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Lactate AND Aging

B E Bass, T Tsai, H Yang, V Perez, D Holzgraefe, J Chewning, J W Frank, C V Maxwell
A study was conducted using 3 groups of gestating gilts and sows (n = 98) to determine the effects of Pichia guilliermondii (Pg), a whole cell inactivated yeast product (CitriStim; ADM Alliance Nutrition), on performance and immune parameters of dams and litters. Within 24 h of breeding, gilts and sows were allotted to 1 of 3 treatments consisting of a control (SC) diet or SC diet supplemented with 0.1 (S1) or 0.2% (S2) Pg. Dietary treatments were maintained through lactation. Colostrum and milk (d 14) samples were collected for IgA, IgG, and IgM analysis...
February 16, 2019: Journal of Animal Science
Zerrin Defne Dundar, Sedat Kocak, Abdullah Sadik Girisgin
INTRODUCTION: In this study, we aimed to investigate the prognostic power of the first lactate level measured in the emergency department (ED), National Early Warning Score (NEWS), and NEWS-lactate (NEWS-L) on ED admission in critically ill geriatric patients. METHODS: This retrospective observational study was conducted in the ED of a university hospital. Consecutive patients ≥65 years of age admitted to our ED between July 1, 2017, and December 31, 2017, and transferred to the intensive care unit after the ED follow-up period were included in the study...
February 7, 2019: American Journal of Emergency Medicine
Kamila Dias, Sergio Garcia, Mohammed Rafiq Islam, Cameron Clark
(1) Background: Pasture varies in its chemical composition from the top of the sward to the base and cattle prefer to eat the leaf fraction. In pasture-based dairy systems, cattle predominantly walk back to pasture voluntarily after each milking, with the first cattle arriving to pasture hours before the last. Here we study the impact of pasture composition according to milking order on milk yield and milk composition for dairy cattle offered grazed ryegrass pasture. (2) Methods: In the first experiment, individual cow milk yield data were recorded on six farms over 8 months...
February 14, 2019: Animals: An Open Access Journal From MDPI
Maria Silvia Cona, Mara Lecchi, Sara Cresta, Silvia Damian, Michele Del Vecchio, Andrea Necchi, Marta Maria Poggi, Daniele Raggi, Giovanni Randon, Raffaele Ratta, Diego Signorelli, Claudio Vernieri, Filippo de Braud, Paolo Verderio, Massimo Di Nicola
Predictive biomarkers of response to immune-checkpoint inhibitors (ICIs) are an urgent clinical need. The aim of this study is to identify manageable parameters to use in clinical practice to select patients with higher probability of response to ICIs. Two-hundred-and-seventy-one consecutive metastatic solid tumor patients, treated from 2013 until 2017 with anti- Programmed death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) ICIs, were evaluated for baseline lactate dehydrogenase (LDH) serum level, performance status (PS), age, neutrophil-lymphocyte ratio, type of immunotherapy, number of metastatic sites, histology, and sex...
February 14, 2019: Cancers
Naseer Ahmad, Priyanka Kushwaha, Anirudha Karvande, Ashish Kumar Tripathi, Priyanka Kothari, Sulekha Adhikary, Vikram Khedgikar, Vijay Kumar Mishra, Ritu Trivedi
Post-menopausal condition augments the biological aging process, characterized by multiple metabolic disorders in which bone loss is the most prevalent outcome and usually coupled with sarcopenia. Coexistence of such associated pathogenesis have much worse health outcomes, compared to individuals with osteoporosis only. Pre- and post-natal bone development demands calcium from mother to fetus during pregnancy and lactation leading to a significant maternal skeletal loss. It follows an anabolic phase around weaning during which there is a notable recovery of the maternal skeleton...
January 10, 2019: Molecular Therapy. Nucleic Acids
Nicolas Herman, Nathalie Bourgès-Abella, Jean-Pierre Braun, Camille Ancel, François Schelcher, Catherine Trumel
BACKGROUND: There are no reference intervals for urinalysis in cattle. HYPOTHESIS/OBJECTIVES: Characterize the urine of healthy cows, establish urine protein-to-creatinine ratio (UPC) reference intervals, and test possible differences among dairy and beef cattle, age groups, or stage of lactation. ANIMALS: Seventy-seven dairy and 74 beef 2.5 to 17 year-old cows of different breeds housed mainly in free stall. METHODS: In this prospective study, urine specimens were collected by catheterization...
February 15, 2019: Journal of Veterinary Internal Medicine
Chanu Rhee, Zilu Zhang, Sameer S Kadri, David J Murphy, Greg S Martin, Elizabeth Overton, Christopher W Seymour, Derek C Angus, Raymund Dantes, Lauren Epstein, David Fram, Richard Schaaf, Rui Wang, Michael Klompas
OBJECTIVES: Sepsis-3 defines organ dysfunction as an increase in the Sequential Organ Failure Assessment score by greater than or equal to 2 points. However, some Sequential Organ Failure Assessment score components are not routinely recorded in all hospitals' electronic health record systems, limiting its utility for wide-scale sepsis surveillance. The Centers for Disease Control and Prevention recently released the Adult Sepsis Event surveillance definition that includes simplified organ dysfunction criteria optimized for electronic health records (eSOFA)...
