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JOURNAL ARTICLE
Ana B Pavel, Carly Garrison, Lingqi Luo, Gang Liu, Daniel Taub, Ji Xiao, Brenda Juan-Guardela, John Tedrow, Yuriy O Alekseyev, Ivana V Yang, Mark W Geraci, Frank Sciurba, David A Schwartz, Naftali Kaminski, Jennifer Beane, Avrum Spira, Marc E Lenburg, Joshua D Campbell
Chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) are clinically and molecularly heterogeneous diseases. We utilized clustering and integrative network analyses to elucidate roles for microRNAs (miRNAs) and miRNA isoforms (isomiRs) in COPD and ILD pathogenesis. Short RNA sequencing was performed on 351 lung tissue samples of COPD (n = 145), ILD (n = 144) and controls (n = 64). Five distinct subclusters of samples were identified including 1 COPD-predominant cluster and 2 ILD-predominant clusters which associated with different clinical measurements of disease severity...
August 11, 2023: Scientific Reports
#22
JOURNAL ARTICLE
Teresa A Beam, Donald G Klepser, Michael E Klepser, David R Bright, Nicklas Klepser, Hannah Schuring, Stephanie Wheeler, Anna Langerveld
Community pharmacists serve a large, diverse population of patients, resulting in the potential to utilize community pharmacies as recruitment sites for clinical research. Beyond traditional roles as one of the most accessible health care professionals in the US healthcare system, pharmacists have played a major role in the response to the COVID-19 pandemic, administering hundreds of thousands of vaccines and tests. However, less emphasis is placed on the ability to leverage community pharmacies as research-focused partners for clinical studies...
June 14, 2023: Research in Social & Administrative Pharmacy: RSAP
#23
JOURNAL ARTICLE
Yu-Ting Zhu, Shuang-Yue Wu, Song Yang, Jie Ying, Lu Tian, Hong-Liang Xu, He-Ping Zhang, Hui Yao, Wei-Yu Zhang, Qin-Qin Jin, Yin-Ting Yang, Xi-Ya Jiang, Nan Zhang, Shun Yao, Shu-Guang Zhou, Guo Chen
BACKGROUND: Ovarian serous cystadenocarcinoma (OSC) is the most prevalent histological subtype of ovarian cancer (OV) and presents a serious threat to women's health. Anoikis is an essential component of metastasis, and tumor cells can get beyond it to become viable. The impact of anoikis on OSC, however, has only been the topic of a few studies. METHODS: The mRNA sequencing and clinical information of OSC came from The Cancer Genome Atlas Target Genotype-Tissue Expression (TCGA TARGET GTEx) dataset...
August 2023: Heliyon
#24
JOURNAL ARTICLE
Urvi Budhbhatti, Chaitanya Joshi, Ajay Chauhan, Deeptiben Bhatt, Chirag Parmar, Vishalbhai Damani, Amrutlal Patel
BACKGROUND: Alzheimer's Disease (AD) is the most common form of dementia, affecting cognitive and behavioral functions. AD is a complex disease resulting from the modest effect of gene interaction and environmental factors, as a result of which the exact pathogenesis is still unknown. AIM: The aim of the present study was to investigate the association between variants of 98 targeted genes with Alzheimer's disease phenotype. METHOD: A total of 98 genes from 32 AD cases and 11 controls were genotyped using the Haloplex target enrichment method and the PCR-RFLP approach...
August 4, 2023: Neuroscience Letters
#25
JOURNAL ARTICLE
Susana López-López, María José Romero de Ávila, María Julia González-Gómez, María Luisa Nueda, Victoriano Baladrón, Eva M Monsalve, José Javier García-Ramírez, María José M Díaz-Guerra
IL-13 signaling polarizes macrophages to a M2 alternatively activated phenotype, which regulates tissue repair and anti-inflammatory responses. However, an excessive activation of this pathway lead to severe pathologies, such as allergic airway inflammation and asthma. In this work, we identified NOTCH4 receptor as an important modulator of M2 macrophage activation. We show that the expression of NOTCH4 is induced by IL-13, mediated by Janus kinases and AP1 activity, probably mediated by IL-13Rα1 and IL-13Rα2 signaling pathway...
