Shixin Chen, Jiangchu Lei, Haochen Mou, Wenkan Zhang, Lingxiao Jin, Senxu Lu, Eloy Yinwang, Yucheng Xue, Zhenxuan Shao, Tao Chen, Fangqian Wang, Shenzhi Zhao, Xupeng Chai, Zenan Wang, Jiahao Zhang, Zengjie Zhang, Zhaoming Ye, Binghao Li
Bone is a common organ for solid tumor metastasis. Malignant bone tumor becomes insensitive to systemic therapy after colonization, followed by poor prognosis and high relapse rate. Immune and bone cells in situ constitute a unique immune microenvironment, which plays a crucial role in the context of bone metastasis. This review firstly focuses on lymphatic cells in bone metastatic cancer, including their function in tumor dissemination, invasion, growth and possible cytotoxicity-induced eradication. Subsequently, we examine myeloid cells, namely macrophages, myeloid-derived suppressor cells, dendritic cells, and megakaryocytes, evaluating their interaction with cytotoxic T lymphocytes and contribution to bone metastasis...
2024: Frontiers in Immunology