Elisabeth A Murphy, Camila Guzman-Cardozo, Ashley C Sukhu, Debby J Parks, Malavika Prabhu, Iman Mohammed, Magdalena Jurkiewicz, Thomas J Ketas, Sunidhi Singh, Marie Canis, Eva Bednarski, Alexis Hollingsworth, Embree M Thompson, Dorothy Eng, Paul D Bieniasz, Laura E Riley, Theodora Hatziioannou, Yawei J Yang
The effects of heterogeneous infection, vaccination and boosting histories prior to and during pregnancy have not been extensively studied and are likely important for protection of neonates. We measure levels of spike binding antibodies in 4600 patients and their neonates with different vaccination statuses, with and without history of SARS-CoV-2 infection. We investigate neutralizing antibody activity against different SARS-CoV-2 variant pseudotypes in a subset of 259 patients and determined correlation between IgG levels and variant neutralizing activity...
August 10, 2023: Nature Communications