Sahereh Mirzaei, Holli A DeVon, Rita M Cantor, Arjen J Cupido, Calvin Pan, Sung Min Ha, Lilian Fernandes Silva, James R Hilser, Jaana Hartiala, Hooman Allayee, Federico E Rey, Markku Laakso, Aldons J Lusis
The role of gut microbe-derived metabolites in the development of metabolic syndrome (MetS) remains unclear. This study aimed to evaluate the associations of gut microbe-derived metabolites and MetS traits in the cross-sectional Metabolic Syndrome In Men (METSIM) study. The sample included 10,194 randomly related men (age 57.65 ± 7.12 years) from Eastern Finland. Levels of 35 metabolites were tested for associations with 13 MetS traits using lasso and stepwise regression. Significant associations were observed between multiple MetS traits and 32 metabolites, three of which exhibited particularly robust associations...
March 20, 2024: Metabolites