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B Schönhofer
Invasive ventilation via endotracheal tube as access to the airways often is treatment of choice of acute respiratory failure. Multifactor-related increases the number of patients who are dependent on the ventilator for a longer period. The prolonged weaning (or "liberation") from mechanical ventilation therefore has an increasing importance.In Germany since the 90s of the last century, weaning units have been established in lung clinics. With the aim of achieving the highest possible quality of treatment in these weaning centers, the network "WeanNet" was founded in 2007 within the German Society of Pneumology and Respiratory Medicine (DGP)...
February 2019: Pneumologie
Tina Toft Kristensen, Palle Lyngsie Pedersen, Jacob Larsen, Anne-Dorthe Feldthusen, Søren Jelstrup, Christina Ellervik
We have previously reported decreased thyroid function within the laboratory reference range and changes in mitochondrial function after hemithyroidectomy. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and coactivator-1β (PGC-1β) are key regulators of mitochondrial biogenesis and function. The aim was to examine the influence of hemithyroidectomy on the longitudinal change in mRNA expression of these genes. In addition, we measured longitudinal changes in mRNA expressions of the mitochoncrial-related genes nuclear factor erythroid-derived 2-like 2 (NFE2L2), mitochondrial transcription factor A (TFAM), and sodium dismutase 2 (SOD2)...
February 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Anja Siegle, Friederike Zu Sayn-Wittgenstein, Martina Roes
PURPOSE: Worldwide the use of medical interventions in childbirth is increasing, which holds true in Germany as well. In response, different approaches are being developed to enhance normal childbirth. Also, in Germany there is now an expert care standard to promote physiological childbirth, which mandates antenatal consultation conducted by midwives. The extent to which antenatal consultation based on this standard has been implemented and the degree of adherence (as intended by the developers) remain unclear...
February 13, 2019: Zeitschrift Für Geburtshilfe und Neonatologie
Albert C Lynch, John A Davies
OBJECTIVE:  The main aim of this study was to evaluate a percutaneous method of bone alignment using a diaphyseal tibial fracture model. MATERIALS AND METHODS:  Mid-shaft diaphyseal fractures were created in 12 large-breed canine tibiae. Interaction pins were inserted into the proximal and distal bone segments. Computed tomography scans of the fractured tibiae and pins were imported into three-dimensional (3D) modelling software and the fractures were virtually reduced...
February 13, 2019: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Matthew D Barnhart, Brian W Bufkin, Alan S Litsky
OBJECTIVE:  The aim of this study was to compare the biomechanical properties of four different methods of artificial cranial cruciate ligament fixation in canine cadaveric tibias and femurs. METHODS:  Femurs and tibias from skeletally mature large breed canine cadavers were assigned into four fixation groups: group 1, 4.5-mm interference screw (IS); group 2, 4.5-mm IS and 4.0-mm screw and spiked washer (SW); group 3, 5.0-mm IS; group 4, 5.0-mm IS + SW. RESULTS:  The mean ultimate load was significantly greater for femur fixations than for tibias, when a SW was added, and for 5...
February 13, 2019: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Jonas Engel, Moritz Kälin, Slavko Rogan
BACKGROUND:  Rapid changes in direction, acceleration, deceleration and deception manoeuvres with rotational movements increase the risk of injuries in floorball players. Up to date, there are no data or facts available from Swiss Floorball League players demonstrating the types of injuries that occur. This study aimed to find out which injuries occur in Swiss National League A floorball players. SUBJECTS/METHODS:  This study was carried out in a retrospective, non- experimental design as a questionnaire survey...
February 13, 2019: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
Marcus Zulian Teixeira
INTRODUCTION:  In addition to the four pillars of homeopathy, vitalism and the miasmatic theory are often used to explain the health-disease process. According to Hahnemann's concepts, homeopathic miasms are the main obstacle to the cure of chronic diseases, with psora being the fundamental cause of all forms of diseases. According to modern genetics, the disease-promoting epigenetic alterations are the fundamental cause of the manifestation of chronic diseases. OBJECTIVE:  This article develops a philosophical-scientific correlation between chronic miasms and disease-promoting epigenetic modifications, aiming to justify the isopathic use of auto-sarcode of an individual's DNA as homeopathic medicine...
