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Hematology , internal medicine

Daniel C McFarland
OBJECTIVE: The education of trainee physicians in hematology-oncology is challenged by inherent stressors of hematology-oncology. Clinical work load, death and dying, and the known phenomenon of empathy decline during clinical education affect trainees. Time spent with patients or Direct Patient Care Time (DPCT) is influenced by many factors, which ultimately affect medical education. Therefore, DPCT may decrease by the end training on a busy hematology-oncology ward rotation. METHODS: Internal medicine interns and residents (n=64) rotating on a hematology-oncology ward rotation were consecutively selected to participate...
April 10, 2019: Psycho-oncology
Aline Wolfensberger, Werner Jakob, Mirjam Faes Hesse, Stefan P Kuster, Angela H Meier, Peter W Schreiber, Lauren Clack, Hugo Sax
OBJECTIVES: Conducting manual surveillance of non-ventilator-associated hospital-acquired pneumonia (nvHAP) using ECDC (European Centre for Disease Prevention and Control) surveillance criteria is very resource intensive. We developed and validated a semi-automated surveillance system for nvHAP, and describe nvHAP incidence and etiology at our hospital. METHODS: We applied an automated classification algorithm mirroring ECDC definition criteria to distinguish patients 'not at risk' from patients 'at risk' for suffering from nvHAP...
March 25, 2019: Clinical Microbiology and Infection
Kinga A Kocemba-Pilarczyk, Barbara Ostrowska, Paulina Dudzik, Michał J Markiewicz, Débora Sotirios Souza Pegos, Chaewon Lim
Diagnostic molecular biology is a fast developing discipline of laboratory medicine widely used in numerous medical branches such as oncology, hematology, immunology, internal medicine, or infectious diseases, which will certainly have a major impact on clinical medicine in the near future. Nowadays, educational process is forced to face the quickly growing overflow of easily accessible data and properly guide the students not to be lead astray in the information chaos. Hence, in view of the foregoing, it appears obvious that modern medical education should put particular stress on selective acquiring, interpreting, and applying integrated multidisciplinary knowledge rather than on just absorbing and memorizing huge amount of scattered information...
March 5, 2019: Biochemistry and Molecular Biology Education
Abdulaziz H Alathel, Linda Nott, Jennifer Bjazevic, Ben H Chew, Kenneth T Pace, Hassan Razvi
INTRODUCTION: Although general guidelines exist directing the management of new/novel oral anticoagulants (NOACs) in the perioperative period for open/endoscopic procedures, no consensus exists for those patients being considered for shock wave lithotripsy (SWL). In order to gauge current practice, we administered a survey to the international endourological community. METHODS: A web-based survey was sent to current Endourological Society members. Respondents were asked whether they would consider SWL in patients receiving NOACs; and if they used SWL how these agents were managed perioperatively...
February 22, 2019: Journal of Endourology
Dina N Greene, Gabrielle Winston McPherson, Jessica Rongitsch, Katherine L Imborek, Robert L Schmidt, Robert M Humble, Nicole Nisly, Nancy J Dole, Susan K Dane, Janice Frerichs, Matthew D Krasowski
BACKGROUND: The complete blood count (CBC) is a cornerstone of patient care. Several of the normal values for the components of the CBC differ by sex and, therefore, male-specific and female-specific reference intervals are required to interpret these laboratory results. Transgender individuals are often prescribed hormone therapy to affirm their gender, with resulting serum hormone concentrations similar to those of cisgender individuals. Gender-specific reference intervals for transgender men and women have not been established for any laboratory measurements, including hematology...
May 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Amal Aboud Alasmari, Anadel Hassan Hakeem, Fatemah Saleh Bin Saleh, Shahad Yousef Alsaigh, Waleed Al Ajroush, Laila Ali Layqah, Salim Alawi Baharoon
Introduction. Skin manifestations are common in hematology ward patients and can result from infection, malignancy, or chemotherapy. The purpose of this study was to identify the most common dermatological problems encountered in the adult hematology ward at King Abdullah Specialist Children Hospital (KASCH). Methods. This was retrospective chart review of 78 dermatology consultations based on electronic health records for all inpatients in hematology wards at KASCH between January 2016 and December 2017. Data were presented as mean ± SD for continuous variables...
2019: Dermatology Research and Practice
Benoit Pernot, Emmanuel Gyan, François Maillot, Penelope Hodges, Marjan Ertault, Nicole Ferreira-Maldent
Lymphomas are common malignancies with highly variable clinical presentations and prognosis. Prognostic value of clinical presentation at onset is still questioned. The objective of this study was to compare the disease presentation and the outcome of lymphomas diagnosed in an Internal Medicine Department of a University Hospital to disease presentation and outcome of patients who were referred to the Hematology Department of the same institution by other departments or healthcare facilities.This retrospective monocentric observational study included 37 patients...
