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Rodolfo Patussi Correia, Flávia Amoroso Matos E Silva, Nydia Strachman Bacal, Paulo Vidal Campregher, Nelson Hamerschlak, Gustavo Pessini Amarante-Mendes
Background: Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic B cells, participating in their expansion, differentiation and survival. Chronic lymphocytic leukemia B cells may also drive functional and phenotypic changes of non-malignant T cells. There are few data about the association between memory T cells and prognosis, especially related to ZAP-70, a common reliable surrogate of the gold standard chronic lymphocytic leukemia prognostic markers...
October 2018: Hematology, transfusion and cell therapy
Laiz Cameirão Bento, Rodolfo Patussi Correia, Anderson Marega Alexandre, Sonia Tsukasa Nosawa, Eduardo de Carvalho Pedro, Andressa da Costa Vaz, Daniela Schimidell, Gustavo Bruniera Peres Fernandes, Carlos Augusto Senne Duarte, Rodrigo de Souza Barroso, Nydia Strachman Bacal
Introduction: Infiltration of the central nervous system (CNS) by hematologic or lymphoid malignant cells can cause extensive neurological damage, be progressive and fatal. However, usually, the cerebrospinal fluid (CSF) has low cellularity and rapid cell degeneration, which can impair cytometry analysis. Storage and transport measures, sample preparation, and staining protocols can interfere with diagnostic accuracy. Objective: To calculate the diagnostic performance of flow cytometry (FC) using a cell stabilizer for sample preservation compared to cytomorphology in the detection of CNS infiltration by lymphoid and hematologic neoplasms...
2018: Frontiers in Medicine
Laiz Cameirão Bento, Rodolfo Patussi Correia, Cristóvão Luis Pitangueiras Mangueira, Rodrigo De Souza Barroso, Fernanda Agostini Rocha, Nydia Strachman Bacal, Luciana Cavalheiro Marti
Myelodysplastic syndromes (MDSs) are a heterogeneous group of hematopoietic stem cell diseases categorized by dysplasia in one or more hematopoietic cell lineages, as well as cytopenia and functional abnormalities in bone marrow cells. Several MDS classification methods have been proposed to categorize the disease and help professionals better plan in patients' treatment. The World Health Organization classification, released in 2008 and revised in 2016, is the currently and the most used classification method worldwide...
2017: Frontiers in Oncology
Rodolfo Patussi Correia, Laiz Cameirão Bento, Ana Carolina Apelle Bortolucci, Anderson Marega Alexandre, Andressa da Costa Vaz, Daniela Schimidell, Eduardo de Carvalho Pedro, Fabricio Simões Perin, Sonia Tsukasa Nozawa, Cláudio Ernesto Albers Mendes, Rodrigo de Souza Barroso, Nydia Strachman Bacal
Objective: To discuss the implementation of technical advances in laboratory diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria for validation of high-sensitivity flow cytometry protocols. Methods: A retrospective study based on analysis of laboratory data from 745 patient samples submitted to flow cytometry for diagnosis and/or monitoring of paroxysmal nocturnal hemoglobinuria. Results: Implementation of technical advances reduced test costs and improved flow cytometry resolution for paroxysmal nocturnal hemoglobinuria clone detection...
July 2016: Einstein
Welbert Oliveira Pereira, Rodolfo Patussi Correia, Nelson Hamerschlak, Nydia Strachman Bacal, Paulo Vidal Campregher
No abstract text is available yet for this article.
March 8, 2016: Einstein
Paulo Augusto Achucarro Silveira, Elvira Deolinda Rodrigues Pereira Velloso, Marjorie Paris Colombini, João Carlos de Campos Guerra, Nydia Strachman Bacal, Alanna Mara Pinheiro Sobreira Bezerra, Denise da Cunha Pasqualin
No abstract text is available yet for this article.
June 2011: Einstein
Elvira Deolinda Rodrigues Pereira Velloso, Carlos Henrique Ares Silveira da Motta, Juliana Braga Furtado, Nydia Strachman Bacal, Paulo Augusto Achucarro Silveira, Cynthia Bachir Moyses, Roberta Sitnik, João Renato Rebello Pinho
OBJECTIVE: To study the frequency of mutations that may lead to a good or bad prognosis, as well as their relation with the karyotype and immunophenotype in patients with acute myeloid leukemia. METHODS: Thirty samples of patients with acute myeloid leukemia were studied, in which FLT3-ITD, FLT3-TKD and NPM1 mutations were investigated. All samples were submitted to immunophenotyping and 25 to karyotyping. RESULTS: An occurrence of 33.3% NPM1 mutation and an equal number of FLT3-ITD mutation were observed...