July 21, 2023: International Immunology
#26
Computational Intelligence And Neuroscience
[This retracts the article DOI: 10.1155/2022/5173836.].
2023: Computational Intelligence and Neuroscience
#27
JOURNAL ARTICLE
Diptika Tiwari, Saswati Sanyal Choudhury, Tina Nath, Sujoy Bose
INTRODUCTION: Notch signaling is crucial during pregnancy with ability to regulate angiogenesis and inflammatory response. Considering the enigmatic importance of Notch signaling in pregnancy including placenta development, gestational disorders and adverse pregnancy; we performed experimental analysis to identify the Notch receptor-ligands association with Preterm delivery (PTD) and linked complication. METHOD: A total of 245 cases [Term n = 135 and Preterm n = 110] were enrolled for the study from Northeast Indian Population...
August 2023: Placenta
#28
JOURNAL ARTICLE
Yuzhen Wang, Fanliang Zhang, Bin Yao, Linhao Hou, Zhao Li, Wei Song, Yi Kong, Yaxin Tan, Xiaobing Fu, Sha Huang
BACKGROUND: Eccrine sweat gland (SG) plays a crucial role in thermoregulation but exhibits very limited regenerative potential. Although SG lineage-restricted niches dominate SG morphogenesis and benefit SG regeneration, rebuilding niches in vivo is challenging for stem cell therapeutic applications. Hence, we attempted to screen and tune the critical niche-responding genes that dually respond to both biochemical and structural cues, which might be a promising strategy for SG regeneration...
2023: Burns and Trauma
#29
JOURNAL ARTICLE
Guannan Su, Liping Du, Hongsong Yu, Minghui Li, Ruocheng Huang, Xiaonan Yang, Detao Wang, Qing Wang, Peizeng Yang
DNA methylation is one of the important epigenetic mechanisms for modulating gene expression. By performing a genome-wide methylation association analysis of whole peripheral blood from 60 Vogt-Koyanagi-Harada disease (VKH) patients and 60 healthy controls, we depicted the global DNA methylation status of VKH disease. Further pyrosequencing validation in 160 patients and 159 controls identified 3 aberrant CpG sites in HLA gene regions including cg04026937 and cg18052547 (located in HLA-DRB1 region), and cg13778567 (HLA-DQA1)...
June 30, 2023: Experimental Eye Research
#30
JOURNAL ARTICLE
Saicharan Ghantasala, Amruth Bhat, Unnati Agarwal, Deeptarup Biswas, Prawesh Bhattarai, Sridhar Epari, Aliasgar Moiyadi, Sanjeeva Srivastava
BACKGROUND: Fluorescence-guided surgery (FGS) using 5-aminolevulinic acid (5-ALA) as adjunct for high-grade gliomas (HGGs) has been on the rise in recent years. Despite being largely effective, we observed multiple histologically similar sub-regions of the same tumor from a few individuals with varying protoporphyrin IX (PpIX) levels. The current study aims at understanding the proteomic changes driving differential metabolism of 5-ALA in HGGs. METHODS: Biopsies were histologically and biochemically assayed...
2023: Neuro-oncology advances
#31
JOURNAL ARTICLE
Bin Zhang, Shaowei Dong, Jian Wang, Tuxiong Huang, Pan Zhao, Jing Xu, Dongcheng Liu, Li Fu, Lingwei Wang, Guangsuo Wang, Chang Zou
Resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI) remains one of the major challenges in lung adenocarcinoma (LUAD) therapy. Here, we find an increased frequency of the L12_16 amino acid deletion mutation in the signal peptide region of NOTCH4 (NOTCH4ΔL12_16 ) in EGFR-TKI-sensitive patients. Functionally, exogenous induction of NOTCH4ΔL12_16 in EGFR-TKI -resistant LUAD cells sensitizes them to EGFR-TKIs. This process is mainly mediated by the reduction of the intracellular domain of NOTCH4 (NICD4) caused by the NOTCH4ΔL12_16 mutation, which results in a lower localization of NOTCH4 in the plasma membrane...