March 2019: Critical Care Medicine
Rhonda S Sebastian, Cecilia Wilkinson Enns, Joseph D Goldman, M Katherine Hoy, Alanna J Moshfegh
OBJECTIVE: To verify the previously untested assumption that eating more salad enhances vegetable intake and determine if salad consumption is in fact associated with higher vegetable intake and greater adherence to the Dietary Guidelines for Americans (DGA) recommendations. DESIGN: Individuals were classified as salad reporters or non-reporters based upon whether they consumed a salad composed primarily of raw vegetables on the intake day. Regression analyses were applied to calculate adjusted estimates of food group intakes and assess the likelihood of meeting Healthy US-Style Food Pattern recommendations by salad reporting status...
February 15, 2019: Public Health Nutrition
Chelsea C McKean, Brandon A Baiamonte, Robert R Kraemer, Daniel B Hollander
The primary goal of this study was to investigate the effects of attention-deficit/hyperactivity disorder (ADHD) medications on exercise-induced hypoalgesia (EIH), heart rate, and perceived exertion. Thirty college-age students (10 Controls, 10 ADHD diagnosis, and 10 ADHD diagnosis with medications) completed 2 sessions: 1) a maximal testing session and 2) an experimental session consisting of 3 consecutive dynamic resistance exercise circuits comprised of 12 repetitions of 9 exercises at 60% of 1-repetition maximum using a 1:1 work to rest ratio...
December 2018: Biology of Sport
Jorge Garrido-Mantilla, Julio Alvarez, Marie Culhane, Jayaveeramuthu Nirmala, Jean Paul Cano, Montserrat Torremorell
BACKGROUND: Influenza A virus (IAV) is an important pathogen in pigs that affects productivity and has important public health implications because of its zoonotic nature. Surveillance is central to the control of influenza, however, detection of IAV infections can be challenging in endemically infected herds with low prevalence of infection. METHODS: In groups of suckling (18-21 days of age) and growing (35-45 days of age) pigs, we compared various sampling approaches to detect, isolate and sequence IAV using individual (nasal swabs, nasal wipes and oropharyngeal swabs), group (oral fluids, surface wipes and sow udder skin wipes) and environmental (airborne particles deposited on surfaces and air samples) sampling approaches...
February 14, 2019: BMC Veterinary Research
Lindsay J Collin, Lauren E McCullough, Kathleen Conway, Alexandra J White, Xinran Xu, Yoon Hee Cho, Sumitra Shantakumar, Susan L Teitelbaum, Alfred I Neugut, Regina M Santella, Jia Chen, Marilie D Gammon
DNA methylation has been implicated in breast cancer aetiology, but little is known about whether reproductive history and DNA methylation interact to influence carcinogenesis. This study examined modification of the association between global DNA methylation and breast cancer risk by reproductive characteristics. A population-based case-control study assessed reproductive history in an interviewer-administered questionnaire. Global DNA methylation was measured from white blood cell DNA using luminometric methylation assay (LUMA) and pyrosequencing assay (long interspersed elements-1 (LINE-1)...
2019: PloS One
Davut Sinan Kaplan, Cahit Bağcı, Mustafa Örkmez, Özge Kömürcü Karuserci, Seyhan Sucu, Hakim Çelik, Seyithan Taysı
Background/aim: The aims of this study were to determine the levels of the total antioxidant status (TAS), the total oxidant status (TOS), the oxidative stress index (OSI), and the concentration of immunoglobulin A (IgA) and M (IgM) in colostrum, and evaluate relationships between these parameters and maternal age, maternal parity, and infant sex. Materials and methods: The analysis was performed in serum samples of colostrum which were collected from 90 mothers on the first day of lactation between 10:00 and 12:00 AM Results: The measurements established that no significant association existed between the TAS level of colostrum and parity, maternal age, or infant sex...
February 11, 2019: Turkish Journal of Medical Sciences
Jan Biegus, Robert Zymliński, Piotr Gajewski, Mateusz Sokolski, Paweł Siwołowski, Justyna Sokolska, Katarzyna Swoboda, Maciej Banasiak, Waldemar Banasiak, Piotr Ponikowski
BACKGROUND: Although lactate is a well-established marker in intensive care, our understanding of its utility in acute heart failure (AHF) is modest and is based on studies with a single measurement of the marker. AIM: Our aim was to investigate whether persistent elevation of lactate during hospitalisation is related to a higher risk of adverse events. METHODS: We conducted a prospective study to assess AHF patients hospitalised in one cardiac centre...