June 2011: Einstein
Alanna Mara Pinheiro Sobreira Bezerra, Denise da Cunha Pasqualin, João Carlos de Campos Guerra, Marjorie Paris Colombini, Elvira Deolinda Rodrigues Pereira Velloso, Paulo Augusto Achucarro Silveira, Cristovão Luis Pitangueira Mangueira, Ruth Hissae Kanayama, Sonia Tsukasa Nozawa, Rodolfo Correia, Ana Carolina Apelle, Welbert de Oliveira Pereira, Rodrigo Gobbo Garcia, Nydia Strachman Bacal
OBJECTIVE: To demonstrate the advantages of correlating flow cytometry immunophenotyping with the pathology/ immunohistochemistry of lymph nodes or nodules in the diagnosis of lymphoproliferative diseases. METHODS: A retrospective study was carried out of 157 biopsy or fine-needle aspiration lymph nodes/ nodule specimens taken from 142 patients, from 1999 and 2009. The specimens were simultaneously studied with fow cytometry and pathology at Hospital Israelita Albert Einstein...
June 2011: Einstein
João Carlos de Campos Guerra, Ruth Hissae Kanayama, Sonia Tsukasa Nozawa, Márcia Regina Ioshida, Irina Yoko Takiri, Robson José Lazaro, Nelson Hamerschlak, Luiz Gastão Mange Rosenfeld, Celso Carlos de Campos Guerra, Nydia Strachman Bacal
OBJECTIVE: To identify antiplatelet antibodies by flow cytometry (direct method) in patients with thrombocytopenia. METHODS: Between January 1997 and March 2004 a total of 15100 patients were referred to the Centro de Hematologia de São Paulo for hematological investigation of several diagnoses (anemia, leukopenia, thrombocytopenia, coagulation abnormalities, adenomegaly, leukemia and others). Of those, 1057 were referred because of thrombocytopenia and were divided into two groups: Group Idiopathic thrombocytopenic purpura, with no identifiable cause; and Group Other thrombocytopenia, which included low normal platelet counts cause to be established, hepatitis C and HIV infection, hypersplenism, EDTA-induced artifacts, laboratory error, and other causes...
June 2011: Einstein
Rodolfo Patussi Correia, Flávia Amoroso Matos Silva, Nydia Strachman Bacal, Paulo Vidal Campregher, Nelson Hamerschlak, Gustavo P Amarante-Mendes
No abstract text is available yet for this article.
January 2014: Revista Brasileira de Hematologia e Hemoterapia
Rodolfo Patussi Correia, Flávia Amoroso Matos E Silva, Nydia Strachman Bacal, Paulo Vidal Campregher, Nelson Hamerschlak, Gustavo P Amarante-Mendes
The role of T-cells in the pathogenesis of chronic lymphocytic leukemia has recently gained much attention due to the importance of the constant interaction between neoplastic B-cells with microenvironment substratum and T-cells. It is believed that these interactions modulate the clinical course of the disease, mainly through the regulation of the expansion, differentiation, and survival of chronic lymphocytic leukemia B-cells. Importantly, this crosstalk may also change the number, function, and memory phenotype of normal T-cells, thereby altering the amplitude and/or efficiency of adaptive immunity in chronic lymphocytic leukemia patients...
2014: Revista Brasileira de Hematologia e Hemoterapia
Welbert de Oliveira Pereira, Nydia Strachman Bacal, Rodolfo Patussi Correia, Ruth Hissae Kanayama, Elvira Deolinda Veloso, Daniela Borri, Nelson Hamerschlak, Paulo Vidal Campregher
BACKGROUND: Cancer development results from the progressive accumulation of genomic abnormalities that culminate in the neoplastic phenotype. Cytogenetic alterations, mutations and rearrangements may be considered as molecular legacy which trace the clonal history of the disease. Concomitant tumors are reported and they may derive from a common or divergent founder clone. B-cell chronic lymphocytic leukemia (B-CLL) and plasma cell myeloma (PCM) are both mature B-cell neoplasms, and their concomitancy, albeit rare, is documented...