June 2, 2023: Nature Communications
#32
JOURNAL ARTICLE
Lawrence Huang, Feng Cheng, Xuetao Zhang, Jacek Zielonka, Matthew A Nystoriak, Weiwei Xiang, Kunal Raygor, Shaoxun Wang, Aditya Lakshmanan, Weiya Jiang, Sai Yuan, Kevin S Hou, Jiayi Zhang, Xitao Wang, Arsalan U Syed, Matea Juric, Takamune Takahashi, Manuel F Navedo, Rong A Wang
Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4*EC ), we show decreased arteriolar tone in vivo during brain AVM initiation. Reduced vascular tone is a primary effect of Notch4*EC , as isolated pial arteries from asymptomatic mice exhibited reduced pressure-induced arterial tone ex vivo. The nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-l-arginine (L-NNA) corrected vascular tone defects in both assays...
May 26, 2023: Science Advances
#33
REVIEW
Yongqing Liu, Pengbo Hu, Liang Xu, Xiuyuan Zhang, Zhou Li, Yiming Li, Hong Qiu
Gastric cancer is the fifth most prevalent cancer and the fourth leading cause of cancer death globally. Delayed diagnosis and pronounced histological and molecular variations increase the complexity and challenge of treatment. Pharmacotherapy, which for a long time was systemic chemotherapy based on 5-fluorouracil, is the mainstay of management for advanced gastric cancer. Trastuzumab and programmed cell death 1 (PD-1) inhibitors have altered the therapeutic landscape, contributing to noticeably prolonged survivorship in patients with metastatic gastric cancer...
April 13, 2023: Cancers
#34
JOURNAL ARTICLE
Eric Hjalmarsson, Marianne Petro, Susanna Kumlien Georén, Ola Winqvist, Lars Olaf Cardell
BACKGROUND: Allergic rhinitis (AR) is a chronic disease with high prevalence. There are currently many treatments available. However, despite an often good therapeutic response, many patients still report impairment in quality of life (QoL) during the pollen season. A skewed T helper (Th)2 polarization is a well-acknowledged pathologic feature of AR. In animal models, local notch signaling in peripheral tissue seems crucial for Th2 cell differentiation and the development of AR. However, the involvement of Notch signaling in Th2 cell differentiation and the development of AR in humans remains unknown...
May 14, 2023: Allergy, Asthma, and Clinical Immunology
#35
JOURNAL ARTICLE
Cheng Qian, Ye Sun, Sichen Di, Hongru Wang, Yijun Tian, Chao Wang, Xingang Cui
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a highly heterogeneous tumor and is the most common subtype of renal cell carcinoma (RCC). Surgery is used to cure most early ccRCC, but the 5-year overall survival (OS) of ccRCC patients is far from satisfactory. Thus, new prognostic features and therapeutic targets for ccRCC need to be identified. Since complement factors can influence tumor development, we aimed to develop a model to predict the prognosis of ccRCC through complement-related genes...
April 28, 2023: Translational Andrology and Urology
#36
JOURNAL ARTICLE
Yuan Tian, Peipei Zhang, Yajun Mou, Wenxiu Yang, Junhong Zhang, Qing Li, Xiaowei Dou
Elucidation of individual Notch protein biology in specific cancer is crucial to develop safe, effective, and tumor-selective Notch-targeting therapeutic reagents for clinical use [1]. Here, we explored the Notch4 function in triple-negative breast cancer (TNBC). We found that silencing Notch4 enhanced tumorigenic ability in TNBC cells via upregulating Nanog expression, a pluripotency factor of embryonic stem cells. Intriguingly, silencing Notch4 in TNBC cells suppressed metastasis via downregulating Cdc42 expression, a key molecular for cell polarity formation...
May 6, 2023: Cell Death Discovery
#37
JOURNAL ARTICLE
Marlena Brzozowa-Zasada, Adam Piecuch, Marek Michalski, Natalia Matysiak, Marek Kucharzewski, Marek J Łos
The Notch signalling pathway is one of the most conserved and well-characterised pathways involved in cell fate decisions and the development of many diseases, including cancer. Among them, it is worth noting the Notch4 receptor and its clinical application, which may have prognostic value in patients with colon adenocarcinoma. The study was performed on 129 colon adenocarcinomas. Immunohistochemical and fluorescence expression of Notch4 was performed using the Notch4 antibody. The associations between the IHC expression of Notch4 and clinical parameters were analysed using the Chi2 test or Chi2 Yatesa test...