February 13, 2019: Homeopathy: the Journal of the Faculty of Homeopathy
Igor Kaidashev, Halyna Morokhovets, Viktoriia Rodinkova, Jean Bousquet
BACKGROUND: Google Trends (GT) may represent a new approach to assessing pollen allergy. However, the development of a pan-European sentinel network has raised a problem of translating terms in different languages. A precise definition of the pollen season onset is crucial for the confirmation of a pollen allergy diagnosis and personalized treatment. Ragweed pollen allergy was investigated due to its high allergenicity and wide expansion in Europe. OBJECTIVES: The study aimed to examine translations of "ragweed" and "hay fever" in native Cyrillic languages, especially in Ukrainian and Russian, and to compare the seasonality of queries in Ukraine with ragweed and mugwort pollen counts...
February 13, 2019: International Archives of Allergy and Immunology
Mesut Savas, Vincent Wester, Yolanda B de Rijke, German Rubinstein, Stephanie Zopp, Kristien Dorst, Sjoerd van den Berg, Felix Beuschlein, Richard A Feelders, Martin Reincke, Elisabeth F C van Rossum
The current diagnostic workup of Cushing's syndrome (CS) requires various tests which only capture short-term cortisol exposure, whereas patients with endogenous CS generally have elevated long-term cortisol levels. Scalp hair assessment has emerged as a convenient test in capturing glucocorticoid concentrations over long periods of time. The aim of this multicenter, multinational, prospective, case-control study was to evaluate the diagnostic efficacy of scalp hair glucocorticoids in screening of endogenous CS...
February 13, 2019: Neuroendocrinology
Satoshi Matsukawa, Seiji Sumigama, Tomomi Kotani, Jingwen Wang, Rika Miki, Yoshinori Moriyama, Tomoko Nakano, Yukio Mano, Hiroyuki Tsuda, Koji Tamakoshi, Fumitaka Kikkawa
BACKGROUND/AIMS: The study aimed to evaluate molecular changes related to trophoblast adhesion in placenta accreta spectrum (PAS) disorders. METHODS: A retrospective analysis of 10 PAS cases in which both the trophoblast adherent site and the non-adherent site were identified was performed in April 2010 and March 2013. Microarray analysis and reverse transcription polymerase chain reaction (RT-PCR) analyses were performed to extract upregulated genes in the adherent site...
February 13, 2019: Gynecologic and Obstetric Investigation
Louise Heydenreich Jensen, Jeppe Madura Larsen, Charlotte Bernhard Madsen, Rune Rønhave Laursen, Lotte Neergaard Jacobsen, Katrine Lindholm Bøgh
BACKGROUND: Infant formulas (IFs) based on hydrolysed cow's milk proteins are central in the management of cow's milk allergy (CMA) in infants and small children. New IF compositions with improved prevention and treatment properties are needed, along with appropriate preclinical animal models, to evaluate these properties before introduction into humans. OBJECTIVES: We aimed to develop preclinical models for the assessment of the primary preventive and desensitising capacity of cow's milk IF in allergy-prone, high-IgE responder Brown Norway rats...
February 13, 2019: International Archives of Allergy and Immunology
Nobuaki Kobayashi, Kuniya Asai, Masafumi Tsurumi, Yusaku Shibata, Hirotake Okazaki, Akihiro Shirakabe, Hiroki Goda, Saori Uchiyama, Kenichi Tani, Masamichi Takano, Wataru Shimizu
OBJECTIVES: We aimed to examine the relations of very high levels of serum uric acid (sUA) with features of culprit lesion plaque morphology determined by optical coherence tomography (OCT) and adverse clinical outcomes in patients with acute coronary syndrome (ACS). METHODS: We retrospectively compared ACS patients according to sUA levels of > 8.0 mg/dL (n = 169), 7.1-8.0 mg/dL (n = 163), 6.1-7.0 mg/dL (n = 259), and ≤6.0 mg/dL (n = 717). Angiography and OCT findings were analyzed in patients with preintervention OCT and the 4 sUA groups (> 8...
February 13, 2019: Cardiology
Mohamed Bekheit, Petru O Bucur, Chloe Audebert, Elodie Miquelestorena-Standley, Irene Vignon-Clementel, Eric Vibert
BACKGROUND: The hepatic volume gain following resection is essential for clinical recovery. Previous studies have focused on cellular regeneration. This study aims to explore the rate of hepatic regeneration of the porcine liver following major resection, highlighting estimates of the early microarchitectural changes that occur during the cellular regeneration. METHODS: Nineteen large white pigs had 75% resection with serial measurements of the hepatic volume, density, blood flow, and architectural changes...