November 2018: Medicine (Baltimore)
Naoyuki Katayama
In March 2017, considering the recent social trend, the Japanese Association of Medical Sciences (JAMS) officially announced the "JAMS Conflicts of Interest (COI) Management Guideline" and the "JAMS Guidance on Criteria for Qualification to Practice Guideline." In response to this announcement, the Japanese Society of Internal Medicine partially revised and announced the "Common Guideline on the Policy of COI in Medical Research," including the "COI Management to Practice Guideline" and the "Treatment Guideline," for its affiliated societies in September 2017...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Claire Harrison
Professor Claire Harrison speaks to Roshaine Wijayatunga, managing commissioning editor: Professor Claire Harrison became a consultant at Guy's and St Thomas' hospital in 2001. She is also deputy clinical director of cancer and hematology. She has influenced major advances in her field, including the description of key mutations and designing/leading global clinical trials, for example, the first JAK inhibitor trial in Europe. She is the chief investigator for several other international and national clinical trials...
December 2017: International Journal of Hematologic Oncology
Philip McCarthy
Philip McCarthy speaks to Roshaine Wijayatunga, Senior Editor: Oncology Philip McCarthy completed his MD at Tufts University School of Medicine, Boston, MA, USA and his Internal Medicine Residency at Yale, New Haven Hospital, New Haven, CT, USA. His Fellowship was completed at Brigham and Women's Hospital and the Dana Farber Cancer Insitute, Harvard University, Boston, MA, USA. His research interests are devoted to developing novel intensive and reduced intensity allogeneic (allo) and autologous (auto) hematopoietic stem cell transplant (HSCT) approaches for the treatment of hematologic disorders, leading to improved patient outcomes and decreased toxicity...
December 2017: International Journal of Hematologic Oncology
Wei Xu, Yanxin Zhu, Yibing Geng
BACKGROUND: By the end of the first quarter of 2017, 1212 standard Clinical Pathways (CPs) had been developed and implemented in China since 2009, however, Chinese standard CPs are still paper-based CPs. OBJECTIVES: To optimize the data structure and content of Chinese standard CPs based on Chinese health standards by two-level modeling approach and archetype method, and develop an Open Metadata Schema for Clinical Pathway (openCP) in China. METHODS: We chose 43 diseases covering 7 departments of internal medicine as samples and source materials including Respiratory, Gastroenterology, Neurology, Cardiology, Nephrology, Endocrinology, and Hematology, and we followed 4 steps to develop openCP: identify reference model of openCP; develop archetype models; standardize archetype terms and metadata; and evaluate its functionality...
September 2018: Methods of Information in Medicine
Frances Collichio, Elaine A Muchmore
The American Society of Hematology (ASH)/ASCO Curricular Milestones is a tool for assessment and teaching for fellows in hematology/oncology. The expectations of the Next Accreditation System of the Accreditation Council of Graduate Medical Education (ACGME) was developed over years from the creation of the six core competencies in 1999 to the current data-driven outcomes-based system. The current internal medicine subspecialty milestones (ACGME reporting milestones) follow the general rubric of the general internal medicine milestones...
May 23, 2018: American Society of Clinical Oncology Educational Book
Eileen Roulis, Catherine Hyland, Robert Flower, Christoph Gassner, Hans H Jung, Beat M Frey
Importance: McLeod syndrome, encoded by the gene XK, is a rare and progressive disease that shares important similarities with Huntington disease but has widely varied neurologic, neuromuscular, and cardiologic manifestations. Patients with McLeod syndrome have a distinct hematologic presentation with specific transfusion requirements. Because of its X-linked location, loss of the XK gene or pathogenic variants in this gene are principally associated with the McLeod blood group phenotype in male patients...
December 1, 2018: JAMA Neurology
Leslie Martin, Ameen Patel, Katrina Piggott, Arthur Wong, Alexandra Patel, Matthew Patel, Yudong Liu, Sukhbinder Dhesy-Thind, Parveen Wasi, John J You
BACKGROUND: Allied health care professionals can contribute meaningfully to goals-of-care discussions with seriously ill hospitalized patients and their families. We sought to explore the perspective of hospital-based allied health care professionals on their role in goals-of-care discussions and to identify barriers to their participation. METHODS: We surveyed allied health care professionals (social workers, physiotherapists, occupational therapists, registered dietitians, speech-language pathologists and pharmacists) on internal medicine, hematology-oncology, medical oncology and radiation oncology wards at 2 tertiary care hospitals in Hamilton, Ontario, from April 2013 to May 2014...
