intestinalis-after-molecular-targeted-therapy
#16
Nauman S Chaudhry, Wenya Linda Bi, Saksham Gupta, Abhishek Keraliya, Naomi Shimizu, E Antonio Chiocca
BACKGROUND: Pneumoperitoneum after surgical manipulation of the abdomen implies a perforation. Rare cases of non-operated cancer patients, largely with gastrointestinal or genitourinary cancers, have been noted to have radiological findings of pneumatosis intestinalis and/or pneumoperitoneum as a complication of molecular-targeted therapy (MTT) without confounding factors for perforation. We present a patient with a cranial malignancy treated with bevacizumab who subsequently manifested with pneumatosis intestinalis...
February 11, 2019: World Neurosurgery
https://read.qxmd.com/read/30758125/palliative-care-use-among-patients-with-bladder-cancer
#17
Lee A Hugar, Samia H Lopa, Jonathan G Yabes, Justin A Yu, Robert M Turner, Mina M Fam, Liam C MacLeod, Benjamin J Davies, Angela B Smith, Bruce L Jacobs
OBJECTIVES: To describe the rate and determinants of palliative care use among Medicare beneficiaries with bladder cancer and encourage a national dialogue on improving coordinated urologic, oncologic, and palliative care in patients with genitourinary malignancies. MATERIALS AND METHODS: Using Surveillance, Epidemiology, and End Results-Medicare data, we identified patients diagnosed with muscle-invasive bladder cancer between 2008-2013. Our primary outcome was receipt of palliative care, defined as the presence of a claim submitted by a Hospice and Palliative Medicine subspecialist...
February 13, 2019: BJU International
https://read.qxmd.com/read/30755571/genitourinary-fistula-a-curse-to-neglected-pregnancy
#18
N Akhter, Z Sultana, A Bhattacharjee
Genitourinary fistula is a psychophysiosocial distress that results in prolonged labour. Gradually, it has become a public health issue globally with advancing of its incidence day by day. A handsome number of mothers are also suffering in Bangladesh from genitourinary fistula. This study was done to observe the patterns of presentations of genitourinary fistula and their fetal outcome. One hundred sixteen (116) consecutive patients were enrolled in the study by purposive sampling as a diagnosed case of genitourinary fistula presented in Department of Obstetrics & Gynecology of Dhaka Medical College Hospital, Dhaka, Bangladesh from January 2017 to September 2017...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30701159/role-of-the-androgen-signaling-axis-in-genitourinary-malignancies
#19
Brian M Shinder, Adam Shupe, Geun Taek Lee, Mark N Stein, Isaac Y Kim, Eric A Singer
As we learn more about the molecular biology of genitourinary malignancies, novel therapeutic strategies can be developed. This is especially crucial for prostate, renal, and bladder cancer, where mortality rates remain high especially in advanced disease states. The androgen signaling axis and the androgen receptor (AR) are areas that are actively being explored for their role in these diseases. Although long been associated with prostate cancer development and progression, the role of AR in renal cell carcinoma (RCC) and bladder cancer is becoming recognized as well...
August 2018: Translational Cancer Research
https://read.qxmd.com/read/30689556/identification-of-biomarkers-associated-with-progression-and-prognosis-in-bladder-cancer-via-co-expression-analysis
#20
Shengjun Shi, Binqun Tian
BACKGROUND: Bladder cancer is one of the most common genitourinary malignancies, with a high rate of recurrence and progression. The prognosis for patients with bladder cancer, especially muscle-invasive bladder cancer, remains poor despite systemic therapy. OBJECTIVE: To explore the underlying disease mechanisms and identify more effective biomarkers for bladder cancer. METHODS: Weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network analysis were applied to identify hub genes correlated with the bladder cancer progression...
January 18, 2019: Cancer Biomarkers: Section A of Disease Markers
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