2013: BMC Research Notes
Shelly L Gable, Courtney L Gosnell, Natalya C Maisel, Amy Strachman
Previous research has shown that receiving social support in the face of negative events (i.e., enacted support) is sometimes correlated with positive outcomes, sometimes unrelated to outcomes, and sometimes associated with negative outcomes. However, people's perception that they have high-quality support available to them when they have a stressor (i.e., perceived support) is consistently and strongly associated with better health, well-being, and relationship functioning. However, both enacted and perceived support available in response to positive event disclosures are consistently associated with positive outcomes...
December 2012: Journal of Personality and Social Psychology
Sandra M Stith, Marjorie Strachman Miller, Jeremy Boyle, Jonathan Swinton, Gary Ratcliffe, Eric McCollum
This article describes a clinical investigation of student-therapists' use of the miracle question (MQ). Data used for this project came from transcribed role-play videotapes by six student-therapists. Transcripts were coded, and findings highlight challenges that prevent beginning therapists from effectively using the MQ. The primary themes that emerged were problems related to introducing, framing, and following up on the MQ. Practical recommendations are offered for improving therapist training in effective use of the MQ...
April 2012: Journal of Marital and Family Therapy
Sandra L Shallcross, Maryhope Howland, Jenna Bemis, Jeffry A Simpson, Patricia Frazier
Capitalization interactions, in which partners share positive events, typically produce positive relationship outcomes (Gable, Gonzaga, & Strachman, 2006). However, the limiting conditions of these interactions have not been examined. In this study, 101 dating couples discussed a positive event in the life of each partner. Ratings of perceived responsiveness were made by both the romantic partner who disclosed a positive event and his/her responding partner. Trained observers then rated each videotaped interaction...
February 2011: Journal of Family Psychology: JFP
Amy Strachman, Emily A Impett, James Matthew Henson, Mary Ann Pentz
PURPOSE: The current study examined the long-term relationship of early adolescent alcohol use to number of sexual partners by emerging adulthood. METHODS: Using data from a 10-year longitudinal study, we collected data on sixth- and seventh-grade students' alcohol use and their lifetime number of sexual partners 10 years later. RESULTS: We found a significant effect of early alcohol use in the sixth and seventh grades on lifetime number of sexual partners 10 years later, controlling for gender, age, race, peer norms, and sensation seeking...
November 2009: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Amy Strachman, Emily A Impett
This daily experience study examined the roles of attachment orientations and daily relationship satisfaction in shaping daily condom use among college students in dating relationships. Seventy-five participants completed an initial measure of attachment orientation and then reported their relationship satisfaction and condom use each day for 14 consecutive days. The results showed that attachment anxiety was associated with less frequent use of condoms on a daily basis. Daily satisfaction was also associated with a decreased likelihood of using condoms, and this association was stronger for those high in attachment anxiety and mitigated for participants high in attachment avoidance...
July 2009: Journal of Sex Research
No abstract text is available yet for this article.
March 1948: Federation Proceedings
Emily At Impett, Amy Strachman, Eli J Finkel, Shelly L Gable
Three studies tested whether adopting strong (relative to weak) approach goals in relationships (i.e., goals focused on the pursuit of positive experiences in one's relationship such as fun, growth, and development) predict greater sexual desire. Study 1 was a 6-month longitudinal study with biweekly assessments of sexual desire. Studies 2 and 3 were 2-week daily experience studies with daily assessments of sexual desire. Results showed that approach relationship goals buffered against declines in sexual desire over time and predicted elevated sexual desire during daily sexual interactions...
May 2008: Journal of Personality and Social Psychology
Shelly L Gable, Gian C Gonzaga, Amy Strachman
Close relationship partners often share successes and triumphs with one another, but this experience is rarely the focus of empirical study. In this study, 79 dating couples completed measures of relationship well-being and then participated in videotaped interactions in which they took turns discussing recent positive and negative events. Disclosers rated how understood, validated, and cared for they felt in each discussion, and outside observers coded responders' behavior. Both self-report data and observational codes showed that 2 months later, responses to positive event discussions were more closely related to relationship well-being and break-up than were responses to negative event discussions...
November 2006: Journal of Personality and Social Psychology
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