April 2018: CMAJ Open
Qian Yang, Jie He, Sheng-Yu He, Kai-Yu Wang, Yi Geng, De-Fang Chen, Xiao-Li Huang, Ping Ou-Yang
Olaquindox, is a growth-promoting feed additive for food-producing animals. As the banned medicinal feed additive, olaquindox in animal feed and water must be concerned as an important hazard index. To improve studies of the toxicity of olaquindox, we provide a toxicological effects of olaquindox on a common freshwater fish, Cyprinus carpio L. The results of acute toxicity tests showed that the 7d-LD50 of olaquindox administered by feeding for common carp was determined to be 3746.3 mg/kg. We also found that the accumulation coefficient of olaquindox in carp was 1...
June 8, 2018: Ecotoxicology and Environmental Safety
M T Al-Qaisi, A Kahn, M D Crowell, G E Burdick, M F Vela, F C Ramirez
Proton pump inhibitors (PPI) are utilized for a variety of indications, including treatment of gastroesophageal reflux disease, peptic ulcer disease, and prevention of gastrointestinal (GI) bleeding. Several studies have documented an increasing prevalence of inappropriate PPI use. Furthermore, recent media reports have highlighted new research data suggesting a possible association between chronic PPI use and several adverse medical outcomes, leading to frequent patient inquiries about these associations. Thus, providers face the challenge of counseling patients about the balance of risks and benefits related to PPI use...
December 1, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Ariela L Marshall, Sarah Jenkins, Amy S Oxentenko, Alfred I Lee, Mark D Siegel, Joel T Katz, Jatin M Vyas, John Del Valle, Joseph R Mikhael
BACKGROUND: Several specialty societies participate in the Choosing Wisely (CW) campaign in an attempt to reduce waste in health care spending. We surveyed internal medicine (IM) residents with an objective of classifying knowledge of and confidence in using the American Society of Hematology (ASH) CW principles in hemostasis, thrombosis, and non-malignant hematology. METHODS: Multi-institutional study of IM residents at 5 academic training programs in the United States...
2018: PloS One
Marc L Martel, Brian H Imdieke, Kayla M Holm, Sara Poplau, William G Heegaard, Jon L Pryor, Mark Linzer
BACKGROUND: Medical scribes are frequently incorporated into the patient care model to improve provider efficiency and enable providers to refocus their attention to the patient rather than the electronic health record (EHR). The medical scribe program was based on four pillars (objectives): (1) provider satisfaction, (2) standardized documentation, (3) documentation components for risk adjustment, and (4) revenue enhancement. METHODS: The medical scribe program was deployed in nine non-resident-supported clinics (internal medicine, ophthalmology, orthopedics, hematology/oncology, urology), with the medical scribes (who have no clinical duties) supporting both physicians and advanced practice providers (nurse practitioners and physician assistants)...
May 2018: Joint Commission Journal on Quality and Patient Safety
Stephan Stilgenbauer, Barbara Eichhorst, Johannes Schetelig, Peter Hillmen, John F Seymour, Steven Coutre, Wojciech Jurczak, Stephen P Mulligan, Anna Schuh, Sarit Assouline, Clemens-Martin Wendtner, Andrew W Roberts, Matthew S Davids, Johannes Bloehdorn, Talha Munir, Sebastian Böttcher, Lang Zhou, Ahmed Hamed Salem, Monali Desai, Brenda Chyla, Jennifer Arzt, Su Young Kim, Maria Verdugo, Gary Gordon, Michael Hallek, William G Wierda
Purpose Venetoclax is an orally bioavailable B-cell lymphoma 2 inhibitor. US Food and Drug Administration and European Medicines Agency approval for patients with 17p deleted relapsed/refractory chronic lymphocytic leukemia [del(17p) CLL] was based on results from 107 patients. An additional 51 patients were enrolled in a safety expansion cohort. Extended analysis of all enrolled patients, including the effect of minimal residual disease (MRD) negativity on outcome, is now reported. Patients and Methods Overall, 158 patients with relapsed/refractory or previously untreated (n = 5) del(17p) CLL received venetoclax 400 mg per day after an initial dose ramp up...
July 1, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Claudia Giardina, Paola M Cutroneo, Eleonora Mocciaro, Giuseppina T Russo, Giuseppe Mandraffino, Giorgio Basile, Franco Rapisarda, Rosarita Ferrara, Edoardo Spina, Vincenzo Arcoraci
Background: Adverse drug reactions (ADRs) are an important public health problem, representing a major cause of morbidity and mortality. However, several countries have no recent studies available. Since 2014, a prospective active pharmacovigilance project, aimed to improve ADRs monitoring in hospital wards (FORWARD) was performed in Sicily. This study, as part of FORWARD project, was aimed to describe ADRs occurred during the hospital stay in Internal Medicine wards. ADRs related to hospital admission, characteristics and preventability of ADRs were also evaluated...
2018: Frontiers in Pharmacology
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