April 19, 2023: International Journal of Molecular Sciences
#38
JOURNAL ARTICLE
Joel T Rämö, Erik Abner, Elon H C van Dijk, Xin Wang, Joost Brinks, Tiit Nikopensius, Margit Nõukas, Heidi Marjonen, Kaisa Silander, Sakari Jukarainen, Tuomo Kiiskinen, Seung Hoan Choi, Risto Kajanne, Juha Mehtonen, Priit Palta, Steven A Lubitz, Kai Kaarniranta, Lucia Sobrin, Mitja Kurki, Suzanne Yzer, Patrick T Ellinor, Tõnu Esko, Mark J Daly, Anneke I den Hollander, Aarno Palotie, Joni A Turunen, Camiel J F Boon, Elizabeth J Rossin
IMPORTANCE: Central serous chorioretinopathy (CSC) is a serous maculopathy of unknown etiology. Two of 3 previously reported CSC genetic risk loci are also associated with AMD. Improved understanding of CSC genetics may broaden our understanding of this genetic overlap and unveil mechanisms in both diseases. OBJECTIVE: To identify novel genetic risk factors for CSC and compare genetic risk factors for CSC and AMD. DESIGN, SETTING, AND PARTICIPANTS: Using International Classification of Diseases, Ninth (ICD-9) and Tenth (ICD-10) Revision code-based inclusion and exclusion criteria, patients with CSC and controls were identified in both the FinnGen study and the Estonian Biobank (EstBB)...
April 20, 2023: JAMA Ophthalmology
#39
JOURNAL ARTICLE
Hao Yu Chen, Christian Dina, Aeron M Small, Christian M Shaffer, Rebecca T Levinson, Anna Helgadóttir, Romain Capoulade, Hans Markus Munter, Andreas Martinsson, Benjamin J Cairns, Linea C Trudsø, Mary Hoekstra, Hannah A Burr, Thomas W Marsh, Scott M Damrauer, Line Dufresne, Solena Le Scouarnec, David Messika-Zeitoun, Dilrini K Ranatunga, Rachel A Whitmer, Amélie Bonnefond, Garðar Sveinbjornsson, Ragnar Daníelsen, David O Arnar, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daníel F Gudbjartsson, Hilma Hólm, Jonas Ghouse, Morten Salling Olesen, Alex H Christensen, Susan Mikkelsen, Rikke Louise Jacobsen, Joseph Dowsett, Ole Birger Vesterager Pedersen, Christian Erikstrup, Sisse R Ostrowski, Christopher J O'Donnell, Matthew J Budoff, Vilmundur Gudnason, Wendy S Post, Jerome I Rotter, Mark Lathrop, Henning Bundgaard, Bengt Johansson, Johan Ljungberg, Ulf Näslund, Thierry Le Tourneau, J Gustav Smith, Quinn S Wells, Stefan Söderberg, Kári Stefánsson, Jean-Jacques Schott, Daniel J Rader, Robert Clarke, James C Engert, George Thanassoulis
AIMS: Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. METHODS AND RESULTS: A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European ancestry participants (13 765 cases) was performed. Seventeen loci were associated with AS at P ≤ 5 × 10-8, of which 15 replicated in an independent cohort of 90 828 participants (7111 cases), including CELSR2-SORT1, NLRP6, and SMC2...
April 11, 2023: European Heart Journal
#40
JOURNAL ARTICLE
Sara Ferreira Pires, Juliana Sobral de Barros, Silvia Souza da Costa, Marília de Oliveira Scliar, André Van Helvoort Lengert, Érica Boldrini, Sandra Regina Morini da Silva, Ljubica Tasic, Daniel Onofre Vidal, Ana Cristina Victorino Krepischi, Mariana Maschietto
DNA methylation may be involved in the development of osteosarcomas. Osteosarcomas commonly arise during the bone growth and remodeling in puberty, making it plausible to infer the involvement of epigenetic alterations in their development. As a highly studied epigenetic mechanism, we investigated DNA methylation and related genetic variants in 28 primary osteosarcomas aiming to identify deregulated driver alterations. Methylation and genomic data were obtained using the Illumina HM450K beadchips and the TruSight One sequencing panel, respectively...
April 5, 2023: Molecular Genetics and Genomics: MGG
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