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Alyssa Azaroff, Emmanuel Tessier, Jonathan Deborde, Rémy Guyoneaud, Mathilde Monperrus
Submarine canyons are important stocks of commercial interest fish, whose consumption is one of the main monomethymercury (MeHg) exposure to humans. Currently, biogeochemistry of mercury in those biologically productive system is unknown. In this work, inorganic mercury (Hg(II)) and organic mercury (MeHg) distributions were measured in sedimentary accumulative zones (slopes and terraces) against adjacent continental shelf sediments. Hg compound concentrations in these sediments show a huge range of concentrations (Hg(II) ranging from 18 to 973 ng g-1 and MeHg ranging from 0...
April 10, 2019: Science of the Total Environment
Huimin Sun, Jiang Jiang, Lina Cui, Wenting Feng, Yugang Wang, Jinchi Zhang
Mangrove and salt marsh ecosystems are one of the most productive ecosystems in terrestrial ecosystems, playing an important role in global carbon (C) cycling. The anaerobic condition in coastal wetland usually impedes the decomposition of soil organic carbon (SOC). However, the intrinsic stabilization mechanisms of SOC other than environmental factors are poorly understood in coastal wetland. In this paper, we investigated the relative contribution of mineral association and chemical compounds in maintaining the stabilization of SOC in the mangrove/salt marsh ecotone, and how the microbial community is involved in the stabilization...
April 10, 2019: Science of the Total Environment
Yin-Hui Huang, Qing-Mei Ge, Yong-Yi Zhao, Hang Cong, Jiang-Lin Zhao, Zhu Tao, Qing-Ying Luo
Fluorescent chemosensors based on a new macrocyclic compound, multifarene[2,2], with modification by triazole-linked pyrene or anthracene were synthesized. These macrocyclic sensors exhibited high affinity and selectivity toward Ag+ over other metal ions, with ratiometric or enhanced response of their fluorescence emissions depending upon the substituent species for coordination to Ag+ , and an unexpected response to a concentration threshold of the metal cations was discovered. The experimental evidences of fluorescence spectra, 1 H NMR titration, IR spectra, and high-resolution mass spectra suggested the coordination behaviors of the sensors with Ag+ , that is, the 1:1 complexes were formed with moderate association constants of about 105  L·mol-1 , and the sulfur atoms on macrocyclic ligand should affinite to the metal cations...
April 9, 2019: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Ofelia R Alzueta, M Consuelo Cuquerella, Miguel A Miranda
2'-Methoxyacetophenone (2M) presents improved UVA absorption as compared with other acetophenone derivatives. On the basis of transient infrared spectroscopy it has been previously claimed that 2M is an interesting photosensitiser for cyclobutane pyrimidine dimers (CPDs) formation. In the present paper, a complete UV-Vis transient absorption spectroscopic characterisation of this compound is provided, including triplet-triplet spectra, triplet lifetimes and rate constants for quenching of 2M by a dimeric thymine derivative...
April 6, 2019: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Manesh Nautiyal, Steff De Graef, Luping Pang, Bharat Gadakh, Sergei V Strelkov, Stephen D Weeks, Arthur Van Aerschot
Aminoacyl-tRNA synthetases (aaRSs) catalyse the ATP-dependent coupling of an amino acid to its cognate tRNA. Being vital for protein translation aaRSs are considered a promising target for the development of novel antimicrobial agents. 5'-O-(N-aminoacyl)-sulfamoyl adenosine (aaSA) is a non-hydrolysable analogue of the aaRS reaction intermediate that has been shown to be a potent inhibitor of this enzyme family but is prone to chemical instability and enzymatic modification. In an attempt to improve the molecular properties of this scaffold we synthesized a series of base substituted aaSA analogues comprising cytosine, uracil and N3 -methyluracil targeting leucyl-, tyrosyl- and isoleucyl-tRNA synthetases...
April 5, 2019: European Journal of Medicinal Chemistry
Wan-Yin Fang, L Ravindar, K P Rakesh, H M Manukumar, C S Shantharam, Njud S Alharbi, Hua-Li Qin
At present more than 250 FDA approved chlorine containing drugs were available in the market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is quite obvious to expect that in coming decades there will be an even greater number of new chlorine-containing pharmaceuticals in market. Chlorinated compounds represent the family of compounds promising for use in medicinal chemistry. This review describes the recent advances in the synthesis of chlorine containing heterocyclic compounds as diverse biological agents and drugs in the pharmaceutical industries for the inspiration of the discovery and development of more potent and effective chlorinated drugs against numerous death-causing diseases...
