Xue-Lei Li, Zhi-Peng Liu, Xing-Xing Su, Yi Gong, Yi-Shi Yang, Xiao-Lin Zhao, Zi-Mu Li, Jun-Jie Ding, Yi Zhu, Da-Long Yin, Chao Yu, Jin-Xue Zhou, Dong Zhang, Rui Ding, Wei Chen, Yao Cheng, Ping Yue, Zi-Ran Wang, Yan-Qi Zhang, Yan Jiang, Xian-Yu Yin, Jie Bai, Hai-Su Dai, Wan Yee Lau, Zhi-Yu Chen
BACKGROUND: The prognostic value of carbohydrate antigen 19-9 (CA19-9) is known to be affected by elevated bilirubin levels in patients with gallbladder carcinoma (GBC). The clinical significance of changes in the ratio of CA19-9 levels to total bilirubin (TB) levels in patients with GBC after curative-intent resection remains unknown. The aim of this study was to determine the prognostic value of changes in preoperative and postoperative CA19-9/TB ratio in these patients. METHODS: Prospectively colleced data on consecutive patients who underwent curative-intent resection for GBC between January 2015 and December 2020 stored in a multicenter database from 10 hospitals were analysed in this retrospective cohort study...
April 17, 2024: International Journal of Surgery