Noriyuki Okubo, Shingo Sugawara, Tohru Fujiwara, Ko Sakatsume, Tsuyoshi Doman, Mihoko Yamashita, Kota Goto, Masaki Tateishi, Misako Suzuki, Ryutaro Shirakawa, Yuka Eura, Koichi Kokame, Masaki Hayakawa, Masanori Matsumoto, Yasunori Kawate, Mizuki Miura, Hiroshi Takiguchi, Yoshimitsu Soga, Shinichi Shirai, Kenji Ando, Yoshio Arai, Takaharu Nakayoshi, Yoshihiro Fukumoto, Hiroyuki Takahama, Satoshi Yasuda, Toshihiro Tamura, Shin Watanabe, Takeshi Kimura, Nobuhiro Yaoita, Hiroaki Shimokawa, Yoshikatsu Saiki, Koichi Kaikita, Kenichi Tsujita, Shinji Yoshii, Hiroshi Nakase, Shin-Ichi Fujimaki, Hisanori Horiuchi
BACKGROUND: Severe aortic stenosis (AS) causes acquired von Willebrand syndrome by the excessive shear stress-dependent cleavage of high molecular weight multimers of von Willebrand factor (VWF). While the current standard diagnostic method is so-called VWF multimer analysis that is western blotting under nonreducing conditions, it remains unclear whether a ratio of VWF Ristocetin co-factor activity (VWF:RCo) to VWF antigen levels (VWF:Ag) of <0.7, which can be measured with an automated coagulation analyzer in clinical laboratories and is used for the diagnosis of hereditary von Willebrand disease...
January 2024: Research and Practice in Thrombosis and Haemostasis