April 10, 2019: European Journal of Medicinal Chemistry
Liang Li, Wenpeng Zhang, Feng Lin, Xinqiang Lu, Wei Chen, Xingzhou Li, Xinbo Zhou, Ruibin Su, Lili Wang, Zhibing Zheng, Song Li
A series of new pyrazolo[3,4-b]pyridin-3-yl pyrimidine derivatives were synthesized and evaluated for the activation of sGC. Compared with riociguat, compound 13a exhibited equivalent in vitro activity on preconstricted rat thoracic aorta rings and in Rat heart Langendorff preparation. Compound 13a also showed acceptable PK profiles, which might become a promising candidate for the treatment of pulmonary hypertension.
April 10, 2019: European Journal of Medicinal Chemistry
Cheng-Neng Mi, Wen-Li Mei, Hao Wang, Li Yang, Wen-Hua Dong, Cui-Juan Gai, Jing-Zhe Yuan, Wen-Xing Long, Hao-Fu Dai
Six 8,12-epoxyguaiane sesquiterpenes (1-6), together with two known 2-(2-phenylethyl)chromone derivatives (7-8) were isolated from agarwood originating from Aquilaria filaria. Their structures were established by spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR, and comparison with the published data. The absolute configuration of compound 1 was unambiguously determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum. All compounds were tested for their α-glucosidase inhibitory activity and cytotoxicity...
April 14, 2019: Fitoterapia
Guolin Yang, Yan Wang, Yiyi Yu, Jing Zheng, Juan Chen, Shaoheng Li, Ruoyun Chen, Chunlei Zhang, C Benjamin Naman, Dequan Yu, Zhengyu Cao
Schefflera kwangsiensis Merr. ex H.L. Li (Araliaceae) is a widely used traditional Chinese medicine for pain management in the clinic. In the present study, we isolated a previously undescribed lupane saponin, designated as schekwanglupaside C (Sch C) from the ethanolic extract of S. kwangsiensis. The structure of Sch C was determined by comprehensive spectroscopic and spectrometric analyses and chemical degradation. In primary cultured cortical neurons, Sch C altered the pattern of spontaneous Ca2+ oscillation (SCO) with a slight increase in the frequency of SCO right after addition and a gradual decrease in the frequency and amplitude of SCO, that dynamic change mimicked by an activator of sarcoplasmic reticulum Ca2+ -ATPase (SERCA)...
April 14, 2019: Fitoterapia
Thuc-Huy Duong, Mehdi A Beniddir, Grégory Genta-Jouve, Huu-Hung Nguyen, Dinh-Phuoc Nguyen, Thi-Anh-Tuyet Nguyen, Dinh-Hung Mac, Joël Boustie, Kim-Phi-Phung Nguyen, Warinthorn Chavasiri, Pierre Le Pogam
The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated 13 C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports...
April 14, 2019: Fitoterapia
Sima Habibi, Majid Zaki-Dizaji, Hosein Rafiemanesh, Bernice Lo, Mahnaz Jamee, Laura Gámez-Díaz, Fereshte Salami, Ali N Kamali, Hamed Mohammadi, Hassan Abolhassani, Reza Yazdani, Asghar Aghamohammadi, Juan-Manuel Anaya, Gholamreza Azizi
BACKGROUND: LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency and immune dysregulation syndrome caused by biallelic mutations in the LRBA gene. These mutations usually abrogate the protein expression of LRBA, leading to a broad spectrum of clinical phenotypes including autoimmunity, chronic diarrhea, hypogammaglobulinemia and recurrent infections. OBJECTIVE: Our aim was to systematically collect all studies reporting on the clinical manifestations, molecular and laboratory findings, and management of patients with LRBA deficiency...
April 14, 2019: Journal of Allergy and Clinical Immunology in Practice
Xu-Zhi Wan, Tian-Tian Li, Ru-Ting Zhong, Hong-Bin Chen, Xue Xia, Lu-Ying Gao, Xiao-Xiang Gao, Bin Liu, Hui-Ying Zhang, Chao Zhao
The contributions to hypoglycemic function and gut microbiota regulation by water and ethanol extracts of the microalgae Chlorella pyrenoidosa and Spirulina platensis were determined. An ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry analysis indicated that most of the compounds in the 55% ethanol extracts of C. pyrenoidosa (CP55) and S. platensis (SP55) were polyunsaturated fatty acids. After an 8-week high-fat high-sucrose diet with C. pyrenoidosa and S...
April 14, 2019: Food and Chemical Toxicology
Rita de Cássia O Collaço, Stephen Hyslop, Valquíria Ac Dorce, Edson Antunes, Edward G Rowan
Scorpionism is frequently accompanied by a massive release of catecholamines and acetylcholine from peripheral nerves caused by neurotoxic peptides present in these venoms, which have high specificity and affinity for ion channels. Tityus bahiensis (T. bahiensis) is the second most medically important scorpion species in Brazil but, despite this, its venom remains scarcely studied, especially with regard to its pharmacology on peripheral (somatic and autonomic) nervous system. Here, we evaluated the activity of T...