February 13, 2019: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Pierlorenzo Pallante, Pasquale Pisapia, Claudio Bellevicine, Umberto Malapelle, Giancarlo Troncone
Molecular cytopathology is a rapidly evolving field of cytopathology that provides biological information about the response to personalised therapy and about the prognosis of neoplasms diagnosed on cytological samples. Biomarkers such as circulating tumour cells and circulating tumour DNA are increasingly being evaluated in blood and in other body fluids. Such liquid biopsies are non-invasive, repeatable, and feasible also in patients with severe comorbidities. However, liquid biopsy may be challenging due to a low concentration of biomarkers...
February 13, 2019: Acta Cytologica
Katia Regina Vasconcelos, Juliana Arid, Silvane Evangelista, Sara Oliveira, André Luiz Dutra, Lea Assed Bezerra Silva, Raquel Assed Bezerra Segato, Alexandre Rezende Vieira, Paulo Nelson-Filho, Erika Calvano Küchler
The aim of this study was to investigate the association between genetic polymorphisms in MMP8, MMP13, and MMP20 with caries experience and developmental defects of enamel (DDE) in children from the Amazon region of Brazil. Den tal caries and DDE data were collected through clinical examination from 216 children. Genomic DNA was extracted from saliva, and genotyping of selected polymorphisms in MMP8 (rs17099443 and rs3765620), MMP13 (rs478927 and rs2252070), and MMP20 (rs1784418) was performed using TaqMan chemistry and endpoint analysis...
February 13, 2019: Caries Research
Mario Peláez-Luna, Claudia Medina-Campos, Luis Uscanga-Domínuez, Jorge Hernandez-Calleros, Carlos Chan-Nuñez, Eduardo Negrete, Arturo Angeles
BACKGROUND: Chronic pancreatitis (CP), pancreatic cancer (PCa), and autoimmune pancreatitis (AIP) often present as a pancreatic mass. Accurate diagnosis is not always possible; up to 8% of surgical procedures are performed in benign pancreatic masses presumed to be malignant. OBJECTIVES: We aimed to compare clinical and imaging characteristics of resected focal type 2 AIP, CP, and PCa and identify factors that could improve preoperative differential diagnosis. METHODS: Charts from patients that underwent pancreatic resection under suspicion of PCa between 2000 and 2014 were reviewed...
February 13, 2019: Digestion
Panos Panagos, Pasquale Borrelli, Jean Poesen
Over the last two decades or so, there has been many research carried out to understand the mechanics and spatial distribution of soil loss by water erosion and to a lesser extent of wind, piping and tillage erosion. The acquired knowledge helped the development of prediction tools useful to support decision-makers in both ex-ante and ex-post policy evaluation. In Europe, recent studies have modelled water, wind and tillage erosion at continental scale and shed new light on their geography. However, to acquire a comprehensive picture of soil erosion threats more processes need to be addressed and made visible to decision-makers...
February 2, 2019: Science of the Total Environment
Robert M Barker-Davies, Andrew Roberts, James Watson, Polly Baker, Alexander N Bennett, Daniel T P Fong, Patrick Wheeler, Mark P Lewis
BACKGROUND: Knee valgus alignment has been associated with lower-limb musculoskeletal injury. This case-control study aims to: assess biomechanical differences between patients with patellar tendinopathy and healthy controls. METHODS: 43 military participants (21 cases, 22 controls) were recorded using 3D-motion capture performing progressively demanding, small knee bend, single leg and single leg decline squats. Planned a priori analysis of peak: hip adduction, knee flexion, pelvic tilt, pelvic obliquity and trunk flexion was conducted using MANOVA...
February 4, 2019: Clinical Biomechanics
Kriszta Farkas, Ellicott C Matthay, Kara E Rudolph, Dana E Goin, Jennifer Ahern
Police use of force is an important public health issue in the US. Recent high-profile incidents suggest a potential link between mental disorders and police use of force, however little research has examined their co-occurrence in the general population. We aimed to assess the overall association between specific mental and substance use disorders (MSUDs) and nonfatal legal intervention injury. We identified nonfatal legal intervention injury cases (n = 90,099) and MSUD diagnoses from all hospital and emergency department (ED) records in California between 2005 and 2014...
February 10, 2019: Preventive Medicine
Brunna Castilhos Petersen, Tássia Huff Tietböhl, Alessandra Marqueze
This study aims to evaluate the contamination of the water of Lagoa Tramandaí on Genidens genidens and Citharichthys spilopterus residents of Lagoa Tramandaí, a region susceptible to environmental damage due to the release of domestic sewage from the municipalities bathed by the lagoon. Thereby, the biota suffers the interference of heavy metals, affecting their behavior and the metabolism of these individuals. The hepatic and muscular glycogen, glucose and plasma lactate of these species were analyzed, as well as the presence of heavy metals in lagoon water...
February 10, 2019: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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