February 14, 2019: Kardiologia Polska
Giovanna Brandi, Nino Stocchetti, Alberto Pagnamenta, Federica Stretti, Peter Steiger, Stephanie Klinzing
BACKGROUND: Hyperventilation-induced hypocapnia (HV) reduces elevated intracranial pressure (ICP), a dangerous and potentially fatal complication of traumatic brain injury (TBI). HV decreases the arteriolar diameter of intracranial vessels, raising the risk of cerebral ischemia. The aim of this study was to characterize the effects of moderate short-term HV in patients with severe TBI by using concomitant monitoring of cerebral metabolism, brain tissue oxygen tension (PbrO2 ), and cerebral hemodynamics with transcranial color-coded duplex sonography (TCCD)...
February 13, 2019: Critical Care: the Official Journal of the Critical Care Forum
S A Begum, T Mahmud, T Rahman, J Zannat, F Khatun, K Nahar, M Towhida, M Joarder, A Harun, F Sharmin
In Bangladesh incidence rate of breast cancer was about 22.5 per 100000 females. Breast cancer has been reported as the highest prevalence rate (19.3 per 100,000) among Bangladeshi women between 15 and 44 years of age. For this prevailing situation a cross-sectional study was designed to assess the knowledge, attitude and practices of community-dwelling women in Bangladesh towards breast cancer at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from July 2013 to June 2014. All female participants attending at outpatient department of BSMMU having age more than 20 years and education at least JSC, purposively selected until the sample size achieved 500...
January 2019: Mymensingh Medical Journal: MMJ
Thierry Léveillard, Nancy J Philp, Florian Sennlaub
The retinal pigment epithelium (RPE) forms the outer blood⁻retina barrier and facilitates the transepithelial transport of glucose into the outer retina via GLUT1. Glucose is metabolized in photoreceptors via the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS) but also by aerobic glycolysis to generate glycerol for the synthesis of phospholipids for the renewal of their outer segments. Aerobic glycolysis in the photoreceptors also leads to a high rate of production of lactate which is transported out of the subretinal space to the choroidal circulation by the RPE...
February 11, 2019: International Journal of Molecular Sciences
Andrea Petrella, Glen Belfry, Matthew Heath
Ten minutes of aerobic or resistance training can 'boost' executive function in older adults. Here, we examined whether the magnitude of the exercise benefit is influenced by exercise intensity. Older adults (N=17: mean age=73 years) completed a volitional test to exhaustion (VO2peak ) via treadmill to determine participant-specific moderate (80% of lactate threshold (LT)), heavy (15% of the difference between LT and VO2peak ) and very-heavy (50% of the difference between LT and VO2peak ) exercise intensities...
February 9, 2019: Brain Research
Sha Tao, Geoffrey E Dahl, Jimena Laporta, John K Bernard, Ruth M Orellana Rivas, Thiago N Marins
Heat stress during late gestation in cattle negatively impacts the performance of the dam and its calf. This brief exposure to an adverse environment before parturition impacts the physiological responses, tissue development, metabolism and immune function of the dam and her offspring, thereby limiting their productivity. During the dry period of a dairy cow, heat stress blunts mammary involution by attenuating mammary apoptosis and autophagic activity, and reduces subsequent mammary cell proliferation, leading to impaired milk production in the next lactation...
February 11, 2019: Journal of Animal Science
Ruoyu Zhang, Thomas Kyriss, Jürgen Dippon, Enole Boedeker, Godehard Friedel
OBJECTIVES: Despite the positive effects of a thoracoscopic approach on improving postoperative outcomes, the risk of major complications following thoracoscopic lobectomy is not negligible. We sought to assess the usefulness of the preoperative determination of serum biomarkers to refine risk stratification in this patient population. METHODS: From 2009 to 2017, 626 patients (285 women, 341 men; median age: 67 years) underwent thoracoscopic lobectomy or anatomical segmentectomy for confirmed or suspected early-stage lung cancer or metastasis at our institution...
February 11, 2019: European Journal of Cardio-thoracic Surgery
Abdullah Yazar, Fatih Akin, Ahmet Sert, Esra Türe, Cemile Topcu, Alaaddin Yorulmaz, Fatih Ercan
OBJECTIVE: Carbon monoxide poisoning (COP) is the leading cause of mortality and morbidity due to poisoning worldwide. Because children are affected more quick and severely from COP, they may require a longer treatment period, even if carboxyhemoglobin (CO-Hb) and/or lactate levels return to normal. Therefore, a new marker that predicts the duration of treatment and the final outcomes of COP is needed. METHODS: This case control study was conducted on 32 carbon monoxide-poisoned patients younger than 18 years who had been admitted to pediatric emergency department...
February 8, 2019: Pediatric Emergency Care
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