April 14, 2019: Neuropharmacology
Nicolas Levy, Jean-Michel Bruneau, Erwann Le Rouzic, Damien Bonnard, Frederic Le Strat, Audrey Caravano, Francis Chevreuil, Julien Barbion, Sophie Chasset, Benoît Ledoussal, François Moreau, Marc Ruff
Penicillin-binding proteins (PBPs) are the targets of the β-lactams, the most successful class of antibiotics ever developed against bacterial infections. Unfortunately, the worldwide and rapid spread of large spectrum β-lactam resistance genes such as carbapenemases is detrimental to the use of antibiotics in this class. New potent PBP inhibitors are needed, especially compounds that resist β-lactamase hydrolysis. Here we describe the structure of the E. coli PBP2 in its Apo form and upon its reaction with 2 diazabicyclo derivatives, Avibactam and CPD4, a new potent PBP2 inhibitor...
April 17, 2019: Journal of Medicinal Chemistry
Kenneth K Laali, Angela Zwarycz, Scott Bunge, Gabriela Borosky, Manabu Nukaya, Gregory Kennedy
A series of deuterated curcuminoids were synthesized, bearing two to six OCD3 groups, in some cases in combination with OCH3 groups, and in others together with fluorines. A model ring deuterated hexamethoxy-CUR-BF2 and its corresponding CUR compound were also synthesized form a 2,4,6-trimethoxybenzaldehyde-3,5-d2 precursor. As with their protio-analogues, the deuterated compounds remained exclusively in the keto-enolic form. The anti-proliferative activity of these compounds were studied by in-vitro bioassay against a panel of 60 cancer cell lines, and more specifically in human colorectal cancer (CRC) cells (HCT116, HT29, DLD-1, RKO, SW837, and Caco2) and in normal colon cells (CCD841CoN)...
April 17, 2019: ChemMedChem
Jang Ho Cho, Ju-Sun Kim, Seung Tae Kim, Jung Yong Hong, Joon Oh Park, Young Suk Park, Do-Hyun Nam, Dong Woo Lee, Jeeyun Lee
We aimed to establish a fluorescence intensity-based colony area sweeping method by selecting the area of highest viability among patient-derived cancer cells (PDC) which has high tumor heterogeneity. Five gastric cancer cell lines and PDCs were screened with 24 small molecule compounds using a 3D micropillar/microwell chip. 100 tumor cells per well were immobilized in alginate, treated with the compounds, and then stained and scanned for viable cells. Dose response curves and IC50 values were obtained based on total or selected area intensity based on fluorescence...
2019: PloS One
Mihnea Bostina
Picornaviruses are small, icosahedral, nonenveloped, positive-sense, single-stranded RNA viruses that form one of the largest and most important viral families. Numerous Picornaviridae members pose serious health or agricultural threats, causing diseases such as poliomyelitis, hepatitis A, or foot-and-mouth disease. The antigenic characterization of picornavirus capsids plays an important role in understanding the mechanism of viral neutralization and the conformational changes associated with genome release, and it can point to regions which can be targeted by small-molecule compounds to be developed as antiviral inhibitors...
April 17, 2019: PLoS Biology
Thomas P Ahern, Anne Broe, Timothy L Lash, Deirdre P Cronin-Fenton, Sinna Pilgaard Ulrichsen, Peer M Christiansen, Bernard F Cole, Rulla M Tamimi, Henrik Toft Sørensen, Per Damkier
PURPOSE: Phthalate exposure is ubiquitous and especially high among users of drug products formulated with phthalates. Some phthalates mimic estradiol and may promote breast cancer. Existing epidemiologic studies on this topic are small, mostly not prospective, and have given inconsistent results. We estimated associations between longitudinal phthalate exposures and breast cancer risk in a Danish nationwide cohort, using redeemed prescriptions for phthalate-containing drug products to measure exposure...
April 17, 2019: Journal of Clinical Oncology
Anjie Xia, Xueyu Qi, Xin Mao, Xiaoai Wu, Xin Yang, Rong Zhang, Zhiyu Xiang, Zhong Lian, Yingchun Chen, Shengyong Yang
A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction...
April 17, 2019: Organic Letters
Xiang Sun, Hong-Xing Ma, Tian-Sheng Mei, Ping Fang, Yulai Hu
Given the versatility and value of the structurally diverse organohalides and CF3 -containing compounds in organic synthesis, we reported a green, oxidant-free electrochemical method using undivided electrochemical cells for radical bromination, chlorination and trifluoromethylation-formyloxylation of the various alkenes with readily available halogen radical (NaCl, NaBr), trifluoromethyl radical (CF3 SO2 Na) sources, and DMF as formyloxylation reagents. The protocol is operationally simple and robust and the Cl- , Br- or CF3 - was directly oxidized at the anode, obviating the need for exogenous chemical oxidants...
April 17, 2019: Organic Letters
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